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Software reliability analysis considering correlated component failures with coupling measurement framework

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Journal of Systems Engineering and Electronics 2015年第5期26卷 1114-1126页

作者： Xiaodan Li Yongfeng Yin lance fiondella Yibin Zhou School of Reliability and System Engineering Beihang University Department of Electrical & Computer Engineering University of Massachusetts

With progression of the digital age, the complexity of software continues to grow. As a result, methods to quantitatively assess characteristics of software have attracted significant attention. These efforts have led to a large number of new measures such as coupling metrics, many of which seek to consider the impact of correlations between components and failures on application reliability. However, most of these approaches set the coupling parameters arbitrarily by making assumptions instead of utilizing experimental data and therefore may not accurately capture actual coupling between components of software application. Since the coupling matrix is often set arbitrarily, the existing approaches to assess software reliability considering component correlation fail to reflect the real degree of interaction and relationships among software components. This paper presents an efficient approach to assess the software reliability considering correlated component failures, incorporating software architecture while considering actual internal coupling of software with an efficient approach based on multivariate Bernoulli(MVB) distribution. The unified framework for software coupling measurement is informed by a comprehensive survey of frameworks for objectoriented and procedure-oriented software. This framework enables the extraction of more accurate coupling among components. The effectiveness of this method is illustrated through an experimental study by applying it to a real-time software application.

关键词： correlated failures software coupling software architecture software reliability

Software reliability analysis considering correlated component failures with coupling measurement framework

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Journal of Systems Science & Complexity 2015年第5期28卷 1114-1126页

With progression of the digital age, the complexity of software continues to grow. AS a result, methods to quantitatively assess characteristics of software have attracted significant atten- tion. These efforts have led to a large number of new measures such as coupling metrics, many of which seek to consider the impact of correlations between components and failures on ap- plication reliability. However, most of these approaches set the coupling parameters arbitrarily by making assumptions instead of utilizing experimental data and therefore may not accurately capture actual coupling between components of software applica- tion. Since the coupling matrix is often set arbitrarily, the existing approaches to assess software reliability considering component correlation fail to reflect the real degree of interaction and rela- tionships among software components. This paper presents an efficient approach to assess the software reliability considering Correlated component failures, incorporating software architec- ture while considering actual internal coupling of software with an efficient approach based on multivariate Bernoulli （MVB） distribu- tion. The unified framework for software Coupling measurement is＇ informed by a comprehensive survey of frameworks for object- oriented and procedure-oriented software. This framework enables the extraction of more accurate coupling among cornponents. The effectiveness of this method is illustrated through an exPerimental study bylapplying it to a real-time software application.

关键词： correlated failures software coupling, software archi-tecture, software reliability

Heart regeneration with human pluripotent stem cells: Prospects and challenges

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Bioactive Materials 2020年第1期5卷 74-81页

作者： Yuqian Jiang Xiaojun lance Lian Department of Biomedical Engineering Pennsylvania State UniversityUniversity ParkPA16802USA Huck Institutes of the Life Sciences Pennsylvania State UniversityUniversity ParkPA16802USA Department of Biology Pennsylvania State UniversityUniversity ParkPA16802USA

Cardiovascular disease,ranging from congenital heart disease to adult myocardial infarction,is the leading cause of death *** pursuit of reliable cardiovascular regenerative medicine,human pluripotent stem cells(hPSCs),including human embryonic stem cells(hESCs)and human induced pluripotent stem cells(hiPSCs),offer plenty of potential cell-based *** are capable of proliferating indefinitely in an undifferentiated state,and are also pluripotent,being able to differentiate into virtually any somatic cell types given specific stepwise cues,thus representing an unlimited source to generate functional cardiovascular cells for heart *** we recapitulated current advances in developing efficient protocols to generate hPSCderived cardiovascular cell lineages,including cardiomyocytes,endothelial cells,and epicardial *** also discussed applications of hPSC-derived cells in combination with compatible bioactive materials,promising trials of cell transplantation in animal models of myocardial infarction,and potential hurdles to bring us closer to the ultimate goal of cell-based heart repair.

关键词： Human pluripotent stem cells Cardiovascular cells Tissue engineering

Comparison of alternative route selection strategies based on simulation optimization

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Chinese Journal of Aeronautics 2016年第6期29卷 1749-1761页

作者： Ye Bojia lance Sherry Chen Chun-Hung Tian Yong National Key Lab of Air Traffic Flow Management Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 210016China Center for Air Transportation Systems Research Department of Systems Engineering&Operations ResearchGeorge Mason UniversityFairfaxVA22030USA

Air traffic flow management(ATFM) is a collaborative process between the airspace provider and the airspace users. The result of the collaboration should be an outcome that maximizes the utility of the system without excessively penalizing any of the agents. This paper develops a discrete-event simulation model which consists of aggregate departure/arrival airports, flight routes, and sectors for evaluating the alternative collaborative route selection strategy. Given the different perspectives from air traffic control center(ACC) and airlines, eight performancemetrics and five alternative route selection strategies represent the past, current and proposed air traffic flow management operations that were evaluated. The Monte Carlo method combined with the Optimal Computing Budget Allocation(OCBA) simulation optimization technique is employed to assess the performance of different strategies. A case study of the upper air routes in central and southern China shows that the proposed model can be readily implemented to simulate different kinds of air traffic flow management strategies and predict the effect of changes on the airspace system. It also shows that the proposed alternative collaborative route selection strategy is an effective way in alleviating the en-route traffic congestion.

关键词： Air traffic control Decision support systems Discrete-event simulation Monte Carlo methods OCBA

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Exporting China’s Successes in Vaccine Preventable Hepatitis

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China CDC weekly 2020年第30期2卷 575-576页

作者： lance E.Rodewald National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Almost four decades of science,innovation,and programmatic effort to control and prevent vaccinepreventable viral hepatitis have paid off spectacularly well in *** the pre-vaccine era,nearly 10% of children were infected by hepatitis B virus(HBV)—especially during childbirth—causing them to be lifelong carriers of HBV,able to infect others,and in great danger of liver cancer and cirrhosis as adults(1).

关键词： vaccine China. hepatitis

Forty and Twenty Years Ago and Now--Virus Elimination Successes and New Challenges

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China CDC weekly 2020年第50期2卷 953-954页

作者： lance E.Rodewald National Immunization Program China CDC Immunization Services Division US CDC(2000-2012) WHO China Country Office(2012-2017)

Forty years ago,smallpox was declared eradicated by the World Health Organization(WHO).As ***,Director of the Smallpox Eradication Programme at the WHO quoted from the 33^(rd) World Health Assembly(1980)(1),“...the world and all its peoples have won freedom from smallpox...a most devastating disease...since earliest time,leaving death,blindness,and disfigurement in its wake and which only a decade ago was rampant in Africa,Asia and South America.”

关键词： death Director disease.

scLM:Automatic Detection of Consensus Gene Clusters Across Multiple Single-cell Datasets

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 330-341页

作者： Qianqian Song Jing Su lance D.Miller Wei Zhang Center for Cancer Genomics and Precision Oncology Wake Forest Baptist Comprehensive Cancer CenterWake Forest Baptist Medical CenterWinston SalemNC 27157USA Department of Cancer Biology Wake Forest School of MedicineWinston SalemNC 27157USA Department of Biostatistics Indiana University School of MedicineIndianapolisIN 46202USA

In gene expression profiling studies,including single-cell RNA sequencing(scRNA-seq)analyses,the identification and characterization of co-expressed genes provides critical information on cell identity and *** co-expression clustering in scRNA-seq data presents certain *** show that commonly used methods for single-cell data are not capable of identifying co-expressed genes accurately,and produce results that substantially limit biological expectations of co-expressed ***,we present single-cell Latent-variable Model(scLM),a gene coclustering algorithm tailored to single-cell data that performs well at detecting gene clusters with significant biologic ***,scLM can simultaneously cluster multiple single-cell datasets,i.e.,consensus clustering,enabling users to leverage single-cell data from multiple sources for novel comparative *** takes raw count data as input and preserves biological variation without being influenced by batch effects from multiple *** from both simulation data and experimental data demonstrate that scLM outperforms the existing methods with considerably improved *** illustrate the biological insights of scLM,we apply it to our in-house and public experimental scRNA-seq *** identifies novel functional gene modules and refines cell states,which facilitates mechanism discovery and understanding of complex biosystems such as cancers.A user-friendly R package with all the key features of the scLM method is available at https://***/QSong-github/scLM.

关键词： Single-cell RNA sequencing Consensus clustering Latent space Markov Chain Monte Carlo Maximum likelihood approach

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“If the world doesn’t share the vaccine,the virus will take on the world”

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China CDC weekly 2021年第13期3卷 265-266页

作者： Zundong Yin lance Rodewald Dan Wu National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina.

What did George Gao mean by the title quote?The statement certainly feels like a warning,but it is a warning that comes with a prescription that carries optimism and *** warning that the virus will“take on the world”has indeed been the world’s experience during the first year of *** the warning is more ominous with the continual emergence of variants of the coronavirus that have differing characteristics-transmission speed,pathogenicity,evasion of immunity to prior infection or immunization(1).

关键词： immunity prescription statement

Opening the black box of donor influence on Digital Earth in Africa

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International Journal of Digital Earth 2013年第S02期6卷 1-21页

作者： Kate T.lance Yola P.Georgiadou Arnold K.Bregt Faculty of Geo-Information Science and Earth Observation University of TwentePO Box 2177500 AEEnschedeThe Netherlands Centre for Geo-Information Wageningen University and Research CentrePO Box 476700 AAWageningenThe Netherlands

Africa’s participation in Digital Earth is *** is a tendency to ascribe this state to prevailing governance and cultural challenges in ***,foreign actors such as donors have an apparent role in shaping geospatial policies and *** far,the complex linkages between external aid and improved social and environmental monitoring and decision-making have been handled as a kind of‘black box’.To better understand the situation,we open the box and focus on the interaction between donors and *** use a heuristic from political science,as well as empirical evidence,to describe the policyinfluencing tools that donors employ based on four basic resources donors possess:organization,authority,treasure,and *** show an evolution of tool usage as donors shift from‘old aid’to‘new aid’*** new tools include:technical assistance for geospatial curriculum development,inscription of standards and data access requirements in contracts and grants,cross-agency project design,best-practice analysis,portfolio management,and the use of language to promote participation and *** these tools reflect donor intent to partner in the realization of Digital Earth,the tools stem from a persisting asymmetric power dynamic between donors and policy-makers.

关键词： foreign aid donors policy outcomes tools geospatial technologies