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正常态金属与氧化物高温超导薄膜界面扩散特性分析

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物理学报 1995年第11期44卷 1831-1838页

作者：康晋锋陈新王佑祥韩汝琦熊光成连贵君李杰吴思诚北京大学微电子学研究所北京100871 中国科学院物理研究所和半导体研究所表面物理国家重点实验室北京100080 北京大学物理系北京100871

利用二次离子质谱(SIMS)技术,分析了Ag和A1与YBa_2Cu_3O_(7-x)(YBCO)超导薄膜接触界面互扩散.结果显示,它们有不同的互扩散特征.利用SIMS的分析结果,可以很好地理解经高温热处理后,Ag/YBCO和A1/YBCO样品具有不同界面电学性质的原因.

关键词： YBCO 超导体银铝界面扩散

Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value

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World Journal of Gastroenterology 2019年第15期25卷 1890-1898页

作者： Yao Cui Hai-feng Xu Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/beijing) Interventional Therapy department peking university Cancer Hospital and institute Ming-Yue Liu Yu-Jie Xu Jun-Chuang He Yun Zhou Shun-Dong Cang department of Oncology Henan Key Laboratory for Precision Medicine in Cancer Henan Provincial People's HospitalPeople's Hospital of Zhengzhou University School of Clinical Medicine Henan University department of Hepatobiliary Surgery Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou University School of Clinical Medicine Henan University

BACKGROUND Exosomes contain proteins, lipids, and biological molecules such as DNA and RNA. Nucleic acids in exosomes are a group of molecules that can act as biomarkers. Currently, there are many reports on exosomal microRNAs, which are ideal biomarkers for the early diagnosis of cancer. However, there are few reports on the role of exosomal microRNAs in the diagnosis and prognosis of hepatocellular carcinoma(HCC).AIM To understand the mechanism of exosomal microRNA-224(miR-224) in the development of HCC and evaluate its diagnostic and prognostic *** Cell culture and transfection of exosomal miRNA-224, real-time quantitative PCR, luciferase reporter assay, and other methods were used to find new biomarkers related to the development of HCC that can be used to diagnose HCC and predict HCC *** targeting glycine N-methyltransferase, incubating exosomes with miR-224 mimic resulted in a significant increase in cell proliferation compared to that of the control group, while incubation with the miR-224 inhibitor significantly reduced cell proliferation. The same results were obtained for the cell invasion assay. Serum exosomal miR-224 did have some ability to differentiate patients with HCC from healthy controls, with an area under the curve of 0.910, and HCC patients with higher serum exosomal miR-224 expression had lower overall *** Exosomal miR-224 is a tumor promotor and can be a marker of diagnosis and prognosis of HCC patients, however, its ability to distinguish liver diseases needs further verification.

关键词： Hepatocellular carcinoma Serum Exosome MicroRNA-224 Biomarker

Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

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Military Medical Research 2024年第1期11卷 98-114页

作者： Guang-Long Ma Wei-feng Lin Faculty of Medicine Centre for Cancer ImmunologyUniversity of SouthamptonSouthampton SO166YDUK department of Molecular chemistry and Materials Science Weizmann Institute of Science76100 RehovotIsrael Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

Immune checkpoint blockade(ICB)therapy for cancer has achieved great success both in clinical results and on the *** the same time,success drives more attention from scientists to improve ***,only a small portion of patients are responsive to this therapy,and it comes with a unique spectrum of side effects termed immunerelated adverse events(irAEs).The use of nanotechnology could improve ICBs’delivery to the tumor,assist them in penetrating deeper into tumor tissues and alleviate their *** nanomedicine has been investigated and used for decades,and is well-recognized as the most successful nano-drug delivery *** successful combination of ICB with liposomal nanomedicine could help improve the efficacy of ICB *** this review,we highlighted recent studies using liposomal nanomedicine(including new emerging exosomes and their inspired nanovesicles)in associating ICB therapy.

关键词： Liposome Exosome Immune checkpoint blockade(ICB)

Cloud Microphysical Characteristics of Typhoon Meranti(2016)during Its Rapid Intensification:Model Validation and SST Sensitivity Experiments

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Journal of Meteorological Research 2024年第3期38卷 542-557页

作者： Rui WANG Yihong DUAN Jianing feng department of Atmospheric and Oceanic Sciences&institute of Atmospheric Sciences Fudan UniversityShanghai200438China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing100081China

Cloud microphysics plays an important role in determining the intensity and precipitation of tropical cyclones(TCs).In this study,a high-resolution numerical simulation by WRF(version 4.2)of Typhoon Meranti(2016)during its rapid intensification(RI)period was conducted and validated by multi-source observations including Cloud-Sat and Global Precipitation Mission satellite *** snow and ice particles content were found to increase most rapidly compared with other hydrometeors during the RI *** all hydrometeors continued to *** graupel content only increased in the initial RI stage,and then decreased afterwards due to precipitation during the RI *** addition,sea surface temperature(SST)sensitivity experiments showed that,although the intensity of the TC increased with a higher SST,not all hydrometeors *** graupel content continued to increase with the increase in SST,mainly due to the accumulation of more lower-temperature supercooled water vapor at the corresponding *** content of snow decreased with the increase in SST because stronger vertical motion at the corresponding height affected the aggregation of ice crystals.

关键词： tropical cyclone rapid intensification cloud microphysical characteristics sea surface temperature(SST)

高分子三线态敏化剂分子中能量迁移的研究 Ⅰ.聚(乙烯基二苯酮-β-乙烯基萘)中的能量迁移的研究

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化学学报 1986年第1期44卷 56-61页

作者：高剑萍吴世康冯新德中国科学院感光化学研究所北京大学化学系北京

本工作对乙烯基二苯酮-β-乙烯基萘共聚物体系分子内的能量迁移和转移进行了研究.在77K玻璃态溶液中,不论以310nm或以370nm波长激发时,共聚物都发生强的萘燐光.各共聚物三线态能量转移量子效率φETT-T大于80％,表明此高分子体系能有效... 详细信息

本工作对乙烯基二苯酮-β-乙烯基萘共聚物体系分子内的能量迁移和转移进行了研究.在77K玻璃态溶液中,不论以310nm或以370nm波长激发时,共聚物都发生强的萘燐光.各共聚物三线态能量转移量子效率φETT-T大于80％,表明此高分子体系能有效地进行三线态能量迁移和转移.

关键词：能量迁移共聚物高分子体系二苯酮三线态乙烯基链烯烃基敏化剂

Optimization of a serpentine flow field with variable channel heights and widths for PEM fuel cells

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Science China(Technological Sciences) 2010年第2期53卷 453-460页

作者： LIN Lin, ZHANG xinxin, feng HuTing & WANG XiaoDong department of Thermal Engineering, School of Mechanical Engineering, university of Science and Technology beijing, Bejing 100083, China 1. department of Thermal Engineering School of Mechanical Engineering University of Science and Technology Beijing Bejing 100083 China

The present study proposes a modified serpentine flow field design in which the channel heights vary along each straight flow path to enhance reactant transport and liquid water removal. An optimization approach, combining a simplified conjugate-gradient method (inverse solver) and a three-dimensional, two-phase, non-isothermal fuel cell model (direct solver), has been developed to optimize the key geometric parameters. The optimal design has tapered channels for channels 1, 3 and 4 and increasing heights for channels 2 and 5 with the flow widths first increasing and then decreasing. The optimal channel heights and widths enhance the efficiency by 22.51% compared with the basic design having all heights and widths of 1 mm. The diverging channels have a greater impact on cell performance than fine adjustments of the channel widths for the present simulation conditions. The channel heights have more effect on the sub-rib convection, while the channel widths affect the uniformity of the fuel delivery more. The reduced channel heights of channels 2–4 significantly enhance the sub-rib convection to effectively transport oxygen to and liquid water out of the diffusion layer. The final diverging channel prevents significant leakage of fuel to the outlet via sub-rib convection.

关键词： PEM fuel cell simplified conjugate-gradient method optimization sub-rib convection

A QUANTUM CHEMICAL STUDY:RELATIONSHIP BETWEEN STRUCTURE AND REACTIVITY AND ORIENTATION IN HYDRATION REACTIONS

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Chinese Science Bulletin 1981年第1期26卷 39-43页

作者：张建成刘新厚刘若圧 institute of photographic chemistry Academia Sinica department of chemistry Beijing Normal University

Ⅰ. INTRODUCTION The acid-catalyzed hydration reaction has a special important place in the study of the mechanism of electrophilic addition to ethylenic bonds. The hydration rate is not cnly related to the nature and number, but also to the position, of the substituents on the alkene. No reasonable interpretation of this has been reported yet. The orientation of hydration reaction of alkene and the addition of hydrogen halides to the

关键词： hydration interpretation straight catalyzed bonds perturbation absolute determining eater additions

On the coupled NBEM and FEM for a class of nonlinear exterior Dirichlet problem in R^(2*)

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Science China Mathematics 2004年第z1期47卷 181-189页

作者： WU Zhengpeng, KANG Tong & YU dehaoinstitute of Computational Mathematics and Scientific/Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, beijing 100080, China department of Applied Mathematics, beijing Broadcasting institute, beijing 100024, China Combinatorial and Computational Mathematics Center, Pohang university of Science and Technology, Phoang 790-784, Republic of Korea Chinese Acad Sci Acad Math & Syst Sci Inst Computat Math & Sci Engn Comp Beijing 100080 Peoples R China beijing Broadcasting Inst Dept Appl Math Beijing 100024 Peoples R China Pohang Univ Sci & Technol Combinatorial & Computat Math Ctr Phoang 790784 South Korea

In this paper, based on the natural boundary reduction advanced by feng and Yu, we couple the finite elementapproach with the natural boundary element method to study theweak solvability and Galerkin approximation of a class ofnonlinear exterior boundary value problems. The analysis is mainlybased on the variational formulation with *** provethe error estimate of the finite element solution and obtain theasymptotic rate of convergence. Finally, we also give anumerical example.

关键词： natural boundary integral method, finite element method, coupling method, error estimate.

Molecular phylogeny of Pneumocystis based on 5.8S rRNA gene and the internal transcribed spacers of rRNA gene sequences

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Science China(Life Sciences) 2008年第5期51卷 445-452页

作者： LI ZiHui1,2, feng XianMin1, LU SiQi1, ZHANG Fan1, WANG fengYun1 & HUANG Song1 1 department of Pathogenic Biology, Capital Medical university, beijing 100069, China 2 beijing Tuberculosis and Thoracic Tumor Research institute, beijing 101100, China 1. department of Pathogenic Biology Capital Medical University Beijing 100069 China 2. beijing Tuberculosis and Thoracic Tumor Research institute Beijing 101100 China

To clarify the phylogenetic relationships and species status of Pneumocystis, the 5.8S rRNA gene and the internal transcribed spacers (ITS, 1 and 2) of Pneumocystis rRNA derived from rat, gerbil and human were amplified, cloned and sequenced. The genetic distance matrix of six Pneumocystis species compared with other fungi like Taphrina and Saccharomyces indicated that the Pneumocystis genus contained multiple species including Pneumocystis from gerbil. The phylogenetic tree also showed that Pneumocystis from human and monkey formed one group and four rodent Pneumocystis formed another group. Among the four members, Pneumocystis wakefieldiae was most closely related to Pneumocystis murina and Pneumocystis carinii, and was least related to gerbil Pneumocystis.

关键词： Pneumocystis phylogeny 5.8S rRNA gene internal transcribed spacers