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国际政治经济学

作者： B.s.·弗雷(B.s. frey)

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胰腺疾病研讨年会小结

国外医学（外科学分册） 1991年第2期18卷 85-86页

作者： frey C F 鲁泽清

本文报道1990年5月在美国san Antonio,Texas州召开的胰腺疾病研讨年会,论文报告分二部份。第一部分: (一)主胰管减压的作用(Karanjia等):主胰管部分缩窄诱发猫的慢性胰腺炎。数周后,胰腺血流明显降低。分泌刺激更进一步降低其血流。导... 详细信息

本文报道1990年5月在美国san Antonio,Texas州召开的胰腺疾病研讨年会,论文报告分二部份。第一部分: (一)主胰管减压的作用(Karanjia等):主胰管部分缩窄诱发猫的慢性胰腺炎。数周后,胰腺血流明显降低。分泌刺激更进一步降低其血流。导管减压后,分泌刺激增加基础胰腺血流量。此实验可解释慢性胰腺炎疼痛的原因。 (二)反折性分光镜检查评估胰腺缺血(Rattner等):反折性分光镜检查根据血红蛋白和氧饱和量的分析来观察胰腺灌注。要求在腹腔内进行检查。

关键词：胰腺疾病

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铝卷材的粉末涂覆

轻合金加工技术 1993年第10期21卷 34-36页

作者： frey sacchi 刘力克

1 前言欧洲一家新建工厂目前用粉末涂料对铝卷材进行连续涂覆。该粉末涂覆工艺使轧制铝卷材获得的涂层硬度和厚度能与已有20年使用历史的铝型材粉末涂层的相媲美,这与以前仅用液体涂料涂覆铝卷的工艺相比,无疑是一种经济的方法。PCC(铝... 详细信息

1 前言欧洲一家新建工厂目前用粉末涂料对铝卷材进行连续涂覆。该粉末涂覆工艺使轧制铝卷材获得的涂层硬度和厚度能与已有20年使用历史的铝型材粉末涂层的相媲美,这与以前仅用液体涂料涂覆铝卷的工艺相比,无疑是一种经济的方法。PCC(铝卷材粉末连续涂覆)的涂层厚度大于普通的液体连续涂覆,与粉末涂覆铝型材的表面质量完全一样,同时,涂覆工艺也具有良好的环境适应性。

关键词：铝卷材粉末涂料涂覆

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The ABA-Deficiency suppressor Locus HAs2 Encodes the PPR Protein LOI1/MEF11 Involved in Mitochondrial RNA Editing

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Molecular Plant 2015年第4期8卷 644-656页

作者： Julien sechet Camille Roux Anne Plessis Delphine Effroy Anne frey Francois Perreau Catherine Biniek Anja Krieger-Liszkay David Macherel Helen M. North Hakim Mireau Annie Marion-Poll INRA Institut Jean-Pierre Bourgin UMR 1318 ERL CNRS 3559 Saclay Plant Sciences RD10 F-78026 Versailles France AgroParisTech Institut Jean-Pierre Bourgin UMR 1318 ERL CNRS 3559 Saclay Plant Sciences RD10 F-78026 Versailles France CEA saclay IBiTec-S CNRS UMR 8221 Serv Bioenerget Biol Struct & Mecanisme F-91191 Gif Sur Yvette France Universite d'Angers UMR IRHS 1345 INRA Agrocampus Ouest F-49045 Angers France Institut Jean-Pierre Bourgin INRA Bat 2 F-78026 Versailles Cedex France Institut Jean-Pierre Bourgin INRA Bat 7 F-78026 Versailles Cedex France Department of Biology New York University 1009 Main Building 100 Washington Square East New York NY 10003-6688 USA

The hotABA-deficiency suppressor2 （has2） mutation increases drought tolerance and the ABA sensitivity of stomata closure and seed germination. Here we report that the HAs2 locus encodes the MITOCHONDRIAL EDITING FACTOR11 （MEF11）, also known as LOVAsTATIN INsENsITIVE1. has21mef11 mutants exhibited phenotypes very similar to the ABA-hypersensitive mutant, hail-1 pp2ca-1 hab 1-1 abil-2, which is impaired in four genes encoding type 2C protein phosphatases （PP2C） that act as upstream negative regulators of the ABA signaling cascade. Like pp2c, mef11 plants were more resistant to progressive water stress and seed germination was more sensitive to paclobutrazol （a gibberellin biosynthesis inhibitor） as well as mannitol and NaCI, compared with the wild-type plants. Phenotypic alterations in mef11 were associated with the lack of editing of transcripts for the mitochondrial cytochrome c maturation FN2 （cCmFN2） gene, which encodes a cytochrome c-heme lyase subunit involved in cytochrome c biogenesis. Although the abundance of electron transfer chain complexes was not affected, their dysfunction could be deduced from increased respiration and altered production of hydrogen peroxide and nitric oxide in reef11 seeds. As minor defects in mitochondrial respiration affect ABA signaling, this suggests an essential role for ABA in mitochondrial retrograde regulation.

关键词： abscisic acid mitochondria pentatricopeptide repeat protein RNA editing drought tolerance germination

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恶性胶质瘤抗血管生成治疗现状

中国现代神经疾病杂志 2008年第5期8卷 403-410页

作者： frey D Czabanka M Vajkoczy P 刘辉杨学军德国柏林大学Charité医院神经外科天津医科大学总医院神经外科 300052

血管生成，即从已存在的微血管系统中生成新的血管，在生理状态及肿瘤生长过程中均可发生。在生理状态下，血管生成过程在胚胎发育、胎儿出生后及女性生殖周期中是不可或缺的。而且，血管生成亦是伤口充分愈合的重要因素。过去数年内，... 详细信息

血管生成，即从已存在的微血管系统中生成新的血管，在生理状态及肿瘤生长过程中均可发生。在生理状态下，血管生成过程在胚胎发育、胎儿出生后及女性生殖周期中是不可或缺的。而且，血管生成亦是伤口充分愈合的重要因素。过去数年内，血管生成机制是研究的焦点，业已证实血管生成是由血管生成因子和抗血管生成因子所调控。当肿瘤生长时这些因子的均衡性被打破，这种不平衡是由于肿瘤细胞过多地产生血管生成因子，

关键词：抗血管生成治疗恶性胶质瘤抗血管生成因子女性生殖周期生理状态肿瘤生长微血管系统生长过程

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Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated： a prospective study using patient-reported outcome measures

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Asian Journal of Andrology 2017年第1期19卷 62-66页

作者： Karan Wadhwa Lina Carmona-Echeveria Timur Kuru Gabriele Gaziev Eva serrao Deepak Parasha Julia frey Ivailo Dimov Jonas seidenader Pete Acher Gordon Muir Andrew Doble Vincent Gnanapragasam Boris Hadaschik Christof Kastner Department of Urology Addenbrookes Hospital Cambridge UK Department of Urology University Hospital Heidelberg Germany Department of Biochemistry University of Cambridge Cambridge UK Cancer Research Centre and statistics and Epidemiology Unit Division of Health Sciences Warwick Medical School University of Warwick Coventry UK Department of Urology Southend University Hospital Southend UK Department of Urology Kings College Hospital London UK CamPARI Prostate Cancer Clinic Addenbrookes Hospital Cambridge UK.

We aimed to determine short-term patient-reported outcomes in men having general anesthetic transperineal （TP） prostate biopsies. A prospective cohort study was performed in men having a diagnostic TP biopsy. This was done using a validated and adapted questionnaire immediately post-biopsy and at follow-up of between 7 and 14 days across three tertiary referral hospitals with a response rate of 51.6%. Immediately after biopsy 43/201 （21.4%） of men felt light-headed, syncopal, or suffered syncope. Fifty-three percent of men felt discomfort after biopsy （with 95% scoring 〈5 in a 0-10 scale）. Twelve out of 196 men （6.1%） felt pain immediately after the procedure. Despite a high incidence of symptoms （e.g., up to 75% had some hematuria, 47% suffered some pain）, it was not a moderate or serious problem for most, apart from hemoejaculate which 31 men suffered. Eleven men needed catheterization （5.5%）. There were no inpatient admissions due to complications （hematuria, sepsis）. On repeat questioning at a later time point, only 25/199 （12.6%） of men said repeat biopsy would be a significant problem despite a significant and marked reduction in erectile function after the procedure. From this study, we conclude that TP biopsy is well tolerated with similar side effect profiles and attitudes of men to repeat biopsy to men having TRUs biopsies. These data allow informed counseling of men prior to TP biopsy and a benchmark for tolerability with local anesthetic TP biopsies being developed for clinical use.

关键词： attitude to rebiopsy patient-reported outcome measures patient satisfaction prostate cancer diagnosis transperineal biopsies transrectal biopsies

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国际政治经济学

Regulation of 11<i>β</i>-Hydroxysteroid Dehydrogenase Type 1 and 2 in Rheumatoid Arthritis

1987年

作者：（瑞士）弗雷（frey B.s.）吴元湛等译

书名原文: International political economics.

ISBN: (纸本)7536601697

书名原文: International political economics.

关键词：经济世界各国经济概况、经济史、经济地理世界经济、国际经济关系

来源：汇雅图书（南通市图书馆... 评论

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International Journal of Clinical Medicine 2012年第4期3卷 254-262页

作者： Christine Beyeler Bernhard Dick Howard A. Bird Brigitte M. frey Academic Department of Musculoskeletal Medicine University of Leeds United Kingdom Departments of Nephrology and Hypertension and Clinical Research University Hospital of Berne Switzerland Institute of Medical Education Department of Rheumatology Clinical Immunology and Allergology

Objective. The sequential activities of the 11β-hydroxysteroid dehydrogenase enzymes type 1 and 2 have not been investigated so far in patients suffering from rheumatoid arthritis before and after starting treatment though the enzymes balancing cortisol and cortisone levels are involved in regulating various inflammatory diseases. Methods. In a retrospective study, a panel of 41 urinary steroid metabolites has been analysed in a group of 18 patients with active rheumatoid arthritis (RA) as they were brought under control with disease modifying drugs. Results. No major changes were found in a variety of androgen, oestrogen and progesterone metabolites, however the ratio of THF + 5αTHF/THE as an index of 11β-HsD1 oxidative activity demonstrated down-regulation with modification correlating significantly with change in acute phase reactants as the disease came under control. These findings were supported by a tendency of a reduced ratio of F/E, an index of 11β-HsD2 oxidative activity, resulting in a significant correlation of the two ratios (p s parallelism of the two enzymes with functions of clinical laboratory parameters during drug-induced improvement of the disease is novel. Conclusions. Urinary steroid metabolites, which alter with disease activity, may provide further insight into the mechanisms by which stress can modify arthritis through hormones.

关键词： Rheumatoid Arthritis Basic Clinical scienc Hormones Inflammation Biomarkers

Formation of tholeiitic basalts by lithosphere-asthenosphere interaction: example from Datong, North China

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Formation of tholeiitic basalts by lithosphere-asthenosphere...