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Chronomodulated chemotherapy for locoregionally advanced nasopharyngeal carcinoma:A phase Ⅱ randomized controlled trial

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Radiation Medicine and Protection 2024年第1期5卷 43-48页

作者： Xiaoxiao Chen feng Jin Weili Wu Yuanyuan Li jinhuan Long Xiuling Luo Xiuyun Juan Li Pengxin Zhang Mang Zhang Department of Head and Neck Oncology Affiliated Cancer Hospital of Guizhou Medical UniversityGuiyang 550004China Departemnt of Oncology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001China

Objective:To validate the safety and efficacy of chronochemotherapy for locoregionally advanced nasopharyngeal carcinoma(NPC).Methods:Participants for this phase II randomized controlled trial were recruited from the Department of Head and Neck Oncology at the Affiliated Cancer Hospital of Guizhou Medical *** enrolled(128 in total,112 in the final analysis)between April 1,2017,and February 28,2018,were randomly divided into the chronochemotherapy and conventional chemotherapy *** the chronochemotherapy group,docetaxel was intravenously administered between 3:30 *** 4:30 *** day 1,followed by intravenous administration of cisplatin between 10:00 *** 10:00 *** day 1to day *** addition,5-fluorouracil was administered through a continuous intravenous pump between 10:00 *** 10:00 a.m.(2nd day)from day 1 to day *** the conventional chemotherapy group,docetaxel(on day 1),cisplatin(on day 2),and 5-fluorouracil(from day 1 to day 5,120 h in total)were administered without time-specific *** groups underwent intensitymodulated radiation therapy with 6-MV *** gross target volume(GTV)comprised the nasopharyngeal GTV and cervical lymph node *** primary endpoint was immune function,quantified by measuring dendritic cell and lymphocyte subsets,whereas the secondary endpoints were therapeutic efficacy and incidence of adverse *** Chi-square test was applied to compare total events between the groups,Mann-Whitney U test was used to compare the DC subsets and toxicities,and Wilcoxon signed-rank test was used to compare the continuous variables between the two ***:Chronochemotherapy preserved immune function,as evidenced by elevated levels of myeloid dendritic cells(P=0.394)and higher CD4/CD8 ratio(P?0.781).No significant difference in overall response rate,measured as the sum of complete and partial response rates,was observed between the groups(P=0.711).A reduction in the incidence of vomiting(P=

关键词： Nasopharyngeal carcinoma Chronochemotherapy Intensity-modulated radiotherapy Dendritic cells Adverse events Randomized controlled trial

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Coupling Analysis of Tourism Development and Rural Revitalization in Yannanfei Tea Field Resort of Guangdong Province

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Journal of Landscape Research 2023年第6期15卷 55-58,64页

作者： CHEN Haiming LIU Jun ZENG Ziye feng jinhuan WU Xinyi WU Zhuohua CHEN Yiyu Tourism and Historical Culture College Zhaoqing UniversityZhaoqingGuangdong 526000China Department of Music Zhaoqing UniversityZhaoqingGuangdong 526000China

By deconstructing the dimensions of rural tourism and rural revitalization and constructing a coupled conceptual model,a coupled evaluation model is *** Tea Field Resort in Guangdong is taken as a research case for empirical analysis,to explore the coupled development trend of the *** results show that①the tourism development of Guangdong Yannanfei Tea Field Resort has a good synergistic relationship with rural *** two complement and promote each other,and rural tourism has significantly promoted the development of rural revitalization.②The coupling development of tourism development and rural revitalization in Guangdong Yannanfei Tea Field Resort is divided into coupling imbalance period and coupling coordination *** results indicate that the coordination between the two has not yet reached a level of good coordination and high-quality *** is recommended that the resort should fully utilize the opportunity of rural revitalization strategy,increase investment in rural tourism,promote the transformation and upgrading of the resort,impel the integration of tea and tourism,and develop new business model of tea-tourism rural vacation.

关键词： Guangdong Yannanfei Tea Field Resort Coupling analysis Rural revitalization

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Structural and magnetic properties of （Nd1—xErx）3 Fe27.3Ti1.7 Compounds

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Chinese Physics B 2003年第5期12卷 573-574页

作者： WangWei-Quan YanYu WangXiang-Qun WangXue-feng jinhuan-Min DepartmentofPhysics JilinUniversityChangchun130023China

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腹腔镜全子宫切除术患者心理弹性水平及危险因素分析

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沈阳医学院学报 2022年第5期24卷 531-534页

作者：冯锦环谭志好许小贞李杏珍邱莹莹曹玉云广东省阳江市阳东区人民医院手术室广东阳江529500

目的:探讨腹腔镜全子宫切除术患者心理弹性水平,并分析其危险因素。方法:回顾性分析2019年1月至2021年3月在我院行腹腔镜全子宫切除术137例患者的临床资料,分别采用心理弹性量表(CD-RISC)、简易应对方式问卷(SCSQ)、领悟社会支持量表(PS... 详细信息

目的:探讨腹腔镜全子宫切除术患者心理弹性水平,并分析其危险因素。方法:回顾性分析2019年1月至2021年3月在我院行腹腔镜全子宫切除术137例患者的临床资料,分别采用心理弹性量表(CD-RISC)、简易应对方式问卷(SCSQ)、领悟社会支持量表(PSSS)于术后1周评估患者心理弹性、应对方式及社会支持度,并分析影响腹腔镜全子宫切除术患者心理弹性水平的危险因素。结果:术后CD-RISC平均分为(62.20±15.87)分。年龄0.05)。经多元线性回归结果显示,年龄<45岁(B=5.065,95%CI:2.747~7.382)、离异或未婚或丧偶(B=7.542,95%CI:4.564~10.519)、初中及以下学历(B=2.827,95%CI:1.265~4.390)、消极应对(B=3.154,95%CI:2.514~6.352)、社会支持低(B=5.120,95%CI:2.601~7.638)均是腹腔镜全子宫切除术患者心理弹性水平较低的危险因素(P<0.05)。结论:腹腔镜全子宫切除术患者心理弹性水平较低,可能受年龄小、离异或未婚或丧偶、文化程度低、消极应对、社会支持低等因素影响,临床应根据上述危险因素制定针对性干预措施,以提高患者心理弹性水平。

关键词：腹腔镜全子宫切除术心理弹性水平危险因素

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急性脑梗死选择性动脉溶栓治疗与护理

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护理研究 2005年第24期19卷 2169-2170页

作者：冯金焕田丽韩青松天津市第三中心医院

综述了急性脑梗死选择性动脉溶栓治疗与护理,详细介绍了脑梗死的发病机理、溶栓时机、适应证、介入治疗方法及护理。

关键词：脑梗死介入性动脉溶栓护理

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儿童慢性乙肝病毒携带者T细胞亚群与HBeAg的关系

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临床医学 2007年第10期27卷 77-79页

作者：王松青范燕谢旭善冯金环山东省青岛市海慈医疗集团青岛266033 青岛市四方区医院

目的研究儿童慢性HBV携带者的T细胞亚群状态。方法设正常对照组(n=32)及儿童慢性HBV携带(ASC)组(n=104),ASC组中又根据HBeAg分为HBeAg阳性(n=56)及阴性组(n=48)。血清HBV标志物经酶联免疫吸附试验(ELISA),T细胞亚群采用碱性磷酸酶-抗碱... 详细信息

目的研究儿童慢性HBV携带者的T细胞亚群状态。方法设正常对照组(n=32)及儿童慢性HBV携带(ASC)组(n=104),ASC组中又根据HBeAg分为HBeAg阳性(n=56)及阴性组(n=48)。血清HBV标志物经酶联免疫吸附试验(ELISA),T细胞亚群采用碱性磷酸酶-抗碱性磷酸(APAAP)免疫组化染色法检测。结果ASC组CD3+、CD4+、CD4+/CD8+明显低于对照组,CD8+明显高于对照组(P<0.01);其中HBeAg阳性组的CD4+、CD4+/CD8+较HBeAg阴性组明显升高(P均<0.01或0.05);CD8+明显降低(P<0.01)。结论儿童慢性HBV携带者存在T细胞亚群功能紊乱。其中,尤以HBeAg阳性者为著。

关键词：慢性乙肝病毒携带乙肝病毒e抗原 T细胞亚群乙肝标志物儿童

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Population genomic analysis reveals domestication of cultivated rye from weedy rye

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Molecular Plant 2022年第3期15卷 552-561页

作者： Yanqing Sun Enhui Shen Yiyu Hu Dongya Wu Yu feng Sangting Lao Chenfeng Dong Tianyu Du Wei Hua Chu-Yu Ye jinhuan Zhu Qian-Hao Zhu Daguang Cai Lidia Skuza Jie Qiu Longjiang Fan Institute of Crop Science&Institute of Bioinformatics Zhejiang UniversityHangzhou 310058China Zhejiang University Zhongyuan Institute Zhengzhou 450000China Shandong(Linyi)Institute of Modern Agriculture of Zhejiang University Linyi 310014China Institute of Ecology Zhejiang UniversityHangzhou 310058China Institute of Crops Zhejiang Academy of Agricultural SciencesHangzhou 322105China CSIRO Agriculture and Food GPO Box 1700CanberraACT 2601Australia Department of Molecular Phytopathology and Biotechnology Christian-Albrechts-University of Kiel24118 KielGermany Institute of Biology University of Szczecin71-415 SzczecinPoland Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200235China

Rye(Secale cereale)is an important crop with multiple uses and a valuable genetic resource for wheat ***,due to its complex genome and outcrossing nature,the origin of cultivated rye remains *** geneticist *** proposed that cultivated rye had been domesticated from weedy rye,rather than directly from wild species like other *** the domestication history of rye will extend our understanding of crop evolution and upend our inherent understanding of agricultural *** this end,in this study we generated the 8.5 Tb of whole-genome resequencing data from 116 worldwide accessions of wild,weedy,and cultivated rye,and demonstrated that cultivated rye was domesticated directly from weedy relatives with a similar but enhanced genomic selection by *** found that a repertoire of genes that experienced artificial selection is associated with important agronomic traits,including shattering,grain yield,and disease ***,we identified a composite introgression in cultivated rye from the wild perennial Secale strictum and detected a 2-Mb introgressed fragment containing a candidate ammonium transporter gene with potential effect on the grain yield and plant growth of *** together,our findings unravel the domestication history of cultivated rye,suggest that interspecific introgression serves as one of the likely causes of obscure species taxonomy of the genus Secale,and provide an important resource for future rye and wheat breeding.

关键词： Secale cereale domestication weedy rye introgression Vavilovian hypothesis

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育阴化湿汤治疗慢性期特应性皮炎疗效及对IL-4与INF-γ的影响

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山东中医药大学学报 2016年第6期40卷 521-523页

作者：吕慧青冯金环王清玲张红于晓倩青岛市中医院皮肤科山东青岛266033 青岛市中医院儿科山东青岛266033

目的：探讨慢性期特应性皮炎应用育阴化湿汤的临床疗效及对免疫状态的影响。方法：随机选取我院2013年6月-2015年12月收治的慢性期特应性皮炎患儿74例作为研究对象,随机分为两组,对照组常规服用抗组胺药左西替利嗪片,观察组在对照组... 详细信息

目的：探讨慢性期特应性皮炎应用育阴化湿汤的临床疗效及对免疫状态的影响。方法：随机选取我院2013年6月-2015年12月收治的慢性期特应性皮炎患儿74例作为研究对象,随机分为两组,对照组常规服用抗组胺药左西替利嗪片,观察组在对照组治疗基础上加服育阴化湿汤治疗,疗程4周。对比分析两组患儿临床疗效、治疗前后血清白介素-4（IL-4）以及干扰素γ（INF-γ）水平。结果：观察组患儿治疗总有效率明显高于对照组（P〈0.05）,治疗后观察组血清IL-4水平较对照组明显下降（P〈0.05）,观察组INF-γ水平较对照组明显升高（P〈0.05）。结论：育阴化湿汤治疗慢性期特应性皮炎患儿临床疗效显著,且能降低血清IL-4水平并使INF-γ水平升高,调节Th1/Th2平衡,改善患儿免疫失衡状态。

关键词：育阴化湿汤慢性期特应性皮炎小儿白介素-4 干扰素-γ 疗效观察

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Busuishengxue ranules mediate their effects upon non-severe aplastic anemia via mitogen-activated protein kinase/extracellular signal-regulated kinase pathway

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Journal of Traditional Chinese Medicine 2014年第1期34卷 23-29页

作者： jinhuan Wang feng Sun Weizheng Sun Yanli Yong Haitao Shi Sijia Liu Limei Liu Department of Hematology First Affiliated HospitalHeilongjiang University of Chinese Medicine Department of Traditional Chinese Medicine Longnan Hospital of Daqing City Department of Encephalopathy Chinese Medicine Hospital of Harbin Renal Department of Internal Medicine Heilongjiang Provincial Academy of Traditional Chinese Medicine

OBJECTIVE:To observe the clinical efficacy of Busuishengxue granules on non-severe aplastic anemia(NSAA)and investigate its effect on the mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK)***:Sixty NSAA patients were divided equally into two *** in the experimental group were treated with Busuishengxue granules,and the control group with Zaizaoshengxue *** treatment course was 6 months and cu-rative efficacy was compared between the two groups as well as with 10 healthy *** cytometry(FCM)was used to detect the intracellular concentration of Ca2+([Ca2+]i).Western blotting was employed to detect the expression of enzymes in the MAPK/ERK ***:The efficacy of Busuishengxue granules was significantly better than that of Zaizaoshengxue tablets(P<0.05).Before treatment,expression of JNK,phospho-ERK 1/2 and p-JNK was higher,and[Ca2+]i higher,than that of the control group(P<0.05).After treatment with Busuishengxue granules,expression of all enzymes related to signal transduction pathways in the blood cells of NSSA patients were altered to different ***:Busuishengxue granules had a better effect with regard to improving symptom scores,increasing the number of blood leukocytes,and increasing hemoglobin levels than Zaizaoshengxue tablets,and they differed slightly in terms of increasing the number of platelets.

关键词：细胞外信号调节激酶丝裂原活化蛋白激酶再生障碍性贫血重型通路 Western印迹法介导临床疗效

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Effect of Stocking Density on Water Quality and(Growth, Body Composition and Plasma Cortisol Content) Performance of Pen-Reared Rainbow Trout(Oncorhynchus mykiss)

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中国海洋大学学报：英文版 2016年第4期15卷 667-675页

作者： LIU Qun HOU Zhishuai WEN Haishen LI Jifang HE feng WANG jinhuan GUAN Biao WANG Qinglong College of Fisheries Ocean University of China Key Laboratory of Mariculture Ministry of EducationOcean University of China

The goal of the study was to examine the effect of stocking density on the water quality of culture area, as well as the growth, body composition and cortisol content of rainbow trout(Oncorhynchus mykiss). Pen-reared trout were stocked in densities of 40, 60, 80 fish individuals m^(-3)(4.6, 6.6, 8.6 kg m^(-3), SD1, SD2 and SD3 groups, respectively) for 300 days. Compared to the water from SD1 and SD2, that from SD3 exhibited significantly higher NH_4^+-N content and COD(chemical-oxygen-demand), and a significant reduction of dissolved oxygen in day 180(40.6 kg m^(-3)). Stocking density was significantly associated with body weight, standard length, VSI(viscerosomatic index), CF(condition factor) and FC(food coefficient) in group SD3, particularly in day 240 and day 300(45 or 49.3 kg m^(-3)). Increased crude fat and decreased crude protein were displayed in high density group when the density reached to 36 kg m^(-3). As a cumulative effect of density-related stress, VSI, CF, FC, moisture, and crude protein content varied over time in each density group(SD1, SD2, and SD3). In summary, trout exhibited a better growth performance in low density(26.3 kg m^(-3)) than those reared in high densities(36 and 45 kg m^(-3)). The results indicate that rainbow trout(114.44 g ± 6.21 g, 19.69 cm ± 0.31 cm) initially stocked in 6.6 or 8.6 kg m^(-3) should be lightened to less than 36 kg m^(-3) after an intensive rearing for 240 days.

关键词： rainbow trout stocking density growth cortisol body composition

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