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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu jiao Wen-Hua Wan Hong-Wei Zhang Xiao Guo Hua Guo Shou-feng jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-feng Zhang Qing-Quan jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

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On Modules with d-Koszul-type Submodules

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Acta Mathematica Sinica,English Series 2009年第6期25卷 1015-1030页

作者： jia feng LU College of Mathematics and Physics Zhejiang Normal University Jinhua 321004 P. R. China

The so-called weakly d-Koszul-type module is introduced and it turns out that each weakly d-Koszul-type module contains a d-Koszul-type submodule. It is proved that, M ∈ W H J^d（A） if and only if M admits a filtration of submodules： 0 belong to U0 belong to U1 belong to ... belong to Up = M such that all Ui/Ui-1 are d-Koszul-type modules, from which we obtain that the finitistic dimension conjecture holds in W H J^d（A） in a special case. Let M ∈ W H J^d（A）. It is proved that the Koszul dual E（M） is Noetherian, Hopfian, of finite dimension in special cases, and E（M） ∈ gr0（E（A））. In particular, we show that M ∈ W H J^d（A） if and only if E（G（M）） ∈ gr0（E（A））, where G is the associated graded functor.

关键词： d-Koszul-type algebras and modules weakly d-Koszul-type modules

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Influences of Structure Disorder and Temperature on Properties of Proton Conductivity in Hydrogen-Bond Molecular Systems

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Communications in Theoretical Physics 2007年第2期47卷 235-243页

作者： PANG Xiao-feng YU jia-feng Institute of Life Science and Technology University of Electronic Science and Technology Chengdu 610054 China International Centre for Materials Physics the Chinese Academy of Sciences Shenyang 110015 China

The dynamic properties of proton conductivity along hydrogen-bonded molecular systems, for example, ice crystal, with structure disorder or damping and finite temperatures exposed in an externally applied electric-field have been numerically studied by Runge-Kutta way in our soliton model. The results obtained show that the proton-soliton is very robust against the structure disorder including the fluctuation of the force constant and disorder in the sequence of masses and thermal perturbation and damping of medium, the velocity of its conductivity increases with increasing of the externally applied electric-field and decreasing of the damping coefficient of medium, but the proton-soliton disperses for quite great fluctuation of the ＂force constant and damping coefficient. In the numerical simulation we find that the proton-soliton in our model is thermally stable in a large region of temperature of T ≤ 273 K under influences of damping and externally applied electric-field in ice crvstal. This shows that our model is available and appropriate to ice.

关键词： proton conductivity structure disorder temperature hydrogen bonded system

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Method of change management based on dynamic machining error propagation

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Science China(Technological Sciences) 2009年第7期52卷 1811-1820页

作者： feng jia jiaNG PingYu State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China

In multistage machining processes(MMPs),the final quality of a part is influenced by a series of machining processes,which are complex *** it is necessary to research the rule of machin-ing error propagation to ensure the machining *** this issue,a change management method of quality control nodes(i.e.,QC-nodes) for machining error propagation is proposed.A new framework of QC-nodes is proposed including association analysis of quality attributes,quality closed-loop control,error tracing and error coordination *** the weighted directed network is introduced to describe and analyze the correlativity among the machining *** order to establish the dynamic machining error propagation network(D-MEPN),QC-nodes are defined as the network nodes,and the correlation among the QC-nodes is mapped onto the *** on the network analysis,the dynamic characteristics of machining error propagation are *** adaptive control method based on the stability theory is introduced for error coordination *** last,a simple example is used to verify the proposed method.

关键词： quality control node complex network error tracing error coordination optimization change management

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Excitation spectra of one-dimensional spin-1/2 Fermi gas with an attraction

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Communications in Theoretical Physics 2022年第12期74卷 154-175页

作者： jia-feng Pan jia-jia Luo Xi-Wen Guan State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China Department of Fundamental and Theoretical Physics Research School of PhysicsAustralian National UniversityCanberra ACT 0200Australia University of Chinese Academy of Sciences Beijing 100049China NSFC-SPTP Peng Huanwu Center for Fundamental Theory Xi'an 710127China

Using an exact Bethe ansatz solution,we rigorously study excitation spectra of the spin-1/2 Fermi gas(called Yang–Gaudin model)with an attractive *** excitations of this model involve particle-hole excitation,hole excitation and adding particles in the Fermi seas of pairs and unpaired *** gapped magnon excitations in the spin sector show a ferromagnetic coupling to the Fermi sea of the single *** numerically and analytically solving the Bethe ansatz equations and the thermodynamic Bethe ansatz equations of this model,we obtain excitation energies for various polarizations in the phase of the Fulde–Ferrell–Larkin–Ovchinnikov-like *** a small momentum(long-wavelength limit)and in the strong interaction regime,we analytically obtained their linear dispersions with curvature corrections,effective masses as well as velocities in particle-hole excitations of pairs and unpaired *** a type of particle-hole excitations display a novel separation of collective motions of bosonic modes within paired and unpaired ***,we also discuss magnon excitations in the spin sector and the application of Bragg spectroscopy for testing such separated charge excitation modes of pairs and single fermions.

关键词： Yang-Gaudin model quantum integrability the Bethe ansatz excitation spectrum

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Majorana zero mode in the vortex of an artificial topological superconductor

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Science China(Physics,Mechanics & Astronomy) 2017年第5期60卷 49-59页

作者： Hao-Hua Sun Jin-feng jia Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) Department of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

Majorana fermion （MF）, an exotic particle that is identical to its own antiparticle, was recently found in solid matter as a quasiparticle excitation, the Majorana zero mode （MZM）, in the vortex of an artificial topological superconductor （TSC）. This artificial TSC, first proposed by Fu and Kane in 2008, is a heterostructure made of a topological insulator BiETe3 and an s-wave superconductor NbSe2. This paper will briefly review the experimental progresses based on the Bi2Te3/NbSe2 heterostructure. All evidences are self-consistent and reveal that the MZM exists in the center of vortex. Those experimental results are also supported by theory. This finding is a milestone in the research ofMajorana fermions in solid state physics and a starting point of MZM＇s application in topological quantum computation.

关键词： Majorana fermion Majorana zero mode topological superconductor heterostructure vortex

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Topological superconductivity in a Bi2Te3/NbSe2 heterostructure:A review

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Chinese Physics B 2019年第6期28卷 5-15页

作者： Hao Zheng Jin-feng jia School of Physics and Astronomy Shanghai Jiao Tong University

Topological superconductors carry globally protected gapless boundary excitations, which are robust under local perturbations, and thus exhibit both fundamental and applicational importance. An unconventional pairing with p-wave symmetry, such as a nontrivial topology in the superconductor’s wavefunction, is required to generate a non-zero Berry phase. Until now, the Bi2 Te3/2 H–NbSe2 heterostructure has proven to be a practical way to realize a topological superconductor in real materials. This complex system, where odd numbers of spin-momentum locked Dirac cone surface states on the topological insulator Bi2 Te3 become superconducting, induced by the proximate effect from the underlying s-wave superconductor 2 H–NbSe2, realizes an effective two-dimensional(2 D) spinless px + i py topological superconductor. In this review article, we summarize the recent experimental progress of the successful synthesis of Bi2 Te3/2 H–NbSe2 heterostructures using molecular beam epitaxy, determining the thickness limit of the heterostructure, detecting the long thought Majorana quasiparticle inside a magnetic vortex core state by means of scanning tunneling microscopy and demonstration of the unique spatial and spin properties of a Majorana zero mode.

关键词： topological insulator topological superconductor Majorana zero mode scanning tunneling microscopy molecular beam epitaxy

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Creating Majorana fermions in topological insulators

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National Science Review 2014年第1期1卷 36-37页

作者： Canhua Liu Jin-feng jia Department of Physics and Astronomy Shanghai Jiao Tong University

Having not been veriied in experiments yet,the concept of Majorana fermions was originally hypothesized in 1937 to describe the spin-1/2 particles that are their own antiparticles,in contrast to Dirac fermions[1],which difer from their antiparticles and cover most of wellknown fermions including quarks,leptons,electrons and their antiparticles.

关键词： Creating Majorana fermions in topological insulators mode

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Notes on Piecewise-Koszul Algebras

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Acta Mathematica Sinica,English Series 2011年第5期27卷 943-952页

作者： jia feng LV Xiao Lan YU Institute of Mathematics Zhejiang Normal University Jinhua 321004 P. R. China Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China

The relationships between piecewise-Koszul algebras and other ＂Koszul-type＂ algebras are discussed. The Yoneda-Ext algebra and the dual algebra of a piecewise-Koszul algebra are studied, and a sufficient condition for the dual algebra A^1 to be piecewise-Koszul is given. Finally, by studying the trivial extension algebras of the path algebras of Dynkin quivers in bipartite orientation, we give explicit constructions for piecewise-Koszul algebras with arbitrary ＂period＂ and piecewise-Koszul algebras with arbitrary ＂jump-degree＂.

关键词： Piecewise-Koszul algebras almost Koszul algebras,/C:-algebras Dynkin quivers

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Planar cell polarity genes, Celsr1-3, in neural development

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Neuroscience Bulletin 2012年第3期28卷 309-315页

作者： jia feng Qi Han Libing Zhou Joint Laboratory for Brain Function and Health Jinan University and The University of Hong KongMedical School of Jinan UniversityGuangzhou 510632China

flamingo is among the ＇core＇ planar cell-polarity genes, protein of which belongs to a unique cadherin subfamily. In contrast to the classic cadherins, composed of several extracellular cadherin repeats, one transmembrane domain and one cytoplasmic segment linked to catenin binding, Drosophila Flamingo has seven transmembrane segments and a cytoplasmic tail with no catenin-binding sequence. In Drosophila, Flamingo has pleotropic roles in controlling epithelial polarity and neuronal morphogenesis. Three mammalian orthologs of flamingo, Celsrl-3, are widely expressed in the nervous system. Recent work has shown that Celsrl-3 play important roles in neural development, such as in axon guidance, neuronal migration, and cilium polarity. CeIsrl-3 single-gene knockout mice exhibit different phenotypes, but there are cooperative interactions among these genes.

关键词： planar cell polarity Celsr genes neural development

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