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Bone Research 2014年第1期2卷 33-42页

作者： Julie L frey David P Stonko Marie-Claude Faugere Ryan C Riddle Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Division of Nephrology Bone & Mineral Metabolism University of Kentucky Veterans Administration Medical Center

The hypoxia inducible factors （Hifs） are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone （PTH）. Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. Consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of β-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH.

关键词： PTH Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone Figure

Capacity Estimation for Ionic Components on Algae Biosorbens by AAS and X-Ray Fluorescence Measurements

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Capacity Estimation for Ionic Components on Algae Biosorbens...

第四届上海国际分析化学研讨会

作者： G.Bunke A.Erko F.frey Technical University of Berlin Inst.of Biotechnology Technical University of Berlin BESSY GmbHBerlin

A relatively new process is the use of immobilized algae biomass as sorption agent for the removal of ionic components from contaminated ***-and macro algae are of particular interest in this *** algae may be cultivat...

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微型硬盘驱动技术与嵌入式应用整合方案

电子设计应用 2006年第10期 115-118页

作者： Graig frey Quick Logic公司

本文着重探讨了消费电子领域硬盘驱动技术与嵌入式应用的整合方案,在方案讨论中着重考虑了设计方案的功耗,硬盘驱动产品通用接口标准,针对微硬盘驱动和主流低功耗嵌入式微处理器连接的不同系统结构应用,以及在某些特定应用中的设计。

关键词：嵌入式应用整合方案驱动技术微型硬盘并行ATA接口硬盘驱动器 IDE接口数字输入/输出

Correlation between the structure of gold and silver model catalysts and their CO oxidation,NOX reduction activities

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A narrative review on endopancreatic interventions: an innovative access to the pancreas

第18届国际真空大会

作者： Krisztina frey Gábor Pet Ferenc Tanczikó László Guczi Institute of Isotopes HASH-1525 BudapestP.O.Box 77Hungary KFKI Research Institute for Particle and Nuclear Physics H-1525 BudapestP.O.Box. 49Hungary

Automotive exhaust gas contains high concentrations of NOx, CO, and hydrocarbons, which are harmful to human health. Although these components can be reduced drastically by the use of a three-way catalyst, nitrous oxide, N2O, which has a strong greenhouse effect, is produced during the catalytic reaction. The present work is aimed at developing a novel family of catalysts, based on gold and silver, to replace the more expensive platinum and rhodium metals.

关键词： model catalysts XPS nanoparticles oxides

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Journal of Pancreatology 2021年第2期4卷 90-98页

作者： Michael C.frey Benjamin Eigl Daniel C.Steinemann Thilo Hackert Fabian Rossler Felix Nickel Beat P.Muller-Stich Kaspar Z’graggen Philip C.Muller Department of Surgery Kantonsspital BadenBaden CAScination AG Bern Department of Surgery Clarunis University Hospital BaselBaselSwitzerland Department of General Visceral and Transplantation SurgeryUniversity Hospital HeidelbergHeidelbergGermany Department of Visceral and Transplant Surgery University Hospital ZurichZurich Department of Surgery Hirslanden Klinik Beau-SiteBernSwitzerland

The natural connection between the duodenum and the pancreatic duct enables a minimally invasive access to the *** this access is already regularly used,mainly for diagnostic and even for certain therapeutic *** per-oral pancreatoscopy the endopancreatic approach allows the direct visualization of the pancreatic duct system potentially improving the diagnostic work-up of pancreatic cystic neoplasms,intrapancreatic strictures and removal of pancreatic duct ***,the endopancreatic access can equally be applied for surgical *** objective of this review is to summarize endoscopic and surgical interventions using the endopancreatic *** surgery stands for a further development of the endoscopic technique:a rigid endoscope is transabdominally introduced over the duodenum and the papilla to enable resections of strictures and inflamed tissue from inside the pancreas under visual *** the orientation and localization of target structures using this minimally invasive approach is difficult,the development of an accurate image guidance system will play a key role for the clinical implementation and widespread use of endoscopic and surgical endopancreatic interventions.

关键词： Computer-assisted surgery Endopancreatic surgery Image-guided surgery Minimally invasive pancreatic surgery Pancreatic surgery

Artificial intelligence in pancreatic surgery:current applications

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Journal of Pancreatology 2023年第2期6卷 74-81页

作者： Christoph Kuemmerli Fabian Rössler Caroline Berchtold Michael C.frey Alexander Studier-Fischer Amila Cizmic Jan Philipp Jonas Thilo Hackert Felix Nickel Philip C.Müller Department of Surgery Clarunis-University Centre for Gastrointestinal and Liver DiseasesBaselSwitzerland Swiss HPB and Transplantation Center Department of Surgery and TransplantationUniversity Hospital ZurichZurichSwitzerland Department for General Visceral and Vascular SurgeryKantonsspital BadenBadenSwitzerland Department of General Visceral and Transplantation SurgeryHeidelberg University HospitalHeidelbergGermany Department of General Visceral and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfHamburgGermany

Surgery plays a central role in the treatment of benign and malignant pancreatic *** intelligence(AI)is an important upcoming technology to support surgeons in pre-,intra-,and postoperative diagnosis,decision-making and training toward an optimized patient *** AI applications show a promising role in the evaluation of preoperative images for prediction of malignancy and resectability,intraoperative decision support,surgical training as well as a postoperative risk stratification to per-sonalize the management of *** scoping review summarizes the most up to date developments of AI in pancreatic surgery with the highest available level of evidence.

关键词： Artificial intelligence Image-guidance Machine learning Pancreas neoplasms Pancreatic ductal carcinoma Personalized medicine Surgery

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技术冲击就业,AI有何不同?

科技与金融 2018年第12期 8-10页

作者： Carl Benedikt frey 牛津大学马丁学院牛津马丁花旗

毫无疑问,技术的进步和AI的发展无处不在,伴随而来的是无尽的机会。人工智能其实是一项应用非常广泛的技术,那些在人工智能方面处于领先的企业,它们在医疗诊断、自动驾驶、物流仓储、国防等行业领域都将处于领先地位。因此,有很多技术... 详细信息

毫无疑问,技术的进步和AI的发展无处不在,伴随而来的是无尽的机会。人工智能其实是一项应用非常广泛的技术,那些在人工智能方面处于领先的企业,它们在医疗诊断、自动驾驶、物流仓储、国防等行业领域都将处于领先地位。因此,有很多技术都在推动各个领域的发展进步。人工智能的出现与应用,可能意味着人类要付出相应代价,因为技术的进步并不是稳定的过程,会有高低起伏和负面影响。牛津大学马丁学院技术和就业项目联合主任、牛津马丁花旗会士Carl Benedikt frey博士就人工智能与就业的关系,展开一系列的讨论,通过历史案例,讲述以前的技术革命给人类的工作带来哪些短期及长期的影响。

关键词：机器人发展中国家图灵测试 AI

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超镁铁岩和镁铁岩的稀土元素地球化学

地球与环境 1985年第S1期 21-28+20页

作者： F.A.frey 于学元

一、上地幔岩石的REE地球化学地幔约占整个地球质量的2/3,在估价整个地球的成分和地壳—地幔—地核体系的成分演化时,必须了解地幔的成分。了解地幔成分的直接途径只能是研究那些由地质作用过程暴露在地壳内的地幔岩石样品。这些岩石... 详细信息

一、上地幔岩石的REE地球化学地幔约占整个地球质量的2/3,在估价整个地球的成分和地壳—地幔—地核体系的成分演化时,必须了解地幔的成分。了解地幔成分的直接途径只能是研究那些由地质作用过程暴露在地壳内的地幔岩石样品。这些岩石为几种

关键词：橄榄岩超基性岩包体球粒陨石拉斑玄武岩拉斑玄武质岩石部分熔融结晶作用 REE

Subtalar Dislocation:Long-Term Follow-Up and CT-Morphology

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Open Journal of Orthopedics 2015年第3期5卷 53-59页

作者： Stefanie Hoelscher-Doht Sonke P. frey Sebastian Kiesel Rainer H. Meffert Hendrik Jansen Department of Trauma HandPlastic and Reconstructive SurgeryUniversity Clinics of WuerzburgWuerzburgGermany Department of Orthopedics and Trauma Surgery Caritas-HospitalBad MergentheimGermany

Introduction: Although rare, subtalar dislocations are severe injuries with long-term alterations such as clinical dysfunction or painful posttraumatic arthritis. The objective of this study was to investigate long-term morphological changes of subtalar dislocations and to correlate them to clinical function. Based on the conclusions, suggestions for therapy guidelines were made in order to improve the functional outcome. Methods: Twenty-two patients (12 with a medial, 9 with a lateral and 1 with an anterior dislocation) were re-examined with an average follow-up time of 10 years. Radiological results of a computer tomography examination of the hindfoot were related to the clinical outcome, and both were discussed in the context of further parameters, such as additional injuries, time until reduction, and post-reduction treatment. Results: Additional injuries were found to affect the clinical outcome and/or the radiological changes. Predictive factors for limited range of motion were severe skin trauma and traumatic brain injuries. Factors that predicted both poor clinical function and clear signs of arthritis included complex talus, ankle and calcaneus fractures, long time until reduction, and infection. Conclusions: In many cases, radiological results can be correlated to clinical outcomes. However, the modulating effects of additional injuries should be considered when planning therapy. In cases with additional fractures of the talus and the calcaneus, suffering pain may be reduced by an early arthrodesis of the talo-cal-canear joint. In cases involving a long stay on an intensive care unit, early functional treatment by passive motion should be discussed in special cases to improve the clinical outcome.

关键词： Subtalar Dislocation Arthritis Outcome Long-Term CT