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E674Q(Shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease

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Genes & Diseases 2024年第2期11卷 1022-1034页

作者： Yongfang Zhang Xinyi Xie Boyu Chen Lina Pan Jianping Li Wanbing Wang Jintao Wang Ran Tang Qiang Huang Xiaofen Chen Rujing Ren Zhentao Zhang wei fu Gang Wang Department of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China Shenzhen Research Institute of Xiamen University ShenzhenGuangdong 518063China

Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PSEN1,and PSEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic ***,a novel missense mutation,APP E674Q(also named“Shanghai APP”),was detected in a Chinese index patient with typical late-onset AD(LOAD)who developed memory decline in his *** results from neuroimaging were consistent with AD,where widespread amyloidβdeposition was demonstrated in 18 F-florbetapir Positron Emission Tomography(PET).APP E674Q is close to theβ-secretase cleavage site and the well-studied Swedish APP mutation(KM670/671NL),which was predicted to be pathogenic in *** dynamics simulation indicated that the E674Q mutation resulted in a rearrangement of the interaction mode between APP and BACE1 and that the E674Q mutation was more prone to cleavage by *** in vitro results suggested that the E674Q mutation was pathogenic by facilitating the BACE1-mediated processing of APP and the production of Aβ.furthermore,we applied an adeno-associated virus(AAV)-mediated transfer of the human E674Q mutant APP gene to the hippocampi of two-month-old C57Bl/6 J ***-E674Q-injected mice exhibited impaired learning behavior and increased pathological burden in the brain,implying that the E674Q mutation had a pathogenicity that bore a comparison with the classical Swedish ***,we report a strong amyloidogenic effect of the E674Q substitution in *** our knowledge,E674Q is the only pathogenic mutation within the amyloid processing sequence causing LOAD.

关键词： Alzheimer's disease Amyloid beta APP mutation E674Q Late onset

Development of a MWDC prototype of the CSR external-target experiment

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-14页

作者： He, Zhou-Bo Qin, Zhi Ma, Peng Yang, He-Run wei, Xiang-Lun Lu, Chen-Gui Wen, Xiang-Jie Zhang, Xiu-Ling Chen, Tao Li, Zhi-Jie Yang, Yuan-Sheng Zhan, Mei-Qiang Liu, Can-Wen Li, Meng Qiu, Tian-Li Gong, Yi-wei Huang, Xin-Jie Yin, Xiao-Hao He, Zhi-Xuan Zhang, Jun-wei Zou, Hai-Chuan fu, Sheng-wei Guo, Dong Yan, Jun-wei Cao, Zhe Deng, Zhi Kong, Jie Xiao, Zhi-Gang Hu, Rong-Jiang Duan, Li-Min Chinese Acad Sci Inst Modern Phys Lanzhou 730000 Peoples R China Univ Chinese Acad Sci Sch Nucl Sci & Technol Beijing 100049 Peoples R China Tsinghua Univ Dept Phys Beijing 100084 Peoples R China Univ Sci & Technol China Hefei 230026 Peoples R China Sichuan Univ Inst Nucl Sci & Technol Key Lab Radiat Phys & Technol Minist Educ Chengdu 610064 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China North China Univ Water Resources & Elect Power Zhengzhou 450000 Peoples R China

The cooling storage ring (CSR) external-target experiment (CEE) is a spectrometer used in construction to study the properties of nuclear matter in high-baryon density regions at the Heavy-Ion Research Facility in Lanzhou (HIRFL). This study presents the design, simulation, manufacturing, and testing of a half-size prototype of a multi-wire drift chamber (MWDC) for the CEE. First, the performance of the MWDC connected to homemade electronics was simulated. The results demonstrated that an energy resolution of 18.5% % for 5.9-keV X-rays and a position resolution of 194 mu m for protons can be achieved by the current design. Because the size of the largest MWDC reached 176 cm x 314 cm, a set of 98 cm x 98 cm prototypes was built using the new techniques. The positioning accuracy of the anode wires in this prototype is better than 20 mu m. After optimization, using commercially available electronics, the prototype can achieved an energy resolution of 19.7% % for a Fe-55 X-ray source. The CEE-MWDC detector and electronics were simultaneously tested. An energy resolution of 22% % was achieved for the Fe-55 source; the track residuals were approximately 330 mu m for the cosmic rays. The results demonstrate that the current design and techniques meet the requirements of the CEE-MWDC array.

关键词： CEE MWDC Garfield plus plus Fe-55 source Position resolution DRIFT CHAMBER HIRFL-CSR

Coupling coordination analysis of Mazu culture,socio-economy and ecological environment of Meizhou Island

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Ecological Economy 2024年第1期20卷 85-100页

作者： fu wei-jia WU Ying-qi LUO Zi-xuan YAO Jun-bing fu Li-jun College of International Management The University of SheffieldWestern BankSheffieldSouth YorkshireS102TNUK Faculty of Business Lingnan UniversityHongkong999077CHINA School of Business Administration Jimei UniversityXiamen 361021CHINA Putian Kelon Environmental Protection Technology Co. LTDPutian 351100CHINA

Taking the pilgrimage,tourism and cultural island of Meizhou Island as an example,the evaluation index system of the coupling and coordinated development of“Mazu culture,socio-economy,eco-environment”(MSE)compound system was *** index weights were determined by AHP-entropy method,and the coupling degree,coordinated degree,comprehensive evaluation index and grey correlation degree of MSE system of Mazu Island from 2012 to 2022 were *** results showed that:(1)the comprehensive evaluation indexes of the three subsystems was on the rise in general,but the evaluation index of the ecological subsystems increased relatively slowly.(2)The coupling degree was only in the running-in stage in 2012,and the other years were in the coordinated coupling stage.(3)The coupling coordination degree increased from 0.35 in 2012 to 0.82 in 2022,the coupling coordination level was changed from mild imbalance to good coordination.(4)Through the comparison of grey correlation degree,the 24 indexes in the evaluation index system had great influence on the coupling coordination degree of MSE *** coupling coordination degree was closely related to the development of socio-economy and the spread of Mazu *** the rapid development of tourism brought about by the spread of Mazu culture,the pressure on the ecological environment will be *** with the rapid growth of tourism and economy,it is equally important to strengthen environmental protection and pay attention to the quality of ecological environment development.

关键词： Meizhou Island Mazu culture socio-economy ecological environment comprehensive evaluation index coupling coordination degree

基于机器学习的流域尺度森林火灾灾害风险预测

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自然灾害学报 2024年第1期33卷 89-98页

作者：郗婕傅微北京建筑大学建筑与城市规划学院北京100044

森林是碳库,具有强大的固碳增汇功能,在应对气候变化中发挥着重要作用。然而,由于极端高温的影响,频繁发生可燃物自燃而引发森林火灾,除了影响区域水文大气循环过程以外,也给人类带来严重的人员伤亡和经济损失。现有森林火灾预测研究主... 详细信息

森林是碳库,具有强大的固碳增汇功能,在应对气候变化中发挥着重要作用。然而,由于极端高温的影响,频繁发生可燃物自燃而引发森林火灾,除了影响区域水文大气循环过程以外,也给人类带来严重的人员伤亡和经济损失。现有森林火灾预测研究主要侧重可燃物研究和火灾监测等方面,较少关注大尺度地形、气象和人类活动对森林火灾的影响,但这些也是除可燃物外导致森林火灾发生的主要因素。以嘉陵江流域重庆段为研究区,区域内山地受自然火灾影响严峻。基于地理信息系统叠加地理空间因子与火灾分布点获得数据集,构建4种机器学习模型,测试模型性能,评价最优模型进行森林火灾灾害风险制图。研究结果表明,模型评估指标受试者工作曲线下面积(area under the curve,AUC)平均值为95.0%,模型性能梯度提升决策树最优,AUC值为98.3%。利用梯度提升决策树(gradient boosting decision tree,GBDT)模型预测森林火灾风险对防范大尺度森林火灾具有一定的可行性,对山城避灾规划起到借鉴作用,规划引导降低森林火灾风险,从而维护生态平衡和生态系统碳汇能力。

关键词：森林火灾机器学习梯度提升决策树灾害风险制图山城避灾规划

Long-Range Electronic Effect-Promoted Ring-Opening Polymerization of Thioctic Acid to Produce Biomimetic Ionic Elastomers for Bioelectronics

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CCS Chemistry 2024年第3期6卷 761-773页

作者： Hongfei Huang Huijing Wang Lijie Sun Ruohan Zhang Luzhi Zhang ZekaiWu Yaxuan Zheng Yang Wang wei fu Youwei Zhang Rasoul Esmaeely Neisiany Zhengwei You State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityResearch Base of Textile Materials for Flexible Electronics and Biomedical Applications(China Textile Engineering Society)Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineShanghai 201620 Institute of Pediatric Translational Medicine Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127 Department of Materials and Polymer Engineering Faculty of EngineeringHakim Sabzevari UniversitySabzevar ***

Poly(disulfide)s have been widely used in flexible wearable electronics,smart materials,and drug *** synthesis of poly(disulfide)s usually utilizes external stimuli or toxic initiators to promote the ***,we indicated that the long-range electronic effect can significantly alter the reactivity of the disulfide ***,we established deprotonation-promoted ring-opening polymerization of thioctic acid(TA)as a highly effective and simple method to synthesize poly(disulfide)s due to the long-range electronic effect and nucleophilic *** external stimuli and initiators,simple mixing of TA and deprotonation reagent,choline bicarbonate,in different ratios at room temperature rapidly produced a series of high molecular weight(up to 772 kDa)ionic liquid crystal poly(disulfide)s elastomers with room temperature self-healing ability,adjustable conductivity(2.39×10^(−2)∼0.28×10^(−2)S m^(−1)),degradability,biocompatibility,antibacterial property,and tissue-like softness(Young’s moduli ranging from 18.2±6.0 to 111.1±36.7 kPa).The experiments and density functional theory calculations also revealed the principle of long-range electronic effect to establish a new synthetic strategy of poly(disulfide)s with superior properties favorable for bioelectronics.

关键词： self-healing elastomers thioctic acid ionic liquid bioelectronics

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载货汽车弯道侧翻路侧预测方法

吉林大学学报（工学版） 2024年第5期54卷 1302-1310页

作者：许清津付锐郭应时吴付威长安大学汽车学院西安710064 长安大学汽车运输安全保障技术交通行业重点实验室西安710064

载货汽车重心高的特点极易因操作不当引发侧翻,为此,依靠现有路侧测量设备提出一种可快速投入使用的车辆弯道侧翻预测方法。首先,提出基于改进KNN的车辆重心高度回归预测模型实现车辆重心高度路侧动态估计;然后,建立基于横向载荷转移率... 详细信息

载货汽车重心高的特点极易因操作不当引发侧翻,为此,依靠现有路侧测量设备提出一种可快速投入使用的车辆弯道侧翻预测方法。首先,提出基于改进KNN的车辆重心高度回归预测模型实现车辆重心高度路侧动态估计;然后,建立基于横向载荷转移率的车辆侧倾估计模型实现侧倾程度路侧估计;最后,提出在线ARIMA模型在线预测车辆侧倾状态。MATLAB/Simulink与TruckSim联合仿真结果表明:本文提出的侧翻预测方法在弯道全程均能准确预测车辆LTR变化趋势和其极限值,从而为路侧设施在弯道发布针对性预警提供依据。

关键词：交通工程侧翻预测在线ARIMA 路侧感知设备重心高度估计 TruckSim仿真

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数据要素价值化助力培育新质生产力

财经问题研究 2024年第9期 48-60页

作者：胡继晔付炜炜中国政法大学商学院北京100088

新质生产力的根本特征之一就是数据生产要素通过创新全面赋能其他生产要素。随着数据生产要素的引入,生产力三要素的内涵和外延都发生了不同程度的演变,传统生产力跃变为新质生产力,而数据价值的应用是区分新旧生产力的关键。数据要素... 详细信息

新质生产力的根本特征之一就是数据生产要素通过创新全面赋能其他生产要素。随着数据生产要素的引入,生产力三要素的内涵和外延都发生了不同程度的演变,传统生产力跃变为新质生产力,而数据价值的应用是区分新旧生产力的关键。数据要素价值化是新质生产力发展的重要动力,为发展新质生产力所要面临的技术创新、要素配置和产业转型等难题提供了突破口。本文立足于数字经济时代生产力三要素改变这一基本事实,以“数据集—数据资源—数据资产—数据资本”的数据全生命周期为基础,从数据价值实现的视角出发,构建“价值形成—价值创造—价值实现—价值共享”的数据价值化理论框架。围绕数据价值化这一进程,本文构建了包含“技术—人才—产业”三个层面的理论分析框架,以厘清数据要素价值化加快培育新质生产力的内在机理和实践路径。本文从交叉学科视角出发,针对数据确权、数据资产入表、估值、交易和数据资产证券化等关键问题,对完善中国数据基础制度、优化营商环境和构建全国一体化数据要素市场提出了政策建议。

关键词：数据价值化新质生产力数据资产数据资本化

循环F_(q-)线性F_(q^(t-))码的一些结论

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数学学报（中文版） 2024年第3期67卷 413-427页

作者：高云符方伟北京物资学院统计与数据科学学院北京101149 南开大学陈省身数学研究所天津300071

令F_(q)是一个含有q个元素的有限域,其中q是素数p的方幂,t≥2是满足t■1(modp)的偶数,且F_(q^(t))是Fq的次数为t的扩域.本文给出F_(q^(t))^(n)上的一个迹双线性型内积Δ,其中n是一个与q互素的正整数.根据定义的迹内积,研究循环Δ-自正... 详细信息

令F_(q)是一个含有q个元素的有限域,其中q是素数p的方幂,t≥2是满足t■1(modp)的偶数,且F_(q^(t))是Fq的次数为t的扩域.本文给出F_(q^(t))^(n)上的一个迹双线性型内积Δ,其中n是一个与q互素的正整数.根据定义的迹内积,研究循环Δ-自正交和循环Δ-自对偶F_(q-)线性F_(q^(2-))码的基和计数.此外,给出一些参数好的F_(q-)线性F_(q^(2-))码.

关键词： F_(q-)线性F_(q^(t-))码 △-双线性型循环△-自正交F_(q-)线性F_(q^(t-))码循环△-自对偶F_(q-)线性F_(q^(t-))码

大气湍流对空间相干光通信的相干探测性能影响

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物理学报 2024年第10期73卷 203-211页

作者：刘宇韬徐苗付兴虎付广伟燕山大学信息科学与工程学院河北省特种光纤与光纤传感重点实验室秦皇岛066004 自然资源部海洋观测技术重点实验室天津300112

空间相干光通信被认为是突破现有高速空间通信瓶颈的重要手段,但其应用受到大气湍流的极大限制.为此,本文首先基于Huygens-Fresnel原理和低频补偿功率谱反演法,研究了高斯光束经大气湍流传输后振幅和相位的随机分布特性;然后,利用相干... 详细信息

空间相干光通信被认为是突破现有高速空间通信瓶颈的重要手段,但其应用受到大气湍流的极大限制.为此,本文首先基于Huygens-Fresnel原理和低频补偿功率谱反演法,研究了高斯光束经大气湍流传输后振幅和相位的随机分布特性;然后,利用相干混频效率及通信误码率模型,获得大气湍流对空间相干光通信系统性能的影响规律;最后,搭建激光外差探测实验系统,定量研究了大气湍流对空间相干光通信相干探测性能的影响.结果表明:弱湍流条件下,空间相干光通信性能几乎不受大气湍流的影响;中等强度湍流影响下,相干混频效率会随着湍流强度的增大而迅速下降,但通过提高单比特光子数可以有效抑制湍流对通信性能的负面影响;强湍流会显著破坏光束相干性,使得相干混频效率趋近于零,即使提高单比特光子数也无法有效改善通信性能.大气湍流是空间相干光通信发展的重要限制因素,该研究可为空间相干光通信系统性能评估提供有益参考.

关键词：空间相干光通信大气湍流混频效率误码率