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Maternal and Fetal Exposure to Four Carcinogenic Environmental Metals

Biomedical and Environmental Sciences 2010年第6期23卷 458-465页

作者： HUAI GUAN feng-yuan piao XIAO-WEI LI QIU-JUAN LI LEI XU KAZUHITO YOKOYAMA Department of Occupational and Environmental Health Dalian Medical University Dalian 116044 Liaoning China Department of Obstetrics and Gynecology No. 210 Hospital of PLA Dalian 116021 Liaoning China Department of Public School of Medicine Mie University Tsu Mie-Prefecture Japan

Objective To examine maternal and fetal exposure levels to four carcinogenic metals, arsenic （As）, cadmium （Cd）, nickel （Ni）, and beryllium （Be）, and to investigate their environmental influences. Methods Metal concentrations in maternal and umbilical cord blood were measured by inductively coupled plasma-mass spectrometry （ICP-MS）. Environmental factors that might play a role in exposure were analyzed using Mann Whitney nonparametric U-tests and multiple linear regression. Results The concentrations of As, Cd, and Ni in umbilical cord blood （5.41, 0.87, and 139.54 gg/L） were significantly lower than those in maternal blood （6.91, 1.93, and 165.93 p.g/L）. There were significant positive correlations between the maternal and cord concentrations of each carcinogen. Our results showed that：（i） exposures to potentially harmful occupational factors during pregnancy were associated with high levels of maternal As, Cd, and Ni; （ii） living close to major transportation routes （〈500 m） or exposure to second-hand smoke during pregnancy increased the maternal Cd levels and （iii） living close to industrial chimneys induced high maternal Ni levels. Multiple linear regression analysis showed that these environmental factors remained significant in models of the influences of these four carcinogens. Conclusion Both mothers and fetuses had been exposed to As, Cd, Ni, and Be. The increased levels of these carcinogens in pregnant women were associated with some detrimental environmental factors, such as occupational exposure, contact with second-hand smoke and living close to major transportation routes or industrial chimneys.

关键词： Carcinogenic metals Exposure in utero Maternal blood Cord blood Environment

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牛黄酸与维生素C对慢性砷暴露小鼠肝组织DNA损伤的保护作用

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世界华人消化杂志 2007年第34期15卷 3567-3571页

作者：刘爽朴丰源曲淑贤孙鲜策姚晓峰叶建新李秋娟大连医科大学卫生学教研室辽宁省大连市116044

目的:观察牛黄酸与维生素C对慢性砷暴露小鼠肝组织DNA损伤的保护作用.方法:将小鼠40只随机分为4组,即:染砷组(4 ppm As_2O_3)、牛黄酸保护组(4 ppm As_2O_3)+150 mg/kg牛黄酸)、维生素C保护组(4 ppm As_2O_3+45 mg/kg维生素C)以及生理... 详细信息

目的:观察牛黄酸与维生素C对慢性砷暴露小鼠肝组织DNA损伤的保护作用.方法:将小鼠40只随机分为4组,即:染砷组(4 ppm As_2O_3)、牛黄酸保护组(4 ppm As_2O_3)+150 mg/kg牛黄酸)、维生素C保护组(4 ppm As_2O_3+45 mg/kg维生素C)以及生理盐水对照组,用HE染色法进行组织病理学观察,用免疫组化及图像分析检测肝组织内8-OH-dG的水平.结果:染砷组小鼠肝组织出现胞质疏松化和气球样变等病理学改变,牛黄酸和维生素C保护组肝组织上述病理学变化较轻.免疫组化结果表明,染砷组肝组织呈现8-OH-dG的高表达(P<0.01).两保护组小鼠肝组织8-OH-dG的表达显著低于染砷组(P<0.01),其中牛黄酸保护组小鼠肝组织8-OH-dG免疫染色总光密度值(0.824±0.1062)显著低于维生素C保护组(246.7±61.81,P=0.012).结论:牛黄酸和维生素C对慢性砷暴露小鼠肝组织DNA损伤具有保护作用,其中牛黄酸的保护作用更明显.

关键词：三氧化二砷肝脏 8-羟基脱氧鸟嘌呤牛黄酸维生素C 免疫组化方法

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Ribavirin and IFN-α combination therapy induces CD4+ T-cell proliferation and Th1 cytokine secretion in patients with chronic hepatitis B

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World Journal of Gastroenterology 2007年第41期13卷 5440-5445页

作者： Fen-Yu Ren Hai Jin Xi-Xu piao feng-Shun piao Department of Gastroenterology and Hepatology Yanbian University Hospital Yanji 133000 Jilin Province China

AIM: To investigate the anti-viral mechanism of combination therapy of interferon (IFN)-α and ribavirin in patients with chronic hepatitis B. METHODS: Twenty patients were assigned to receive either IFN-α plus ribavirin (group A,n = 14) or no treatment as a control (group B,n = 6). Patients were analyzed for T-cell proliferative responses specific for hepatitis B virus (HBV)-antigen and cytokine production by peripheral blood mononuclear cells (PBMCs). RESULTS: Combination therapy induced HBV-antigen specific CD4+ T-cell proliferative responses in four patients (28.6%). Production of high levels of HBV-specific IFN-γ,tumor necrosis factor (TNF)-α,interleukin (IL)-12 by PBMCs was found in five patients (35.7%),who showed significantly lower HBV DNA levels in serum at 12 mo after treatment ended (P = 0.038) and at 24 mo of follow-up (P = 0.004) than those without high levels of cytokine production. CONCLUSION: HBV-antigen specific CD4+ T cells may directly control HBV replication and secretion of anti-viral T helper 1 (Th1) cytokines by PBMCs during combination therapy of chronic hepatitis B with ribavirin and IFN-α.

关键词： Hepatitis B Interferon-alpha Ribavirin CD4+ T cells Th1

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Electrocatalytic oxygen reduction performances of surface Ag granular packs electrodeposited from dual-phase Ag_(35.5)Zn_(64.5) precursor alloys by triangle wave potential cycling

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Rare Metals 2021年第12期40卷 3531-3542页

作者： Jia-Yu Luo piao-piao Han Zhen-Hua Dan Tao Tang feng-Xiang Qin Hui Chang Lian Zhou College of Materials Science and Engineering and Tech Institute for Advanced Materials Nanjing Tech UniversityNanjing 210009China State Key Laboratory of Advanced Metals and Materials University of Science and Technology BeijingBeijing 110083China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

Surface Ag granular packs(SAgPs) have been fabricated from dual-phase Ag_(35.5)Zn_(64.5) precursor alloy consisting of both e and c phases by using a facile one-step triangle wave potential cycling in 0.5 mol·L^(-1) *** the continuous potential cyclic sweeping, the c phases preferentially dissolve during the anodic scan and dominant reduction reactions of Ag cations lead to redeposition and accumulation of Ag atoms together to form SAg Ps during cathodic scan. The e phases stay inactive to form a continuous skeleton in the inner regions. SAg Ps with an average particle size of 94-129 nm can be obtained at scan rates of 25, 50 and 100 mV·s^(-1) for 100 triangle wave potential cycles. SAgPs formed at a scan rate of 50 mV·s^(-1) exhibit superior oxygen reduction reaction performances with the onset potential of 0.93 V, half-wave potential of 0.72 V and an electron transfer number of *** above-mentioned SAgPs have superior stabilities as ORR catalysts.

关键词： Surface Ag granular packs Dual-phase Ag_(35.5)Zn_(64.5)precursor alloy Triangle wave potential cycling Oxygen reduction reaction catalysts Selective dissolution Intermetallic phases

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Evaluation of Surface Roughness of Aluminum Alloy in Burnishing Process Based on Chaos Theory

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Chinese Journal of Mechanical Engineering 2023年第1期36卷 90-103页

作者： Zhipeng yuan Zhenyu Zhou Zhiguo Jiang Zeyu Zhao Cong Ding Zhongyu piao College of Mechanical Engineering Zhejiang University of TechnologyHangzhou310012ZhejiangChina Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou310012China

Burnishing experiments with different burnishing parameters were performed on a computer numerical control milling machine to characterize the surface roughness of an aluminum alloy during *** chaos theory was employed to investigate the nonlinear features of the burnishing *** experimental results show that the power spectrum is broadband and continuous,and the Lyapunov exponentλis positive,proving that burnishing has chaotic *** chaotic characteristic parameter,the correlation dimension D,is sensitive to the time behavior of the system and is used to establish the corresponding relationship with the surface *** correlation dimension was the largest,when the surface roughness was the ***,when the correlation dimension curve decreases,the roughness curve *** correlation dimension and surface roughness exhibit opposite variation *** higher the correlation dimension,the lower the surface *** surface roughness of the aluminum alloy can be characterized online by calculating the correlation dimension during burnishing.

关键词： Aluminum alloy burnishing Power spectrum Correlation dimension Lyapunov exponent Surface roughness

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Comprehensive risk assessment for early neurologic complications after liver transplantation

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World Journal of Gastroenterology 2016年第24期22卷 5548-5557页

作者： Si-yuan Wu Teng-Wei Chen An-Chieh feng Hsiu-Lung Fan Chung-Bao Hsieh Kuo-piao Chung Division of Organ Transplantation Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Institute of Health Policy and Management College of Public Health National Taiwan University

AIM: To determine risk factors for early neurologic complications(NCs) after liver transplantation from perspective of recipient, donor, and surgeon. METHODS: In all, 295 adult recipients were enrolled consecutively between August 2001 and February 2014 from a single medical center in Taiwan. Any NC in the first 30 d post-liver transplantation, and perioperative variables from multiple perspectives were collected and analyzed. The main outcome was a 30-d NC. Generalized additive models were used to detect the non-linear effect of continuous variables on outcome, and to determine cut-off values for categorizing risk. Risk factors were identified using multiple logistic regression analysis. RESULTS: In all, 288 recipients were included, of whom 142(49.3%) experienced at least one NC, with encephalopathy being the most common 106(73%). NCs prolonged hospital stay(35.15 ± 43.80 d vs 20.88 ± 13.58 d, P 27.6 kg/m^2, Child-Pugh class C, history of preoperative hepatoencephalopathy or mental disorders, day 7 tacrolimus level > 8.9 ng/m L, and postoperative intraabdominal infection were more likely associated with NCs. Novel risk factors for NCs were donor age < 22 or ≥ 40 years, male-to-male gender matching, graftrecipient weight ratio 0.9%-1.9%, and sequence of transplantation between 31 and 174. CONCLUSION: NCs post- liver transplantation occurs because of factors related to recipient, donor, and surgeon. Our results provide a basis of risk stratification for surgeon to minimize neurotoxic factors during transplantation.

关键词： Risk Liver transplantation Neurotoxicity syndromes Donor Learning curve

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A new member of the structured light family:optical spatiotemporal vortices

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Light(Science & Applications) 2023年第10期12卷 2003-2005页

作者： Fu feng Xiaocong yuan Research Center for Humanoid Sensing Zhejiang LabHangzhou 311100China Nanophotonics Research Centre Shenzhen UniversityShenzhen 518060China

The burgeoning growth of structured light has opened up new possibilities for harnessing the spatiotemporal coupling effects in *** spatiotemporal vortices,as a subset of spatiotemporal light,have emerged as a focal point of recent research,owing to their distinctive characteristics and vast range for *** unique structured light will endow photons with a new degree of freedom,promising to revolutionize researchers’understanding of *** thorough research on optical spatiotemporal vortices will establish a solid foundation for the development of innovative physical mechanisms and advanced applications in photonics.

关键词： light subset optical

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Dark Matter Particle Explorer observations of high-energy cosmic ray electrons plus positrons and their physical implications

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Science China(Physics,Mechanics & Astronomy) 2018年第10期61卷 2-13页

作者： Qiang yuan Lei feng Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Center for High Energy Physics Peking UniversityBeijing 100871China

The DArk Matter Particle Explorer （DAMPE） is a satellite-borne, high-energy particle and 3,-ray detector, which is dedicated to indirectly detecting particle dark matter and studying high-energy astrophysics. The first results about precise measurement of the cosmic ray electron plus positron spectrum between 25 GeV and 4.6 TeV were published recently. The DAMPE spectrum reveals an interesting spectral softening arount 0.9 TeV and a tentative peak around 1.4 TeV. These results have inspired extensive discussion. The detector of DAMPE, the data analysis, and the first results are introduced. In particular, the physical interpretations of the DAMPE data are reviewed.

关键词： dark matter cosmic rays electrons plus positrons pulsars

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Modified series model for cross-plane thermal conductivity of short-period Si/Ge superlattices

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Science China(Physics,Mechanics & Astronomy) 2015年第6期58卷 66-73页

作者： feng yuan LIANG XinGang Department of Engineering Mechanics Key Laboratory for Thermal Science and Power Engineering of Ministry of EducationTsinghua University

Superlattices have great application potentials in thermo-electric materials and solid laser *** complicated heat transport mechanisms due to size effects,multi-interfaces and mini-band are very important issues for the prediction of thermal *** this paper,the short-period Si/Ge superlattices are investigated by a modified series model based on the Debye-Callaway *** Lambert Law is used to describe the phonon emission within hemisphere *** addition,the phonon interface transmission coefficients obtained from the phonon wave packet simulation are incorporated into boundary condition of the model,which removes the fitting parameters in the *** agreement with experiment is *** effects of temperature,wavelength-dependent phonon transmission,superlattice periods,as well as the thickness of Ge layer are considered in this paper.

关键词： superlattices thermal conductivity Debye-Callaway model Lambert Law

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Protein Requirements in Healthy Adults: A Meta-analysis of Nitrogen Balance Studies

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Biomedical and Environmental Sciences 2014年第8期27卷 606-613页

作者： LI Min SUN feng piao Jian Hua YANG Xiao Guang Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention School of public health Peking university

Objective The goal of this study was to analyze protein requirements in healthy adults through a meta-analysis of nitrogen balance studies. Methods A comprehensive search for nitrogen balance studies of healthy adults published up to October 2012 was performed, each study were reviewed, and data were abstracted. The studies were first evaluated for heterogeneity. The average protein requirements were analyzed by using the individual data of each included studies. Study site climate, age, sex, and dietary protein source were compared. Results Data for 348 subjects were gathered from 28 nitrogen balance studies. The natural logarithm of requirement for 348 individuals had a normal distribution with a mean of 4.66. The estimated average requirement was the exponentiation of the mean of the log requirement, 105.64 mg N/kg·d. No significant differences between adult age, source of dietary protein were observed. But there was significant difference between sex and the climate of the study site （P〈0.05）. Conclusion The estimated average requirement and recommended nutrient intake of the healthy adult population was 105.64 mg N/kg·d （0.66 g high quality protein/kg·d） and 132.05 mg N/kg·d （0.83 g high quality protein/kg·d）, respectively.

关键词： Protein requirement Nitrogen balance Estimated average requirement Recommendednutrient intake

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