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Toxicokinetics and the related metabolites in rainbow trout(Oncorhynchus mykiss) after exposure to decabromodiphenyl ether

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Science China chemistry 2010年第11期53卷 2379-2386页

作者： feng chenglian,xu yiping,zha jinmiao,luo qian,shan xiaoquan & wang zijian state key laboratory of environmental aquatic chemistry Research Center for Eco-environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China state key laboratory of environmental aquatic chemistry Research Center for Eco-environmental Sciences Chinese Academy of Sciences Beijing China

Decabromodiphenyl ether(BDE209) is poorly absorbed by mammals,and little information is available on the toxicokinetics of BDE209 and its metabolites in *** the present study,rainbow trout(Oncorhynchus mykiss) were administered to 100 ng/g and 500 ng/g body wet weight of BDE209 via a single intraperitoneal injection and parent BDE209 and its metabolites were sequentially monitored for 28 *** results showed that toxicokinetic profiles of BDE209 could be described by the one-compartment *** the higher dose group(500 ng/g wet weight),the calculated half-life(t1/2) and elimination rate(ke) were 17.7 d and 0.039/d in the liver,and 100.3 d and 0.007/d in the muscle,*** major methoxylated brominated diphenyl ethers(MeO-BDEs) were detected with 2,2',4,4'-tetrabromo-5-methoxydiphenyl ether(5-MeO-BDE47) being detected in all tissue *** was no significant temporal change of 5-MeO-BDE47 concentration in the muscle,whereas an exponential increase was observed in the ***,the metabolism rate of BDE209 depended on the administered ***209 was hardly accumulated in the muscle of rainbow trout,while the liver was a primary metabolic ***-BDEs were formed via metabolism of BDE209,which probably played a significant role in fish toxicology as a potential indicator.

关键词： decabromodiphenyl ether(BDE209) polybrominated diphenyl ethers(PBDEs) methoxylated brominated diphenyl ethers(MeO-BDEs) toxicokinetics rainbow trout

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Debrominated and methoxylated polybrominated diphenyl ether metabolites in rainbow trout(Oncorhynchus mykiss) after exposure to decabromodiphenyl ether

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Journal of environmental Sciences 2010年第9期22卷 1425-1434页

作者： chenglian feng,yiping xu,Yue He,qian luo,jinmiao zha,zijian wang state key laboratory of environmental aquatic chemistry,Research Center for Eco-environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China. state key laboratory of environmental aquatic chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Decabromodiphenyl ether （BDE209） is the primary component in a commonly used flame retardant. Previous studies had proved that BDE209 itself was not toxic, while its metabolites including debrominated diphenyl ethers （De-BDEs） and methoxylated brominated diphenyl ethers （MeO-BDEs） posed a potential threat to organisms. Many studies had indicated that BDE209 could metabolize quickly in mammals, but lacking in the basic data about the metabolism of BDE209 in fish. In the present study, two replicate treatment groups of rainbow trout （Oncorhynchus rnykiss） were exposed to BDE209 via a single intraperitoneal injection approximately 100 and 500 ng/g, respectively. Muscle, liver and blood samples were collected to analyze the specific metabolites on day 1 and day 28 post injection. The highest concentration of BDE209 was detected in muscle tissues, from 796.1 ng/g wet weight （day 1） to 687.1 ng/g wet weight （day 28） in high dose group, suggesting that BDE209 could accumulate slightly in muscle tissues. However, BDE209 was not detected in the blood for all treatments. Most congeners of De-BDEs were found in muscle and liver tissues, with the highest concentration in the liver. The main De-BDEs were nona-, octa-, hepta- and penta-De-BDEs. A total of seven MeO-BDE metabolites were observed among different fish tissues. Blood had the highest contribution of the MeO-BDE metabolites. Each MeO-BDE congener increased over the 28 days. These results in contrast to other studies suggested possible species-specific differences in metabolic abilities.

关键词： decabromodiphenyl ether (BDE209) methoxylated brominated diphenyl ethers (MeO-BDEs) debrominated diphenyl ethers (De-BDEs) rainbow trout

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