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Mesenchymal stem cells from the human umbilical cord ameliorate fulminant hepatic failure and increase survival in mice

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Hepatobiliary & pancreatic Diseases International 2015年第2期14卷 186-193页

作者： Jin-feng Yang Hong-Cui Cao Qiao-Ling pan Jiong Yu Jun Li Lan-Juan Li The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis andTreatment of Infectious Diseases

BACKGROUND：Cell therapy has been promising for various *** investigated whether transplantation of human umbilical cord mesenchymal stem cells（h UCMSCs）has any therapeutic effects on D-galactosamine/lipopolysaccharide（Gal N/LPS）-induced fulminant hepatic failure in ***：h UCMSCs isolated from human umbilical cord were cultured and transplanted via the tail vein into severe combined immune deficiency mice with Gal N/LPS-induced fulminant hepatic *** transplantation,the localization and differentiation of h UCMSCs in the injured livers were investigated by immunohistochemical and genetic analy- ses. The recovery of the injured livers was evaluated histologi- cally. The survival rate of experimental animals was analyzed by the Kaplan-Meier method and log-rank test. RESULTS： hUCMSCs expressed high levels of CD29, CD73, CD13, CD105 and CD90, but did not express CD31, CD79b, CD133, CD34, and CD45. Cultured hUCMSCs displayed adip- ogenic and osteogenic differentiation potential. Hematoxylin and eosin staining revealed that transplantation of hUCMSCs reduced hepatic necrosis and promoted liver regeneration. Transplantation of hUCMSCs prolonged the survival rate of mice with fulminant hepatic failure. Polymerase chain reaction for human alu sequences showed the presence of human cells in mouse livers. Positive staining for human albumin, human alpha-fetoprotein and human cytokeratin 18 suggested the for- mation of hUCMSCs-derived hepatocyte-like cells in ***： hUCMSC was a potential candidate for stem cell based therapies. After transplantation, hUCMSCs partially repaired hepatic damage induced by GalN/LPS in mice. hUC- MSCs engrafted into the injured liver and differentiated into hepatocyte-like cells.

关键词： human umbilical cord mesenchymal stem cells fulminant hepatic failure cell transplantation hepatic differentiation

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ICP-MS法测定土壤样品中的锡

江西化工 2019年第2期35卷 148-150页

作者：黎锐能萧婉仪何光涛张娜娜王攀峰广东地质实验测试中心广东广州510080 核工业二〇三研究所陕西咸阳712000

采用混合酸分解样品,稀硝酸溶液提取,ICP-MS法分析测定土壤中的锡。经有证国家标准土壤样品验证,本方法的精密度(RSD,n=6)为0.90%～2.51%,准确度为0.38%～7.50%,检出限为0.24μg/g,测定下限为0.96μg/g,该方法样品处理过程简单快捷,分... 详细信息

采用混合酸分解样品,稀硝酸溶液提取,ICP-MS法分析测定土壤中的锡。经有证国家标准土壤样品验证,本方法的精密度(RSD,n=6)为0.90%～2.51%,准确度为0.38%～7.50%,检出限为0.24μg/g,测定下限为0.96μg/g,该方法样品处理过程简单快捷,分析检测的结果准确,满足土壤污染详查的分析检测要求,适于土壤中锡的快速、准确的测定。

关键词： ICP-MS 土壤锡

Trends in mortality of emergency departments patients in China

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World Journal of Emergency Medicine 2019年第3期10卷 152-155页

作者： Chang pan Xiao-ran Huang Jiao-jiao pang Kai Cheng feng Xu Yu-guo Chen Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong University Jinan China Clinical Research Center for Emergency and Critical Care Medicine of Shandong Province Institute of Emergency and Critical Care Medicine of Shandong University Qilu Hospital of Shandong University Jinan China Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province Qilu Hospital of Shandong University Jinan China The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese Ministry of Health and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu Hospital of Shandong University Jinan China Department of Emergency Medicine Department of Emergency and Critical Care Medicine Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou China Medical College Shantou University Shantou China

BACKGROUND: Emergency medical service system (EMSS) in China is becoming more important. However, studies on mortality of emergency departments (EDs) patients in tertiary hospitals and on the trends in mortality of ED patients all over China are stagnant. The objective of this study was to quantify and describe the trends in mortality of ED patients in China. METHODS: Nine tertiary teaching hospitals were selected from tertiary teaching hospitals in different regions. The annual numbers of ED visits and deaths of these hospitals in 2004, 2009 and 2014 were recorded and analyzed. Chi-square test was used to compare the mortality of the EDs’ visits. Moreover, data on the mortality of ED patients in China from 2005 to 2015 were summarized and analyzed from the China Health and Family Planning Statistical Yearbooks (2006–2016). RESULTS: From 2004 to 2014, the overall annual mortalities in EDs increased among the tertiary hospitals (P<0.001). However, the overall annual mortality in EDs all over China decreased from 0.12% in 2005 to 0.08% in 2015. And the mortalities of EDs patients in the eastern, central and western regions of China all decreased. In addition, the average mortality of EDs patients in northern China was obviously higher than that in southern China (P<0.05). CONCLUSION: The ED mortality was increased in tertiary hospitals while decreased all over China during the past decade, which may be partly caused by some critical challenges faced by China’s EMSS, such as overcrowding and long length of stay in EDs of tertiary hospitals.

关键词： Mortality Emergency departments Tertiary hospitals Trends

液压劈裂静态爆破在石方破碎施工中的应用研究

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价值工程 2024年第1期43卷 122-124页

作者：黄图杰曾云峰王鑫潘富远广西路建工程集团有限公司南宁530001

文章以钦州市灵山县某段在建高速公路为工程实例,通过对花岗岩球形风化体分布特点的路基石方段开挖比选不同的爆破施工工艺,然后采用液压劈裂静态爆破施工工艺进行应用研究,并对其设计了施工参数,最后通过现场施工验证了液压劈裂静态爆... 详细信息

文章以钦州市灵山县某段在建高速公路为工程实例,通过对花岗岩球形风化体分布特点的路基石方段开挖比选不同的爆破施工工艺,然后采用液压劈裂静态爆破施工工艺进行应用研究,并对其设计了施工参数,最后通过现场施工验证了液压劈裂静态爆破施工工艺的合理性。

关键词：花岗岩液压劈裂静态爆破

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内源性CO和NO与小儿哮喘关系的研究

实用儿科临床杂志 1997年第6期12卷 361-362页

作者：蒋东波李华强史源潘捷沈际皋姚忠凯覃世文潘凤赵锦宁第三军医大学附属大坪医院野战外科研究所重庆630042

目的:探讨小儿哮喘时血浆一氧化碳（CO）和一氧化氮（NO）的含量变化及意义。方法哮喘患儿21例，20名健康儿童为对照，分别在急性发作期和缓解期采静脉血测定血浆CO和NO水平。对测定结果进行统计学分析。结果发作期哮喘患儿血浆CO明显... 详细信息

目的:探讨小儿哮喘时血浆一氧化碳（CO）和一氧化氮（NO）的含量变化及意义。方法哮喘患儿21例，20名健康儿童为对照，分别在急性发作期和缓解期采静脉血测定血浆CO和NO水平。对测定结果进行统计学分析。结果发作期哮喘患儿血浆CO明显高于正常儿童（分别为1．66±035、1．06±0.12mg／L，t=7．26，P＜0.001），缓解期CO降至正常水平（1．13±0．14mg／L，t=1．56，P＞0．05）；发作期哮喘息地血浆NO2／NO3水平亦明显高于正常儿童（分别为32．8±3．9、29．3±0．28μmol／L，t=3．28，P＜0．01），缓解期NO2／NO3水平亦降至正常水平（29．7±3．0μmol／L，t=0．39，P＞0．05）。且哮喘患儿血浆CO和NO水平呈显著正相关（r=0.485，P＜0．05）。结论小儿哮喘发作期血浆CO和NO水平明显高于缓解期患儿及正常儿童。内源性CO和NO在哮喘发病机制中占有重要地位。

关键词：一氧化碳一氧化氮哮喘儿童

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蓖麻杂交种白蓖22选育报告

吉林农业科学 2015年第1期40卷 17-18页

作者：张云万刘伟李英会王立群王辉苏江顺潘丰吉林省白城市农业科学院吉林白城137000 吉林省通榆县新兴乡农业站吉林通榆137208 吉林省洮南市福顺乡农业站吉林洮南137100

蓖麻白蓖22是吉林省白城市农业科学院以不育系＂KNC-12＂为母本,恢复系＂KNH-8＂为父本杂交组配而成的蓖麻杂交种。2011～2012年连续两年参加吉林省蓖麻杂交种区域试验,籽实产量2754.34 kg/hm^2,2012年同时参加吉林省蓖麻杂交种生产试验... 详细信息

蓖麻白蓖22是吉林省白城市农业科学院以不育系＂KNC-12＂为母本,恢复系＂KNH-8＂为父本杂交组配而成的蓖麻杂交种。2011～2012年连续两年参加吉林省蓖麻杂交种区域试验,籽实产量2754.34 kg/hm^2,2012年同时参加吉林省蓖麻杂交种生产试验,产量2671.16 kg/hm^2。是新兴的绿色能源作物。

关键词：蓖麻杂交种选育能源作物栽培技术

施用液体复合肥对水稻产量、品质及经济效益的影响

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广东农业科学 2015年第16期42卷 7-11页

作者：龚林严程明涂攀峰邓兰生王莎莎张承林华南农业大学农学院广东广州510642 广州一翔农业技术有限公司广东广州510650

通过田间试验，研究合理使用液体复合肥套餐（A，B，C）对松嫩平原高产水稻产量、品质和经济效益的影响。选择3个典型种植户，综合比较常规肥料施肥和液体肥料施肥对水稻的影响。结果表明，与常规施肥比较，液体复合肥处理明显提高结实... 详细信息

通过田间试验，研究合理使用液体复合肥套餐（A，B，C）对松嫩平原高产水稻产量、品质和经济效益的影响。选择3个典型种植户，综合比较常规肥料施肥和液体肥料施肥对水稻的影响。结果表明，与常规施肥比较，液体复合肥处理明显提高结实粒数，增产6．08％～18．35％，增产效果显著；液体肥料处理产出投人比分别达2．55、2．72和2．52，较常规肥料处理提高18．87％、9．85％和4．24％，净收益分别较常规施肥处理提高34．78％、16．04％和9．11％，显著提高农民经济效益；液体肥料在水稻上的应用还可减少施肥用工，用工成本可降低795～930元／hm^2。液体肥料通过合理的施肥方式施用，能够提高水稻的产量、品质、经济效益以及节省人工，在水稻上的应用是可行的。

关键词：液体肥料水稻产量经济效益

Multi-optimizationofasphericalmechanismforminimallyinvasivesurgery

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Journal of Central South University 2017年第6期24卷 1406-1417页

作者： NIU Guo-jun pan Bo ZHANG Fu-hai feng Hai-bo FU Yi-li State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China

In order to obtain the remote center motion(RCM) mechanism with better performance indexes and avoid the collision of multi-manipulators in minimally invasive surgery(MIS), a novel multi-objective optimization model was presented. There were two optimization objectives: a global kinematic performance index and a comprehensive stiffness index. Other indexes to characterize the design requirements such as collision probability, workspace, mechanism parameter, mass, and wall thickness were considered as constraints. Angles between two adjacent joints and cross-section dimensions of links were chosen as the design variables. The non-dominated sorting genetic algorithm II(NSGA-II) was adopted to solve the complex multi-objective optimization problem. Then, a 3-degree of freedom(DoF) MIS robotic prototype based on optimization results has been built up. The experiments to test the spatial position change of the remote center point and to test the absolute position accuracy and repetitive position accuracy of the MIS robot were achieved, and the experimental results meet the requirements of MIS.

关键词： minimally invasive surgery medical robot multi-objective optimization remote centre motion

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超高层结构水平挠度变形研究

建筑技术 2018年第7期49卷 766-768页

作者：李素霞梁权刘占省谢婧王竞超巴盼锋北京建工四建工程建设有限公司北京100075 北京工业大学北京100124 北京建工集团有限责任公司北京100055

国瑞·西安金融中心工程施工中,对超高层结构的水平挠度变形进行实测和模拟分析,研究阴阳面不均匀温差和风荷载对结构水平挠度变形的影响。采用midas Gen对超高层结构进行水平位移变形模拟,与实测数据进行对比分析,得出超高层结构整体... 详细信息

国瑞·西安金融中心工程施工中,对超高层结构的水平挠度变形进行实测和模拟分析,研究阴阳面不均匀温差和风荷载对结构水平挠度变形的影响。采用midas Gen对超高层结构进行水平位移变形模拟,与实测数据进行对比分析,得出超高层结构整体竖向变形规律。

关键词：超高层结构水平挠度不均匀温差风荷载