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Neural Regeneration Research 2021年第2期16卷 242-246页

作者： francisco j.barrantes Biomedical Research Institute(BIOMED)UCA-CONICET Buenos AiresArgentina

Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary *** classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the neuromuscular junction,the nicotinic acetylcholine *** variants of the disease involve autoimmune attack of non-receptor scaffolding proteins or enzymes essential for building or maintaining the integrity of this peripheral *** review summarizes the participation of the above proteins in building the neuromuscular junction and the destruction of this cholinergic synapse by autoimmune aggression in myasthenia *** review also covers the application of a powerful biophysical technique,superresolution optical microscopy,to image the nicotinic receptor in live cells and follow its motional *** hypothesis is entertained that anomalous nanocluster formation by antibody crosslinking may lead to accelerated endocytic internalization and elevated turnover of the receptor,as observed in myasthenia gravis.

关键词： agrin autoimmune diseases muscle end-plate muscle specific kinase MuSK myasthenia gravis nanoscopy neuromuscular junction nicotinic acetylcholine receptor rapsyn superresolution microscopy

Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol

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BIOCELL 2021年第6期45卷 1479-1484页

作者： francisco j.barrantes Laboratory of Molecular Neurobiology Institute of Biomedical Research(BIOMED)UCA-CONICETFaculty of Medical SciencesBuenos AiresArgentina

Cholesterol is a major lipid in biological *** not only plays a structural role but also modulates a wide range of functional properties of neurotransmitter and hormone receptors and ion *** membraneembedded segments of the paradigm neurotransmitter receptor for acetylcholine(nAChR)contain linear sequences of amino acids with the capacity to recognize *** cholesterol consensus domains have been designated as“CARC”and its mirror sequence“CRAC”.CARC preferentially occurs in the exoplasmic-facing membrane leaflet,and CRAC,in the cytoplasmic-facing *** motifs are highly conserved among ion-channel and neurotransmitter receptor proteins in vertebrate nervous systems,where they recognize cholesterol,and in prokaryotic homologues in bacteria,where they recognize *** phylogenetically conserved trait is an indication that the hopanoids in some bacteria and cholesterol in eukaryotes subserve analogous functions,probably contributing to the stability of membrane-embedded protein *** studies from our laboratory using superresolution optical microscopy(“nanoscopy”)have disclosed other interrelated functional and structural properties exerted by cholesterol on the *** neutral lipid content at the cell surface influences both the macromolecular organization of the receptor and its translational mobility(diffusion)in the plane of the membrane.

关键词： Cholesterol Pentameric ligand-gated ion channel Nicotinic acetylcholine receptor Membrane proteins Evolution Nanoscopy Cholesterol-recognition domains

Controversies around the treatment of peritoneal metastases of colorectal cancer

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World journal of Gastrointestinal Oncology 2025年第1期17卷 260-264页

作者： francisco j Morera-Ocon Clara Navarro-Campoy Ticiano Guastella francisco Landete-Molina Department of General Surgery Hospital General de RequenaRequena 46340Spain Department of Gynecology and Obstetrics Hospital 9 OctubreValencia 46015Spain Department of Pathology Hospital General de RequenaRequena 46340Spain

In this editorial we examine the article by Wu et al published in the World journal of Gastrointestinal *** resection for peritoneal metastases from colorectal cancer(CRC)has been gradually accepted in the medical oncology community.A randomized trial(PRODIGE 7)on cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)failed to prove any benefit of oxaliplatin in the overall survival of patients with peritoneal metastases from colorectal ***,isolated systemic chemotherapy for CRC stage IV has demonstrated a reduced response in peritoneal metastases than that obtained in other metastatic sites such as the *** tool is required in those patients to achieve more local control of the *** groups in peritoneal surgery continue to use HIPEC in their procedures,using other agents than oxaliplatin for peritoneal cavity infusion,such as mitomycin *** patients present with complex surgical issues to manage,and consequently a large burden of complications has to be ***,identifying patients who will benefit from CRS with or without HIPEC would be of great interest.

关键词： Colorectal cancer Peritoneal metastasis Hyperthermic intraoperative chemotherapy Treatment strategies Peritoneal Surface Oncology GroupInternational

Ferrofluid moving thin films for active flow control

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Chinese journal of Aeronautics 2021年第5期34卷 115-119页

作者： francisco j.ARIAS Department of Fluid Mechanics Polytechnic University of CataloniaESEIAATC/Colom 1108222 BarcelonaSpain

Ferrofluid moving thin films and their possible significance with regard to active flow control for lift and attack angle enhancement are *** this strategy,a very thin film of ferrofluid is strongly attached at the wall of the wing by a normal magnetic field from below and pumped tangentially along the *** a simplified physical model and from the available experimental data on moving walls,the expected lift enhancement and effect on the attack angle were *** research and design is required in order to explore the possibilities in the use of ferrofluid moving thin films.

关键词： Active flow control Boundary layer separation Ferrofluid

Local Fourier Analysis for Edge-Based Discretizations on Triangular Grids

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Numerical Mathematics(Theory,Methods and Applications) 2015年第1期8卷 78-96页

作者： Carmen Rodrigo francisco Sanz francisco j.Gaspar francisco j.Lisbona Department of Applied Mathematics University of ZaragozaC/Maria de Luna 350018ZaragozaSpain BIFI University of Zaragoza C/Pedro Cerbuna 1250009ZaragozaSpain Department of Applied Mathematics University of ZaragozaC/Pedro Cerbuna 1250009ZaragozaSpain

In this paper,we present a local Fourier analysis framework for analyzing the different components within multigrid solvers for edge-based discretizations on triangular *** different stencils associated with edges of different orientation in a triangular mesh make this analysis *** resulting tool is demonstrated for the vector Laplace problem discretized by mimetic finite difference *** from the local Fourier analysis,as well as experimentally obtained results,are presented to validate the proposed analysis.

关键词： Multigrid local Fourier analysis edge-based discretizations mimetic finite differences

Shear velocity criterion for incipient motion of sediment

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Water Science and Engineering 2014年第2期7卷 183-193页

作者： francisco j.M.SIMOES U.S. Geological Survey Geomorphology and Sediment Transport LaboratoryGolden CO 80403 USA

The prediction of incipient motion has had great importance to the theory of sediment transport. The most commonly used methods are based on the concept of critical shear stress and employ an approach similar, or identical, to the Shields diagram. An alternative method that uses the movability number, defined as the ratio of the shear velocity to the particle＇s settling velocity, was employed in this study. A large amount of experimental data were used to develop an empirical incipient motion criterion based on the movability number. It is shown that this approach can provide a simple and accurate method of computing the threshold condition for sediment motion.

关键词： incipient motion sediment transport Shields diagram critical shear stress criticalshear velocity movability number

Creating and moving nanoantenna cold spots anywhere

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Light(Science & Applications) 2022年第10期11卷 2335-2344页

作者： Alex j.Vernon francisco j.Rodriguez-Fortuno Department of Physics King's College LondonStrandLondon WC2R 2LSUnited Kingdom

Cold spots are sub-wavelength regions which might emerge near a nanoantenna,should one or more components of some far-field illumination cancel out with scattered *** show that by changing only the polarisation,amplitude,and phase of two plane waves,a unique,zero-magnitude and highly sub-wavelength cold spot can be created and moved anywhere in the space around a nanoantenna of any arbitrary *** can be achieved using ultra-fast modulated pulses,or a time-harmonic *** disturbed by a change in the nanoantenna's material or position,a manufactured cold spot is fragile and could be used in nanoscale *** technique exploits the linearity of Maxwell's equations and could be adapted to manipulate any phenomena governed by the linear wave equation,including acoustic *** is a means for potentially ultra-fast sub-wavelength electric field manipulation.

关键词： illumination scattered arbitrary

Diffusion dynamics and characterization of attogram masses in optically trapped single nanoparticles using laser-induced plasma imaging

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Nano Research 2023年第5期16卷 7470-7480页

作者： Pablo Purohit francisco j.Fortes javier Laserna UMALASERLAB Departamento de Química AnalíticaUniversidad de MálagaC/Jiménez Fraud 4Malaga 29010Spain Niels Bohr Institute University of CopenhagenBlegdamsvej 172100 CopenhagenDenmark

In the present work,a wavelength-selected plasma imaging analysis system is presented and used to track photons emitted from single-trapped nanoparticles in air at atmospheric *** isolated nanoentities were atomized and excited into plasma state using single nanosecond laser *** use of appropriate wavelength filters alongside time-optimized acquisition settings enabled the detection of molecular and atomic emissions in the *** photon detection efficiency of the imaging line resulted in a signal>400 times larger than the simultaneously-acquired dispersive spectroscopy *** increase in sensitivity outlined the evolution of diverse physicochemical processes at the single particle scale which included heat and momentum transfer from the plasma into the particle as wells as chemical *** imaging detection of excited fragments evidenced different diffusion kinetics and time frames for atoms and molecules and their influence upon both the spectroscopic emission readout and fabrication processes using the plasma as a ***,the origin of molecular species,whether naturally-occurring or derived from a chemical reaction in the plasma,could also be studied on the basis of compositional gradients found on the *** of detection for the inspected species ranged from tens to hundreds attograms,thus leading to an exceptional sensing principle for single nanoentities that may impact several areas of science and technology.

关键词： single nanoparticle inspection wavelength-selected laser-induced plasma imaging laser fabrication attogram characterization atomic/molecular diffusion

Real Renormings on Complex Banach Spaces

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Chinese Annals of Mathematics,Series B 2008年第3期29卷 239-246页

作者： francisco j GARC■A-PACHECO Alejandro MIRALLES Department of Mathematical Sciences Kent State University Departamento de Análisis Matemático Universidad de Valencia

The authors prove that every complex Banach space admits an equivalent real norm that is far away from being a complex norm. Furthermore, this real norm can be chosen to share many properties with complex norms, but i... 详细信息

关键词： Complex norms Real norms Hilbert space

A SHORT NOTE ABOUT EXPOSED POINTS IN REAL BANACH SPACES

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Acta Mathematica Scientia 2008年第4期28卷 797-800页

作者： Antonio Aizpuru francisco j Garcia-Pacheco Departamento de Matemá ticas Universidad de Cá diz Department of Mathematical Sciences Kent State University

We express the set of exposed points in terms of rotund points and non-smooth *** long as we have Banach spaces each time＂bigger＂,we consider sets of non-smooth points each time＂smaller＂.

关键词： Exposed point exposed face rotund point smooth point