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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 79-91页

作者： Yingying Zhang Zizhen Zhao Jingli Li Qinghua Wang Zhigang Fan Zhibo Yuan yixiao feng Ailing Fu College of Pharmaceutical Sciences Southwest UniversityChongqing 400716China

Colorectal cancer(CRC)is a common digestive tract tumor *** microorganisms,including Fusobacterium nucleatum(***)and Escherichia coli(***),are abundant in colonic mucosa and can promote the cancer progression and ***,a therapeutic strategy is proposed to deliver effective drugs to colorectum for both anticancer and *** we used thin-film dispersionmethod to encapsulate hemiprotonic phenanthroline-phenanthroline^(+)(ph-ph^(+))into *** results showed that the drug-loading nanomicelle had good dispersion,and the particle size was about 28 *** vitro assay indicated that the nanomicelle was active against CRC-related obligate and facultative *** human CRC cells,the nanomicelle could effectively inhibit cell proliferation and induce *** vivo distribution showed that the nanomicelle could release ph-ph^(+) mainly in the *** CRC model mice,the nanomicelle significantly reduced tumor number and volume,and decreased the bacteria load and colorectal ***,the study identifies that the ph-ph^(+) nanomicelle has the potential to apply in treating CRC,and also suggests that anticancer combined with antimicrobial therapy would be a feasible way for CRC therapy.

关键词： CRC Drug-loading nanomicelle Antibacteria Inflammation

Antimicrobial resistance characteristics and phylogenetic relationships of pleuromutilin-resistant Enterococcus isolates from different environmental samples along a laying hen production chain

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Journal of Environmental Sciences 2024年第3期137卷 195-205页

作者： Cong Lin Yuxuan feng Xianjun Xie Haoyu Zhang Jie Wu yixiao Zhu Jing Yu Jingyi feng Wen Su Shanming Lai Anyun Zhang Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province Key Laboratory of Bio-Resource and Eco-Environment of Ministry of EducationCollege of Life SciencesSichuan UniversityChengdu 610065China

Antimicrobial resistance in the laying hen production industry has become a serious public health *** antimicrobial resistance and phylogenetic relationships of the common conditional pathogen Enterococcus along the laying hen production chain have not been systematically clarified.105 Enterococcus isolates were obtained from 115 environmental samples (air,dust,feces,fies,sewage,and soil) collected along the laying hen production chain (breeding chicken,chick,young chicken,and commercial laying hen).These Enterococcus isolates exhibited resistance to some clinically relevant antibiotics,such as tetracycline (92.4%),streptomycin (92.4%),and erythromycin (91.4%),and all strains had multidrug resistance *** genome sequencing characterized 29 acquired antibiotic resistance genes (ARGs) that conferred resistance to 11 classes of antibiotics in 51pleuromutilin-resistant Enterococcus isolates,and lsa(E),which mediates resistance to pleuromutilins,always co-occurred with lnu(B).Alignments with the Mobile Genetic Elements database identified four transposons (Tn554,Tn558,Tn6261,and Tn6674) with several ARGs(erm(A),ant(9)-la,fex(A),and optrA) that mediated resistance to many clinically important ***,we identified two new transposons that carried ARGs in the Tn554 family designated as Tn7508 and Tn7492.A complementary approach based on conventional multi-locus sequence typing and whole genome single nucleotide polymorphism analysis showed that phylogenetically related pleuromutilin-resistant Enterococcus isolates were widely distributed in various environments on different production *** results indicate that environmental contamination by antimicrobial-resistant Enterococcus requires greater attention,and they highlight the risk of pleuromutilin-resistant Enterococcus and ARGs disseminating along the laying hen production chain,thereby warranting effective disinfection.

关键词： Antimicrobial resistance Enterococcus Laying hen production chain Pleuromutilin

Mesoporous silica SBA-15 functionalized with phosphonate and amino groups for uranium uptake

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Science China Chemistry 2012年第9期55卷 1705-1711页

作者： WANG XiaoLiang YUANLiYong WANG YanFei LI ZiJie LIU YaLan feng yixiao ZHAO YuLiang CHAI ZhiFang SHI WeiQun Department of Applied Chemistry School of Chemistry and Chemical EngineeringUniversity of South ChinaHengyang 421001China Key Laboratory of Nuclear Analytical Techniques Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Mesoporous silicas have a very attractive ability of sorption and enrichment of metal ions due to their huge surface area and facile functionalization by organic *** this work,phosphonate-amino bifunctionalized mesoporous silica SBA-15(PA-SBA-15) as U(VI) sorbent was fabricated through post-grafting *** obtained mesoporous silica was characterized by SEM,XRD,NMR and nitrogen sorption/desorption experiments,which revealed the existence of ordered mesoporous structure with uniform pore diameter and large surface *** adsorptivity of PA-SBA-15 for U(VI) from aqueous solution was investigated using batch sorption technique under different experimental *** preliminary results show that the U(VI) sorption by PA-SBA-15 is very quick with equilibrium time of less than 1 h,and the U(VI) uptake is as large as 373 mg/g at pH 5.5 under 95 ℃.The sorption isotherm has been successfully modeled by the Langmuir isotherm,suggesting a monolayer homogeneous sorption of U(VI) in *** sorption is pH-dependent due to the pH-dependent charge of sorbent in the aqueous *** thermodynamics research shows that the sorption is a feasible and endothermic *** on these results,PA-SBA-15 could be a promising solid phase sorbent for highly-efficient removal of U(VI) ions from waste water and enrichment of U(VI) from a solution at a very low level.

关键词： SBA-15 吸收功能氨基酸膦酸酯介孔分子筛 Langmuir吸附介孔二氧化硅固相吸附剂

Corrigendum to “Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs)” [Genes & Diseases 5 (2018) 137–149]

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Genes & Diseases 2023年第2期10卷 630-631页

作者： Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang yixiao feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C. Haydon Hue H. Luu Tong-Chuan He Hua Gan Departments of Nephrology Orthopaedic SurgeryCardiologyGeneral SurgeryPlastic Surgeryand Clinical Laboratory MedicineThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine and the Affiliated Hospitals of Chongqing Medical UniversityChongqing 400016China Department of Biochemistry and Molecular Biology China Three Gorges University School of MedicineYichangHubei 443002China Department of Clinical Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330031China Key Laboratory of Orthopaedic Surgery of Gansu Province and the Department of Orthopaedic Surgery The Second Hospital of Lanzhou UniversityLanzhouGansu 730030China

The authors regret having an image assembly error in Figure 3A,in which the image for "imPOD Synaptopodin DAPl stain"groupwas erroneouslyduplicatedwiththe imagefrom the"tsPOD-33C SynaptopodinDAPIstain"*** confirm the error is restricted to the image assembly,and the underlying data and conclusions are correct and *** authors would like to apologize for any inconvenience caused.

关键词： Cor cytes glomerular

Corrigendum to “Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference” [Genes & Diseases 5(2018):172–184]

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Genes & Diseases 2023年第2期10卷 632-637页

作者： Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu yixiao feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C. Haydon Michael J. Lee Russell R. Reid Jennifer Moriatis Wolf Qiong Shi Hue H. Luu Tong-Chuan He Yaguang Weng Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine Chongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA The School of Pharmacy and the Affiliated Hospitals of Chongqing Medical University Chongqing 400016China Key Laboratory of Orthopaedic Surgery of Gansu Province and the Department of Orthopaedic Surgery The Second Hospital of Lanzhou UniversityLanzhouGansu 730030China Department of Biochemistry and Molecular Biology China Three Gorges University School of MedicineYichangHubei 443002China Department of Surgery The Affiliated Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Orthopaedic Surgery Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China Department of Orthopaedic Surgery Xiangya Second Hospital of Central South UniversityChangshaHunan 410011China Department of Surgery Laboratory of Craniofacial Biology and DevelopmentSection of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

The authors regret having several image assembly ***,in Figure 3A panel b,the image for "AdsimB9-4 only"group was erroneously duplicated with an overlapping image from the"AdRFp"group;and the image for"AdsimB9-1+BMP9"groupwas erroneouslyduplicatedwithan overlapping image from"AdsimB9-8+BMP9"*** Figure 4Apanel a,the images for"BMP9"group and "BMP9+simB9-4"group were erroneously duplicated with an overlapping image from"simB9-4"*** Figure 5A,the image for"BMP9+simB9-4/Day3"group was erroneously duplicated with an overlapping image from"BMP9+simB9-7/Day3"group;and the image for"BMP9+simB9-4/Day5"group was erroneously duplicated with an overlapping image from an unrelated *** Figure 6B,the image for"BMP9+simB9-7/Day 11"group was erroneously duplicated with an overlapping image from the"BMP9+simB9-4/Day 11"group.

关键词： Figure BMP9 Cor

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永磁同步电机在线参数辨识研究

重庆理工大学学报（自然科学） 2023年第7期37卷 289-296页

作者：郗建国冯毅潇赵宾鹏高建平河南科技大学车辆与交通工程学院河南洛阳471003

针对基本粒子群算法在永磁同步电机参数辨识过程中存在辨识时间长、收敛速度慢等问题,提出混沌映射与信息传递相结合的混沌遗传粒子群算法(CHPSO)对永磁同步电机进行参数在线辨识。通过混沌映射产生混沌粒子,并与前一次参数辨识结果相结... 详细信息

针对基本粒子群算法在永磁同步电机参数辨识过程中存在辨识时间长、收敛速度慢等问题,提出混沌映射与信息传递相结合的混沌遗传粒子群算法(CHPSO)对永磁同步电机进行参数在线辨识。通过混沌映射产生混沌粒子,并与前一次参数辨识结果相结合,生成初始化种群,再引入动态惯性权重系数,提高粒子多样性。采用分步辨识和循环更新的方法,解决参数辨识的欠秩问题。仿真结果表明:该算法对电机参数进行辨识的结果偏差分别为定子电阻1.32%,磁链1.08%,d轴电感0.92%,q轴电感1.16%。台架实验证明了辨识方案的有效性。

关键词：永磁同步电机参数在线辨识粒子群算法混沌映射

Corrigendum to “The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs” [Genes & Diseases 5 (2018) 62–74]

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Genes & Diseases 2023年第2期10卷 627-629页

作者： Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu yixiao feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C. Haydon Hue H. Luu Lan Zhou Russell R. Reid Tong-Chuan He Xingye Wu Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine Chongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Clinical Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006China Departments of Clinical Laboratory Medicine General SurgeryOrthopedic SurgeryNephrologyand CardiologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China The Children's Hospital Chongqing Medical UniversityChongqing 400014China Department of Laboratory Medicine and Clinical Diagnostics The Affiliated Yantai HospitalBinzhou Medical UniversityYantai 264100China Department of Immunology and Microbiology Beijing University of Chinese MedicineBeijing 100029China Key Laboratory of Orthopaedic Surgery of Gansu Province and the Department of Orthopaedic Surgery The Second Hospital of Lanzhou UniversityLanzhou 730030China Department of Surgery The Affiliated Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biochemistry and Molecular Biology China Three Gorges University School of MedicineYichang 443002China Department of Orthopaedic Surgery Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China Department of Orthopaedic Surgery Xiangya Second Hospital of Central South UniversityChangsha 410011China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing 401147China The Affiliated Hospital of Stomatology of Chongqing Medical University Chongqing 401147China Department of Surgery Laboratory of Craniofacial Biology and DevelopmentSection of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

The authors regret having an image assembly error in Figure 5Ca,in which the image for the "Oh dBiFP-AdRFp"group was erroneously duplicated with an overlapping image from the"36h BiFP dBIFP-AdR-simH19"*** confirm the error is restricted to the image assembly,and the underlying data and conclusions are correct and *** authors would like to apologize for any inconvenience caused.

关键词： image Figure unchanged

基于摩擦热效应的刷式密封摩擦副匹配性实验研究

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中国机械工程 2024年第4期35卷 636-645,690页

作者：杨艺潇孙丹兰可心赵欢冯毓钟张杰一沈阳航空航天大学航空发动机学院辽宁省航空宇航推进系统先进测试技术重点实验室沈阳110136 中国航发贵州黎阳航空动力有限公司贵阳550081 中国航空发动机集团有限公司沈阳发动机研究所沈阳110015 中国航空发动机集团有限公司航空发动机动力传输航空科技重点实验室沈阳110015

刷丝与转子涂层相互作用产生的摩擦热效应直接影响刷式密封的密封性能和使用寿命。分析了刷式密封摩擦副之间的摩擦热效应理论,设计搭建了刷式密封摩擦副摩擦热效应实验装置,设计加工了6种不同结构参数与刷丝材料的刷式密封实验件和4种... 详细信息

刷丝与转子涂层相互作用产生的摩擦热效应直接影响刷式密封的密封性能和使用寿命。分析了刷式密封摩擦副之间的摩擦热效应理论,设计搭建了刷式密封摩擦副摩擦热效应实验装置,设计加工了6种不同结构参数与刷丝材料的刷式密封实验件和4种不同涂层材料的摩擦转盘,实验研究了工况参数、结构参数以及不同摩擦副材料对刷式密封摩擦热效应的影响,通过对比分析刷式密封最高温度以及磨损前后摩擦副的磨损形貌及磨损量,获取了刷丝与转子涂层材料的匹配性关系。研究结果表明:刷式密封最高温度会随着摩擦时长的增加先迅速升高后趋于稳定,随着干涉量的增大而升高,干涉量由0.3 mm增大至0.4 mm,刷丝平均最高温升达39.96℃;最高温度随着刷丝束厚度的增加而升高,随着后挡板保护高度的增大而降低;当刷丝材料为钴基高温合金GH605时,最佳转子涂层材料为WC,当刷丝材料为镍基高温合金GH4169时,最佳转子涂层材料为ZrO_(2),此两种匹配材料能够在相同工况下产生较低的摩擦热量,且耐磨性能高于其他匹配材料。

关键词：刷式密封摩擦热效应摩擦副匹配性干涉量

维普期刊数据库博看期刊

Breast cancer development and progression:Risk factors,cancer stem cells,signaling pathways,genomics,and molecular pathogenesis

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Genes & Diseases 2018年第3期5卷 77-106页

作者： yixiao feng Mia Spezia Shifeng Huang Chengfu Yuan Zongyue Zeng Linghuan Zhang Xiaojuan Ji Wei Liu Bo Huang Wenping Luo Bo Liu Yan Lei Scott Du Akhila Vuppalapati Hue H.Luu Rex C.Haydon Tong-Chuan He Guosheng Ren Chongqing Key Laboratory of Molecular Oncology and Epigenetics Departments of General SurgeryClinical Laboratory MedicineOrthopaedic SurgeryPlastic Surgery and Burnand OtolaryngologyHead and Neck SurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Biochemistry and Molecular Biology China Three Gorges University School of MedicineYichang 443002China Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine Chongqing Medical UniversityChongqing 400016China Stem Cell Biology and Therapy Laboratory Ministry of Education Key Laboratory of Child Development and DisordersThe Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Clinical Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences The Affiliated Hospital of StomatologyChongqing Medical UniversityChongqing 401147China Student Inquiry Research Program Illinois Mathematics and Science Academy(IMSA)AuroraIL 60506USA

As the most commonly occurring cancer in women worldwide,breast cancer poses a formidable public health challenge on a global *** cancer consists of a group of biologically and molecularly heterogeneous diseases originated from the *** the risk factors associated with this cancer varies with respect to other cancers,genetic predisposition,most notably mutations in BRCA1 or BRCA2 gene,is an important causative factor for this *** cancers can begin in different areas of the breast,such as the ducts,the lobules,or the tissue in *** the large group of diverse breast carcinomas,there are various denoted types of breast cancer based on their invasiveness relative to the primary tumor *** is important to distinguish between the various subtypes because they have different prognoses and treatment *** there are remarkable parallels between normal development and breast cancer progression at the molecular level,it has been postulated that breast cancer may be derived from mammary cancer stem *** breast development and mammary stem cells are regulated by several signaling pathways,such as estrogen receptors(ERs),HER2,and Wnt/b-catenin signaling pathways,which control stem cell proliferation,cell death,cell differentiation,and cell ***,emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer,especially for triple-negative breast *** review provides a comprehensive survey of the molecular,cellular and genetic aspects of breast cancer.

关键词： BRCA1/2 Breast cancer Cancer stem cells Estrogen receptors HER2 Noncoding RNAs Triple-negative breast cancer Tumor heterogeneity

风吸力下檩条绕定点弯扭失稳承载力计算及其与试验对比

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建筑结构 2015年第6期45卷 80-85页

作者：冯一笑童根树张磊浙江大学建筑工程学院杭州310058

关于风吸力作用下C形和Z形简支檩条稳定承载力的计算,欧洲规范(Eurocode 3)和我国《门式刚架轻型房屋钢结构技术规程》(CECS 102∶2002)都取其受压下翼缘作为弹性地基上的压杆来求解临界荷载。然而,该方法的计算值与已有试验值相比过于... 详细信息

关于风吸力作用下C形和Z形简支檩条稳定承载力的计算,欧洲规范(Eurocode 3)和我国《门式刚架轻型房屋钢结构技术规程》(CECS 102∶2002)都取其受压下翼缘作为弹性地基上的压杆来求解临界荷载。然而,该方法的计算值与已有试验值相比过于保守。由檩条绕固定轴扭转屈曲的总势能可求得风吸力作用下C形和Z形檩条的弹性临界弯矩,计算其正则化长细比,然后采用修正的欧洲钢结构协会(ECCS)钢梁整体屈曲的稳定系数公式,计算檩条的弹塑性稳定系数,从而求得檩条的稳定承载力。对比结果表明,此方法的计算值与试验值更吻合。

关键词：风吸力檩条临界荷载