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计算机应用 2015年第2期35卷 476-480页

作者：孔飞吴定会纪志成轻工过程先进控制教育部重点实验室(江南大学) 江苏无锡214122

针对柔性作业车间调度问题(FJSP),提出了一种改进的双层粒子群优化(ITLPSO)算法。首先,以机器的最大完工时间最小化为优化目标,建立了一个柔性作业车间调度模型;然后,介绍了改进的双层PSO算法,为了避免陷入局部最优和提高收敛速度,算法... 详细信息

针对柔性作业车间调度问题(FJSP),提出了一种改进的双层粒子群优化(ITLPSO)算法。首先,以机器的最大完工时间最小化为优化目标,建立了一个柔性作业车间调度模型;然后,介绍了改进的双层PSO算法,为了避免陷入局部最优和提高收敛速度,算法中加入了停滞阻止策略和凹函数递减策略;最后,对相关实例进行求解,并与已有算法作了比较。实验结果表明,与标准PSO算法和双层粒子群优化(TLPSO)算法相比,最大完工时间的最优值分别减少了11和6,最大完工时间的平均值分别减少了15.7和4,收敛速度明显提高。经过性能分析,所提算法可以明显提高柔性作业车间的调度效率,从而获得了更优的调度方案。

关键词：柔性作业车间双层粒子群优化算法调度优化凹函数递减策略停滞阻止策略

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高校研究生奖学金发展历程与理论基础试析

价值工程 2020年第2期39卷 293-294页

作者：张昭孔飞西安理工大学研究生院

文章首先利用中国知网梳理了近年来有关研究生奖学金的文献,分析出这一领域的研究数量不多,波动大,趋势不稳定。同时该领域主要研究内容包括了研究生奖学金制度的形成和发展历程、相关的价值功能、理论基础以及研究生奖学金制度存在的... 详细信息

文章首先利用中国知网梳理了近年来有关研究生奖学金的文献,分析出这一领域的研究数量不多,波动大,趋势不稳定。同时该领域主要研究内容包括了研究生奖学金制度的形成和发展历程、相关的价值功能、理论基础以及研究生奖学金制度存在的问题和对策。分析认为今后有关“研究生奖学金”的探讨应该注重大量实证研究,将定量和定性研究相结合,借鉴国外奖学金经验,利用信息化手段构建更加合理的评定指标体系。

关键词：研究生奖学金培养机制激励理论价值功能

High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang Hai-Xia Fu Yuan kong Yue-Ying Li Qian-fei Wang Xiao-Jun Huang Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

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专利审查创造性判断中参数和用途的限定分析

江苏科技信息 2017年第23期34卷 8-9页

作者：杨云孔菲国家知识产权局专利局材料部北京100088 国家知识产权局专利局专利审查协作湖北中心材料部湖北武汉430205

在审查实践中,审查员与申请人争论的焦点常集中在解决的技术问题和预料不到的技术效果上。文章将从一个实际的案例入手,对于采用参数、用途表征的权利要求,如何确定发明实际要解决的技术问题,是否取得意料不到的技术效果,进而判断权利... 详细信息

在审查实践中,审查员与申请人争论的焦点常集中在解决的技术问题和预料不到的技术效果上。文章将从一个实际的案例入手,对于采用参数、用途表征的权利要求,如何确定发明实际要解决的技术问题,是否取得意料不到的技术效果,进而判断权利要求是否具有创造性。

关键词：创造性参数用途技术问题技术效果

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong kong Mei-Ling Xu Jun-Jun Zhang Guang-Qiang Chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang Zhang Rong-Zheng Chen Peng-fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

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超高速直流输电线路保护方向元件

电力自动化设备 2014年第8期34卷 83-88页

作者：孔飞张保会王艳婷甄威张爱玲西安交通大学电气工程学院陕西西安710049 四川电力科学研究院四川成都610072 许继集团有限公司河南许昌461000

为提高直流输电线路单端暂态量保护的可靠性与灵敏度,提出了一种基于故障行波能量的超高速直流输电线路故障方向元件,该元件基于不同故障方向时故障前行波与反行波能量之间大小的差异有效判别故障方向。利用由RTDS与现场控制保护装置的... 详细信息

为提高直流输电线路单端暂态量保护的可靠性与灵敏度,提出了一种基于故障行波能量的超高速直流输电线路故障方向元件,该元件基于不同故障方向时故障前行波与反行波能量之间大小的差异有效判别故障方向。利用由RTDS与现场控制保护装置的闭环测试系统,对该方向元件性能进行了测试。测试结果表明,该方向元件适用于不同电压等级输电工程,在直流输电工程不同运行方式下,均可以超高速正确判别故障方向,且不受故障位置、过渡电阻的影响,可以有效提高单端暂态量保护性能,并可构成纵联方向保护。

关键词：高压直流输电继电保护方向元件平波电抗器信号衰减故障行波行波能量

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土石混合料-土工织物界面剪切特性研究

中国公路学报 2024年第1期37卷 35-43页

作者：刘飞禹姚嘉敏孔剑捷上海大学力学与工程科学学院上海200444

土石混合料加筋结构常见于高填方边坡工程中,其稳定性受筋土界面相互作用的影响。为了研究土石混合料-土工织物界面的相互作用机理,利用了室内大型直剪仪进行一系列直剪试验,分析了5种含石量(0%、25%、50%、75%、100%)、3种压实度(88%、... 详细信息

土石混合料加筋结构常见于高填方边坡工程中,其稳定性受筋土界面相互作用的影响。为了研究土石混合料-土工织物界面的相互作用机理,利用了室内大型直剪仪进行一系列直剪试验,分析了5种含石量(0%、25%、50%、75%、100%)、3种压实度(88%、92%、96%)以及3种竖向应力(100、200、300 kPa)对界面剪切特性的影响,并建立了界面剪胀系数的经验公式。结果表明:界面在低含石量(0%~25%)下表现出剪切软化趋势,在高含石量(50%~100%)下表现出剪切硬化趋势,且剪切应力-剪切位移曲线出现较为明显的波动现象;界面最大竖向位移随含石量和压实度的增大呈现出增大趋势,随竖向应力的增大呈现出减小趋势。界面摩擦角在低含石量下基本保持稳定,而后随含石量的增大表现出先增大后减小的趋势;界面似黏聚力的增长速率随压实度的增大而减小;结合含石量、竖向应力等因素,建立了剪胀系数经验公式,该公式能够较为准确地描述界面的体积变化情况。

关键词：路基工程筋土界面直剪试验土石混合料含石量压实度剪胀系数

等离子体射流阵列辅助薄膜沉积对环氧树脂表面电气特性的影响

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高电压技术 2018年第9期44卷 3089-3096页

作者：马翊洋章程孔飞王婷婷陈根永邵涛郑州大学电气工程学院中国科学院电工研究所中国科学院大学中国南方电网有限责任公司电网技术研究中心

直流电场下的绝缘材料表面电荷积聚现象对电气设备的安全运行造成威胁。为了加快环氧树脂(ER)表面电荷的消散,文中采用纳秒脉冲电源激励的大气压等离子体射流(APPJ)阵列,对环氧树脂表面进行扫描处理,沉积SiOx薄膜,之后利用傅里叶变换红... 详细信息

直流电场下的绝缘材料表面电荷积聚现象对电气设备的安全运行造成威胁。为了加快环氧树脂(ER)表面电荷的消散,文中采用纳秒脉冲电源激励的大气压等离子体射流(APPJ)阵列,对环氧树脂表面进行扫描处理,沉积SiOx薄膜,之后利用傅里叶变换红外光谱仪(FTIR)、扫描电子显微镜(SEM)、高阻计、表面电位测试系统等装置对改性前后的样品表面理化特性进行表征分析。实验结果表明:射流阵列扫描沉积在环氧树脂表面引入了Si—O—Si、Si—OH和OH等基团,并且形成的薄膜使材料表面粗糙度降低。改性后的环氧树脂表面电导率提升23个数量级,使表面电荷初始积聚量减少,消散速度加快,陷阱能级的深度与密度均有所降低,闪络电压由未处理时的-6.5 kV提升至扫描沉积4次时的-9.3 kV。相对于单管射流改性,射流阵列可产生更大面积的低温等离子体,具有更高的处理效率和实用性。

关键词：射流阵列 SiOx薄膜表面电荷环氧树脂闪络电压

The medium-temperature dependence of jet transport coefficient in high-energy nucleus-nucleus collisions

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Nuclear Science and Techniques 2024年第7期35卷 173-191页

作者： Man Xie Qing-fei Han En-Ke Wang Ben-Wei Zhang Han-Zhong Zhang Key Laboratory of Atomic and Subatomic Structure and Quantum Control(MOE) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of MatterInstitute of Quantum Matter South China Normal UniversityGuangzhou510006China Guangdong-Hong kong Joint Laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou 510006China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan430079China

The medium-temperature T dependence of the jet transport coefficient̂q was studied via the nuclear modification factor RAA(p_(T))and elliptical flow parameter v_(2)(p_(T))for large transverse momentum p_(T) hadrons in high-energy nucleus-nucleus *** a next-to-leading-order perturbative QCD parton model for hard scatterings with modified fragmentation functions due to jet quenching controlled by q,we check the suppression and azimuthal anisotropy for large p_(T) hadrons,and extract q by global fits to RAA(pT)and v_(2)(pT)data in A+A collisions at RHIC and LHC,*** numerical results from the best fits show that q∕T^(3) goes down with local medium-temperature T in the parton jet *** with the case of a constant q∕T^(3),the going-down T dependence of q∕T^(3) makes a hard parton jet to lose more energy near T_(c) and therefore strengthens the azimuthal anisotropy for large pT *** a result,v_(2)(p_(T))for large pT hadrons was enhanced by approximately 10%to better fit the data at RHIC/*** the first-order phase transition from QGP to the hadron phase and the additional energy loss in the hadron phase,v_(2)(p_(T))is again enhanced by 5-10%at RHIC/LHC.

关键词： Jet quenching Jet transport parameter Hadron suppression Elliptic flow coefficient Energy loss asymmetry