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Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome

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Chinese Journal of Natural Medicines 2018年第3期16卷 161-174页

作者： LV qi WANG Kai qiAO Si-Miao DAI Yue WEI zhi-feng Department of Pharmacology of Chinese Materia Medica China Pharmaceutical University

Although the etiology of inflammatory bowel disease is still tmcertain, increasing evidence indicates that the excessive activation of NLRP3 inflammasome plays a major role. Norisoboldine （NOR）, an alkaloid isolated from Radix Linderae, has previously been demonstrated to inhibit inflammation and IL-1,8 production. The present study was to examine the effect of NOR on colitis and the underlying mechanism related to NLRP3 inflammasome activation. Our results showed that NOR alleviated colitis symptom in mice induced by 2, 4, 6-trinitrobenzene sulfonic acid （TNBS）. Moreover, it significantly reduced expressions of cleaved IL-lfl, NLRP3 and cleaved Caspase-1 but not ASC in colons of mice. In THP-1 cells, NOR suppressed the expressions of NLRP3, cleaved Caspase-1 and cleaved IL-1β but not ASC induced by lipopolysaccharide （LPS） and adenosine triphosphate （ATP）. Furthermore, NOR could activate aryl hydrocarbon receptor （AhR） in THP-1 cells, inducing CYP1A1 mRNA expression, and promoting dissociation of AhR/HSP90 complexes, association of AhR and ARNT, AhR nuclear translocation, XRE reporter activity and binding activity of AhR/ARNT/XRE. Both siAhR and a-naphthoflavone （a-NF） markedly diminished the inhibition of NOR on NLRP3 inflammasome activation. In addition, NOR elevated Nrf2 level and reduced ROS level in LPS- and ATP-stimulated THP-1 cells, which was reversed by either siAhR or α-NF treatment. Finally, correlations between activation of AhR and attenuation of colitis, inhibition of NLRP3 inflammasome activation and up-regulation of Nrf2 level in colons were validated in mice with TNBS-induced colitis. Taken together, NOR ameliorated TNBS-induced colitis in mice through inhibiting NLRP3 inflammasome activation via regulating AhR/Nrf2/ROS signaling pathway.

关键词： Norisoboldine Inflammatory bowel disease NLRP3 inflammasome Aryl hydrocarbon receptor

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Space time frequency coding for dual polarization MIMO in hybrid mobile satellite system

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The Journal of China Universities of Posts and Telecommunications 2013年第4期20卷 8-14页

作者： WANG Kai-dong GUO Ling-zhi TAO Xiao-feng CUI qi-mei Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications

The hybrid mobile satellite system operating in a single frequency network （SFN） mode is increasingly becoming attractive. The combination of satellite component （SC） and terrestrial component （TC） promises a better quality of service （QoS）. Multimedia broadcast and multicast services （MBMS） are expected to be prevailed in this kind of system. Several space frequency （SF） or space time （ST） codes have been proposed to enhance the system performance due to the lack of reverse link and omni-directional transmission. However, they mostly consider the system with only one SC and one TC and fail to make full use of available diversities. This paper presents a novel way to realize the dual polarization multiple input multiple output （MIMO） transmission by using the space time frequency （STF） code. The theoretical analysis and simulations indicate that the application of STF code can improve the system performance dramatically. A higher diversity gain can be achieved due to the cooperative transmission of SC and TC, while the coding gain can be enhanced by the reusing of STF code between SCs or TCs. Even if some of the links are lost, it can still work properly and benefit from the STF code. The relative relay can result in a degradation up to 0.5 dB in the coding gain.

关键词： MIMO dual polarization hybrid mobile satellite system SFN STF code diversity gain

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Impacts of Dirty Data on Classification and Clustering Models:An Experimental Evaluation

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Journal of Computer Science & Technology 2021年第4期36卷 806-821页

作者： zhi-Xin qi Hong-zhi Wang An-Jie Wang School of Computer Science and Technology Harbin Institute of TechnologyHarbin 150001China

Data quality issues have attracted widespread attentions due to the negative impacts of dirty data on data mining and machine learning *** relationship between data quality and the accuracy of results could be applied on the selection of the appropriate model with the consideration of data quality and the determination of the data share to ***,rare research has focused on exploring such *** by this,this paper conducts an experimental comparison for the effects of missing,inconsistent,and conflicting data on classification and clustering *** the experimental results,we observe that dirty-data impacts are related to the error type,the error rate,and the data *** on the findings,we suggest users leverage our proposed metrics,sensibility and data quality inflection point,for model selection and data cleaning.

关键词： data quality classification clustering model selection data cleaning

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数字图像处理在测井曲线矢量化中的应用

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西南民族大学学报（自然科学版） 2005年第1期31卷 148-151页

作者：刘波余艳梅罗峰滕奇志四川大学电子信息学院成都610064

针对测井曲线的矢量化问题,在讨论频域和空域的测井曲线图像预处理优缺点的基础上,采用了矢量跟踪的方法来处理测井曲线.对不同油田的20多种测井图纸样本进行了测试,实验表明矢量化的精度可达98％.

关键词：测井曲线矢量化图像处理频域分析空域分析矢量跟踪

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Real-time motion deblurring algorithm with robust noise suppression

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第5期11卷 375-380页

作者： Hua-jun feng Yong-pan WANG zhi-hai XU qi LI Hua LEI Ju-feng ZHAO State Key Lab of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China

In an image restoration process,to obtain good results is challenging because of the unavoidable existence of noise even if the blurring information is already *** suppress the deterioration caused by noise during the image deblurring process,we propose a new deblurring method with a known ***,the noise in the measurement process is assumed to meet the Gaussian distribution to fit the natural noise ***,the first and second orders of derivatives are supposed to satisfy the independent Gaussian distribution to control the non-uniform *** results show that our method is obviously superior to the Wiener filter,regularized filter,and Richardson-Lucy(RL) ***,owing to processing in the frequency domain,it runs faster than the other algorithms,in particular about six times faster than the RL algorithm.

关键词： Motion blurring Motion kernel Gaussian distribution

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Absolute Orientation of Molecules with Competing Hydrophilic Head Groups at the Air/Water Interface Probed with Sum Frequency Generation Vibrational Spectroscopy

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Chinese Journal of Chemical Physics 2009年第2期22卷 197-203页

作者： feng Wang zhi Huang zhi-feng Cui Hong-fei Wang Department of Physics Anhui Normal University Wuhu 241000 China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Molecular Reaction Dynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

The constructive or destructive spectral interference between the molecular groups oriented up and down at the interface in the sum-frequency generation （SFG） spectra provides a direct measurement of the absolute orientation of these molecular groups. This simple approach can be employed to interrogate absolute molecular orientations other than using the complex absolute phase measurement in the SFG studies. We used the -CN group in the p-cyanophenol （PCP） molecule as the internal phase standard, and we measured the phases of the SFG fields of the -CN groups in the 3,5-dimethyl-4-hydroxy-benzonitrile （35DMHBN） and 2,6-dimethyl-4-hydroxy-benzonitrile （26DMHBN） at the air/water interface by measuring the SFG spectra of the aqueous surfaces of the mixtures of the PCP, 35DMHBN, and 26DMHBN solutions. The results showed that the 35DMHBN had its -CN group pointing into the aqueous phase; while the 26DMHBN, similar to the PCP, had its -CN group pointing away from the aqueous phase. The tilt angles of the -CN group for both the 35DMHBN and 26DMHBN molecules at the air/water interface were around 25°-45° from the interface normal. These results provided insights on the understanding of the detailed balance of the competing factors, such as solvation of the polar head groups, hydrogen bonding and hydrophobic effects, etc., on influencing the absolute molecular orientation at the air/water interface.

关键词： Sum frequency generation vibrational spectroscopy Air/water interface Molecule orientation p-cyanophenol

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Mineral phase reconstruction behavior of direct reduction and smelting titanium slag at high temperature and slow cooling

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Rare Metals 2015年第6期34卷 440-444页

作者： Yi-Jie Wang Shu-Ming Wen qi-Cheng feng zhi-Wen Ye Min Wang State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and Technology Faculty of Land Resource Engineering Kunming University of Science and Technology Advanced Analysis and Measurement Center Yunnan University

Titanium slag in this study was produced by subjecting titanomagnetite concentrate to direct reductionelectric furnace smelting. Processing mineralogy and mineral phase reconstruction behavior at high temperature and slow cooling treatment were examined by chemical analysis, X-ray diffraction （XRD）, optical microscopy （OM）, scanning electron microscopy （SEM）, and energydispersive spectroscopy （EDS）. Anosovite solid solution is the main titanium product by the direct reduction and smelting process. Results of slow-cooling experiments show that crystal volume and size increase as cooling rate decreases. Anosovite and gangue mineral crystals develop fully with large crystal volume and size at a cooling rate of 2 ***-1. Moreover, the growth of anosovite crystal was characterized by crystal nucleation and growth theory. These results provide further insights into the separation of anosovite from gangue by mineral processing.

关键词： Direct reduction Smelting titanium slag Anosovite Slow cooling Crystal

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COMPLETE MONOTONICITY FOR A NEW RATIO OF FINITELY MANY GAMMA FUNCTIONS

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Acta Mathematica Scientia 2022年第2期42卷 511-520页

作者： feng qi Institute of Mathematics Henan Polytechnic UniversityJiaozuo 454010China School of Mathematical Sciences Tiangong UniversityTianjin 300387China

In this paper,by deriving an inequality involving the generating function of the Bernoulli numbers,the author introduces a new ratio of finitely many gamma functions,finds complete monotonicity of the second logarithmic derivative of the ratio,and simply reviews the complete monotonicity of several linear combinations of finitely many digamma or trigamma functions.

关键词： Bernoulli number ratio generating function complete monotonicity gamma function digamma function trigamma function logarithmic derivative linear combination inequality

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A Novel Fractional Plastic Damage Model for Quasi-brittle Materials

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Acta Mechanica Solida Sinica 2021年第5期34卷 706-717页

作者： Peng-Fei Qu qi-zhi Zhu Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China College of Civil and Transportation Engineering Hohai UniversityNanjing210098China

In this work,a novel constitutive model is developed within the framework of fractional plasticity to delineate the coupling between inelastic deformation and damage of quasi-brittle *** with the common challenge of determining plastic flow direction,we resort herein to the Riemann–Liouville definition of fractional derivatives,instead of introducing an additional plastic *** pre-peak hardening behavior is described using an exponential function,while the post-peak softening response is viewed as the consequence of material *** describing damage evolution,a damage criterion is constructed in terms of plastic volume dilation related to micro-crack *** is conducive to supply a new insight for describing the complex influence of the non-orthogonality of plastic flow on damage *** numerical applications,a semi-implicit return mapping algorithm is *** predictive performance of the model is evaluated by comparing numerical simulations with experimental data under various loading paths.

关键词： Quasi-brittle materials Fractional plasticity Damage Dilatancy Numerical algorithm

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A Novel Gait Pattern Recognition Method Based on LSTM-CNN for Lower Limb Exoskeleton

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Journal of Bionic Engineering 2021年第5期18卷 1059-1072页

作者： Chao-feng Chen zhi-jiang Du Long He Yong-jun Shi Jia-qi Wang Wei Dong State Key Laboratory of Robotics and System Harbin Institute of Technology(HIT)Harbin 150001China China South Industries Group Corporation Weapon Equipment Research InstituteBeijing 102202China

This paper describes a novel gait pattern recognition method based on Long Short-Term Memory(LSTM)and Convolutional Neural Network(CNN)for lower limb *** Inertial Measurement Unit(IMU)installed on the exoskeleton to collect motion information,which is used for LSTM-CNN *** article considers five common gait patterns,including walking,going up stairs,going down stairs,sitting down,and standing *** the LSTM-CNN model,the LSTM layer is used to process temporal sequences and the CNN layer is used to extract *** optimize the deep neural network structure proposed in this paper,some hyperparameter selection experiments were carried *** addition,to verify the superiority of the proposed recognition method,the method is compared with several common methods such as LSTM,CNN and *** results show that the average recognition accuracy can reach 97.78%,which has a good recognition eff ***,according to the experimental results of gait pattern switching,the proposed method can identify the switching gait pattern in time,which shows that it has good real-time performance.

关键词： Lower limb exoskeleton Gait pattern recognition LSTM-CNN Recognition accuracy Real-time performance

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