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Relationship of lipid and lipoprotein ratios with coronary severity in patients with new on-set coronary artery disease complicated with type 2 diabetics

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Journal of Geriatric Cardiology 2016年第8期13卷 685-692页

作者： Ying DU juan CHEN Man-Hua CHEN Sheng-Hua YANG Sha LI Yuan-Lin GUO Cheng-Gang ZHU Rui-Xia xu Qian DONG Jian-Jun LI Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Diseases Chinese Academyof Medical Sciences and Peking Union Medical College Beijing China Department of Cardiology the Central Hospital of Wuhan Wuhan Hubei China

Background Diabetes mellitus （DM） is associated with coronary artery disease （CAD） progression. Although previous studies have demonstrated the association of lipid and lipoprotein ratios with CAD, no data are currently available concerning the relationship between lipid and lipoprotein ratios and the severity of new on-set CAD in diabetics. Therefore, the aim of the present study was to investigate the usefulness of lipid and lipoprotein ratios in predicting the severity of CAD in patients with type 2 DM （T2DM）. Methods A total of 380 consecutive T2DM patients with new on-set CAD were enrolled in the present study. Then, they were classified into the three groups ac-cording to Gensini score （GS） tertiles. The relationship between lipid and lipoprotein ratios currently used and the GS was investigated. Results Positive correlations of natural log-transformed GS （lnGS） with apolipoprotein B to apoA-I ratio （apoB/apoA-I）, non-high-density lipoprotein cholesterol to apoA-I ratio （non-HDL-C/apoA-I）, and low-density lipoprotein cholesterol to apoA-I ratio （LDL-C/apoA-I） were found （r = 0.18, 0.13, 0.12, respectively, all P 〈 0.05）. Multivariate logistic analysis indicated apoB/apoA-I as the strongest predictor for high GS （OR = 5.67, 95% CI： 1.45-23.92, P = 0.003）. Area under receivers operating characteristic curve of apoB/apoA-I was 0.63 （95% CI： 0.60-0.66, P = 0.001） for predicting high GS. The optimal cutoff value of apoB/apoA-I to predict high GS was 0.72 with the sensitivity of 61.2% and the specificity of 62.1%. Conclusions Lipid and lipoprotein ratios might be useful for predicting the severity of new on-set CAD in T2DM patients, and the apoB/apoA-I appeared as the most significant predictor in this population.

关键词： Coronary artery disease Lipid Lipoprotein Type 2 diabetes mellitus

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苹果近红外光谱无损检测技术的研究进展

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食品与生物技术学报 2012年第6期31卷 570-574页

作者：宫元娟匡立学冯叙桥沈阳农业大学食品营养质量与安全研究所辽宁沈阳110866 沈阳农业大学工程学院辽宁沈阳110866 沈阳农业大学食品学院辽宁沈阳110866

介绍了NIR(近红外)无损检测技术的基本原理和数据处理方法,综述了国内外应用NIR无损检测技术在苹果糖度、酸度等内部品质以及褐变和病害等内部缺陷方面的研究现状,展望了苹果NIR光谱无损检测技术研究方向和应用前景。

关键词：近红外无损检测苹果

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High-fidelity topological quantum state transfers in a cavity-magnon system

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Chinese Physics B 2023年第8期32卷 150-155页

作者：包茜茜郭刚峰杨煦谭磊 Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu ProvinceLanzhou UniversityLanzhou 730000China Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000China

We propose a scheme for realizing high-fidelity topological state transfer via the topological edge states in a onedimensional cavity-magnon *** is found that the cavity-magnon system can be mapped analytically into the generalized Su-Schrieffer-Heeger model with tunable cavity-magnon *** is shown that the edge state can be served as a quantum channel to realize the photonic and magnonic state transfers by adjusting the coupling strength between adjacent cavity ***,our scheme can realize the quantum state transfer between photonic state and magnonic state by changing the cavity-magnon coupling *** the numerical simulation,we quantitatively show that the photonic,magnonic and magnon-to-photon state transfers can be achieved with high fidelity in the cavity-magnon ***,three different types of quantum state transfer schemes can be even transformed into each other in a controllable *** Su-Schrieffer-Heeger model based on the cavity-magnon system provides us a tunable platform to engineer the transport of photon and magnon,which may have potential applications in topological quantum processing.

关键词： topological state transfer cavity-magnon system high fidelity

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Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction,Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation

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Chinese Journal of Natural Medicines 2021年第6期19卷 422-431页

作者： SHI xu-Qin ZHU Zhen-Hua YUE Shi-Jun TANG Yu-Ping CHEN Yan-Yan PU Zong-Jin TAO Hui-juan ZHOU Gui-Sheng DUAN Jin-Ao Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulaeand National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative MedicineNanjing University of Chinese MedicineNanjing 210023China School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing 210023China Institute of Mental Health Suzhou Psychiatric HospitalSoochow University Affiliated Guangji HospitalSuzhou 215100China Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility and State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Researchand Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationShaanxi University of Chinese MedicineXi’an 712046China

Colon cancer-related anemia(CCRA)is mainly caused by systemic inflammation,intestinal bleeding,iron deficiency and chemotherapy-induced myelosuppression in colon ***,the best therapeutic schedule and related mechanism on CCRA were still *** on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction(DBD),Fe and rhEPO based on CCRA and gut microbiota modulation were conducted in this ***,CCRA model was successfully induced by subcutaneous inoculation of CT-26 and ***,rhEPO+DBD high dosage+Fe(EDF)and rhEPO+DBD high dosage(ED)groups had the best blood enrichment ***,EDF group also showed antitumor *** sequencing results of gut microbiota showed that compared to P group,the relative abundances of Lachnospiraceae and opportunistic pathogen(Odoribacter)in ED and EDF groups were ***,EDF also decreased the relative abundances of cancer-related bacteria(Helicobacter,Lactococcus,Alloprevotella)and imbalance-inducing bacteria(Escherichia-Shigella and Parabacteroides)and increased the relative abundances of butyrate-producing bacteria(Ruminococcaceae_UCG-014),however,ED showed the opposite effects to EDF,this might be the reason of the smaller tumor volume in EDF *** findings proposed the best treatment combination of DBD,rhEPO and Fe in CCRA and provided theoretical basis and literature reference for CCRA-induced intestinal flora disorder and the regulatory mechanism of EDF.

关键词： Danggui Buxue Decoction Cancer-related anemia Gut microbiota modulation Fe rhEPO

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陕北能源区典型沉积物降水入渗补给系数研究

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矿业安全与环保 2023年第4期50卷 116-122页

作者：许峰煤炭科学研究总院北京100013 中煤科工西安研究院(集团)有限公司陕西西安710054 陕西省煤矿水害防治技术重点实验室陕西西安710077

陕北能源区地处我国西北干旱半干旱地区,是黄土与风积沙的过渡区,该区蒸发强烈,降水稀少,地下水作为该区域重要的供水水源,主要接受垂向上的降水补给。为研究黄土与风积沙的降水入渗过程及其降水入渗补给系数,通过野外取样、室内参数测... 详细信息

陕北能源区地处我国西北干旱半干旱地区,是黄土与风积沙的过渡区,该区蒸发强烈,降水稀少,地下水作为该区域重要的供水水源,主要接受垂向上的降水补给。为研究黄土与风积沙的降水入渗过程及其降水入渗补给系数,通过野外取样、室内参数测定,并运用Hydrus-1d建立包气带水分运移数值模型,模拟陕北能源区内2种沉积物的水分运移过程。以接近多年平均降水水平的2015年为例,模拟结果显示风积沙地的降水入渗深度超过6.2 m,而黄土地的降水入渗深度很难超过5.0 m,且两者的降水入渗补给系数分别为0.255和0.111。研究结果对准确计算陕北能源区地下水资源量,进而更好地指导区域水资源系统规划、生态环境保护和经济可持续发展具有重要意义。

关键词：陕北能源区黄土风积沙降水入渗补给系数

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Initial experience with a novel method for cognitive transperineal magnetic resonance imaging-targeted prostate biopsy

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Asian Journal of Andrology 2020年第4期22卷 432-436页

作者： Hai-feng Wang Rui Chen Bi-Ming He Min Qu Yan Wang Heng-Zhi Lin Qing-Song Yang xu Gao Ying-Hao Sun Department of Urology Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200433China Department of Radiology Shanghai Changhai HospitalSecond Military Medical UniversityShanghai 200433China

A cognitive magnetic resonance imaging(MRI)-targeted prostate biopsy conducted by an experienced clinician enhances the detection rate of(high-grade)prostate cancer;however,this method is less successful in the hands of inexperienced ***,an alternative method of conducting a cognitive MRI-targeted biopsy that can be successfully performed by the inexperienced clinicians should be ***-six males suspected of prostate cancer were analyzed using systematic biopsy and cognitive MRI-targeted biopsy based on our novel three-dimensional matrix positioning ***,the core principle of the latter procedure was to put the MRI and ultrasound images into the same virtual coordinate ***,the targeted biopsy was transformed to target a coordinate for the suspected lesion in the ***,patients were assessed for the presence/absence of prostate cancer or high-grade prostate *** to our results,the overall detection rate of prostate cancer was 70.8%(68/96),and the detection rate of high-grade prostate cancer was 56.3%(54/96).Specifically,the detection rate of prostate cancer by systematic biopsy was 54.2%(52/96)and that by targeted biopsy was 59.4%(57/96;P=0.560).Clearly,the combined application of targeted biopsy could remarkably increase the detection rates of prostate cancer(P=0.025)and high-grade prostate cancer(P=0.009).Taken together,the findings of this study suggest that the combination of systematic biopsy with our three-dimensional matrix positioning-driven cognitive-targeted biopsy is superior to systematic biopsy in detecting prostate cancer and high-grade prostate cancer.

关键词： cognitive fusion targeted biopsy three-dimensional

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Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

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Bone Research 2024年第2期12卷 334-348页

作者： Ziqian Xiang Pengfei Zhang Chunwang Jia Rongkun xu Dingren Cao Zhaoning xu Tingting Lu Jingwei Liu Xiaoxiong Wang Cheng Qiu Wenyang Fu Weiwei Li Lei Cheng Qiang Yang Shiqing feng Lianlei Wang Yunpeng Zhao Xinyu Liu Department of Orthopaedics Qilu Hospital of Shandong UniversityJinan 250012China University of Health and Rehabilitation Sciences Qingdao 226000China Xiangya School of Medicine Central South UniversityChangsha 410013China School of Nursing and Rehabilitation Shandong UniversityJinan 250012China Department of Pediatrics Cangzhou Central HospitalCangzhou 061011China Department of Pediatric Surgery Qilu Hospital of Shandong UniversityJinan 250012China Department of Pathology Qilu Hospital of Shandong UniversityJinan 250012China Department of Spine Surgery Tianjin HospitalTianjin UniversityTianjin 30021China The Second Hospital of Shandong University Cheeloo College of MedicineShandong UniversityJinan 250012China

To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be ***,Piezo1 channel was identified as a key iron transporter in response to mechanical ***1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron ***,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical ***,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.

关键词： stress overload channel

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In vivo astrocyte-to-neuron reprogramming for central nervous system regeneration:a narrative review

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Neural Regeneration Research 2023年第4期18卷 750-755页

作者： Zuliyaer Talifu Jia-Yi Liu Yun-Zhu Pan Han Ke Chun-Jia Zhang Xin xu feng Gao Yan Yu Liang-Jie Du Jian-Jun Li School of Rehabilitation Capital Medical UniversityBeijingChina Department of Spinal and Neural Functional Reconstruction China Rehabilitation Research CenterBeijingChina Chinese Institute of Rehabilitation Science BeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory of Neural Injury and Rehabilitation BeijingChina School of Rehabilitation Sciences and Engineering University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

The inability of damaged neurons to regenerate within the mature central nervous system(CNS)is a significant neuroscientific *** are an essential component of the CNS and participate in many physiological processes including blood-brain barrier formation,axon growth regulation,neuronal support,and higher cognitive functions such as *** reprogramming studies have confirmed that astrocytes in the mature CNS can be transformed into functional *** on in vitro work,many studies have demonstrated that astrocytes can be transformed into neurons in different disease models to replace damaged or lost ***,many findings in this field are controversial,as the source of new neurons has been *** review summarizes progress in reprogramming astrocytes into neurons in vivo in animal models of spinal cord injury,brain injury,Huntington’s disease,Parkinson’s disease,Alzheimer’s disease,and other neurodegenerative conditions.

关键词： astrocyte astrocyte-to-neuron central nervous system in vivo nerve regeneration neurological disorders reprogramming review

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Constructing interfacial electric field and Zn vacancy modulated ohmic junctions ZnS/NiS for photocatalytic H_(2) evolution

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Green Energy & Environment 2024年第12期9卷 1847-1856页

作者： Yi-lei Li xu-jia Liu Yun-biao Wang Ying Liu Rui-hong Liu Hui-ying Mu Ying-juan Hao Xiao-jing Wang Fa-tang Li Hebei Key Laboratory of Photoelectric Control on Surface and Interface College of ScienceHebei University of Science and TechnologyShijiazhuang050018China Key Laboratory of Theoretical and Computational Photochemistry Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing100875China

Adjusting the interfacial transport efficiency of photogenerated electrons and the free energy of hydrogen adsorption through interface engineering is an effective means of improving the photocatalytic activity of semiconductor ***,hollow ZnS/NiS nanocages with ohmic contacts containing Zn vacancy(V_(Zn)-ZnS/NiS)are synthesized using ZIF-8 as *** internal electric field is constructed by Fermi level flattening to form ohmic contacts,which increase donor density and accelerate electron transport at the V_(Zn)-ZnS/NiS *** experimental and DFT results show that the tight interface and V_(Zn) can rearrange electrons,resulting in a higher charge density at the interface,and optimizing the Gibbs free energy of hydrogen *** optimal hydrogen production activity of V_(Zn)-ZnS/NiS is 10,636 mmol h^(-1) g^(-1),which is 31.9 times that of V_(Zn)-*** study provides an idea for constructing sulfide heterojunctions with ohmic contacts and defects to achieve efficient photocatalytic hydrogen production.

关键词： Zn vacancy Ohmic contact Donor density Hollow nanocages Photocatalytic H_(2)production

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Identification of Prognostic Genes for Colon Cancer through Gene Coexpression Network Analysis

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Current Medical Science 2021年第5期41卷 1012-1022页

作者： Dan-wen WANG Zhang-shuo YANG Jian xu Li-jie YANG Tie-cheng YANG Hua-qiao WANG Mao-hui feng Fei SU Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Key Laboratory of Tumor Biological Behavior of Hubei Province Wuhan 430071China Centerfor Clinical Medicine of Peritoneal Cancer of Wuhan Wuhan 430071China Clinical Cancer Study Center of Hubei Province Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Oncology the First Hospital of Lanzhou UniversityLanzhou 730000Chin

Objective:The present study was aimed to identify novel key genes,prognostic biomarkers and molecular pathways implicated in tumorigenesis of colon ***:The microarray data GSE41328 containing 10 colon cancer samples and 10 adjacent normal tissues was analyzed to identify 4763 differentially expressed ***,another microarray data GSE17536 was performed for weighted gene co-expression network analysis(WGCNA).Results:In present study,12 co-expressed gene modules associated with tumor progression were identified for further *** red module showed the highest association with pathological stage by Pearson's correlation *** enrichment analysis revealed that genes in red module focused on cell division,cell proliferation,cell cycle and metabolic related ***,a total of 26 key hub genes were identified,and GEPIA database was subsequently selected for *** junction-recognizing protein(HJURP)and cell division cycle 25 homolog C(CDC25C)were identified as effective prognosis biomarkers,which were all detrimental to *** set enrichment analyses(GSEA)found the two hub genes were enriched in“oocyte meiosis”,“oocyte maturation that are progesterone-mediated”,“p53 signaling pathway”,and“cell cycle”.Furthermore,the immunohistochemistry and western blotting showed that HJURP was highly expressed in colon cancer ***:HJURP was identified as a key gene associated with colon cancer progression and prognosis by WGCNA,which might influence the prognosis by regulating cell cycle pathways.

关键词： colon cancer biomarkers weighted gene co-expression network analysis prognosis pathological stage

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