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流体排溢及迁移控制着亚平宁山脉北部中新世冷泉碳酸盐岩的形成

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海洋地质 2008年第3期24卷 73-74页

作者： Silvia Mecozzi Stefano Conti daniela fontana 陈红锋（译）陈弘（校对）意大利摩德纳·雷焦·艾米利亚大学不详

在亚平宁山脉北部中新世的前陆盆地和“卫星式”沉积盆地（前陆盆地系统楔顶的延伸部分），出现大量的碳酸盐岩露头，它们与现代冷泉碳酸盐岩一样具有特定的古生态学、沉积学、成分以及同位素等方面的特征。这些碳酸盐岩主要出现在大型... 详细信息

在亚平宁山脉北部中新世的前陆盆地和“卫星式”沉积盆地（前陆盆地系统楔顶的延伸部分），出现大量的碳酸盐岩露头，它们与现代冷泉碳酸盐岩一样具有特定的古生态学、沉积学、成分以及同位素等方面的特征。这些碳酸盐岩主要出现在大型的浊积岩体（Cervarola山和Mamoso砂质有孔虫建造）和陆坡半结核体中（Vicchio和Verghereto泥灰岩，Ghiolidiletto泥岩）。它们形成独立的具有特殊结构和特定生物化石（化能供养的蛤类和双壳类）的不规则块状灰岩，具有典型的18C亏损特征，显示了甲烷对其形成的影响。

关键词：冷泉碳酸盐岩亚平宁山脉中新世迁移控制前陆盆地系统流体沉积盆地古生态学

Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 390-400页

作者： Matilde Bongianni Mauro Catalan daniela Perra Elena fontana Francesco Janes Claudio Bertolotti Luca Sacchetto Stefano Capaldi Matteo Tagliapietra Paola Polverino Valentina Tommasini Giulia Bellavita Elham Ataie Kachoie Roberto Baruca Andrea Bernardini Mariarosaria Valente Michele Fiorini Erika Bronzato Stefano Tamburin Laura Bertolasi Lorenzo Brozzetti Maria Paola Cecchini Gianluigi Gigli Salvatore Monaco Paolo Manganotti Gianluigi Zanusso Department of Neurosciences Biomedicineand Movement SciencesPoliclinico G.B.RossiUniversity of Verona37134 VeronaItaly Neurology Unit Department of MedicineSurgery and Health SciencesOspedale CattinaraUniversity of Trieste34128 TriesteItaly Neurology Unit University of Udine Academic Hospital33100 UdineItaly Department of Surgical Sciences DentistryGynecology and PediatricsUniversity of Verona37134 VeronaItaly Biocrystallography Laboratory Department of BiotechnologyUniversity of Verona37134 VeronaItaly Otolaryngology Unit Department of MedicineSurgery and Health SciencesOspedale CattinaraUniversity of Trieste34128 TriesteItaly.

Background: In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucleinopathies. It is unknown whether these variable results might be related to a different distribution of pathological α-syn in OM. Thus, we investigated whether nasal swab (NS) performed in areas with a different coverage by olfactory neuroepithelium, such as agger nasi (AN) and middle turbinate (MT), might affect the detection of pathological α-syn. Methods: NS was performed in 66 patients with PD and 29 non-PD between September 2018 and April 2021. In 43 patients, cerebrospinal fluid (CSF) was also obtained and all samples were analyzed by RT-QuIC for α-syn. Results: In the first round, 72 OM samples were collected by NS, from AN (NSAN) or from MT (NSMT), and 35 resulted positive for α-syn RT-QuIC, including 27/32 (84%) from AN, 5/11 (45%) from MT, and 3/29 (10%) belonging to the non-PD patients. Furthermore, 23 additional PD patients underwent NS at both AN and MT, and RT-QuIC revealed α-syn positive in 18/23 (78%) NSAN samples and in 10/23 (44%) NSMT samples. Immunocytochemistry of NS prepara-tions showed a higher representation of olfactory neural cells in NSAN compared to NSMT. We also observed α-syn and phospho-α-syn deposits in NS from PD patients but not in controls. Finally, RT-QuIC was positive in 22/24 CSF samples from PD patients (92%) and in 1/19 non-PD. Conclusion: In PD patients, RT-QuIC sensitivity is significantly increased (from 45% to 84%) when NS is performed at AN, indicating that α-syn aggregates are preferentially detected in olfactory areas with higher concentration of olfactory neurons. Although RT-QuIC analysis of CSF showed a higher diagnostic accuracy compared to NS, due to the non-invasiveness, NS might be considered as an ancillary procedure for PD diagnosis.

关键词： Parkinson disease Alpha-synuclein Real-time quaking-induced conversion assay Olfactory mucosa Cerebrospinal fluid

Different Methods to Estimating the Cost of Equity: An Analysis on a Sample of Too Big to Fail Banks

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Management Studies 2019年第5期7卷 452-464页

作者： Coluccia daniela fontana Stefano Solimene Silvia University of Rome Sapienza RomeItaly

In this study, a comparison was made between the Capital Asset Pricing Model (CAPM), the most widely used methodology, and an actuarial method with the use of credit default swaps (CDSs) and the method based on the inverse of the multiple P/E. These three models are used to estimate the cost of equity. The comparison was made on a sample of 24 banks selected among the largest for assets in the world (too big to fail banks) belonging to 11 different countries. The results show that the CAPM estimates a premium for the higher risk than the one obtained with the actuarial method and the method based on the inverse of the P/E (except for 2013).

关键词： cost of equity CDS probability of default price to earnings ratio

Correction: Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 389-389页

Correction:Translational Neurodegeneration(2022)11:37 https://***/10.1186/s40035-022-00311-3 In the original publication of this article[1],“AN”is miss-ing in the column heading“Patients underwent NS at the(n=46)”in Table 1 due to a typesetting *** correct column heading should be“Patients underwent NS at the AN(n=46)”.Moreover,the asterisk symbol*in“27(84)*”and“5(45)*”should be *** addition,the phrase“using FLOQBrushes(Copan Italia,Brescia,Italy)”needs be added in the first sentence under the header“OM sample collection”of the Methods section.

关键词： heading optimization removed