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Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43

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World Journal of Gastroenterology 2025年第8期31卷 82-95页

作者： Wei Yang Rui Liu feng xu Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Medical School Xiangyang Vocational and Technical CollegeXiangyang 441021Hubei ProvinceChina

BACKGROUND Colonic motility dysfunction is a common symptom of ulcerative colitis(UC),significantly affecting patients’quality of *** suggests that glial cell line-derived neurotrophic factor(GDNF)plays a role in restoring colonic *** To investigate whether GDNF enhances aberrant colonic motility in mice with experimental colitis via connexin 43(Cx43).METHODS An experimental colitis model was induced in male C57BL/6 mice using dextran sodium sulfate(DSS).The measurement of colonic transit time was conducted,and colon tissues were evaluated through transmission electron microscopy and hematoxylin and eosin *** mice were treated with exogenous GDNF and Gap 19,a selective Cx43 *** Cx43 and GDNF levels were detected via immunofluorescence,immunohistochemistry,and real-time polymerase chain *** levels of inflammatory markers,including interleukin-1β,tumor necrosis factor-α,interleukin-6,and C-reactive protein,were quantified using enzyme-linked immunosorbent *** Experimental colitis was successfully induced using DSS,and the findings exhibited that the colonic transit time was significantly delayed in colitis mice relative to the UC group(P<0.01).GDNF treatment improved colonic transit time and alleviated intestinal inflammation in DSS-induced colitis mice(P<0.05).In the UC+Gap19+GDNF group,colitis symptoms,colonic transit time,and inflammatory marker levels remained comparable to those in the UC group,indicating that the therapeutic effects of GDNF in UC mice were blocked by Gap *** GDNF improves colonic motility in mice with experimental colitis through a partially Cx43-mediated *** holds promise as a therapeutic option for improving colonic motility in patients with colitis.

关键词： Glial cell line-derived neurotrophic factor Ulcerative colitis Colonic motility Connexin 43 Dextran sodium sulfate model

High Efficiency Mixed Amine Adsorbents for Directly Capturing Carbon Dioxide from Air

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Chemical Research in Chinese Universities 2025年第1期41卷 138-145页

作者： WU Yilu ZHENG Haolong XIA Zihan FU Chengmin xu feng YAN Jian School of Environment and Chemical Engineering Foshan UniversityFoshan528000P.R.China Guangzhou Zhixin High School Guangzhou510080P.R.China

The development of effective adsorbents with high amine efficiency and CO_(2)adsorption almost unaffected by humidity is extremely *** this study,we introduce an innovative solid amine adsorbent,TETA/DEA@FS,composed of triethylenetetramine(TETA)and diethanolamine(DEA)functionalized fumed silica(FS),which exhibits exceptional capability in selectively capturing trace CO_(2)from N_(2).TETA/DEA@FS shows an exceptionally high capacity of CO_(2)adsorption of 1.13 mmol/g at the temperature of 298 K and the pressure of 0.0004 bar(1 bar=100 kPa),and achieves an unprecedented CO_(2)/N_(2)IAST selectivity of 1.70×10^(12).TETA/DEA@FS exhibits high amine efficiency,with breakthrough experiments demonstrating that CO_(2)adsorption remains nearly unaffected by ***,TETA/DEA@FS demonstrates rapid CO_(2)adsorption kinetics and outstanding cyclic stability.

关键词： Direct air capture(DAC) CO_(2) N_(2) Triethylenetetramine Diethanolamine

Copper-catalyzed Larock-type cyclization/debenzylation of yne-allylic esters with aliphatic amines

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Science China Chemistry 2025年

作者： Rongkang Huang Yuepeng Lu feng xu Jianhang Huang Cuiju Zhu Hao xu Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction State Key Laboratory of Green Pesticide College of Chemistry Central China Normal University

Herein, we describe a strategy for constructing pyrroles via a copper-catalyzed [4 + 1] annulation of yne-allylic esters and aliphatic amines. The key innovation of this approach is the development of copper-ammonium intermediates that facilitate selective C–N bond cleavage under mild conditions. This method demonstrates broad applicability, accommodating both aliphatic secondary amines and aliphatic primary amines, while exhibiting excellent tolerance toward a wide range of functional groups. Furthermore, the ease of subsequent transformations underscores its potential utility in the synthesis of bioactive compounds. Preliminary mechanistic investigations suggest the involvement of a copper-ammonium species, providing insight into the reaction's underlying process.

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Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen xu feng Yuan Shi Xin-Lin Li Zheng-Rong Shi Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

Early prediction cardiac arrest in intensive care units:the value of laboratory indicator trends

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World Journal of Emergency Medicine 2025年第1期16卷 67-70页

作者： Wentao Sang Jiaxin Ma xuan Zhang Shuo Wu Chang Pan Jiaqi Zheng Wen Zheng Qiuhuan Yuan Jian Zhang Jingjing Ma feng xu Department of Emergency Medicine Qilu HospitalShandong UniversityJinan 250012China Chest Pain Center Qilu HospitalShandong UniversityJinan 250012China Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu HospitalShandong UniversityJinan 250012China Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu HospitalShandong UniversityJinan 250012China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical Sciencesthe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu HospitalShandong UniversityJinan 250012China

The incidence of in-hospital cardiac arrest (IHCA) has increased over the past decade,with more than half occurring in intensive care units (ICUs).^([1])ICU cardiac arrest (ICU-CA)presents unique challenges,with worse outcomes than those in monitored wards,highlighting the need for early detection and intervention.^([2])Up to 80%of patients exhibit signs of deterioration hours before IHCA.^([3])Although early warning scores based on vital signs are useful,their eff ectiveness in ICUs is limited due to abnormal physiological parameters.^([4])Laboratory markers,such as sodium,potassium,and lactate,are predictive of poor outcomes,^([5])but static measurements may not capture the patient’s *** in laboratory indicators,such as variability and extremes,may offer better predictive value.^([6])This study aimed to evaluate ICU-CA predictive factors,with a focus on vital signs and trends of laboratory indicators.

关键词： prediction signs arrest

Early Crack Propagation Behavior of Laser Metal Deposited Ti-6Al-4V Alloy Under High Cycles Fatigue Loading

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稀有金属材料与工程 2025年第1期54卷 62-75页

作者： Li Yanping Huang Wei He Yan xu feng Zhao Sihan Guo Weiguo School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China School of Astronautics Northwestern Polytechnical UniversityXi'an 710072China

The crack initiation and early propagation are of great significance to the overall fatigue life of *** order to investigate the anisotropic fracture behavior of laser metal deposited Ti-6Al-4V alloy(LMD Ti64)during the early stage,the fourpoint bending fatigue test was carried out on specimens of three different directions,as well as the forged *** results indicate the anisotropic crack initiation and early propagation of LMD *** direction perpendicular to the deposition direction exhibits a better fatigue resistance than the other *** crack initiation position and propagation path are dominated by the microstructure in the vicinity of *** Ti64 has a typical small crack effect,and the early crack propagation velocities in three directions are *** by the slip system of LMD Ti64,secondary cracks frequently occur,which are often found to have an angle of 60°to the main *** electron backscatter diffraction analysis indicates that LMD Ti64 has preferred orientations,i.e.,strong 0001//Z texture and 001//Z *** crystallographic orientation will change as the direction of columnarβgrains turns over,resulting in the fatigue anisotropy of LMD Ti64 in crack initiation and early crack propagation process.

关键词： fatigue resistance crack propagation behavior microstructure laser metal deposit Ti-6Al-4V anisotropy

Chinese clinical practice consensus for device-supported treatment in adults with post-cardiac arrest syndrome(2024 Edition)

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World Journal of Emergency Medicine 2025年第1期16卷 3-9页

作者： Chuanbao Li Shengchuan Cao Yue Zheng Mengzhi Zong Haitao Zhang xuezhong Yu feng xu Yuguo Chen the Chinese Clinical Practice Consensus for Device-supported Treatment in Adults with Post-cardiac Arrest Syndrome Work group Department of Emergency Medicine Chest Pain CenterShandong Provincial Clinical Research Center for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinan 250012China Department of Critical Care Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China State Key Laboratory of Complex Severe and Rare Diseases Emergency DepartmentPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China 不详

During cardiac arrest (CA),severe ischemia and hypoxia occur in tissues and organs of the entire body,inflammatory cytokines are released,and ischemiareperfusion injury occurs after the return of spontaneous circulation (ROSC),leading to multiple organ dysfunction in the body;this condition is called post-CA syndrome(PCAS).^([1])According to the BASeline Investigation of Out-of-Hospital Cardiac Arrest (BASIC-OHCA) study,the crude incidence of emergency medical service (EMS)-assessed OHCA was 95.7 per 100,000 individuals,and only1.2%of those individuals survived to hospital discharge or30 d after being resuscitated by the EMS in China.

关键词： cardiac organs return

[Skin mechanomedicine]

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Zhonghua yi xue za zhi 2025年第7期105卷 489-496页

作者： S M Geng J H Hu Q Zhao Y Q feng X Wang H Liu F xu Department of Dermatology Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004 China Center for Dermatology Disease Precision Medical Institute Xi'an 710115 China. Bioinspired Engineering and Biomechanics Center (BEBC) School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 China Ministry of Education Key Laboratory of Biomedical Information Engineering School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 China.

Traditional research on skin diseases has mainly focused on biological characteristics for a long time. Recently, the integration of biomechanics and mechanobiology has introduced mechanical factors into skin disease research. The interaction between mechanical factors and skin's physiological and pathological changes has gradually been transformed in clinical diagnosis and treatment. The two emerging fields, mechanodiagnostics and mechanotherapy, have been developed to address clinical needs. However, clinicians often lack a comprehensive understanding of skin mechanical characteristics and the mechanobiological mechanisms in dermatology. Thus, we propose the concept of "skin mechanomedicine". By summarizing relevant research at home and abroad, this paper systematically elucidates the multiscale mechanical characteristics of skin diseases and their impact on biological behavior from four perspectives: skin biomechanics, skin mechanobiology, skin mechanodiagnostics, and skin mechanotherapy. Meanwhile, in-depth exploration was conducted on the potential application of mechanical factors in the diagnosis and treatment of skin diseases, aiming to provide new research perspectives and solutions for the diagnosis and treatment of skin diseases.

关键词：皮肤皮肤生物力学皮肤力生物学皮肤力诊断学皮肤力治疗学

跨场景整合:地方政府数字平台综合治理机制探讨--以T市J区为案例

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江淮论坛 2025年第1期 153-160页

作者：李志强许峰南京信息工程大学环境与健康研究院共同富裕研究院南京210044 台州行政学院浙江台州318012

基层社会治理现代化面对数字化、网络化、智能化趋势,需全面推进数字平台综合治理体系建设,全方位提升数字平台治理能级。基于浙江省T市J区的数字综合治理经验,结合整体性治理和场景融合理论,聚焦平台赋能和场景整合的逻辑关系,建构了... 详细信息

基层社会治理现代化面对数字化、网络化、智能化趋势,需全面推进数字平台综合治理体系建设,全方位提升数字平台治理能级。基于浙江省T市J区的数字综合治理经验,结合整体性治理和场景融合理论,聚焦平台赋能和场景整合的逻辑关系,建构了地方政府数字平台治理跨场景结构优化、功能完善和合作价值提升的整体逻辑,提出跨平台优化多维数字结构场景、跨时空融合多元数字功能场景及跨地域建构多层数字行动场景的基层治理整合模式。阐述了从分散应对到整体响应的场景要素融合、数字驱动到平台链接的场景功能集成和弥散管理到精细治理的场景价值贯通三大路径,为地方政府数字化改革和基层智慧治理创新提供有益借鉴。

关键词：基层治理数字化改革平台治理跨场景联动