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Deep optics preconditioner for modulation-free pyramid wavefront sensing

Photonics Research 2024年第2期12卷 301-312页

作者： felipe guzmán JORGE TAPIA CAMILO WEInBERGER nICOLÁS HERnÁnDEZ JORGE BACCA BEnOIT nEICHEL ESTEBAn VERA School of Electrical Engineering Pontificia Universidad Católica de Valparaı´soValparaı´soChile Department of Systems Engineering Universidad Industrial de SantanderBucaramangaColombia Laboratoire d’Astrophysique de Marseille MarseilleFrance

The pyramid wavefront sensor(PWFS)can provide the sensitivity needed for demanding adaptive optics applications,such as imaging exoplanets using the future extremely large telescopes of over 30 m of diameter(D).However,its exquisite sensitivity has a limited linear range of operation,or dynamic range,although it can be extended through the use of beam modulation—despite sacrificing sensitivity and requiring additional optical *** by artificial intelligence techniques,this work proposes to train an optical layer—comprising a passive diffractive element placed at a conjugated Fourier plane of the pyramid prism—to boost the linear response of the pyramid sensor without the need for cumbersome *** develop an end-2-end simulation to train the diffractive element,which acts as an optical preconditioner to the traditional least-square modal phase estimation *** results with a large range of turbulence conditions show a noticeable improvement in the aberration estimation performance equivalent to over 3λ∕D of modulation when using the optically preconditioned deep PWFS(DPWFS).Experimental results validate the advantages of using the designed optical layer,where the DPWFS can pair the performance of a traditional PWFS with 2λ∕D of *** and adding an optical preconditioner to the PWFS is just the tip of the iceberg,since the proposed deep optics methodology can be used for the design of a completely new generation of wavefront sensors that can better fit the demands of sophisticated adaptive optics applications such as ground-to-space and underwater optical communications and imaging through scattering media.

关键词： process optics pyramid

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Quantification of corneal neovascularization after ex vivo limbal epithelial stem cell therapy

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 988-995页

作者： Adriano Guarnieri Javier Moreno-Monta?és Belén Alfonso-Bartolozzi Alfonso L.Sabater María García-guzmán Enrique J.Andreu felipe Prosper Department of Ophthalmology Clínica Universidad de Navarra Department of Cell Therapy Clínica Universidad de Navarra

AIM: To assess cultured limbal epithelial stem cell transplantation in patients with limbal stem cell deficiency by analyzing and quantifying corneal ***: This retrospective, interventional case series included eight eyes with total limbal stem cell deficiency. Ex vivo limbal epithelial stem cells were cultured on human amniotic membrane using an animalfree culture method. The clinical parameters of limbal stem cell deficiency, impression cytology, and quantification of corneal neovascularization were evaluated before and after cultured limbal stem cell transplantation. The area of corneal neovascularization,vessel caliber(VC), and invasive area(IA) were analyzed before and after stem cell transplantation by image analysis software. Best-corrected visual acuity(BCVA),epithelial transparency, and impression cytology were also ***: One year after surgery, successful cases showed a reduction(improvement) of all three parameters of corneal neovascularization [neovascular area(nA), VC, IA], while failed cases did not. nA decreased a mean of 32.31%(P =0.035), invasion area29.37%(P =0.018) and VC 14.29%(P =0.072). BCVA improved in all eyes(mean follow-up, 76 ±21mo).Epithelial transparency improved significantly from 2.00 ±0.93 to 0.88±1.25(P =0.014). Impression cytology showed that three cases failed after limbal epithelial stem cell therapy before 1y of ***: This method of analyzing andmonitoring surface vessels is useful for evaluating the epithelial status during follow-up, as successful cases showed a bigger reduction in corneal neovascularization parameters than failed cases. Using this method,successful cases could be differentiated from failed cases.

关键词： limbal stem cell corneal neovascularization stem cell therapy impression cytology limbal stem cell deficiency

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Indigestible fraction of guava fruit:Phenolic profile,colonic fermentation and effect on HT-29 cells

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Food Bioscience 2022年第2期46卷 563-571页

作者： Francisco J.Blancas-Benitez Jara P´erez-Jim´enez JAdriana Sa˜nudo-Barajas nuria E.Rocha-guzm´an Gustavo A.Gonz´alez-Aguilar Juscelino Tovar Sonia G.S´ayago-Ayerdi Tecnol´ogico nacional de M´exico/Instituto Tecnol´ogico de Tepic Laboratorio Integral de Investigaci´on en AlimentosAv.Tecnol´ogico 2595CP 63175TepicNayaritMexico Institute of Food Science Technology and Nutrition(ICTAN-CSIC)Jos´e Antonio Novais 1028040MadridSpain Centro de Investigaci´on en Alimentaci´on y Desarrollo A.C.Unidad Culiac´an.ApdoPostal 32-A.80129Culiac´anSinaloaMexico Tecnol´ogico nacional de M´exico/Instituto Tecnol´ogico de Durango Departamento de Ingenierías Química y Bioquímica BlvdFelipe Pescador 1830Ote.Col.Nueva VizcayaCP 3408078000DurangoDgo.Mexico Coordinaci´on de Tecnología de Alimentos de Origen Vegetal Lab.de Antioxidantes y Alimentos FuncionalesCentro de Investigaci´on en Alimentaci´on y DesarrolloA.C.Carretera a la Victoria Km 0.6Col.La VictoriaHermosillo Sonora83000Mexico Department of Food Technology Engineering and NutritionLund UniversityP.O.Box 124SE-22100LundSweden

Guava fruit is rich in phenolic compounds(PCs),whose metabolic fate has not been ***-digestible carbohydrates and PCs in whole guava(WG)and seedless guava(SG)were submitted to an in vitro colonic fermentation,followed by evaluation of the anti-proliferative activity of the fermentation extracts in HT-29 cancer cell *** main PCs in both samples were(+)-gallocatechin and gallic acid,while procyanidin B was the most abundant one associated with soluble indigestible fraction and quercetin predominated in the insoluble indigestible *** fermentability index at 24 h was 78.84%in WG and 84.74%for SG,near to the value for raffinose used as reference,with butyric acid as the main short chain fatty acids(SCFA)*** greatest antiproliferative effects were observed in the SG at 12 h of fermentation and WG at 24 h of *** results allow to suggest consumption of guava fruit,either with or without seeds,as a feasible way to maintain colonic health.

关键词： Short chain fatty acids(SCFA) Phenolic compounds Indigestible fraction In vitro colonic fermentation Antiproliferative Psidium guajava L

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