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Science China Materials 2024年第10期67卷 3272-3281页

作者： Xin feng Xuefeng Liang Xinxia Li Zhou Fang Weiqiang Wei Lisheng Zhang yan he Huifang Li College of Electromechanical Engineering Shandong Engineering Laboratory for Preparation and Application of High-Performance Carbon-MaterialsQingdao University of Science&TechnologyQingdao 266061China

The chemical structure of covalent organic frameworks(COFs)plays a key role in their response to the surface doping strategy used for tuning their electronic character,but it is still not fully *** explore a rational design proposal for their chemical structure,the electronic properties of three n-doped typical COFs,including boroncontaining(COF-1),triazine-based(CTF),and C–C bondlinked(GCOF)COFs,were investigated theoretically in this *** expected,the chemical doping effects are different for these *** dispersion of the frontier bands,the nuclear-independent chemical shift(NICS)aromaticity index results,distribution of the electron localization function(ELF),and Hirshfeld charge population plots show that part of the transferred electron from dopants will be offset by the intralayer charge transfer of ***,chemical doping effects are more significant if the electron distribution in the COFs is more *** means the response of COFs to the surface doping strategy should be dominated by the conjugation degree of their chemical *** results prove that the intrinsic conjugation degree of COFs plays a key role in such doping functionalization strategies,which are expected to provide more useful information for the initial structure design of COF materials and facilitate their practical applications as active electronic transport materials in nanoscale devices.

关键词： COF monolayers adsorption doping strategy energy level alignment conjugation degree density functional theory

少精弱精方联合枸橼酸氯米芬和维生素E对少精弱精症患者的临床疗效

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中成药 2024年第2期46卷 474-477页

作者：赫艳梅何旭锋嘉兴市中医医院浙江嘉兴314000

目的考察少精弱精方联合枸橼酸氯米芬和维生素E对少精弱精症患者的临床疗效。方法 102例患者随机分为对照组和观察组,每组51例,对照组给予枸橼酸氯米芬和维生素E,观察组在对照组基础上加用少精弱精方,疗程3个月。检测临床疗效、精液参... 详细信息

目的考察少精弱精方联合枸橼酸氯米芬和维生素E对少精弱精症患者的临床疗效。方法 102例患者随机分为对照组和观察组,每组51例,对照组给予枸橼酸氯米芬和维生素E,观察组在对照组基础上加用少精弱精方,疗程3个月。检测临床疗效、精液参数(精子存活率、精液量、精子密度、精子向前活动率、a级精子、a+b级精子)、血清性激素(睾酮、黄体生成素、促卵泡生成素)、精液凋亡因子(Caspase-3、Caspase-8)、不良反应发生率变化。结果观察组总有效率高于对照组(P0.05)。结论少精弱精方联合枸橼酸氯米芬和维生素E可安全有效地改善少精弱精症患者血清性激素水平,降低精液凋亡因子水平,提高临床疗效、精子质量和活力。

关键词：少精弱精方枸橼酸氯米芬维生素E 少精弱精症

A comparative study of acupuncture combined with rehabilitation gymnastics on postoperative anal function of lower rectal cancer

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World Journal of Clinical Cases 2024年第18期12卷 3491-3496页

作者： Zhan-Lun Liu Yi-Wei he yan-feng Liu Ni Wang Wei Li Li-Zhong Shen Department of Digestive Surgery Hebei Provincial Hospital of Traditional Chinese MedicineShijiazhuang 050000Hebei ProvinceChina

BACKGROUND From the anal function,inflammatory response and other indicators,acupuncture combined with rehabilitation gymnastics was applied to patients with cancer undergoing low resection,aiming to improve the prognosis of *** To explore the effects of acupuncture combined with rehabilitation gymnastics on anal function after lower rectal cancer *** From January 2020 to December 2022,128 patients who underwent rectal cancer surgery in the Department of Oncology of hebei Provincial Hospital of Traditional Chinese Medicine Hospital were selected and divided into two groups using the random number table method,with 64 patients in each *** in the control group were not treated with acupuncture or rehabilitation gymnastics and served as blank *** in the study group were treated with acupuncture and rehabilitation gymnastics from the 7th postoperative *** anal incontinence scores,changes in serum interleukin-4,interleukin-6,and interleukin-10 Levels,and serum motilin,5-hydroxytryptamine,and vasoactive intestinal peptide levels were *** There were no significant differences in serum interleukin-4,interleukin-6,and interleukin-10 Levels between the groups before treatment(P>0.05).After treatment,these levels were better than those of the control group(Phere was no significant difference in the anal incontinence scores between the groups before and 7 d after surgery(P>0.05).Anal incontinence scores in the study group were lower than those in the control group at 14 d,21 d,and 28 d postoperatively(Phere were no significant differences in serum motilin,5-hydroxytryptamine,or vasoactive intestinal peptide levels between the groups before treatment(P>0.05).After treatment,these levels were higher in the study group than in the control group,and vasoactive intestinal peptide level was lower in the study group than in the control group(P<0.05).CONCLUSION Acupuncture combined with rehabilitation gymnas

关键词： Low rectal cancer Anal function Acupuncture Rehabilitation gymnastics

财政“省直管县”改革对“经济-粮食”空间偏差的影响

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当代财经 2024年第4期 44-57页

作者：何强韦锋漆雁斌四川农业大学经济学院四川成都611130

粮食安全和经济发展是国家安全的重要基础和保障,但“经济-粮食”空间偏差(即关系不协调)不仅会延缓我国建设农业强国的战略步伐,而且会阻碍我国经济高质量发展。为此,利用2000—2020年我国1864个县级面板数据,研究了财政“省直管县”... 详细信息

粮食安全和经济发展是国家安全的重要基础和保障,但“经济-粮食”空间偏差(即关系不协调)不仅会延缓我国建设农业强国的战略步伐,而且会阻碍我国经济高质量发展。为此,利用2000—2020年我国1864个县级面板数据,研究了财政“省直管县”改革对县域“经济-粮食”空间偏差的影响以及内在机制。结果表明:财政“省直管县”改革在一定程度上会加大“经济-粮食”空间偏差,即财政“省直管县”改革会加大粮食生产与经济发展的不协调程度。机制分析发现,“经济-粮食”空间偏差的加大是因为财政分权程度和非农经济发展水平的提高,以及农业市场活力的下降。异质性分析发现,相较于其他地区,财政“省直管县”改革对中西部地区和集中连片特困地区“经济-粮食”空间偏差的影响最大;在不受粮食生产责任政策的约束下,财政“省直管县”改革的政策效应以经济增长为主。因此,需要优化财政“省直管县”改革实施模式,扭转县级政府“离粮”发展倾向;建立粮食安全与晋升激励的衔接机制,修正县级政府“趋经济、离粮食”的导向;完善利益补偿机制,纾解产粮大县财政压力;构建改革县的财权监督机制,严控财政资源支出方向。

关键词：财政分权财政“省直管县”改革 “经济-粮食”空间偏差粮食安全

Biosynthetic pathway of prescription cucurbitacin IIa and high-level production of key triterpenoid intermediates in engineered yeast and tobacco

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Plant Communications 2024年第6期5卷 154-172页

作者： Geng Chen Zhaokuan Guo yanyu Shu yan Zhao Lei Qiu Shaofeng Duan Yuan Lin Simei he Xiaobo Li Xiaolin feng Guisheng Xiang Bo Nian Yina Wang Zhiyuan Li Chongkang yang yang Shi Yingchun Lu Guanze Liu Shengchao yang Guanghui Zhang Bing Hao State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan The Key Laboratory of Medicinal Plant Biology of Yunnan ProvinceNational&Local Joint Engineering Research Center on Germplasms Innovation&Utilization of Chinese Medicinal Materials in Southwest ChinaYunnan Agricultural UniversityKunming 650201China Yunnan Characteristic Plant Extraction Laboratory KunmingYunnan 650106China

Cucurbitacin IIa is a triterpenoid isolated exclusively from hemsleya plants and a non-steroidal anti-inflammatory drug that functions as the main ingredient of prescription hemslecin capsules and tablets in *** biology provides new strategies for production of such valuable cucurbitacins at a large scale;however,the biosynthetic pathway of cucurbitacin IIa has been unknown,and the heterologous production of cucurbitacins in galactose medium has been expensive and low *** this study,we characterized the functions of genes encoding two squalene epoxidases(HcSE1-2),six oxidosqualene cyclases(HcOSC1-6),two CYP450s(HcCYP87D20 and HcCYP81Q59),and an acyltransferase(HcAT1)in cucurbitacin IIa biosynthesis by heterologous expression in Saccharomyces cerevisiae and Nicotiana *** achieved high-level production of the key cucurbitacin precursor 11-carbonyl-20b-hydroxy-Cuol from glucose in yeast via modular engineering of the mevalonate pathway and optimization of P450 expression *** resulting yields of 46.41 mg/l 11-carbonyl-20b-hydroxy-Cuol and 126.47 mg/l total cucurbitacin triterpenoids in shake flasks are the highest yields yet reported from engineered ***,production of 11-carbonyl-20b-hydroxy-Cuol by transient gene expression in tobacco resulted in yields of 1.28 mg/g dry weight in *** work reveals the key genes involved in biosynthesis of prescription cucurbitacin IIa and demonstrates that engineered yeast cultivated with glucose can produce high yields of key triterpenoid *** describe a low-cost and highly efficient platform for rapid screening of candidate genes and high-yield production of pharmacological triterpenoids.

关键词： cucurbitacin IIa oxidosqualene cyclase OSC 11-carbonyl-20b-hydroxy-Cuol Saccharomyces cerevisiae Nicotiana benthamiana hemsleya chinensis

Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric Cardiology 2024年第5期21卷 506-522页

作者： Yi XU Tian XU Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei WANG Wei YOU Pei-Na MENG Yu-he ZHOU Xiang-Qi WU Zhi-Ming WU Mei-En ZHAN yan-Qing WANG De-feng PAN Fei YE Department of Cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina Department of Cardiology Clinical Medicine School of Nanjing UniversityNanjingChina Department of Cardiology Tianchang People’s HospitalTianchangChina Department of Cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P her in the several NR(s NR, defined as RI ≤ 0.85) group than in the non-s NR *** The NR of LCx O is associated with more in-stent NIH post-PCI for distal LMb lesions with a 2-stent strategy,and NR with RI ≤ 0.85 is linked to percent NIH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

Aptamer-Based Cell-Surface Profiling with Single-Cell Resolution Enables Precise Cancer Characterization

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CCS Chemistry 2024年第1期6卷 196-207页

作者： Liujun Xu Yawei feng Tong Wang Shenhuan Li Kangli Xu Yue Sun Yi Luo Yishan Ye yan Miao Yun Dong Zhenzhen Guo Qing Zhang Benshang Li he Huang Xue-Qiang Wang Liping Qiu Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan 410082 The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of MedicineChinese Academy of SciencesHangzhouZhejiang 310022 Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240 Bone Marrow Transplantation Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 Institute of hematology Zhejiang UniversityHangzhou 310003 Department of hematology and Oncology Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200127

Molecular profiling of cell-surface proteins is a powerful strategy for precise cancer *** mass cytometry(MC)enables synchronous detection of over 40 cellular parameters,its full potential in disease classification is challenged by the limited types of recognition probes currently *** this work,we synthesize a panel of heavy isotopeconjugated aptamers to profile cancer-associated signatures on the surface of hematological malignancy(HM)*** on 15 molecular signatures,we performed cell-surface profiling that allowed the precise classification of 8 HM cell *** with machine-learning technology,this aptamer-based MC platform also achieved multiclass identification of HM subtypes in clinical sampleswith 100%accuracy in the training cohort and 80%accuracy in the test ***,we report an effective and practical strategy for precise cancer classification at the singlecell level,paving the way for its clinical use in the near future.

关键词： molecular profiling cancer diagnosis mass cytometry aptamers machine learning

Molecular dynamics study of primary radiation damage in TiVTa concentrated solid-solution alloy

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Chinese Physics B 2024年第3期33卷 530-535页

作者：赵永鹏豆艳坤贺新福曹晗王林枫邓辉球杨文 Reactor Engineering Technology Research Division China Institute of Atomic EnergyBeijing 102413China School of Physics and Electronics Hunan UniversityChangsha 410082China

The primary radiation damage in pure V and TiVTa concentrated solid-solution alloy(CSA)was studied using a molecular dynamics *** have performed displacement cascade simulations to explore the generation and evolution behavior of irradiation *** results demonstrate that the defect accumulation and agglomeration in TiVTa CSA are significantly suppressed compared to pure *** peak value of Frenkel pairs during cascade collisions in TiVTa CSA is much higher than that in pure V due to the lower formation energy of point ***,the longer lifetime of the thermal spike relaxation and slow energy dissipation capability of TiVTa CSA can facilitate the recombination of point *** defect agglomeration rate in TiVTa CSA is much lower due to the lower binding energy of interstitial clusters and reduced interstitial ***,the occurrence probability of dislocation loops in TiVTa CSA is lower than that in pure *** reduction in primary radiation damage may enhance the radiation resistance of TiVTa CSA,and the improved radiation tolerance is primarily attributed to the relaxation stage and long-term defect evolution rather than the ballistic *** results can provide fundamental insights into irradiation-induced defects evolution in refractory CSAs.

关键词： concentrated solid-solution alloy primary radiation damage molecular dynamics simulation

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两类数论函数的β次混合均值

数学的实践与认识 2024年第3期54卷 203-212页

作者：李勰贺艳峰延安大学数学与计算机科学学院陕西延安716000

运用初等与解析的方法,结合素数分布的性质,研究了函数[SL(n)-SM(n)]^(β)和[F(n)-p(n)]^(β)的混合均值,并给出了两个渐进公式.

关键词： Smarandache LCM函数 Smarandache可乘函数可加函数

整合素α6靶向自组装促凋亡纳米多肽对中枢神经系统急性淋巴细胞白血病的靶向治疗

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Engineering 2024年第4期35卷 226-240页

作者： Jia-Cong Ye Wan-Qiong Li Mei-Ling Chen Qian-Kun Shi Hua Wang Xin-Ling Li Ying-he Li Jie yang Qiao-Li Wang Fang Hu yan-feng Gao Shu-Wen Liu Mu-Sheng Zeng Guo-Kai feng Guangdong Provincial Key Laboratory of New Drug Screening&NMPA Key Laboratory of Drug Metabolism Research and Evaluation School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Oncology in South China&Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Biomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of NephrologySouthern Medical UniversityGuangzhou 510515China

There is currently no effective targeted therapeutic strategy for the treatment of central nervous system acute lymphoblastic leukemia(CNS-ALL).Integrinα6 is considered a potential target for CNS-ALL diagnosis and therapy because of its role in promoting CNS-ALL disease *** targeted peptide D(RWYD)(abbreviated RD),with nanomolar affinity to integrinα6 was identified by peptide scanning techniques such as alanine scanning,truncation,and ***,we developed a therapeutic nanoparticle based on the integrinα6-targeted peptide for treating *** self-assembled proapoptotic nanopeptide_(D)(RWYD)-_(D)(KLAKLAK)_(2)-G_(D)(FFY)(abbreviated RD-KLA-Gffy)contains the integrinα6-targeted peptide RD,the well-known proapoptotic peptide_(D)(KLAKLAK)_(2)(abbreviated KLA),and the self-assembling tetrapeptide GD(FFY)(abbreviated Gffy).The functional mechanism of RD-KLA-Gffy is clarified using different *** results demonstrate that RD-KLA-Gffy is highly enriched in CNS-ALL lesions and induces tumor cell apoptosis,thus reducing CNS-ALL disease burden and prolonging the survival of CNS-ALL mice without obvious ***,the combined use of RD-KLA-Gffy and methotrexate(MTX)shows a potent antitumor effect in treating CNS-ALL,indicating that RD-KLA-Gffy plays an important role in suppressing CNS-ALL progression either as a single agent or in combination with MTX,which shows promise for application in CNS-ALL therapy.

关键词： Central nervous system acute lymphoblastic leukemia Integrinα6 Targeted peptide Proapoptotic Nanopeptide