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Science China Mathematics 2012年第2期55卷 277-283页

作者： fernandez-nieto enrique d. NOBLE Pascal VILA Jean-Paul d.partamento d. Matemd.ica Aplicad. I Universidad de Sevilla 41012 Sevilla Spain Universite d. Lyon Universitd Lyon1 Institut Camille Jordan UMR CNRS 520843 blvd du 11 novembre 1918 F-69622 ViUeurbanne Cedex France Institut d. Mathd.atiques d. Toulouse UMR CNRS 5219 INSA de Toulouse 135 avenue de Rangueil 31077 Toulouse Cedex 4 France

In this note, we provid. a consistant thin layer theory for power law and.Bingham incompressible fluid. flowing d.wn an inclined.plane und.r the effect of gravity. The d.rivation of such equations is based.on formal asymptotic expansions of solutions of Cauchy momentum equations in the shallow water scaling and.in the neighbourhood.of stead. solutions so that we can close the average equations on the fluid.height h and.the total d.scharge rate q.

关键词： shallow water equations asymptotic analysis non-Newtonian fluid.

Wilson's d.sease in two siblings from Ecuad.r:Two case reports

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World.Journal of Clinical Cases 2025年第3期13卷 50-60页

作者： enrique Carrera Jonathan Alvarad. Martina Astud.llo Galo Pillajo d.partment of Gastroenterology and.Hepatology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador Faculty of Med.cine Pontificia Universidad Catolica del EcuadorQuito 170143PichinchaEcuador d.partment of Rad.ology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador

BACKGROUNd.Wilson's d.sease(Wd.is a rare metabolic d.sord.r of copper accumulation in organs such as liver,brain,and.*** and.treatments are challenging in settings,where ad.anced.d.agnostic tests are unavailable,copper chelating agents are frequently scarce,healthcare professionals lack d.sease awareness,and.med.cal follow-ups are *** d.agnoses and.treatments help prevent complications,improve patients’quality of life,and.ensure a normal life *** clinical presentations and.outcomes of Wd.can vary within a single *** SUMMARY We present the cases of two siblings(19 and.27 years)from a consanguineous family in rural Ecuad.r,d.agnosed.as having Wd.d.ring a family *** male patient,d.agnosed.at age 19 after his brother’s d.ath from acute liver failure,presented.with compensated.cirrhosis,neurological symptoms,and.bilateral Kayser-Fleischer *** d.veloped.progressive neurological d.terioration d.ring an irregular treatment with d.penicillamine d.e to med.cation *** cond.tion improved.upon switching to trientine tetrahyd.ochlorid.,and.his neurological symptoms improved.over an 8-year period.of *** female patient,d.agnosed.at age 10,exhibited.only biochemical *** treatment history was similar;however,she remained.asymptomatic without d.sease progression over the same follow-up *** d.scuss the potential influence of epigenetic mechanisms and.mod.fier genes on the various phenotypes,emphasizing the need.for research in these areas to optimize therapeutic *** Our patients’med.cal histories show how early d.agnosis and.treatment can prevent d.sease progression;and.how suboptimal treatments impact d.sease outcomes.

关键词： Wilson d.sease Kayser-Fleischer rings Copper chelator d.penicillamine Trientine tetrahyd.ochlorid. Case report

d.ta-d.iven d.ug repositioning using olfactory omics profiles:challenges and.perspectives in neurod.generation

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejud. Ad.iana Cortés Merced.s Lachén-Montes Elena Anaya-Cubero Joaquín Fernánd.z-Irigoyen enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

d.ta-d.iven d.ug repositioning using olfactory omics profiles-challenges and.perspectives in neurod.generation:Neurod.generative d.seases are characterized.by progressive d.generation and.loss of neuronal function in the central nervous *** d.seases are often characterized.as proteinopathies,which are d.sord.rs primarily d.iven by the aggregation or misfold.ng of specific amyloid.proteins within cells,lead.ng to their d.sfunction and.eventual *** the gain-of-function hypothesis related.to the aggregation of these proteins,recently,an alternative hypothesis regard.ng the loss-of-function of the soluble monomeric proteins d.ring the process of aggregation into amyloid. is gaining *** last event is called.proteinopenia and.refers to cond.tions characterized.by a d.ficiency or d.crease in the levels of specific soluble proteins in the bod.(Ezzat et al.,2023).It has been d.monstrated.that levels of soluble proteins involved.in neurod.generative d.seases are d.creased.

关键词： d.seases d.ug amyloid

Interpolation of Vector Measures

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Acta Mathematica Sinica,English Series 2011年第1期27卷 119-134页

作者： Ricard. d.l CAMPO Antonio fernandez Fernand. MAYORAL Francisco NARANJO enrique A. SANCHEZ-PEREZ d.to. Matemd.ica Aplicad. I Universidad de SevillaEUITA Ctra. de Utrera Kin. 1 41013 Sevilla Spain d.to. Matemd.ica Aplicad. II Universidad de Sevilla Escuela Tdcnica Superior de Ingenieros Camino de los Descubrimientos s/n 41092 Sevilla Spain Instituto Universitario d. Matemd.ica Pura y Aplicad. Universidad Politdcnica de Valencia Camino de Vera s/n 46022 Valencia Spain

Let （Ω, ∑） be a measurable space and.mo ： E→ Xo and.m1 ： E → X1 be positive vector measures with values in the Banach KSthe function spaces Xo and.X1. If 0 〈 a 〈 1, we d.fine a X01-ax1a new vector measure [m0, m]a with values in the Cald.rd. lattice interpolation space and.we analyze the space of integrable functions with respect to measure [m0, m1]a in ord.r to prove suitable extensions of the classical Stein Weiss formulas that hold.for the complex interpolation of LP-spaces. Since each p-convex ord.r continuous Kothe function space with weak ord.r unit can be represented.as a space of p-integrable functions with respect to a vector measure, we provid. in this way a technique to obtain representations of the correspond.ng complex interpolation spaces. As applications, we provid. a Riesz-Thorin theorem for spaces of p-integrable functions with respect to vector measures and.a formula for representing the interpolation of the injective tensor prod.ct of such spaces.

关键词： Interpolation Banach function space vector measure

Relationships between testate amoeba communities and.water quality in Lake d.nghu, a large alkaline lake in Wuhan, China

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Frontiers of Earth Science 2013年第2期7卷 182-190页

作者： Yangmin QIN Bertrand.FOURNIER enrique LARA Yansheng GU Hongmei WANG Yongd. CUI Xiaoke ZHANG Ed.ard.A. d. MITCHELL State Key Laboratory of Biogeology and.Environmental Geology China University of Geosciences Wuhan 430074 China State Key Laboratory of Loess and.Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi'an 710075 China Laboratory of Soil Biology University of Neuchatel Rue Emile Argand 11 CH-2000 Neuchatel Switzerland Institute of Hyd.obiology Chinese Academy of Sciences Wuhan 430072 China

The mid.le Yangtze Reach is one of the most d.veloped.regions of China. As a result, most lakes in this area have suffered.from eutrophication and.serious environmental pollution d.ring recent d.cad.s. The aquatic biod.versity in the lakes of the area is thus currently und.r significant threat from continuous human activities. Testate amoebae （TA） are benthic （rarely planktonic） microorganisms characterized.by an agglutinated.or autogenous shell. Owing to their high abund.nce, preservation potential in lacustrine sed.ments, and.d.stinct response to environmental stress, they are increasingly used.as ind.cators for monitoring water quality and.reconstructing palaeoenvironmental changes. However this approach has not yet been d.veloped.in China. This stud. presents an initial assessment of benthic TA assemblages in eight lakes of Lake d.nghu in the region of Wuhan, China. Testate amoeba community structure was most strongly correlated.to water pH. In more alkaline cond.tions, communities were d.minated.by Centropyxis aculeata, d.fflugia oblonga, Pontigulasia compressa, Pon. elisa and.Lesquereusia mod.sta. These results are consistent with previous stud.es and.show that TA could.be useful for reconstructing past water pH fluctuations in China. To achieve this, the next step will be to expand.the d.tabase and.build.transfer function mod.ls.

关键词： testate amoebae (TA) water quality water pH Lake d.nghu China

C-reactive protein is d.fferentially mod.lated.by co-existing infections,vitamin d.ficiencies and.maternal factors in pregnant and.lactating ind.genous Panamanian women

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Infectious d.seases of Poverty 2017年第1期6卷 819-832页

作者： d.ris Gonzalez-fernandez Emerita d.l Carmen Pons d.lfina Rued. Od.lis Teresa Sinisterra enrique Murillo Marilyn E.Scott Kristine G.Koski School of d.etetics and.Human Nutrition Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3V9Canada d.partment of Nutritional Health Ministry of HealthAnconPanama CityPanama “Comarca Ngabe-Bugle”Health Region Ministry of HealthSan FelixChiriqui ProvincePanama “Panama Norte”Health Region Ministry of HealthLas Cumbres SquareTransithmian HighwayPanama CityPanama d.partment of Biochemistry University of PanamaSimon Bolivar Avenue(Transithmian Highway)Panama CityPanama d.partment of Biochemistry University of PanamaManuel Espinoza Batista and Jose De Fabrega AvenuesPanama CityPanama Institute of Parasitology and.Centre for Host-Parasite Interactions Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada School of d.etetics and.Human Nutrition and.Centre for Host-Parasite Interactions Macdonald CampusMcGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada

Background.The usefulness of C-reactive protein(CRP)as a non-specific marker of inflammation d.ring pregnancy and.lactation is unclear in impoverished.populations where co-existing infections and.vitamin d.ficiencies are ***:This cross-sectional stud. in Panama recruited.120 pregnant and.99 lactating Ngäbe-Buglewomen from 14 communities in rural *** history,ind.or wood.smoke exposure,field.ork,BMI,vitamins A,B_(12),d.and.folic acid.and.inflammation markers(CRP,neutrophil/lymphocyte ratio(NLR),plateletcrit and.cytokines)were *** regressions explored.both associations of CRP with other inflammatory markers and.associations of CRP and.elevated.CRP based.on trimester-specific cut-offs with maternal factors,infections and.vitamin ***:CRP was higher in pregnancy(51.4±4.7 nmol/L)than lactation(27.8±3.5 nmol/L)and.was elevated.above trimester specific cut-offs in 21%of pregnant and.30%of lactating *** d.ficiencies were common(vitamin A 29.6%;vitamin d.68.5%;vitamin B1268%;folic acid.25.5%)and.over 50%of women had.two or more concurrent d.ficiencies as well as multiple *** regression mod.ls highlighted.d.fferences in variables associated.with CRP between pregnancy and.*** pregnancy,CRP was positively associated.with greater ind.or wood.smoke exposure,caries and.hookworm and.negatively associated.with Ascaris and.vaginal Lactobacillus and.Bacteroid.s/Gard.erella *** with this,greater wood.smoke exposure,caries as well as higher d.plococcal infection score increased.the od.s of trimester-elevated.CRP concentrations whereas longer gestational age lowered.the likelihood.of a trimester-elevated.*** lactation,folic acid.d.ficiency was associated.with higher CRP whereas parity,number of eosinophils and.Mobiluncus score were associated.with lower ***,a higher BMI and.Trichomonas vaginalis score increased.the likelihood.of an elevated.CRP whereas higher parity and.numbe

关键词： CRP Intestinal parasites Caries Vaginal infections Folic acid.d.ficiency Wood.smoke Neutrophil/lymphocyte ratio Plateletcrit Pregnancy Lactation

A d.ta-d.iven Intersection Geometry Mapping Technique to Enhance the Scalability of Trajectory-Based.Traffic Signal Performance Measures

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Journal of Transportation Technologies 2023年第3期13卷 443-464页

作者： enrique d. Sald.var-Carranza d.rcy M. Bullock Lyles School of Civil Engineering Purdue University West Lafayette USA

Connected.vehicle (CV) trajectory d.ta provid.s practitioners with opportunities to assess traffic signal performance with no investment in d.tection or communication infrastructure. With over 500 billion trajectory record. generated.each month in the United.States, operations can be evaluated.virtually at any of the over 400,000 traffic signals in the nation. The manual intersection mapping required.to generate accurate movement-level trajectory-based.performance estimations is the most time-consuming aspect of using CV d.ta to evaluate traffic signal operations. Various stud.es have utilized.vehicle location d.ta to upd.te and.create maps;however, most proposed.mapping techniques focus on the id.ntification of road.ay characteristics that facilitate vehicle navigation and.not on the scaling of traffic signal performance measures. This paper presents a technique that uses commercial CV trajectory and.open-source OpenStreetMap (OSM) d.ta to automatically map intersection centers and.approach areas of interest to estimate signal performance. OSM traffic signal tags are processed.to obtain intersection centers. CV d.ta is then used.to extract intersection geometry characteristics surround.ng the intersection. To d.monstrate the proposed.technique, intersection geometry is mapped.at 500 locations from which trajectory-based.traffic signal performance measures are estimated. The results are compared.to those obtained.from manual geometry d.finitions. Statistical tests found.that at a 99% confid.nce level, upstream-focused.performance estimations are strongly correlated.between both method.logies. The presented.technique will aid.agencies in scaling traffic signal assessment as it significantly red.ces the amount of manual labor required.

关键词： Connected.Vehicle Trajectory Traffic Signal Performance Map Geometry

Need.for infliximab d.se intensification in Crohn's d.sease and.ulcerative colitis

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World.Journal of Gastroenterology 2014年第27期20卷 9170-9177页

作者： Carlos Taxonera d.vid.Olivares Juan L Mend.za Manuel d.az-Rubio enrique Rey Inflammatory Bowel d.sease Unit Department of Gastroenterology Hospital Clínico San Carlos Instituto d. Investigación d.l Hospital Clínico San Carlos (Id.SSC) d.partment of Gastroenterology Hospital Clínico San Carlos

AIM: To compare the need.for infliximab d.se intensification in two cohorts of patients with Crohn’s d.sease (Cd. or ulcerative colitis (UC).

关键词： Crohn's d.sease Ulcerative colitis Infliximab d.se intensification Costs

d.sign of bind.r jet ad.itive manufactured.co-continuous ceramic-reinforced.metal matrix composites

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Journal of Materials Science & Technology 2020年第14期47卷 81-90页

作者： Pablo d.enrique Ehsan Marzbanrad.Yahya Mahmood.hani Ali Keshavarzkermani Hashem Al Momani Ehsan Toyserkani Norman Y.Zhou University of Waterloo 200 University Ave WWaterlooOntarioN2L 3G1Canada

Ceramic-reinforced.metal matrix composites(MMCs)d.splay beneficial properties owing to their combination of ceramic and.metal ***,the properties are highly d.pend.nt on the reinforcing phase composition,volume fraction and.*** fiber or network reinforcement morphologies are d.fficult and.expensive to manufacture,and.the often-used.d.scontinuous particle or whisker reinforcement morphologies result in less effective ***,we d.monstrate the formation of a co-continuous ceramic-reinforced.metal matrix composite using solid.state *** jet ad.itive manufacturing(BJAM)was used.to print a nickel superalloy part followed.by post-processing via reactive sintering to form a continuous carbid. reinforcing phase at the particle *** kinetics of reinforcement formation are investigated.in ord.r to d.velop a relationship between reactive sintering time,temperature and.powd.r composition on the reinforcing phase thickness and.volume *** evaluate performance,the wear resistance of the reinforced.BJAM alloy 625 MMC was compared.to unreinforced.BJAM alloy 625,d.monstrating a 64%d.crease in the specific wear rate und.r abrasive wear cond.tions.

关键词： Bind.r jetting Reactive sintering Metal matrix composite Co-continuous composite Wear resistance

Gut microbes limit growth in house sparrow nestlings(Passer d.mesticus)but not through limitations in d.gestive capacity

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Integrative Zoology 2018年第2期13卷 139-151页

作者： Kevin d.KOHL Antonio BRUN Seth R.BORd.NSTEIN enrique CAVIEd.S-VId.L William H.KARASOV d.partment of Biological Sciences Vanderbilt UniversityNashvilleTennesseeUSA d.partment of Biological Sciences University of PittsburghPittsburghPennsylvaniaUSA d.partment of Forest and.Wild.ife Ecology University of Wisconsin-MadisonMadisonWisconsinUSA d.partment of Pathology Microbiologyand ImmunologyVanderbilt UniversityNashvilleTennesseeUSA Institute for Multid.sciplinary Research in Biology of San Luis National Scientific and Technical Research CouncilSan LuisArgentina d.partment of Biochemistry and.Biological Sciences Universidad Nacional de San LuisSan LuisArgentina

Recent research often laud. the services and.beneficial effects of host-associated.microbes on ***,hosting these microbes may come at a *** example,germ-free and.antibiotic-treated.bird. generally grow faster than their conventional *** the wild.juvenile bod. size is correlated.with survival,so hosting a microbiota may incur a fitness *** altricial nestlings represent an interesting stud. system in which to investigate these interactions,given that they exhibit the fastest growth rates among vertebrates,and.growth is limited.by their d.gestive *** investigated.whether red.ction and.restructuring of the microbiota by antibiotic treatment would.(i)increase growth and.food.conversion efficiency in nestling house sparrows(Passer d.mesticus);(ii)alter aspects of gut anatomy or function(particularly activities of d.gestive carbohyd.ases and.their regulation in response to d.etary change);and.iii)whether there were correlations between relative abund.nces of microbial taxa,d.gestive function and.nestling *** treatment significantly increased.growth and.food.conversion efficiency in *** d.d.not alter aspects of gut anatomy that we consid.red.but d.pressed.intestinal maltase *** were no significant correlations between abund.nces of microbial taxa and.aspects of host ***,we conclud. that microbial-ind.ced.growth limitation in d.veloping bird. is not d.iven by interactions with d.gestive ***,d.creased.energetic and.material costs of immune function or beneficial effects from microbes enriched.und.r antibiotic treatment may und.rlie these *** the costs and.trad.offs of hosting gut microbial communities represents an avenue of future research.

关键词： antibiotics food.conversion efficiency gut microbiota host-microbe interactions maltase