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Hierarchically Structured Nb_(2)O_5 Microflowers with Enhanced Capacity and Fast-Charging Capability for Flexible Planar Sodium Ion Micro-Supercapacitors

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Nano-Micro Letters 2024年第4期16卷 97-109页

作者： Jiaxin Ma Jieqiong qin Shuanghao Zheng Yinghua Fu Liping Chi Yaguang Li Cong Dong Bin Li feifei Xing Haodong Shi Zhong‑Shuai Wu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023People’s Republic of China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001People’s Republic of China College of Science Henan Agricultural UniversityNo.63 Agricultural RoadZhengzhou 450002People’s Republic of China Dalian National Laboratory for Clean Energy Chinese Academy of Sciences457 Zhongshan RoadDalian 116023People’s Republic of China University of Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049People’s Republic of China Hebei Key Lab of Optic‑Electronic Information and Materials The College of Physics Science and TechnologyInstitute of Life Science and Green DevelopmentHebei UniversityBaoding 071002People’s Republic of China

Planar Na ion micro-supercapacitors(NIMSCs) that offer both high energy density and power density are deemed to a promising class of miniaturized power sources for wearable and portable microelectron-ics. Nevertheless, the development of NIMSCs are hugely impeded by the low capacity and sluggish Na ion kinetics in the negative electrode.Herein, we demonstrate a novel carbon-coated Nb_(2)O_5 microflower with a hierarchical structure composed of vertically intercrossed and porous nanosheets, boosting Na ion storage performance. The unique structural merits, including uniform carbon coating, ultrathin nanosheets and abun-dant pores, endow the Nb_(2)O_5 microflower with highly reversible Na ion storage capacity of 245 mAh g^(-1) at 0.25 C and excellent rate capability.Benefiting from high capacity and fast charging of Nb_(2)O_5 microflower, the planar NIMSCs consisted of Nb_(2)O_5 negative electrode and activated car-bon positive electrode deliver high areal energy density of 60.7 μWh cm^(-2),considerable voltage window of 3.5 V and extraordinary cyclability. Therefore, this work exploits a structural design strategy towards electrode materials for application in NIMSCs, holding great promise for flexible microelectronics.

关键词： Nb_(2)O_5 nanosheets Microflowers Sodium ion micro-supercapacitors Flexibility Energy storage

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Enhancing m6A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期 1749-1763页

作者： Tian qin Yuxin Jin Yiming qin feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya Hospital Central South University Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Department of Sports Medicine Xiangya Hospital Central South University

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine（m6A） modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m6A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein（METTL14） in the locomotor cortex was high after spinal cord injury and accompanied by elevated m6A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m6A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m6A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

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Temporal-spatial risk assessment of COVID-19 under the influence of urban spatial environmental parameters:The case of Shenyang city

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Building Simulation 2023年第5期16卷 683-699页

作者： Sui Li Zhe Li Yixin Dong Tiemao Shi Shiwen Zhou Yumeng Chen Xun Wang feifei qin School of Architecture and Planning Shenyang Jianzhu UniversityShenyangLiaoning 110168China Institute of Ecological Urban Planning and Green Building Shenyang Jianzhu UniversityShenyangLiaoning 110168China School of Architecture Tianjin UniversityTianjin 300072China Institute of Spatial Planning and Design Shenyang Jianzhu UniversityShenyangLiaoning 110168China School of Science Shenyang Jianzhu UniversityShenyangLiaoning 110168China

Respiratory infection is the main route for the transmission of coronavirus pneumonia,and the results have shown that the urban spatial environment significantly influences the risk of infection.Based on the Wells-Riley model of respiratory infection probability,the study determined the human respiratory-related parameters and the effective influence range;extracted urban morphological parameters,assessed the ventilation effects of different spatial environments,and,combined with population flow monitoring data,constructed a method for assessing the risk of Covid-19 respiratory infection in urban-scale grid cells.In the empirical study in Shenyang city,a severe cold region,urban morphological parameters,population size,background wind speed,and individual behavior patterns were used to calculate the distribution characteristics of temporal and spatial concomitant risks in urban areas grids under different scenarios.The results showed that the correlation between the risk of respiratory infection in urban public spaces and the above variables was significant.The exposure time had the greatest degree of influence on the probability of respiratory infection risk among the variables.At the same time,the change in human body spacing beyond 1 m had a minor influence on the risk of infection.Among the urban morphological parameters,building height had the highest correlation with the risk of infection,while building density had the lowest correlation.The actual point distribution of the epidemic in Shenyang from March to April 2022 was used to verify the evaluation results.The overlap rate between medium or higher risk areas and actual cases was 78.55%.The planning strategies for epidemic prevention and control were proposed for the spatial differentiation characteristics of different risk elements.The research results can accurately classify the risk level of urban space and provide a scientific basis for the planning response of epidemic prevention and control and the safety of public activities.

关键词： COVID-19 virus infection rate GIS data simulations urban morphological parameters analysis infection risk assessment epidemic containment planning

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A new control for the pneumatic muscle bionic legged robot based on neural network

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IET Cyber-Systems and Robotics 2022年第4期4卷 339-355页

作者： Chaoyue Xu feifei qin Kun Zhou Binrui Wang Yinglian Jin College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhouChina

The bionic joints composed of pneumatic muscles(PMs)can simulate the motion of biological joints.However,the PMs themselves have non-linear characteristics such as hysteresis and creep,which make it difficult to achieve high-precision trajectory tracking control of PM-driven robots.In order to effectively suppress the adverse effects of non-linearity on control performance and improve the dynamic performance of PM-driven legged robot,this study designs a double closed-loop control structure based on neural network.First,according to the motion model of the bionic joint,a mapping model between PM contraction force and joint torque is proposed.Second,a control strategy is designed for the inner loop of PM contraction force and the outer loop of bionic joint angle.In the inner control loop,a feedforward neuron Proportional-Integral-Derivative controller is designed based on the PM three-element model.In the control outer loop,a sliding mode robust controller with local model approximation is designed by using the radial basis function neural network approximation capability.Finally,it is verified by simulation and physical experiments that the designed control strategy is suitable for humanoid motion control of antagonistic PM joints,and it can satisfy the requirements of reliability,flexibility,and bionics during human–robot collaboration.

关键词： double closed-loop control legged robot neural network pneumatic muscle

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Investigating the Immunogenic Cell Death‑Dependent Subtypes and Prognostic Signature of Triple‑Negative Breast Cancer

Phenomics

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Phenomics 2024年第1期4卷 34-45页

作者： Youyang Shi Yuanyuan Wu feifei Li Kexin Jiang Xiaofang Fang Yu Wang Xiaoyun Song Rui Wang Lixin Chen Jinzhou Zheng Chunyu Wu Yuenong qin Xiaofei Liu Sheng Liu Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineWanping South Road725Shanghai 200033China First Clinical College Shandong University of Traditional Chinese MedicineNo.16369Jingshi RoadLixia DistrictJinan 250011ShandongChina

Recently,immunotherapy has emerged as a promising and efective method for treating triple-negative breast cancer(TNBC).However,challenges still persist.Immunogenic cell death(ICD)is considered a prospective treatment and potential combinational treatment strategy as it induces an anti-tumor immune response by presenting the antigenic epitopes of dead cells.Nevertheless,the ICD process in TNBC and its impact on disease progression and the response to immunotherapy are not well understood.In this study,we observed dysregulation of the ICD process and verifed the altered expression of prognostic ICD genes in TNBC through quantitative real-time polymerase chain reaction(qRT-PCR)analysis.To investigate the potential role of the ICD process in TNBC progression,we determined the ICD-dependent subtypes,and two were identifed.Analysis of their distinct tumor immune microenvironment(TIME)and cancer hallmark features revealed that Cluster 1 and 2 corresponded to the immune“cold”and“hot”phenotypes,respectively.In addition,we constructed the prognostic signature ICD score of TNBC patients and demonstrated its clinical independence and generalizability.The ICD score could also serve as a potential biomarker for immune checkpoint blockade and may aid in the identifcation of targeted efective agents for individualized clinical strategies.

关键词： Immunogenic cell death Triple-negative breast cancer Tumor immune microenvironment Prognostic signature

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Infection with SARS-CoV-2 can cause pancreatic impairment

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2143-2160页

作者： Wei Deng Linlin Bao Zhiqi Song Ling Zhang Pin Yu Yanfeng Xu Jue Wang Wenjie Zhao Xiuqin Zhang Yunlin Han Yanhong Li Jiangning Liu Qi Lv Xujian Liang Fengdi Li feifei Qi Ran Deng Siyuan Wang Yibai Xiong Ruiping Xiao Hongyang Wang Chuan qin NHC Key Laboratory of Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking UniversityBeijing 100871China State Key Laboratory of Biomembrane and Membrane Biotechnology Peking-Tsinghua Center for Life SciencesBeijing 100871China Chinese Academy of Engineering Eastern Hepatobiliary Surgery Hospital225 Changhai RoadYangpu DistrictShanghai 200438China International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438PR China National Laboratory for Oncogenes and Related Genes Cancer Institute of Shanghai Jiao Tong UniversityShanghai 200441PR China Changping National laboratory(CPNL) Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity National Health Commission of the People’s Republic of ChinaBeijingPR China

Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of diabetes.Herein,we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates(NHPs)models and 121 vaccinated and infected NHPs from 2020 to 2023 and COVID-19 patients.Multi-label immunofluorescence revealed direct infection of both exocrine and endocrine pancreatic cells by the virus in NHPs and humans.Minor and limited phenotypic and histopathological changes were observed in adult models.Systemic proteomics and metabolomics results indicated metabolic disorders,mainly enriched in insulin resistance pathways,in infected adult NHPs,along with elevated fasting C-peptide and C-peptide/glucose ratio levels.Furthermore,in elder COVID-19 NHPs,SARS-CoV-2 infection causes loss of beta(β)cells and lower expressed-insulin in situ characterized by islet amyloidosis and necrosis,activation ofα-SMA and aggravated fibrosis consisting of lower collagen in serum,an increase of pancreatic inflammation and stress markers,ICAM-1 and G3BP1,along with more severe glycometabolic dysfunction.In contrast,vaccination maintained glucose homeostasis by activating insulin receptorαand insulin receptorβ.Overall,the cumulative risk of diabetes post-COVID-19 is closely tied to age,suggesting more attention should be paid to blood sugar management in elderly COVID-19 patients.

关键词： infected elevated homeostasis

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One droplet reaction for synthesis of multi-sized nanoparticles

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Nano Research 2023年第4期16卷 5850-5856页

作者： Bingda Chen feifei qin Meng Su Daixi Xie Zeying Zhang Qi Pan Huadong Wang Xu Yang Sisi Chen Jingwei Huang Dominique Derome Jan Carmeliet Yanlin Song Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Chair of Building Physics Department of Mechanical and Process EngineeringETH Zürich(Swiss Federal Institute of Technology in Zürich)Zürich 8092Switzerland Department of Civil and Building Engineering Universitéde SherbrookeSherbrooke QC J1K 2R1Canada

Reaction kinetics of nanoparticles can be controlled by tuning the Peclet number(Pe)as it is an essential parameter in synthesis of multi-sized nanoparticles.Herein,we propose to implement a self-driven multi-dimension microchannels reactor(MMR)for the one droplet synthesis of multi-sized nanoparticles.By carefully controlling the Pe at the gas-liquid interface,the newly formed seed crystals selectively accumulate and grow to a specific size.By the combination of microchannels of different widths and lengths,one droplet reaction in the same apparatus achieves the synchronous synthesis of diverse nanoparticles.MMR enables precise control of nanoparticle diameter at 5 nm precision in the range of 10-110 nm.The use of MMR can be extended to the synthesis of uniform Ag,Au,Pt,and Pd nanoparticles,opening towards the production and engineering of nanostructured materials.This approach gives the chance to regulate the accumulation probability for precise synthesis of nanoparticles with different diameters.

关键词： gas-liquid interface accumulation effect one droplet reaction multi-sized nanoparticles

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基于改进量子粒子群优化算法的机器人逆运动学求解

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中国机械工程 2024年第2期35卷 293-304页

作者：陈卓凡周坤秦菲菲王斌锐中国计量大学机电工程学院杭州310018

针对工业机器人在逆运动学求解过程中存在的位姿奇异、解不唯一、求解精度低等问题,提出了一种改进量子粒子群算法。首先,利用D-H参数法建立机器人运动学模型,以机械臂末端最小位姿误差为主要优化目标,加入运动前后关节角变化最小、行... 详细信息

针对工业机器人在逆运动学求解过程中存在的位姿奇异、解不唯一、求解精度低等问题,提出了一种改进量子粒子群算法。首先,利用D-H参数法建立机器人运动学模型,以机械臂末端最小位姿误差为主要优化目标,加入运动前后关节角变化最小、行程平稳连续的约束条件,设计了目标函数;其次,通过采用Levy飞行策略改进粒子更新方式、非线性地动态调整收缩膨胀因子、采用变权重方法计算最优平均位置等方法设计了一种改进量子粒子群优化(IQPSO)算法;然后,模拟单点位姿和连续轨迹两种不同的求解情况进行三种算法(IQPSO、APSO、QPSO)的仿真对比实验,结果表明IQPSO算法具有收敛速度快、求解精度高等优点;最后,将IQPSO算法用于机械臂本体进行实物验证,实验结果表明IQPSO算法求解出的插值点所组成的轨迹连续且平滑,进一步证明了该算法应用于实际运动控制中的稳定性和可行性。

关键词：工业机器人逆运动学求解目标函数改进量子粒子群优化算法

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Transition prediction and sensitivity analysis for a natural laminar flow wing glove flight experiment

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Chinese Journal of Aeronautics 2021年第8期34卷 34-47页

作者： Tihao YANG Hai ZHONG Yifu CHEN Yayun SHI Junqiang BAI feifei qin Northwestern Polytechnical University Xi'an 710072China Chinese Flight Test Establishment Xi'an 710089China Xi’an Jiaotong University Xi'an 710049China ETH Zürich(Swiss Federal Institute of Technology in Zurich) Zurich 8093Switzerland

Natural laminar flow technology can significantly reduce aircraft aerodynamic drag and has excellent technical appeal for transport aircraft development with high aerodynamic efficiency.Accurately and efficiently predicting the laminar-to-turbulent transition and revealing the maintenance mechanism of laminar flow in a transport aircraft’s flight environment are significant for developing natural laminar flow wings.In this research,we carry out natural laminar flow flight experiments with different Reynolds numbers and angles of attack.The critical N-factor is calibrated as 9.0 using flight experimental data and linear stability theory from a statistical perspective,which makes sure that the relative error of transition location is within 5%.We then implement a simplified e^(N) transition prediction method with a similar accuracy compared with linear stability theory.We compute the sensitivity information for the simplified eN method with an adjointbased method,using the automatic differentiation technique(ADjoint).The impact of Reynolds numbers and pressure distributions on TS waves is analyzed using the sensitivity information.Through the sensitivity analysis,we find that:favorable pressure gradients not only suppress the development of TS waves but also decrease their sensitivity to Reynolds numbers;there exist three special regions which are very sensitive to the pressure distribution,and the sensitivity decreases as the local favorable pressure gradient increases.The proposed sensitivity analysis method enables robust natural laminar flow wings design.

关键词： e^(N)method Flight experiment Natural laminar flow Sensitivity analysis Transition prediction

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Cochlear implantation outcomes in children with common cavity deformity;a retrospective study

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Journal of Otology 2017年第3期12卷 138-142页

作者： Li Zhang Jianxin Qiu feifei qin Mei Zhong Gyanendra Shah Department of Otorhinolaryngology First Affiliated Hospital of Anhui Medical UniversityChina

Objective: A common cavity deformity(CCD) is a deformed inner ear in which the cochlea and vestibule are confluent forming a common rudimentary cystic cavity that results in profound hearing loss. There are few studies paying attention to common cavity. Our group is engrossed in observing the improvement of auditory and verbal abilities in children who have received cochlear implantation(CI), and comparing these targets between children with common cavity and normal inner ear structure.Material and methods: A retrospective study was conducted in 12 patients with profound hearing loss that were divided into a common cavity group and a control group, six in each group matched in sex, age and time of implantation, based on inner ear structure. Categories of Auditory Performance(CAP) and speech intelligibility rating(SIR) scores and aided hearing thresholds were collected and compared between the two groups. All patients wore CI for more than 1 year at the Cochlear Center of Anhui Medical University from 2011 to 2015.Results: Postoperative CAP and SIR scores were higher than before operation in both groups(p < 0.05), although the scores were lower in the CCD group than in the control group(p < 0.05). The aided threshold was also lower in the control group than in the CCD group(p < 0.05).Conclusion: Even though audiological improvement in children with CCD was not as good as in those without CCD, CI provides benefits in auditory perception and communication skills in these children.

关键词： Cochlear implant Common cavity Outcome Inner ear deformity Hearing threshold

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