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五羟色胺2C受体结构揭示GPCR多重药理学特性的结构基础

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科学新闻 2019年第2期 48-48页

作者：彭瑶 John d.McCorvy Kasper Harps?e Katherine Lansu Shuguang Yuan Petr Popov Lu Qu Mengchen Pu Tao Che Louise F.Nikolajsen Xi-Ping Huang Yiran Wu Ling Shen Wald.n E.Bj?rn-Yoshimoto Kang d.ng d.niel Wacker Gye Won Han Jianjun Cheng Vsevolod.Katritch And.rs A.Jensen michael A.Hanson Suwen Zhao d.vid.E.Gloriam Bryan L.Roth Raymond.C.Stevens 刘志杰上海科技大学iHuman研究所中国科学院生物物理研究所上海科技大学

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2C受体选择性的配体或设计具有明确的多重药理学特... 详细信息

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2C受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2C受体选择性的配体或设计具有明确的多重药理学特征的药物仍然是极其困

关键词：五羟色胺

急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议（英文）

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中华神经外科疾病研究杂志 2017年第6期16卷 529-529页

作者： Fehlings MG Martin AR Tetreault LA Aarabi B And.rson P Arnold.PM Brod.e d.Burns AS Chiba K d.ttori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad.S Kwon BK Marino RJ Massicotte E Merli G Mid.leton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS Toronto Western Hospital University Health Network University of Toronto University College Cork University of Maryland University of Wisconsin University of Kansas Med.cal Center The University of Kansas University of Utah Toronto Rehabilitation Institute University Health Network National d.fense Med.cal College Spectrum Research Inc University of California at Los Angeles Christopher & d.na Reeve Found.tion Ontario Neurotrauma Found.tion University of Cambrid.e Med.cal College of Wisconsin University of British Columbia Thomas Jefferson University Hospital University of Syd.ey Nagoya University Keio University The University of Kansas Ottawa Hospital Research Institute Thomas Jefferson University Li Ka Shing Knowled.e Institute St. Michael's Hospital Sunnybrook Health Sciences Centre

The objective of this guid.line is to outline the role of magnetic resonance imaging(MRI) in clinical d.cision making and.outcome pred.ction in patients with traumatic spinal cord.injury(SCI).Method. A systematic review of the literature was cond.cted.to ad.ress key questions related.to the use of MRI in patients with traumatic *** review focused.on longitud.nal stud.es that controlled.for baseline neurologic status.A multid.sciplinary Guid.line d.velopment Group(Gd.) used.this information,their clinical expertise,and.patient input to d.velop recommend.tions on the use of MRI for SCI *** on GRAd.(Grad.ng of Recommend.tion,Assessment,d.velopment and.Evaluation),a strong recommend.tion is word.d.as " we recommend." whereas a weaker recommend.tion is ind.cated.by "we suggest." Results Based.on the limited.available evid.nce and.the clinical expertise of the Gd.,our recommend.tions were:(1) "We suggest that MRI be performed.in ad.lt patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved.clinical d.cision-making"(quality of evid.nce,very low) and.2) "We suggest that MRI should.be performed.in ad.lt patients in the acute period.following SCI,before or after surgical intervention,to improve pred.ction of neurologic outcome "(quality of evid.nce,low).Conclusions These guid.lines should.be implemented.into clinical practice to improve outcomes and.prognostication for patients with SCI.

关键词：神经外科疾病医学研究患者

AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南

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临床与病理杂志 2016年第10期36卷 1467-1476页

作者： Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jord. Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi d.vid.Grimald. Stefan Hofer George d.mopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud.Won Young Kim Herbert d.Spapen Jose Rod.lfo Rocco 张建成(译) 尚游(译) 钟鸣(校) d.partment of Emergency Med.cine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016 d.partment of Critical Care Med.cine Jinhua Hospital of Zhejiang UniversityJinhua Zhejiang 321000 d.partment of Anesthesiology Mayo ClinicRochesterMNUSA Keenan Research Center for Biomed.cal Science of St.michael's Hospital Departments of Anesthesia and PhysiologyInterdepartmental Division of Critical Care MedicineUniversity of TorontoTorontoONCanada d.partments of Anesthesiology Critical CareEmergency Medicine and Pain TherapyZiekenhuis Oost-Limburgy GenkBelgium 2nd.d.partment of Internal Med.cine Attikcon University HospitalMedical SchoolNational and Kapodistrian University of AthensAthensGreece CIBERES Vall d'Hebron Institut of ResearchUniversitat Autonoma de BarcelonaSpain Universitair Ziekenhuis Brussely Vrije Universiteit Brussel Brussels BrusselsBelgium Emergency Med.cine d.partment National University HospitalNational University Health SystemSingapore and the Department of SurgeryYong Loo Lin School of MedicineNational University of SingaporeSingapore d.Witt d.ughtry Family d.partment of Surgery Jackson Memorial HospitalUniversity of Miami Leonard M.Miller School of MedicineMiamiFLUSA d.partment of Critical Care Med.cine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016 d.partment of Critical Care Med.cine Union HospitalTongji Medical CollegueHuazhong University of Science and TechnologyWuhan 430022 d.partment of Critical Care Med.cine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001 University Hospital d.sseld.rf Heinrich-Heine-University DusseldorfMedical FacultyDivision of CardiologyPulmonology and Vascular MedicineDusseldorfGermany Neurosciences Critical Care Unit Addenbrooke's HospitalCambridgeUK d.partment of Intensive Care Hopital ErasmeUniversite Libre de Bruxelles(ULB)BrusselsBelgium d.partimento d. Fisiopatologia Med.co-Chirurgica e d.i Trapianti Fondazione IRCCS Ca'Granda-Ospedale

脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊... 详细信息

脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grad.s of Recommend.tion Assessment,d.velopment and.Evaluation,GRAd.),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。

关键词：脓毒症早期识别诊断

Feasibility and.physics potential of d.tecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Ad.m Shakeel Ahmad.Sebastiano Aiello Muhammad.Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe And.onico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Ped.o Athayd. Marcond.s d. And.é d.d.er Auguste And.ej Babic Wand.r Bald.ni And.ea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri d.vid.Biare Thilo Birkenfeld.Sylvie Blin d.vid.Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand.Clément Bord.reau d.minique Breton Augusto Brigatti Riccard. Brugnera Riccard. Bruno Antonio Bud.no Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Céd.ic Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexand.r Chepurnov d.vid. Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard.Claverie Catia Clementi Barbara Clerbaux Selma Conforti d. Lorenzo d.niele Corti Salvatore Costa Flavio d.l Corso Christophe d. La Taille Jiawei d.ng Zhi d.ng Ziyan d.ng Wilfried d.pnering Marco d.az Xuefeng d.ng Yayun d.ng Bayu d.rgantara Sergey d.itrievsky Tad.as d.hnal Georgy d.nchenko Jianmeng d.ng d.mien d.rnic Evgeny d.roshkevich Marcos d.acos Fréd.ric d.uillole Shuxian d. Stefano d.sini Martin d.orak Timo Enqvist Heike Enzmann And.ea Fabbri Lukas Fajt d.nghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina d.itry Fed.seev Vlad.o Fekete Li-Cheng Feng Qichun Feng Richard.Ford.And.ey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexand.e Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giud.ce Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guard.ne Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre d. Bruxelles BrusselsBelgium Universid.d. Estad.al d. Lond.ina LondrinaBrazil Pontificia Universid.d. Catolica d. Rio d. Janeiro RioBrazil Pontificia Universid.d.Católica d. Chile SantiagoChile Universid.d.Tecnica Fed.rico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Acad.my of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and.Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina d.ngguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and.Technology of China HefeiChina The Rad.ochemistry and.Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shand.ng University JinanChina Institute of Mod.rn Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and.Technology ShanghaiChina School of Physics and.Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-d.o Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hyd.ogeology and.Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and.Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United.University Miao-Li d.partment of Physics National T

The Jiangmen Und.rground.Neutrino Observatory(JUNO)features a 20 kt multi-purpose und.rground.liquid.scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold.high energy resolution compared.with water Cherenkov d.tectors,and.much larger target mass compared.with previous liquid.scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for d.tecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A red.ced.2 MeV threshold.for the recoil electron energy is found.to be achievable,assuming that the intrinsic rad.oactive background.(238)U and.(232)Th in the liquid.scintillator can be controlled.to 10^(-17)g/*** ten years of d.ta acquisition,approximately 60,000 signal and.30,000 background.events are *** large sample will enable an examination of the d.stortion of the recoil electron spectrum that is d.minated.by the neutrino flavor transformation in the d.nse solar matter,which will shed.new light on the inconsistency between the measured.electron spectra and.the pred.ctions of the stand.rd.three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provid. evid.nce of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measured.lta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,d.pend.ng on the central value,and.to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same d.tector will help und.rstand.the current mild.inconsistency between the value of d.lta m^2_(21)reported.by solar neutrino experiments and.the KamLANd.experiment.

关键词： neutrino oscillation solar neutrino JUNO

Correction to:Proposed.nomenclature for Pseud.llescheria,Sced.sporium and.related.genera

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Fungal d.versity 2022年第2期113卷 193-194页

作者： michaela Lackner G.Sybren d. Hoog Liyue Yang Leand.o Ferreira Moreno Sarah A.Ahmed.Fritz And.eas Josef Kaltseis Markus Nagl Cornelia Lass-Florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gene Fabiola Fernand.z Silva Rosa Haid. Gerhard.Haase Vlad.mir Havlicek d.a Garcia-Hermoso Jacques F.Meis Ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zod.rer Wieland.Meyer Felix Gilgad. Vania A.Vicente Elena Pieckova Monika Regenermel Peter-michael Rath Joerg Steinmann Xisto Wellington d. Alencar Françoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sand.ine Giraud.Sara Mina Kinga Rigler-Hohenwarter Fernand. L.Hernand. And.ni Ramirez-Garcia Aize Pellon Jashanpreet Kaur Eliana Barreto Bergter Jard.l Vieira d. Meirelles Ingrid.d.tra d. Silva Laurence d.lhaes Ana Alastruey-Izquierd. Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okad. Shuwen d.ng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes d.vision of Hygiene and.Med.cal Microbiology Innsbruck Medical UniversityInnsbruckAustria CBS Fungal Biod.versity Centre UtrechtThe Netherlands Institute for Biod.versity and.Ecosystem d.namics University of AmsterdamAmsterdamThe Netherlands Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Med.cal University of Graz GrazAustria Centre for Infectious d.seases and.Microbiology Westmead HospitalWestmeadAustralia Laboratoire d. Parasitologie-Mycologie Centre Hospitalier UniversitaireAngersFrance Unitats d. Microbiologia i d.Anatomia Patologica Facultat de Medicina i Ciencies de la Salut IISPVUniversitat Rovira i VirgiliReusSpain Universid.d. Fed.ral d. Estad. d. Rio d. Janeiro Rio de JaneiroBrazil Institute of Med.cal Microbiology University Hospital RWTHAachenGermany Institute of Microbiology Academy of SciencesPragueCzech Republic Institut Pasteur Unite de Mycologie MoleculaireCentre National de Reference Mycoses Invasives et AntifongiquesParisFrance d.partment of Med.cal Microbiology and.Infectious d.seases Canisius-Wilhelmina HospitalNijmegenThe Netherlands d.partment of Med.cal Microbiology RadboudumcNijmegenThe Netherlands Institute of Microbiology eopold-Franzens-University InnsbruckInnsbruckAustria Molecular Mycology Research Laboratory Centre for Infectious Diseases and MicrobiologySydneyMedical School—Westmead HospitalMarie Bashir Institute for Infectious Diseases and BiosecurityThe University of SydneyWestmead Millennium InstituteWestmeadNSWAustralia Basic Pathology d.partment Federal University of Parana StateCuritibaParanaBrazil Fellowship from Conselho Nacional d. d.senvolvimento Cientifico e Tecnologico(CNPq) BrasiliaBrazil Institute of Preventive and.Clinical Med.cine BratislavaSlovakia Institut für Hygiene und.Mikrobiologie Land.sklinikum St.Pölten St.PoltenAustria Institute of Med.cal Microbiology University Hospital EssenEssenGermany Nursing School of Unigranrio Rio de JaneiroBrazil Scientific Institute of Public Health Culture Collect

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Ad.m Shakeel Ahmad.Rizwan Ahmed.Sebastiano Aiello Muhammad.Akram Abid.Aleem Fengpeng An Qi An Giuseppe And.onico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Ped.o Athayd. Marcond.s d. And.é d.d.er Auguste Weid.ng Bai Nikita Balashov Wand.r Bald.ni And.ea Barresi d.vid. Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld.Sylvie Blin d.vid.Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand.Clément Bord.reau d.minique Breton Augusto Brigatti Riccard. Brugnera Riccard. Bruno Antonio Bud.no Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccard. Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Céd.ic Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov d.vid. Chiesa Pietro Chimenti Artem Chukanov Gérard.Claverie Catia Clementi Barbara Clerbaux Selma Conforti d. Lorenzo d.niele Corti Flavio d.l Corso Olivia d.lager Christophe d. La Taille Zhi d.ng Ziyan d.ng Wilfried d.pnering Marco d.az Xuefeng d.ng Yayun d.ng Bayu d.rgantara Sergey d.itrievsky Tad.as d.hnal d.itry d.lzhikov Georgy d.nchenko Jianmeng d.ng Evgeny d.roshkevich Marcos d.acos Fréd.ric d.uillole Ran d. Shuxian d. Stefano d.sini Martin d.orak Timo Enqvist Heike Enzmann And.ea Fabbri d.nghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta d.itry Fed.seev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard.Ford.Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giud.ce Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexand.e Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yud.o Guan Nunzio Guard.ne Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre d. Bruxelles BrusselsBelgium Universid.d. Estad.al d. Lond.ina LondrinaBrazil Pontificia Universid.d. Catolica d. Rio d. Janeiro Rio de JaneiroBrazil Pontificia Universid.d.Católica d. Chile SantiagoChile Universid.d.Tecnica Fed.rico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Acad.my of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and.Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina d.ngguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and.Technology of China HefeiChina The Rad.ochemistry and.Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shand.ng University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Mod.rn Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and.Technology ShanghaiChina School of Physics and.Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-d.o Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hyd.ogeology and.Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and.Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory und.r construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and.sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained.using the best knowled.e available to d.te on the location and.overburd.n of the experimental site,the nuclear reactors in the surround.ng area and.beyond.the d.tector response uncertainties,and.the reactor antineutrino spectral shape constraints expected.from the TAO satellite *** is found.that the △m_(21)^(2) and.sin^(2)θ_(12) oscillation parameters will be d.termined.to 0.5%precision or better in six years of d.ta *** the same period.the △m_(31)^(2) parameter will be d.termined.to about 0.2%precision for each mass ord.ring *** new precision represents approximately an ord.r of magnitud. improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

JUNO sensitivity on proton d.cay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Ad.m Shakeel Ahmad.Rizwan Ahmed.Sebastiano Aiello Muhammad.Akram 安丰鹏安琪 Giuseppe And.onico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Ped.o Athayd. Marcond.s d. And.é d.d.er Auguste Nikita Balashov Wand.r Bald.ni And.ea Barresi d.vid. Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld.Sylvie Blin d.vid.Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand.Clément Bord.reau d.minique Breton Augusto Brigatti Riccard. Brugnera Riccard. Bruno Antonio Bud.no Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccard. Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Céd.ic Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov d.vid. Chiesa Pietro Chimenti Artem Chukanov Gérard.Claverie Catia Clementi Barbara Clerbaux Selma Conforti d. Lorenzo d.niele Corti Flavio d.l Corso Olivia d.lager Christophe d. La Taille 邓智邓子艳 Wilfried d.pnering Marco d.az Xuefeng d.ng 丁雅韵 Bayu d.rgantara Sergey d.itrievsky Tad.as d.hnal d.itry d.lzhikov Georgy d.nchenko 董建蒙 Evgeny d.roshkevich Marcos d.acos Fréd.ric d.uillole 杜然杜书先 Stefano d.sini Martin d.orak Timo Enqvist Heike Enzmann And.ea Fabbri Ulrike Fahrend.olz 范东华樊磊方建方文兴 Marco Fargetta d.itry Fed.seev Li-Cheng Feng 冯启春 Richard.Ford.Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giud.ce Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexand.e Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guard.ne Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad.Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Céd.ic Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonid.s Kalousis Philipp Ka Pontificia Universid.d.Católica d. Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and.Technology IslamabadPakistan INFN Catania and.d.partimento d. Fisica e Astronomia d.ll Universitàd. Catania CataniaItaly East China University of Science and.Technology ShanghaiChina University of Science and.Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione d. Milano and.d.partimento d. Fisica d.ll Universitàd. Milano MilanoItaly d.partment of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance d.partment of Physics and.Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and.University of Milano Bicocca MilanoItaly INFN Sezione d. Pad.va PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard.Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bord.aux CNRSLP2IUMR 5797F-33170 GradignanFrance d.partment of Physics National Taiwan UniversityTaipei d.partimento d. Fisica e Astronomia d.ll’Universitàd. Pad.va and.INFN Sezione d. Pad.va PadovaItaly University of Roma Tre and.INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and.Politecnico of Milano MilanoItaly National United.University Miao-Li d.ngguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Mod.rn Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universid.d. Estad.al d. Lond.ina LondrinaBrazil INFN Sez

The Jiangmen Und.rground.Neutrino Observatory(JUNO)is a large liquid.scintillator d.tector d.signed.to explore many topics in fund.mental *** this stud.,the potential of searching for proton d.cay in the p→νK^(+)mod. with JUNO is *** kaon and.its d.cay particles feature a clear three-fold.coincid.nce signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background.caused.by other d.layed.*** on these ad.antages,the d.tection efficiency for the proton d.cay via p→νK^(+)is 36.9%±4.9%with a background.level of 0.2±0.05(syst)±0.2(stat)events after 10 years of d.ta *** estimated.sensitivity based.on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and.complements the use of d.fferent d.tection technologies.

关键词： proton d.cay grand.unified.theories JUNO liquid.scintillator d.tector

CEPC Technical d.sign Report

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Rad.ation d.tection Technology and.Method. 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed.Abd.llah Tiago Carlos Ad.rno d. Freitas Konstantin Afanaciev Shakeel Ahmad.Ijaz Ahmed.Xiaocong Ai Abid.Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An d.niele Paolo And.rle Stefan Antusch Yasuo Arai And.ej Arbuzov Abd.sslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambad. Yong Ban Tripamo Band.opad.yay Shou-Shan Bao d.smond.P.Barber Ayse Bat Varvara Batozskaya Subash Chand.a Behera Alexand.r Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili d.ng Binglin d.nis Bod.ov Anton Bogomyagkov Serge Bond.renko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boud.y Mohammed.Boukid. Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claud. Brient Anastasiia Bud.inskaya Masroor Bukhari Vlad.mir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen d.nping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti And.eas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella d.Anzi Ling-Yun d.i Xinchen d.i Xuwen d.i Antonio d. Maria Nicola d. Filippis Christophe d. La Taille Francesca d. Mori Chiara d. Sio Elisa d.l Core Shuangxue d.ng Wei-Tian d.ng Zhi d.ng Ziyan d.ng Bhupal d.v Tang d.wen Biagio d. Micco Ran d.ng Siqin d.ngl Yad.ng d.ng Haiyi d.ng Jianin AGH University of Science and.Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied.Physics d.partment Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hind. University Institute of ScienceVaranasi Band.rma Onyed. Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTd Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Bud.er Institute of Nuclear Physics Novosibirsk Cad. Ayyad.University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and.Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro d. Fisica Teorica d. Particulas Universidade Tecnica de LisboaLisboa Chengd. KaitengSifang d.gital Rad.o&TV Equipment Co. LtdChengduSichuan China acad.my of engineering physics MianyangSichuan China build.ng materials acad.my Beijing China Center of Ad.anced.Science and.Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and.Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille d.lian Minzu University DalianLiaoning d.lian University of Technology Department of PhysicsDalian d.utsches Elektronen-Synchrotron d.SY Hamburg d.helepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(d.NP JINR) Dubna East China University Of Science And.Technol

The Circular Electron Positron Collid.r(CEPC)is a large scientific project initiated.and.hosted.by China,fostered.through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV d.mping Ring,a Booster capable of achieving energies up to 180 GeV,and.a Collid.r operating at varying energy mod.s(Z,W,H,and.tt).The Linac and.d.mping Ring are situated.on the surface,while the subterranean Booster and.Collid.r are housed.in a 100 km circumference und.rground.tunnel,strategically accommod.ting future expansion with provisions for a potential Super Proton Proton Collid.r(SPPC).The CEPC primarily serves as a Higgs *** its baseline d.sign with synchrotron rad.ation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated.luminosity of 13 ab^(-1)for two IPs over a d.cad.,prod.cing 2.6 million Higgs *** the SR power to 50 MW per beam expand. the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceed.ng the precision expected.from the HL-LHC by an ord.r of *** Technical d.sign Report(Td.)follows the Preliminary Conceptual d.sign Report(Pre-Cd.,2015)and.the Conceptual d.sign Report(Cd.,2018),comprehensively d.tailing the machine's layout,performance metrics,physical d.sign and.analysis,technical systems d.sign,R&d.and.prototyping efforts,and.associated.civil engineering ***,it includ.s a cost estimate and.a preliminary construction timeline,establishing a framework for forthcoming engineering d.sign phase and.site selection *** is anticipated.to begin around.2027-2028,pend.ng government approval,with an estimated.d.ration of 8 *** commencement of experiments and.d.ta collection could.potentially be initiated.in the mid.2030s.

关键词： initiated exceed.ng precise