检索结果-南通市图书馆

CEPC Technical Design Report

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen guoming chen Hua-xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen xiang chen xiaoyu chen xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

联合应用异烟肼对顽固性神经痛治疗效果的初步研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中山大学学报（医学科学版） 2011年第3期32卷 355-358页

作者：丰岩清国宁刘俊秀黄帆陈曦赖蓉中山大学附属第一医院神经科广东广州510080

【目的】评估联合应用异烟肼(INH)治疗在难治性神经病理性疼痛(NP)治疗中的价值。【方法】采用前瞻性、联合用药的自身对照研究,36例患有难治性NP的病人入组,这些病人对卡马西平和加巴喷丁联合治疗无效,给以异烟肼8mg/kg联合治疗,观察期... 详细信息

【目的】评估联合应用异烟肼(INH)治疗在难治性神经病理性疼痛(NP)治疗中的价值。【方法】采用前瞻性、联合用药的自身对照研究,36例患有难治性NP的病人入组,这些病人对卡马西平和加巴喷丁联合治疗无效,给以异烟肼8mg/kg联合治疗,观察期8周,检测其疗效和副作用。治疗前后采用采用视觉模拟量表(VAS)、睡眠干扰评分和病人总体印象改变表(PGIC)进行疗效评定。【结果】经过8周治疗后,VAS评分较加用异烟肼前有明显下降(配对t检验P<0.01),VAS评分由治疗前的61.76下降至32.94,下降幅度达46.7%。痛觉过敏明显减少,23例病人(63.9%)PGIC改善。另外,病人的平均睡眠分数也有明显改善。【结论】联合应用异烟肼可能是一种对治疗NP潜在有效的治疗方法,尤其对难治性NP可能有效。INH的作用机制不明,其疗效仍需要在大样本的RCT研究中进一步确定。

关键词：神经病理性疼痛,难治性/治疗异烟肼

中国人视神经脊髓炎疾病谱NMO-IgG/anti-AQP4抗体检测方法学的比较

在线全文

学校读者我要写书评

暂无评论

中山大学学报（医学科学版） 2010年第6期31卷 872-877页

作者：孙巧松刘俊秀丰岩清国宁陈曦赖蓉黄帆中山大学附属第一医院神经科广东广州510080

【目的】建立NMO-IgG/anti-AQP4抗体检测的间接免疫荧光法(IIF),细胞分析法(CBA)和荧光免疫沉淀法(FIPA)法;研究并比较不同的检测方法对中国人群NMO疾病谱的检测效率。【方法】建立3种检测NMO-IgG/anti-AQP4抗体的方法,包括IIF、CBA和F... 详细信息

【目的】建立NMO-IgG/anti-AQP4抗体检测的间接免疫荧光法(IIF),细胞分析法(CBA)和荧光免疫沉淀法(FIPA)法;研究并比较不同的检测方法对中国人群NMO疾病谱的检测效率。【方法】建立3种检测NMO-IgG/anti-AQP4抗体的方法,包括IIF、CBA和FIPA。应用盲法检测病人血清106例,其中视神经脊髓炎(NMO)组24例,纵形扩展性脊髓炎(LETM)组22例,多发性硬化(MS)组30例,健康对照(HC)组30例;对其检测的阳性率进行分析。【结果】通过3种方法检测,发现NMO组NMO-IgG/anti-AQP4抗体阳性率分别为IIF(62.5%,15/24),CBA(91.7%,22/24)及FIPA(75.0%,18/22),LETM组为IIF(59.1%,13/22),CBA(86.4%,19/22)及FIPA(72.3%,16/22),MS组IIF、CBA及FIPA均为(3.3%,1/30)。正常对照组未见该抗体阳性表达。NMO组及LETM组血清NMO-IgG/anti-AQP4抗体阳性率明显高于MS和健康对照组。【结论】在中国人群NMO疾病谱患者中,IIF、CBA和FIPA的检测效率基本和美欧报道一致。IIF是该抗体检测的基础方法;CBA法看起来最为敏感;FIPA检测可以量化该抗体,可用于临床高通量大样品筛查。

关键词：视神经脊髓炎 NMO-IgG 抗水通道蛋白4抗体荧光免疫沉淀细胞法间接免疫荧光法

小鼠侧脑室注射卡介苗诱导NMO-IgG/AQP4抗体的表达

在线全文

学校读者我要写书评

暂无评论

中山大学学报（医学科学版） 2013年第1期34卷 41-47页

作者：刘俊秀赖蓉国宁钟德霞陈曦黄帆黄曦丰岩清中山大学附属第一医院神经科广东广州510080 中山大学中山医学院免疫学教研室广东广州510080

【目的】通过小鼠侧脑室注射卡介苗(BCG)致中枢神经系统结核分枝杆菌(MTB)感染,检测小鼠血清中是否有视神经脊髓炎(NMO)-IgG/水通道蛋白4(AQP4)-Ab的表达。【方法】雌性C57BL/6J小鼠40只,6～8周,随机分为4组:5×106CFU BCG组、1×106CFU... 详细信息

【目的】通过小鼠侧脑室注射卡介苗(BCG)致中枢神经系统结核分枝杆菌(MTB)感染,检测小鼠血清中是否有视神经脊髓炎(NMO)-IgG/水通道蛋白4(AQP4)-Ab的表达。【方法】雌性C57BL/6J小鼠40只,6～8周,随机分为4组:5×106CFU BCG组、1×106CFU BCG组、0.01 mol/L PBS组、正常组。右侧侧脑室注射,注射后1周脑室注射追加1次。小鼠BCG注射后第7、14、21、28天,分别取血并检测血清中NMO-IgG/AQP4-Ab。注射后第28天处死小鼠行抗酸杆菌培养,并对脑和脊髓进行HE、抗酸、LFB髓鞘染色,免疫组化检测病灶处AQP4、GFAP的表达及C5b9沉积情况。【结果】脑室注射后,BCG组小鼠行为活动降低,出现肢体瘫痪,甚至死亡,其中5×106CFU BCG组表现严重,死亡率高。注射卡介苗21 d时小鼠血清检测发现5×106CFU BCG组中2只小鼠血清NMO-IgG/AQP4-Ab阳性,1×106CFU BCG组中4只小鼠血清中抗体阳性。第28天时5×106CFU BCG组的两只血清阳性的小鼠死亡,1×106CFU BCG组中原抗体阳性的小鼠血清中抗体仍为阳性。病理检测显示脑和脊髓出现炎性细胞浸润,病灶处抗酸染色阳性,出现脱髓鞘改变。组织培养3周后可见MTB生长,免疫组化显示病灶区域AQP4、GFAP表达降低,部分炎性细胞及血管周围出现补体C5b9沉积。【结论】中枢神经系统MTB直接感染可诱导产生NMO-IgG/AQP4-Ab。

关键词：视神经脊髓炎 NMO—IgG 水通道蛋白4 结核分枝杆菌卡介苗

NMO-IgG/anti-AQP4抗体的检测及其特异性的研究

在线全文

学校读者我要写书评

暂无评论

中华临床医师杂志（电子版） 2010年第11期4卷 67-71页

作者：孙巧松刘俊秀丰岩清方毅敏国宁赖蓉陈曦黄帆中山大学附属第一医院神经科广州510080 广州市胸科医院神经结核科中山大学附属第一医院神经外科广州510080 中山大学附属第一医院康复科广州510080

目的 NMO-IgG/anti-AQP4抗体已被多数研究证实为是视神经脊髓炎(NMO)或其疾病谱的一种特异性抗体。然而,该抗体的特异性尚未在中枢神经系统(CNS)感染性疾病中做过特异性的测试。本研究的目的是检测结核性脑膜炎(TBM)患者血清中是否有NMO... 详细信息

目的 NMO-IgG/anti-AQP4抗体已被多数研究证实为是视神经脊髓炎(NMO)或其疾病谱的一种特异性抗体。然而,该抗体的特异性尚未在中枢神经系统(CNS)感染性疾病中做过特异性的测试。本研究的目的是检测结核性脑膜炎(TBM)患者血清中是否有NMO-IgG/anti-AQP4抗体的表达,并和NMO疾病谱进行比较。方法建立常规NMO-IgG检测的间接免疫荧光法(IIF)和检测AQP4-Ab的细胞分析法(CBA)。IIF法以鼠脑为底物检测NMO-IgG,并测定其滴度,同时应用免疫双标法验证NMO-IgG与AQP4-Ab分布的一致性。应用CBA法检测患者血清中AQP4-Ab的表达情况。盲法检测血清172例,其中NMO24例,纵形扩展性脊髓炎(LETM)22例,多发性硬化(MS)30例,TBM46例,肺结核患者30例,健康对照20例;对其检测的阳性率进行分析。结果研究发现NMO-IgG/anti-AQP4抗体不仅存在于NMO疾病谱中,在TBM患者血清中也可以普遍检测到该抗体。NMO-IgG的血清阳性率分别为:TBM76.1%(35/46),NMO62.5%(15/24),LETM59.1%(13/22);TBM组抗体滴度明显高于NMO组和LETM组。CBA法检测的血清阳性率分别为:TBM91.3%(42/46),NMO91.7%(22/24),LETM86.4%(19/22)。肺结核、MS和健康对照血清阳性率很低。结论本研究结果显示,CNS结核感染可导致NMO-IgG/anti-AQP4抗体的产生。该发现使传统的NMO-IgG/AQP4-Ab为疾病特异性抗体的观念受到挑战,提示该抗体可能是反映CNS破坏性脱髓鞘的生物学标记。

关键词：视神经脊髓炎结核,脑膜水通道蛋白质4 抗体特异性

The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

在线全文

学校读者我要写书评

暂无评论

Psychoradiology 2022年第1期2卷 32-42页

作者： xiao chen Bin Lu Hui-xian Li Xue-Ying Li Yu-Wei Wang Francisco Xavier Castellanos Li-Ping Cao ning-Xuan chen Wei chen Yu-Qi cheng Shi-xian Cui Zhao-Yu Deng Yi-Ru fang Qi-Yong Gong Wen-Bin guo Zheng-Jia-Yi Hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian Yi-fan Liao yan-Song liu Zhe-ning liu Jian-Ping Lu qing-Hua Luo Hua-qing Meng Dai-Hui Peng Jiang Qiu Yue-Di Shen Tian-Mei Si yan-qing Tang Chuan-Yue Wang Fei Wang Hua-ning Wang Kai Wang xiang Wang Ying Wang Zi-Han Wang xiao-Ping Wu Chun-Ming xie Guang-rong xie Peng xie xiu-feng Xu Hong yang Jian yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang Zhang Wei Zhang Zhi-jun Zhang jun-Juan Zhu xi-Nian Zuo Jing-Ping Zhao Yu-feng Zang the DIRECT consortium Chao-Gan yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

全国多中心使用糖皮质激素风湿病患者骨质疏松调查

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华临床免疫和变态反应杂志 2017年第3期11卷 277-284页

作者：张学武姚海红梅轶芳王辉高娟林志国张海宏王言赵彦萍王亮李洋李英楠聂英坤徐亮舒强刘花香李向培厉小梅徐晋刘璘琛王艳艳沈友轩冷晓梅吴庆军王立赵岩丁进李治琴牛敏冯媛陈倩蕴冷南王聪华刘湘源王芳王秀娟张舸刘宏潇周惠琼王丽英赵千子李胜光段婷周明珠赵义黄彦弘路跃武黄桂芬韩峰戚务芳张娜董笑影孙文闻高丽霞王俊祥陈海英顾光李芳姜国平刘涛王晋平陈雁飞王晓云刘斌李法新夏丽萍张榕赵丽娟张冶宇郭韵薛江霞刘冬梅王岩岩戴冰冰刘伟刘畅华冰珠丁从珠顾菲孙怡宁莫凌菲张斌宁旺斌潘静沈凌汛连莉黄文辉林泽英北京大学人民医院风湿免疫科北京100044 哈尔滨医科大学附属第一医院风湿免疫科哈尔滨150001 哈尔滨医科大学附属第二医院风湿免疫科哈尔滨150001 皖南医学院弋矶山医院风湿免疫科安徽芜湖241001 山东大学齐鲁医院风湿免疫科济南250012 安徽省立医院风湿免疫科合肥230001 东南大学附属中大医院风湿免疫科南京210009 江苏省人民医院风湿免疫科南京210029 北京协和医院风湿免疫科北京100730 第四军医大学西京医院风湿免疫科西安710032 北京大学第三医院风湿免疫科北京100191 卫生部北京医院风湿免疫科北京100730 首都医科大学附属世纪坛医院风湿免疫科北京100038 北京市海淀医院风湿免疫科北京100080 中国中医科学院广安门医院风湿免疫科北京100053 中日友好医院风湿免疫科北京100029 解放军总医院第一附属医院风湿免疫科北京100037 首都医科大学附属北京友谊医院风湿免疫科北京100050 首都医科大学附属宣武医院风湿免疫科北京100053 北京积水潭医院风湿免疫科北京100035 首都医科大学附属北京朝阳医院风湿免疫科北京100020 天津市武警医院风湿免疫科天津300019 天津市第一中心医院风湿免疫科天津300192 天津医科大学总医院风湿免疫科天津300052 河北医科大学第二医院风湿免疫科石家庄050000 河北医科大学第三医院风湿免疫科石家庄050051 河北省人民医院风湿免疫科石家庄050057 吉林省人民医院风湿免疫科长春130021 吉林大学第一医院风湿免疫科长春130021 甘肃省人民医院风湿免疫科兰州730000 兰州大学第一医院风湿免疫科兰州730000 兰州大学第二医院风湿免疫科兰州730030 青岛大学医学院附属医院风湿免疫科青岛266003 济南市中心医院风湿免疫科济南250013 中国医科大学附属第一医院风湿免疫科沈阳110001 中国医科大学附属盛京医院风湿免疫科沈阳110004 大连医科大学附属第二医院风湿免疫科大连116027 大连市中心医院风湿免疫科大连116033 南京市鼓楼医院风湿免疫科南京210008 西安交通大学附属第一医院风湿免疫科西安710061 西安市红十字会医院风湿免疫科西安710000 中南大学湘雅医院风湿免疫科长沙410008 武汉市第一医院风湿免疫科武汉430033 华中科技大学同济医学院附属协和医院风湿免疫科武汉430022 安徽医科大学第一附属医院风湿免疫科合肥230022 广州医学院第二附属医院风湿免疫科广州510260

目的了解中国服用糖皮质激素风湿病患者骨质疏松的发病情况和诊疗现状,以期引起对骨质疏松防治的重视。方法 2012年11月1日至2013年1月31日,在全国46家风湿病专科医院对3 136例曾经或正在服用糖皮质激素的风湿病患者进行临床资料、用药... 详细信息

目的了解中国服用糖皮质激素风湿病患者骨质疏松的发病情况和诊疗现状,以期引起对骨质疏松防治的重视。方法 2012年11月1日至2013年1月31日,在全国46家风湿病专科医院对3 136例曾经或正在服用糖皮质激素的风湿病患者进行临床资料、用药情况及骨量调查,了解骨量减少和骨质疏松的发生率。结果 (1)所有调查患者中,主要病种为类风湿关节炎(1 069例)和系统性红斑狼疮(983例)。3 136例患者中90%存在骨量减少或骨质疏松,其中骨质疏松的发生率为41.4%。44.7%的患者在调查当时糖皮质激素用量(等效于泼尼松)>7.5 mg/d,调查当时糖皮质激素剂量≤2.5 mg/d者仍有58.5%存在骨质疏松。(2)随着年龄增加,骨质疏松及骨折的发病率明显增加;小于30岁的患者骨量减少和骨质疏松总发生率为74.4%。(3)女性风湿病患者骨密度异常比例高于男性,平均停经年龄低于正常人群(45.8岁)。(4)抗骨质疏松药物使用不规范,32.7%的患者从未预防性给予抗骨质疏松药物治疗,在T<-2.5的患者中,35.6%未给予预防性抗骨质疏松治疗。主要用药为钙和维生素D,20.9%的患者仅给予钙剂单独治疗,仅有4%使用膦酸盐类药物。结论我国应用糖皮质激素的风湿病患者骨量减少和骨质疏松发生率明显增高,且预防性用药不规范。

关键词：骨质疏松糖皮质激素类