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Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice

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Science china(Life Sciences) 2024年第7期67卷 1325-1337页

作者： Chengcheng Song Yingying Qin Yan Li Bingyi yang Ting Guo Wenqing Ma Dian Xu Keyan Xu Fangfang fu Li Jin Yanhua wu Shuyan Tang Xiaojun Chen {2. Zhang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Medical Genetics and GenomicsFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250021China State Key Laboratory of Reproductive Medicine and Offspring Health Key Laboratory of Reproductive Endocrinology of Ministry of EducationNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthShandong UniversityJinan 250021China department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China department of Gynecology the Tenth People’s Hospital of Tongji UniversityShanghai 200072China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health Hospital of China Welfare InstituteShanghai 200030China

Premature ovarian insufficiency(POI)is a heterogeneous female disorder characterized by the loss of ovarian function before the age of *** represents a significant detriment to female ***,the known POI-causative genes currently account for only a fraction of *** elucidate the genetic factors underlying POI,we conducted whole-exome sequencing on a family with three fertile POI patients and identified a deleterious missense variant in *** a subsequent replication study involving 1,030 POI patients,this variant was not only confirmed but also accompanied by the discovery of three additional predicted deleterious RNF111 *** variants collectively account for eight cases,representing 0.78%of the study cohort.A further study involving 500 patients with diminished ovarian reserve also identified two additional RNF111 ***,RNF111 encodes an E3 ubiquitin ligase with a regulatory role in the TGF-β/BMP signaling *** analysis revealed that RNF111/RNF111 is predominantly expressed in the oocytes of mice,monkeys,and *** further investigate the functional implications of RNF111 variants,we generated two mouse models:one with a heterozygous missense mutation(Rnf111+/M)and another with a heterozygous null mutation(Rnf111^(+/-)).Both mouse models exhibited impaired female fertility,characterized by reduced litter sizes and small ovarian ***,RNA-seq and quantitative proteomics analysis unveiled that Rnf111 haploinsufficiency led to dysregulation in female gonad development and negative regulation of the BMP signaling pathway within mouse *** conclusion,our findings strongly suggest that monoallelic deleterious variants in RNF111 can impair female fertility and induce POI in both humans and mice.

关键词： POI RNF111 female fertility ovarian reserve

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Modifying temperature-related cardiovascular mortality through green-blue space exposure

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Environmental Science and Ecotechnology 2024年第4期20卷 269-277页

作者： Kejia Hu Shiyi Wang Fangrong Fei Jinglu Song feng Chen Qi Zhao Yujie Shen Jingqiao fu Yunquan Zhang Jian Cheng Jieming Zhong Xuchao {2. Jiayu wu School of Public Health Zhejiang UniversityHangzhou310058China Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province Hangzhou310058China College of Agriculture and Biotechnology Zhejiang UniversityHangzhou310058China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310051China department of Urban Planning and Design Xi'an Jiaotong-Liverpool UniversitySuzhou215123China Zhejiang Institute of Meteorological Sciences Hangzhou310008China School of Public Health Shandong UniversityJinan250012China Ocean College Zhejiang UniversityZhoushan316021China School of Public Health Wuhan University of Science and TechnologyWuhan430065China School of Public Health Anhui Medical UniversityHefei230032China

Green-blue spaces(GBS)are pivotal in mitigating thermal ***,their management lacks guidelines rooted in epidemiological evidence for specific planning and *** we show how various GBS types modify the link between non-optimal temperatures and cardiovascular mortality across different thermal *** merged fine-scale population density and GBS data to create novel GBS exposure index.A case time series approach was employed to analyse temperature-cardiovascular mortality association and the effect modifications of type-specific GBSs across 1085 subdistricts in south-eastern *** findings indicate that both green and blue spaces may significantly reduce high-temperature-related cardiovascular mortality risks(e.g.,for low(5%)***(95%)level of overall green spaces at 99th *** mortality temperature(MMT),Ratio of relative risk(RRR)=1.14(95%CI:1.07,1.2.);for overall blue spaces,RRR=1.2.(95%CI:1.12.1.2.)),while specific blue space types offer protection against cold temperatures(e.g.,for the rivers at 1st vs MMT,RRR=1.17(95%CI:1.07,1.2.)).Notably,forests,parks,nature reserves,street greenery,and lakes are linked with lower heat-related cardiovascular mortality,whereas rivers and coasts mitigate cold-related cardiovascular *** spaces provide greater benefits than green *** severity of temperature extremes further amplifies GBS's protective *** study enhances our understanding of how type-specific GBS influences health risks associated with non-optimal temperatures,offering valuable insights for integrating GBS into climate adaptation strategies for maximal health benefits.

关键词： Green space Blue space Temperature Mortality china

Protective Effects of Danmu Extract Syrup on Acute Lung Injury Induced by Lipopolysaccharide in Mice through Endothelial Barrier Repair

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Chinese Journal of Integrative Medicine 2024年第3期30卷 243-250页

作者： XU Han XU Si-cong LI Li-yan wu Yu-huang TAN Yin-feng CHEN Long LIU Pei LIANG Chang-fu HE Xiao-ning LI Yong-hui Hainan Provincial Key Lab of Research&Development on Tropic Herbs Hainan Medical UniversityHaikou571199China department of Stomatology the Second Affiliated Hospital of Hainan Medical UniversityHaikou571199China

Objective:To investigate the effects of Danmu Extract Syrup(DMS) on lipopolysaccharide(LPS)-induced acute lung injury(ALI) in mice and explore the ***:Seventy-two male Balb/C mice were randomly divided into 6 groups according to a random number table(n=12.,including control(normal saline),LPS(5 mg/kg),LPS+DMS 2.5 mL/kg,LPS+DMS 5 mL/kg,LPS+DMS 10 mL/kg,and LPS+Dexamethasone(DXM,5 mg/kg) *** pretreatment with DMS and DXM,the ALI mice model was induced by LPS,and the bronchoalveolar lavage fluid(BALF) were collected to determine protein concentration,cell counts and inflammatory *** lung tissues of mice were stained with hematoxylin-eosin,and the wet/dry weight ratio(W/D) of lung tissue was *** levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-1βin BALF of mice were detected by enzyme linked immunosorbent *** expression levels of Claudin-5,vascular endothelial(VE)-cadherin,vascular endothelial growth factor(VEGF),phospho-protein kinase B(p-Akt) and Akt were detected by Western blot ***:DMS pre-treatment significantly ameliorated lung histopathological *** with the LPS group,the W/D ratio and protein contents in BALF were obviously reduced after DMS pretreatment(P1).The number of cells in BALF and myeloperoxidase(MPO) activity decreased significantly after DMS pretreatment(P1).DMS pre-treatment decreased the levels of TNF-α,IL-6 and IL-1β(P1).Meanwhile,DMS activated the phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) pathway and reversed the expressions of Claudin-5,VE-cadherin and VEGF(P1).Conclusions:DMS attenuated LPS-induced ALI in mice through repairing endothelial *** might be a potential therapeutic drug for LPS-induced lung injury.

关键词： Danmu Extract Syrup acute lung injury inflammatory factors vascular endothelial growth factor phosphoinositide 3-kinase/protein kinase B Chinese medicine Nauclea officinalis

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Bioactive phytochemicals and associated multifunctional health-promoting effects of Polygonati Rhizoma

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Food Science and Human Wellness 2024年

作者： Shuzhen Wang feng He Yunli Xiao fu Xiang Lan Lu Wei wu Chi-Tang Ho Shiming Li College of Biology and Agricultural Resources， Huanggang Normal university School of Computer and Information Technology， Beijing Jiaotong university department of Food Science， Rutgers university New Brunswick

Polygonati Rhizoma， a functional food and a traditional Chinese medicine broadly used in china and several Southeast Asia countries， possesses effective health-promoting activities. Prepared from three plants in Polygonatum family (P. kingianum， P. sibiricum， and P. cyrtonema)， Polygonati Rhizoma has drawn increasing attention due to its remarkable immune-enhancing and metabolic regulatory activities in recent years. In this review， we summarized the updated research of chemical constituents and biological activities of Polygonati Rhizoma， especially the metabolic regulation， immunomodulatory effects， and anti-fatigue activities， aiming to provide a comprehensive understanding， broaden the usage and promote more in-depth exploration of Polygonati Rhizoma as a functional food.

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The thymic stromal cell line MTSC4 induced thymocyte apoptosis in a non-MHC-restricted manner

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Cell Research 2004年第2期14卷 125-133页

作者： Xue Ying HE~1, Juan LI~1, Xiao Ping QIAN~1, Wen Xian fu~1, Yan LI~1, Li wu~2. Wei feng CHEN~1 ~1{2. of Immunology, peking university Health Science Center,38 Xueyuan Road, Beijing 100083, china. ~2.he Walter and Eliza Hall Institute, PO Royal Melbourne Hospital, Victoria 3050, Australia. Chen WF Peking Univ Ctr Hlth Sci Dept Immunol 38 Xueyuan Rd Beijing 100083 Peoples R China

Mouse thymic stromal cell line 4 （MTSC4） is one of the stromal cell lines established in our laboratory. While losing the characteristics of epithelial cells, they express some surface markers shared with thymic dendritic cells （TDCs）. To further study the biological functions of these cells, we compared the capability of MTSC4 with TDCs in the induction of thymocyte apoptosis, using thymic reaggregation culture system. Apoptosis of thymocytes induced by MTSC4 and TDCs was measured by Annexin V and PI staining and analyzed by flow cytometry. We found that MTSC4 selectively augmented the apoptosis of CD4+8+ （DP） thymocytes. This effect was Fas/FasL independent and could not be blocked by antibodies to MHC class Ⅰ and class Ⅱ molecules. In addition, MTSC4 enhanced the apoptosis of DP thymocytes from different strains of mice, which implies that MTSC4-induced thymocyte apoptosis is not mediated by the TCR recognition of self peptide/MHC molecules. In contrast to MTSC4, thymocyte apoptosis induced by TD

关键词： MHC thymic dendritic cells thymic stromal cell line thymocyte apoptosis.

Development and prospect of telemedicine

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Intelligent Medicine 2024年第1期4卷 1-9页

作者： Zhiyue Su Chengquan Li Haitian fu Liyang Wang Meilong wu Xiaobin {2. university College London LondonWC1E 6BTUnited Kingdom School of Clinical Medicine Tsinghua UniversityBeijing 100084China Division of Hepatobiliary and Pancreas Surgery Department of General SurgeryShenzhen People’s Hospital(The Second Clinical Medical College of Jinan UniversityThe First Affiliated Hospital of Southern University of Science and Technology)ShenzhenGuangdong 518020China

With the continuous improvement and development of modern network information technology and the continuous improvement of people’s demands for health care,the traditional health care model has evolved,giving birth to a new telemedicine health care *** refers to the comprehensive application of information technology for medical information transmission and long-distance communication between different *** integrates medicine,computer technology,and communication technology for remote monitoring,diagnosis,consultation,case discussion,teaching,and surgery as well as a series of medical *** the continuous development of communication technology,telemedicine is also constantly *** a relatively novel technology,telemedicine is sought after by major *** the advancement of internet technology,digitization and informatization have been gradually applied in telemedicine,but due to various factors,telemedicine still has great *** paper summarized the development status of telemedicine;discussed in detail the development of telemedicine at home and abroad;reviewed the application of telemedicine as well as the feasibility and limitations of its promotion and development;and put forward an outlook for the future development of telemedicine.

关键词： Telemedicine Medical service Application development

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao feng Yao Jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe Jia feng-Qi Zhang Wei Wang Qi Liu yang Ren Xun-Li Wang Xiao-Ya Cui Xiao-yang Wang Ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-Long Gao Jia-Ming Guo Zeng-Bao Jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu Rui Huang Ling-Kun Zhang Yi-Ping Lu Xu-Bo Li Huai-Jun Lin Yan Ma Wei-Ming yang Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang Huang De-Zhuang Wang Qing-feng Liu Fei-yang Wang Hui Liu Hong-Hui wu Li-Qiang Wang yang Lu Nan Wang Tian-Li Wang Wei-Bing Liao Yi-Han Wang Yuan wu Yu-Zhen Yin Jie Pan Yi Zhang Qing Wang Jian-yang Zhang Tao yang Yasir Sohail Jin-Yu Zhang Hua Ji Qiang Li Wei-Di Liu Zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo wu School of Materials Science and Engineering Nanjing University of Science and Technology Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

Clonidine,moxonidine,folic acid,and mecobalamin improve baroreflex function in stroke-prone,spontaneously hypertensive rats

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Acta Pharmacologica Sinica 2007年第10期28卷 1550-1558页

作者： Xiu-juan MA~(1,2.,fu-ming SHEN~1,Ai-jun LIU~1,Ke-yong SHI~(1,2.,Ying-liang wu~2.Ding-feng SU~(1,2.3)~1 {2. of Pharmacology Second Military Medical university,Shanghai 2.0433,china ~2.School of Pharmacy,Shenyang Pharmaceu-tical university,Shenyang 110016,china ment of Pharmacology Second Military Medical University Shanghai 200433 China. dfsu@***.

Aim:To investigate the effect of clonidine,moxonidine,folic acid,andmecobalamin on arterial baroreflex (ABR) function in stroke-prone spontane-ously hypertensive rats (SHR-SP) and the possible mechanisms ***:Eighty-one SHR-SP were divided into 7 *** groups weredesignated for the intragastric (ig) administration of clonidine (1.0 and 10.0μg/kg),moxonidine (0.1 and 1.0 mg/kg),folic acid (1.0 mg/kg),and mecobalamin(1.0 mg/kg).Three groups were for the intracerebroventricular (icv) injectionof clonidine (4 μg/4 μL),moxonidine (5 μg/4 μL),and mecobalamin (2. μg/4 μL).Blood pressure (BP) was recorded in the conscious state for 30 min andbaroreflex sensitivity (BRS) was determined respectively before and after ***:Clonidine and moxonidine significantly decreased BP,prolonged the heart period (HP),and increased BRS when administered as ei-ther ig or icv *** BP and HP were unchanged by ig folic acid ormecobalamin ***,BRS was significantly increased by ***:Clonidine,moxonidine,folic acid,and mecobalamin improvedimpaired ABR function in *** central mechanism was involved in thiseffect of either clonidine or *** improved ABR func-tion through the peripheral mechanism.

关键词： clonidine moxonidine folic acid mecobalamin arterial baroreflex stroke-prone spontaneously hypertensive rats

Mirrorless MEMS imaging:a nonlinear vibrational approach utilizing aerosol-jetted PZT-actuated fiber MEMS scanner for microscale illumination

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Microsystems & Nanoengineering 2024年第1期10卷 175-192页

作者： Wei-Chih Wang Ming-Yao Li Kuan-Chang Peng Yi-feng Hsu Benjamin Estroff Pao-Yun Yen David Schipf Wen-Jong wu department of Power Mechanical Engineering National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchuTaiwan 30013China Institute of NanoEngineering and Microsystems National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchuTaiwan 30013China department of Mechanical Engineering University of WashingtonSeattleWA 98195USA department of Electrical Engineering University of WashingtonSeattleWA 98195USA department of Engineering Science and Ocean Engineering National Taiwan UniversityTaiwanChina

This study introduces a novel image capture and lighting techniques using a cutting-edge hybrid MEMS scanner system designed for compact microscopic *** scanner comprises a tapered optical fiber waveguide and innovative aerosol-jet printed PZT(lead zirconate titanate)bimorph push-pull actuators on a stainless-steel substrate,effectively addressing issues that are commonly associated with PZT on silicon substrates such as fracture and layer *** leveraging nonlinear vibration,the scanner achieves a spiral scan pattern from a single signal input,in addition to the expected two-dimensional scanning and target illumination from two phase-shifted *** capability is further enhanced by a novel process to taper the optical fiber,which reduces illumination scattering and tunes the fiber to the resonant frequencies of the *** precisely tapered tip enables large fields of view while maintaining independent 2.axis scanning through one-degree-of-freedom *** validation showcases the successful generation of a spiral scan pattern with a 60μm diameter scan area and a 10 Hz frame rate,effectively reconstructing scanned images of 5μm lines,cross patterns(15μm in length with a 5μm gap),and structures of a Psychodidae wing.

关键词： steel fiber scanner