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Pharmacological and toxicological studies of famous Chinese medicine Hua-feng-dan

中国药理学与毒理学杂志 2019年第10期 829-829页

作者： ZHANG feng XU Shang-fu LI Li-sheng LIU Jie SHI Jing-shan Zunyi Medical University

Hua-feng-dan（HFD） is a famous traditional Chinese medicine with 370 years of clinical use for stroke paraplegia, epilepsy, facial nerve palsy, moutheye skewed, and other neurodegenerative diseases, and is listed as an intangible cultural heritage of China. HFD contains 15 herbs, minerals and animal products undergoing a special fermentation process to satisfy the "lifting and floating" theory of Chinese medicine. However, the pharmacological basis of HFD remains elusive. We initially discovered its anti-inflammatory effects in rat neuron-glia co-cultures. Further studies found that 35 d administration of HFD at the clinical dose ameliorated the dopaminergic neuron loss and microglia activation in chronic LPS+rotenone rat PD models and in chronic LPS+MPTP mouse PD models, with significant reduction of pro-inflammatory cytokine production and cellular ROS levels. HFD contains heavy metals with increasing concern of its ***, removal or reduction of realgar and cinnabar from HFD resulted in abolished or reduced beneficial effects. To further evaluate the safety of HFD, a series of experiments were conducted, including cultured cells,acute and subacute toxicity studies in rodents, and the results clearly demonstrated that realgar（As4S4） and cinnabar（Hg S）-containing HFD is much less toxic than environmental arsenic compounds（NaAsO2and NaH2AsO4）and mercury compounds（HgCl2and Me Hg）, with much less absorption from the gastrointestinal tract. The gut-brain axis is now implicated in neurodegeneration, and LPS +rotenone or LPS+MPTP induced alterations in gut microbiota, which were significantly ameliorated by HFD. HFD itself also modulates gut microbiome, shedding light on gut-brain axis as one of the possible pharmacological mechanisms. In summary, HFD is effective in preventing dopaminergic neuron loss in both in vivo and in vitro models,and this effect appears to be related to its anti-inflammatory effects and modulation effects on gut *** and cin

关键词： Hua-feng-dan neuroprotection hepatotoxicity nephrotoxicity arsenic mercury

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MimiBS： Mimicking Base-Station to Provide Location PrivacyProtection in Wireless Sensor Networks

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Journal of Computer Science & Technology 2017年第5期32卷 991-1007页

作者： Ling-Fang Zeng dan feng Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China

In a wireless sensor network (WSN), sink node/base station (BS) gathers data from surrounding nodes and sends them to a remote server via a gateway. BS holds important data. Therefore, it is necessary to hide its location from an inside/outside attacker. Providing BS location anonymity against a local and global adversary, we propose a novel technique called MimiBS 'Mimicking Base-Station'. The key idea is the integration of aggregator nodes (ANs) with sensor nodes (SNs), while fine tuning TTL (time to live) value for fake packets, and setting some threshold value for real packet counter rpctr. MimiBS creates multiple traffic-hotspots (zones), which shifts the focus from BS to the newly created ANs hotspots. Multiple traffic-hotspots confuse the adversary while determining the real BS location information. We defend the BS location information anonymity against traffic analysis attack, and traffic tracing attack. MimiBS gives an illusion of having multiple BSs, and thus, if the attacker knows any about AN, he/she will be deceived between the real BS and ANs. MimiBS outperforms BLAST (base-station location anonymity and security technique), RW (random walk), and SP (shortest path), while conducting routing without fake packets, with fake packets, without energy consideration, and with energy consideration respectively.

关键词： base station location privacy wireless sensor network balanced energy consumption aggregator node

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Seismic design analysis of the country masonry school buildings in the meizoseismal area

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Earthquake Engineering and Engineering Vibration 2011年第3期10卷 359-367页

作者： feng Yuan Yi dan Bi Qiong China Southwest Architecture Design ＆ Research Institute Chengdu 610042 China

Several reinforcing schemes are illustrated that are based on the loading characteristics of typical country masonry school buildings with sparsely spaced transversal walls and large depth. From the seismic damage observed following the Wenchuan Earthquake, the effects of reinforcing schemes, tie-columns and tie-beams on the seismic resistance of masonry buildings are analyzed. The concept of improving the ductility of these types of buildings is presented. Finally, some suggestions are proposed for the design of masonry buildings with sparsely spaced transversal walls and large depth.

关键词： masonry school buildings tie-columns tie-beams ductility wall between the windows Wenchuan earthquake seismic damage

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Mlock:building delegable metadata service for the parallel file systems

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Science China(Information Sciences) 2015年第3期58卷 66-79页

作者： ZHANG Quan feng dan WANG Fang WU Sen Wuhan National Laboratory for Optoelectronics School of Computer Huazhong University of Science and Technology Information & Telecommunication Company State Grid Hubei Electric Power Company

The ever-growing demand for high performance computation calls for progressively larger parallel distributed file systems to match their *** file systems can achieve high performance for large I/O operations through distributing load across numerous data ***,they fail to provide quality service for applications pertaining to small *** this paper,we propose a delegable metadata service(DMS)for hiding latency of metadata accesses and optimizing small-file *** addition,four techniques have been designed to maintain consistency and efficiency in DMS:pre-allocate serial metahandles,directory-based metadata replacement,packing transaction operations and fine-grained lock *** schemes have been employed in Cappella parallel distributed file system,and various experiments complying with industrial standards have been conducted for evaluation of its *** results show that our design has achieved significant improvement in performance of both metadata operations and small-file ***,this scheme is widely applicable for integration within many other distributed file systems.

关键词： delegable metadata service metadata performance consistency small file parallel file system

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A high-performance and endurable SSD cache for parity-based RAID

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Frontiers of Computer Science 2019年第1期13卷 16-34页

作者： Chu LI dan feng Yu HUA Fang WANG Wuhan National Lab for Optoelectronics Key Laboratory of Information Storage System(School of Computer Science and TechnologyHuazhong University of Science and Technology) Ministry of Education of ChinaWuhan 430074China

Solid-state drives (SSDs)have been widely used as caching tier for disk-based RAID systems to speed up dataintensive ***,traditional cache schemes fail to effectively boost the parity-based RAID storage sys- tems (e.g.,RAID-5/6),which have poor random write performance due to the small-write ***'s worse,intensive cache writes can wear out the SSD quickly,which causes performance degradation and cost *** this article,we present the design and implementation of KDD, an efficient SSD-based caching system which Keeps Data and Deltas in *** write requests hit in the cache, KDD dispatches the data to the RAID storage without updating the parity blocks to mitigate the small write penalty, and compactly stores the compressed deltas in SSD to reduce the cache write traffic while guaranteeing reliability in case of disk *** addition,KDD organizes the metadata partition on SSD as a circular log to make the cache persistent with low *** evaluate the performance of KDD via both simulations and prototype *** results show that KDD effectively reduces the small write penalty while extending the lifetime of the SSD-based cache by up to 6.85 times.

关键词： solid-state drive (SSD) parity-based RAID small write problem write endurance

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Using Walsh-m Composite Sequence and LDPC-QPSK Joint Iteration to Reduce ISI in Long-range Underwater Acoustic Systems

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Journal of Harbin Institute of Technology(New Series) 2013年第1期20卷 87-92页

作者： Fang Fu dan-feng Zhao College of Information and Communication Engineering Harbin Engineering University

To reduce inter-symbol-interference (ISI) in underwater acoustic (UWA) communication systems, a method based on LDPC-QPSK joint iteration and Walsh-m composite sequence is proposed in this paper. The method is intended for use in long-range and low signal-to-noise ratio (SNR) UWA communications. At the transmitter, Walsh-m composite sequence is introduced to resist multipath effect. At the receiver, a soft-input soft-output (SISO) module is implemented in a joint iterative process between QPSK demodulator and LDPC decoder. This method is demonstrated in three types of UWA channel models: positive, negative and invariable sound velocity gradients channels. It is shown that through contrastive simulation experiments, this method is more efficient than conventional methods based on independent decoding and demodulation. After two rounds of joint iteration, the proposed method can obtain 2.5 dB over conventional method at BER of 10-5. Numerical results verify that the proposed method is a good candidate for long-range underwater acoustic communication systems.

关键词： underwater acoustic communication joint iterative LDPC decoding QPSK demodulation Walsh-m composite sequence

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Beyond mirroring:multi-version disk array with improved performance and energy efficiency

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第9期12卷 721-729页

作者： Bo MAO Su-zhen WU dan feng Department of Computer Science and Engineering University of Nebraska-Lincoln Lincoln 68588 USA Computer Science Department Xiamen University Xiamen 361005 China College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

Performance and power consumption are two important design objectives for data centers consisting of thousands or tens of thousands of disks （or disk arrays）. To leverage the two objectives, in this study we propose a multi-version disk array （MDA）. The main idea of MDA is to exploit the I/O workload characteristics to guide the replication strategy by replicating multiple versions of the popular data blocks and simply offioading the write data to the free space of the reserved version region, thus achieving high performance in the burst period and low power consumption in the idle period. Our prototype implementation of MDA and the performance evaluations show that the performance of MDA outperforms that of traditional RAID10 by up to 34.4% and 42.3% in terms of the average response time for the online transaction processing （OLTP） application I/O and search engine I/O, respectively. Moreover, the energy efficiency of MDA outperforms that of RAID10 by up to 48.7% and 36.4%, respective to the aforementioned measures.

关键词： Storage systems Disk arrays Power consumption Performance evaluation

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Extending attributes page:a scheme for enhancing the reliability of storage system metadata

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第8期10卷 1106-1113页

作者： Juan WANG dan feng Fang WANG Cheng-tao LU MOE Key Lab of Data Storage System Huazhong University of Science and Technology Wuhan 430074 China

In an object-based storage system,a novel scheme named EAP(extending attributes page) is presented to enhance the metadata reliability of the system by adding the user object file information attributes page for each user object and storing the file-related attributes of each user object in object-based storage *** EAP scheme requires no additional hardware equipments compared to a general method which uses backup metadata servers to improve the metadata *** a Markov chain,this paper compares the metadata reliability of the system using the EAP scheme with that using only metadata servers to offer the file metadata *** results demonstrate that the EAP scheme can dramatically enhance the reliability of storage system metadata.

关键词： Metadata server Metadata reliability Markov model Extending attributes page (EAP)

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Algebraic-Based Nonbinary LDPC Codes with Flexible Field Orders and Code Rates

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China Communications 2017年第4期14卷 111-119页

作者： Hengzhou Xu dan feng Cheng Sun Baoming Bai State Key Laboratory of Integrated Service Networks Xidian University Xi'an 710071 China Science and Technology on Communication Networks Laboratory Shijiazhuang 050081 China

In this paper, we study the rank of matrices over GF(2~p),and propose two construction methods for algebraic-based nonbinary LDPC codes from an existing LDPC code, referred to as the original code. By multiplying all elements of each column of the binary parity-check matrix H corresponding to the original code with the same nonzero element of any field, the first class of nonbinary LDPC codes with flexible field order is proposed. The second method is to replace the nonzero elements of some columns in H with different nonzero field elements in a given field, and then another class of nonbinary LDPC codes with various rates is obtained. Simulation results show that the proposed nonbinary LDPC codes perform well over the AWGN channel with the iterative decoding algorithms.

关键词： nonbinary LDPC codes algebraic-based LDPC codes rank iterative algorithms

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Exploiting flash memory characteristics to improve performance of RAIS storage systems

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Frontiers of Computer Science 2019年第5期13卷 913-928页

作者： Linjun MEI dan feng Lingfang ZENG Jianxi CHEN Jingning LIU Wuhan National Laboratory for Optoelectronics School of Computer Huazhong University of Science and Technology Wuhan 430074 China

Redundant array of independent SSDs (RAIS) is generally based on the traditional RAID design and implementation. The random small write problem is a serious challenge of RAIS. Random small writes in parity-based RAIS systems generate significantly more pre-reads and writes which can degrade RAIS performance and shorten SSD lifetime. In order to overcome the well-known write-penalty problem in the parity-based RAID5 storage systems, several logging techniques such as Parity Logging and Data Logging have been put forward. However, these techniques are originally based on mechanical characteristics of the HDDs, which ignore the properties of the flash memory. In this article, we firstly propose RAISL, a flash-aware logging method that improves the small write performance of RAIS storage systems. RAISL writes new data instead of new data and pre-read data to the log SSD by making full use of the invalid pages on the SSD of RAIS. RAISL does not need to perform the pre-read operations so that the original characteristics of workloads are kept. Secondly, we propose AGCRL on the basis of RAISL to further boost performance. AGCRL combines RAISL with access characteristic to guide read and write cost regulation to improve the performance of RAIS storage systems. Our experiments demonstrate that the RAISL significantly improves write performance and AGCRL improves both of write performance and read performance. AGCRL on average outperforms RAIS5 and RAISL by 39.15% and 16.59% respectively.

关键词： solid state drives RAIS properties performance

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