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SIMULATION, ANALYSIS AND OPTIMIZATION OF CONTAINER TERMINALS PROCESSES

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第3期3卷 1-20页

作者： AGOSTINO BRUZZONE francesco longo LETIZIA NICOLETTI ELEONORA BOTTANI ROBERTO MONTANARI Simulation Team University of Genoa Via Magliotto 217100 SavonaItaly MSC-LES Mechanical Department University of CalabriaVia P.Bucci 44C 87036 Rende(CS)Italy Department of Industrial Engineering University of Parma Viale G.P.Usberti 181/A43124 ParmaItaly

The freight logistics includes all the processes needed to supply industry,retailers and wholesalers and final customers with *** processes generate a flow of goods that,in the global supply chain,mainly relies on the activities carried out within worldwide container *** this paper,the authors present a simulation model of a real container *** some preliminary analyses,the simulation model is first used with Design of Experiments and Analysis of Variance to investigate the effects of different resources allocations(i.e.,number of forklifts and tractors)and some parameters(i.e.,inter-arrival times,container unloading time)on the container terminal performances in terms of total number of handled containers per ***,based on the results achieved through the Design of Experiments and Analysis of Variance,the simulation model is used with genetic algorithms to carry out a range allocation optimization on berth assignment to incoming ships and number of tractors serving each quay *** aim of the optimization is the minimization of the average time spent by each ship in the port area(decreasing,as consequence,costs and increasing service level provided to final customers).

关键词： Container terminals supply chain node simulation optimization genetic algorithms analysis of variance.

Combined chemo-radiotherapy in locally advanced nasopharyngeal carcinomas

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World Journal of Clinical Oncology 2013年第2期4卷 47-51页

作者： francesco Perri Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo francesco longo Paolo Muto Concetta Schiavone Fabio Sandomenico francesco Caponigro Head and Neck Medical Oncology Unit National Tumor Institute of Naples80131 NaplesItaly Medical Oncology Unit Hospital of Salerno84090 SalernoItaly Medical Oncology Unit University Federico II of Naples80131 NaplesItaly Otolaryngology Unit National Tumor Institute of Naples80131 NaplesItaly Fabio Sandomenico Radiotherapy UnitNational Tumor Institute of Naples80131 NaplesItaly

AIM:To provide efficacy and safety data about the combined use of radiotherapy and chemo-radiotherapy in nasopharyngeal carcinoma(NPC).METHODS:We reviewed data of 40 patients with locally advanced NPC treated with induction chemotherapy followed by concomitant chemo-radiotherapy(CCRT)(22/40 patients)or CCRT alone(18/40)from March 2006 to March *** underwent fiberoscopy with biopsy of the primitive tumor,and computed tomography scan of head,neck,chest and abdomen with and without *** was used both as induction and as concomitant chemotherapy,while 3D conformal radiation therapy was delivered to the nasopharynx and relevant anatomic regions(total dose,70 Gy).The treatment was performed using 6 MV photons of the linear accelerator administered in 2 Gy daily fraction for five days *** retrospective analysis was approved by the review boards of the participating *** gave their consent to treatment and to anonymous analysis of clinical ***:Thirty-three patients were males and 7 were *** follow-up time was 58 mo(range,1-92 mo).In the sub-group of twenty patients with a follow-up time longer than 36 mo,the 3-year survival and disease free survival rates were 85%and 75%,*** response rate both in patients treated with induction chemotherapy followed by CCRT and in those treated with CCRT alone was 100%.Grade 3 neutropenia was the most frequent acute side-effect and it occurred in 20 *** 2 mucositis was seen in 29 patients,while grade 2 xerostomia was seen in 30 *** toxicity was manageable and it did not cause any significant treatment *** the whole sample population,long term toxicity included grade 2 xerostomia in 22 patients,grade 1 dysgeusia in 17 patients and grade 1 subcutaneous fibrosis in 30 ***:Both CCRT and induction chemotherapy followed by CCRT showed excellent activity in locally advanced *** role of adjuvant chemotherapy remains

关键词： Nasopharyngeal carcinoma Induction chemotherapy Concurrent chemoradiotherapy Adjuvant chemotherapy Locally advanced disease

Locking plates for distal fibula fractures in young and elderly patients:A retrospective study

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World Journal of Orthopedics 2023年第7期14卷 540-546页

作者： francesco Roberto Evola Giovanni francesco Di Fede Giuseppe Evola Martina Barchitta Antonella Agodi Gianfranco longo Department of Surgery Division of Orthopedics and Trauma Surgery“Cannizzaro”HospitalCatania 95100Italy Department of Radiodiagnostics Division of Radiology“S.Marta and S.Venera”HospitalAcireale 95024Italy Department of Surgery Division of Surgery“Garibaldi”HospitalCatania 95100Italy Department of Medical and Surgical Sciences and Advanced Technologies“GF Ingrassia” University of CataniaCatania 95100Italy

BACKGROUND Ankle fractures are common injuries in the young and elderly *** prevent post-traumatic arthritis,an anatomic reconstruction of the ankle structure is *** reduction and internal fixation is the treatment of choice among *** plates allow stability of the fracture if bone quality is *** plates might offer an advantage for the treatment of lateral malleolar fracture in patients with comminution,severe instability,distal fractures,or osteoporotic *** hospital introduced a new locking plate for fracture of the distal *** To evaluate locking plates in terms of outcomes and complications in young and elderly *** We retrospectively reviewed a total of 67 patients treated for displaced distal fibula *** data,number of comorbidities,use of inter fragmentary screw,complication,time of fracture healing,partial or full weight bearing,and reoperation were recorded for all *** outcome was assessed by the American Orthopedic Foot and Ankle Society clinical scoring *** were obtained at 4,8,12,16,20,and 24 wk until radiographic union was *** All patients displayed complete bony union on radiographic assessment,and no patients developed any serious *** observed two superficial infections,one delayed wound healing,and two plate *** differences were observed between the two age groups in terms of radiographic healing(11.9 wk in younger patients vs 13.7 wk in older patients;P=0.011)and in the American Orthopedic Foot and Ankle Society score at 6 mo after surgery(88.2 in younger patients vs 86.0 in older patients;P=0.001)and at 12 mo after surgery(92.6 in younger patients vs 90.0 in older patients;P=0.000).CONCLUSION Locking plates provide a stable and rigid fixation in multifragmentary and comminuted fractures or in the presence of poor bone quality.

关键词： Ankle fracture Locking plate Distal fibula fracture Outcome Complications Osteoporosis

Concentration and Preservation of Very Low Abundance Biomarkers in Urine, such as Human Growth Hormone (hGH), by Cibacron Blue F3G-A Loaded Hydrogel Particles

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Nano Research 2008年第6期1卷 502-518页

作者： Claudia Fredolini francesco Meani K.Alex Reeder Sally Rucker Alexis Patanarut Palma J.Botterell Barney Bishop Caterina longo Virginia Espina Emanuel F.Petricoin III Lance A.Liotta Alessandra Luchini Department of Urology S.Giovanni Bosco HospitalTorino 10154Italy Department of Medicine and Experimental Oncology University of TurinTurin 10126Italy Gynecology and Obstetrics Department University of BresciaBrescia 25100Italy Department of Dermatology and Venereology University of Modena and Reggio EmiliaModena 41100Italy Center for the Applied Proteomics and Molecular Medicine George Mason UniversityManassasVA 20110USA Chemistry and Biochemistry Department George Mason UniversityManassasVA 20110USA.

Urine is a potential source of diagnostic biomarkers for detection of diseases,and is a very attractive means of non-invasive biospecimen ***,proteomic measurement in urine is very challenging because diagnostic biomarkers exist in very low concentration(usually below the sensitivity of common immunoassays)and may be subject to rapid *** nanoparticles functionalized with Cibacron Blue F3G-A(CB)have been applied to address these challenges for urine biomarker *** chose one of the most difficult low abundance,but medically relevant,hormones in the urine:human growth hormone(hGH).The normal range of hGH in serum is 1 to 10 ng/mL but the urine concentration is suspected to be a thousand times less,well below the detection limit(50 pg/mL)of sensitive clinical hGH *** demonstrate that CB particles can capture,preserve and concentrate hGH in urine at physiological salt and urea concentrations,so that hGH can be measured in the linear range of a clinical immunometric *** and cadaveric hGH were captured from synthetic and human urine,concentrated and measured with an Immulite chemiluminescent *** of hGH less than 0.05 ng/mL(the Immulite detection limit)were concentrated to 2 ng/mL,with a urine volume of 1 *** response studies using 10 mL of urine demonstrated that the concentration of hGH in the particle eluate was linearly dependent on the concentration of hGH in the starting solution,and that all hGH was removed from *** if the starting urine volume is 100 mL,the detection limit will be 0.1 pg/*** from a healthy donor whose serum hGH concentration was 1.34 ng/mL was studied in order detect endogenous *** from a volume of 33 mL,the particle eluate had an hGH concentration of 58 pg/mL,giving an estimated initial concentration of hGH in urine of 0.175 pg/*** nanotechnology described here appears to have the desired precision,accuracy and sensitivity to suppor

关键词： Urine proteomics Cibacron Blue F3G-A human growth hormone hydrogel nanoparticles N-isopropylacrylamide

Observatory science with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares francesco longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves

Functional Characterization of Bifidobacteria of Human Origin: A Case Study by the Students of Food Science and Technology of the University of Foggia (Southern Italy)

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Food and Nutrition Sciences 2014年第13期5卷 1153-1161页

作者： Emanuela Ciuffreda Angino Veronica Antonietta Cifelli Rossana Foti Rosaria Ilenia Forte Fabio Graziani Andrea Giuseppe longo Angela longo Valeria Maglia Emilio francesco Ricciardi Alessandra Sabatino Annamaria Tomaiuolo Maria Rosaria Corbo Milena Sinigaglia Antonio Bevilacqua Department of the Science of Agriculture Food and Environment (SAFE) University of Foggia Foggia Italy

The aim of this paper was to study the potential technological and probiotic properties of bifidobacteria isolated from human feces. Bifidobacteria, naturally present in the dominant colonic microbiota, represent up to 25% of the cultivable faecal bacteria in adults and 80% in infants. Bifidobacteria have been shown to adhere and colonize in high numbers different types of cultured intestinal epithelial cells;moreover some authors reported that some strains are able to stabilize the intestinal microbiota during and after antibiotic therapy, modulate the immune system, protecting against chemically induced intestinal inflammation and reducing symptoms of colitis. Eight isolates of bifidobacteria were studied to assess their technological and probiotic traits;the technological characterization relied on the assessment of enzymatic activities (proteolytic and lipolytic activity), growth under various conditions (pH, temperature and addition of salt), acidifying ability and metabolism (arginine deamination, esculin, esculin hydrolysis and citrate metabolism). The study of the probiotic characteristics focused on the evaluation of the survival at low pH and with bile salts added, antibiotic resistance, and hydrophobic properties. As a result of this process, two promising strains were selected for further studies.

关键词： Bifidobacteria Technology Probiotic Traits Functional Characterization

Reporting rotator cuff tears on magnetic resonance arthrography using the Snyder's arthroscopic classification

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世界放射学杂志：英文版（电子版） 2017年第3期9卷 126-133页

作者： Alberto Aliprandi Carmelo Messina Paolo Arrigoni Michele Bandirali Giovanni Di Leo Stefano longo Sandro Magnani Chiara Mattiuz Filippo Randelli Silvana Sdao francesco Sardanelli Luca Maria Sconfienza Pietro Randelli Servizio di Radiologia IRCCS Policlinico San Donato Scuola di Specializzazione in Radiodiagnostica Università degli Studi di Milano Unità Operativa di Ortopedia e Traumatologia Ⅱ IRCCS Policlinico San Donato Dipartimento di Scienze Biomediche per la Salute Università degli Studi di Milano Unità Operativa di Ortopedia e Traumatologia V IRCCS Policlinico San Donato Unità Operativa di Radiologia/Diag-nostica per Immagini con Servizio di Radiologia Interventistica IRCCS Istituto Ortopedico Galeazzi Unità Operativa Complessa I Divisione Istituto Ortopedico Gaetano Pini

AIM To determine diagnostic performance of magnetic resonance arthrography(MRA) in evaluating rotator cuff tears(RCTs) using Snyder's classification for *** One hundred and twenty-six patients(64 males, 62 females; median age 55 years) underwent shoulder MRA and arthroscopy, which represented our reference standard. Surgical arthroscopic reports were reviewed and the reported Snyder's classification was recorded. MRA examinations were evaluated by two independent radiologists(14 and 5 years' experience) using Snyder's classification system, blinded to arthroscopy. Agreement between arthroscopy and MRA on partial-and fullthickness tears was calculated, first regardless of their extent. Then, analysis took into account also the extent of the tear. Interobserver agreement was also calculated the quadratically-weighted Cohen kappa *** On arthroscopy, 71/126 patients(56%) had a fullthickness RCT. The remaining 55/126 patients(44%) had a partial-thickness RCT. Regardless of tear extent, out of 71 patients with arthroscopically-confirmed fullthickness RCTs, 66(93%) were correctly scored by both readers. All 55 patients with arthroscopic diagnosis of partial-thickness RCT were correctly assigned as having a partial-thickness RCT at MRA by both readers. Interobserver reproducibility analysis showed total agreement between the two readers in distinguishing partial-thickness from full-thickness RCTs, regardless of tear extent(k = 1.000). With regard to tear extent, in patients in whom a complete tear was correctly diagnosed, correct tear extent was detected in 61/66 cases(92%); in the remaining 5/66 cases(8%), tear extent was underestimated. Agreement was k = 0.955. Interobserver agreement was total(k = 1.000).CONCLUSION MRA shows high diagnostic accuracy and reproducibility in evaluating RCTs using the Snyder's classification for reporting. Snyder's classification may be adopted for routine reporting of MRA.

关键词： Arthroscopy Magnetic resonance imaging Shoulder Arthrography Supraspinatus tendon Rotator cuff tear