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Kinetic evaluation of the size-dependent decomposition performance of solvent-free microcellular polylactic acid foams

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Chinese Science Bulletin 2012年第34期57卷 83-89页

作者： GUO GePu MA QingYu WANG fang zhao Bo ZHANG Dong key Laboratory of Optoelectronics of Jiangsu Province School of Physics and TechnologyNanjing Normal UniversityNanjing 210046China Center of Analysis and Testing Nanjing Normal UniversityNanjing 210046China College of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210046China Institute of Acoustics Key Laboratory of Modern AcousticsMinistry of EducationNanjing UniversityNanjing 210093China

A thermal gravimetric method is described for evaluating the kinetics of cell size-dependent decomposition and lifetime estima- tion for microcellular tissue engineering scaffolds made of biodegradable polylactic acid(PLA)*** foam cell sizes from 550 to 20?m were fabricated experimentally using a solvent-free solid-state foaming technique under saturation pressures from 1 to 5 *** thermal properties of the PLA foams with respect to the cell sizes were measured using thermal gravimetric analy- sis in a nitrogen atmosphere and the activation energy and pre-exponential factor were derived to evaluate the decomposition ki- netics and estimate *** was found that small cell sizes can be achieved under high saturation pressures and that the thermal stability of PLA decreases after the fabrication *** cell size-dependent thermal stability and degradation rate indicate that a PLA foam of larger cell sizes has a shorter degradation time,a few tenths that of the PLA raw material,at a temperature of 37°C. The results suggest that it is feasible to optimize fabrication parameters to obtain appropriate cell sizes and lifetimes that satisfy the application requirements for various *** study provides the basis for precise scaffold design and quantitative analysis of PLA foams in tissue engineering applications.

关键词：分解动力学泡沫细胞聚乳酸无溶剂热性能评价微孔寿命估计

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基于网络药理学探讨《种福堂公选良方》辟瘟丹预防新型冠状病毒感染作用机制

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中国中医药图书情报杂志 2024年第5期48卷 53-57页

作者：吴俊仪肖静方艳张伟娜赵静吴夏秋浙江中医药大学公共卫生学院浙江杭州310053 中国中医科学院中医药信息研究所北京100700 中国中医科学院中医临床基础医学研究所北京100700

目的运用网络药理学方法探讨辟瘟丹预防新型冠状病毒感染(COVID-19)的作用机制。方法通过TCMSP数据库检索辟瘟丹的化学成分及作用靶点;通过GeneCards、OMIM、PharmGKB、TTD和DrugBank数据库查询COVID-19的相关靶点;借助STRING网站进行... 详细信息

目的运用网络药理学方法探讨辟瘟丹预防新型冠状病毒感染(COVID-19)的作用机制。方法通过TCMSP数据库检索辟瘟丹的化学成分及作用靶点;通过GeneCards、OMIM、PharmGKB、TTD和DrugBank数据库查询COVID-19的相关靶点;借助STRING网站进行蛋白质互相作用分析;利用Cytoscape3.9.0软件构建药物成分-靶点网络,分析获得辟瘟丹预防COVID-19的核心靶点;利用R语言和KOBAS数据库分别进行GO和keGG富集分析。结果辟瘟丹化学成分共115个,靶点共2378个,辟瘟丹和COVID-19有重叠靶点101个,核心靶点为TP53、HSP90AA1、AKT1、MAPK3;keGG富集分析得到信号通路102条,主要涉及IL-17信号通路、TNF信号通路、P53信号通路、AGE-RAGE信号通路等;GO分析后共得到生物学过程2359个、细胞组成423个、分子功能161个。结论辟瘟丹能够通过TP53、HSP90AA1、AKT1、MAPK3靶点,IL-17、TNF、P53、AGE-RAGE信号通路途径达到调节细胞凋亡、促进机体免疫、抗病毒等作用,发挥预防COVID-19的药理作用。

关键词：辟瘟丹新冠病毒网络药理学

Synthesis of 2,2'-(Substituted Arylmethylene)bis(1,6,6-trimethyl- 6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) Derivatives

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Chinese Chemical Letters 2005年第11期16卷 1451-1454页

作者： Jiang ke QIN Xian Zhang BU Yu fang WANG Zhi Yun DU Xing Yuan WANG Zhi Shu HUANG Lin MA Lin Kun AN Lian Quan GU School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510080 School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275

The reactions of tanshinone IIA with aromatic aldehydes have been investigated and several 2, T-（substituted arylmethylene） bis （1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]- furan- 10, 11-dione） derivative... 详细信息

关键词： Tanshinone IIA aromatic aldehydes reaction.

Research of Lignin Modified Phenol Formaldehyde Resin Bonded Magnesia Carbon Bricks

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China's Refractories 2015年第2期24卷 46-50页

作者： fang Wei zhao Lei LIANG Feng LEI Zhongxing CHEN Hui CHEN Huan The State key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology

In order to reduce the cost and to improve the low temperature bonding strength of phenol formaldehyde resin（ PF）,the lignin modified phenol formaldehyde resin（ LPF） was synthesized using calcium lignosulfonate as a partial replacement of phenol,and sodium hydroxide as catalyzer. Then the magnesia carbon bricks were prepared using the LPF as binder. Different process conditions of LPFs such as calcium lignosulfonate additions（ 10%,20%,30%,40% and 50%,in mass,the same hereinafter）,catalyzer additions（ extra added,1%,2%,3%,4% and 5%） and reaction times（ 1,1. 5,2,2. 5 and 3 h） were investigated. Effects of prepared LPFs on properties of magnesia carbon bricks（ baked at 200 ℃ for 24 h） were researched in order to modify the synthesizing conditions of LPFs. Cold physical properties and hot modulus of rupture of magnesia carbon bricks bonded by LPF and by traditional PF after baked at 200 ℃ for 24 h and fired at 1 200 ℃ for 3 h were compared,respectively. The results show that the optimal synthesizing conditions of LPF for preparing magnesia carbon bricks are 30% calcium lignosulfonate,1% catalyzer,and 2 h reaction time. The magnesia carbon bricks bonded by the optimal LPF achieve：（ 1） the bulk densities 2. 84 g · cm- 3and 2. 82g·cm- 3,apparent porosities 9. 6% and 14. 6%,moduli of rupture 17. 8 MPa and 6. 4 MPa,crushing strengths72. 3 MPa and 48. 7 MPa,after baked at 200 ℃ and1 200 ℃,respectively;（ 2） the hot modulus of rupture7. 3 MPa after fired at 1 400 ℃. The above properties are better than those of the magnesia carbon brick bonded by PF.

关键词： calcium lignosulphonate modified phenol formaldehyde resin magnesia carbon brick strength

18F-FDG PET/CT与MRI异机融合在高级别脑胶质瘤鉴别诊断中的价值

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中国CT和MRI杂志 2024年第3期22卷 1-4页

作者：姜双士刘烜利王超冯洪燕王科涂宁韩芳卜丽红武汉大学人民医院PET中心湖北武汉430061 大连大学附属中山医院PET中心辽宁大连116001

目的探讨18F-FDG PET/CT与MRI异机融合在高级别脑胶质瘤(HGG)诊断中的价值。方法回顾性分析90例经组织病理学证实的高级别脑胶质瘤(HGG)(n=31)、原发性中枢神经系统淋巴瘤(PCNSL)(n=20)和脑转移瘤(BM)(n=39)患者。所有患者同一天先后... 详细信息

目的探讨18F-FDG PET/CT与MRI异机融合在高级别脑胶质瘤(HGG)诊断中的价值。方法回顾性分析90例经组织病理学证实的高级别脑胶质瘤(HGG)(n=31)、原发性中枢神经系统淋巴瘤(PCNSL)(n=20)和脑转移瘤(BM)(n=39)患者。所有患者同一天先后接受18F-FDG PET/CT和MRI双倍剂量增强扫描。采用视觉分析3组患者的病灶分布和形态特征,以及半定量参数最大标准化摄取值(SUVmax)、标准化摄取值均值(SUVmean)、肿瘤与对侧相应部位正常脑组织SUVmax的比值(T/N),采用Mann-Whitney U检验和多因素回归分析及受试者工作特征(ROC)曲线分析两两组间关系。评价异机融合18F-FDG PETCT/MRI在HGG鉴别诊断中的价值。结果增强特征、占位效应和病灶部位在HGG、PCNSL和BM组间差异具有统计学意义(P<0.05);半定量分析中,PCNSL的SUVmax、SUVmean和T/N值均显著高于HGG(P<0.05)和BM(P<0.05)。ROC曲线分析显示,强化特征和SUVmean在区分HGG和PCNSL方面具有良好的诊断效能(AUC=0.927);SUVmax和强化特征可以作为PCNSL和BM组间良好的分类预测模型(AUC=0.918)。结论18F-FDG PET/CT代谢参数联合MR双倍剂量增强形态学特征在诊断和鉴别颅内HGG中具有重要的价值和意义。

关键词：神经胶质瘤氟脱氧葡萄糖F18 正电子发射断层显像术体层摄影术 X线计算机磁共振成像

Effects of regenerated tissue extracts after liver injury on the proliferation,differentiation,migration and invasion of SK-HEP1 cells

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 235-239页

作者： Na Cheng Xiao-Ran Liu Da-Wei Liu fang Liu Jin Xiang Di Yang Guo-Qiang zhao Department of Pathology The Third Affiliated HospitalSun Yat-sen University Emergency Department The First Affiliated Hospital of Hainan Medical University Department of Pathology The First Affiliated HospitalSun Yat-sen University Department of Oncology Nanfang HospitalSouthern Medical University Department of Pathology Sun Yat-sen University Cancer Center Department of Pathology Nanhai District People's Hospital Pathology Teaching and Research Section Sun Yat-sen University Zhongshan School of Medicine

Objective: To study the effects of regenerated tissue extracts after liver injury on the proliferation, differentiation, migration and invasion of SK-HEP1 cells. Methods: Regenerated tissue extracts after liver injury were used to induce SK-HEP1 cells after enrichment, their effects on the proliferation, differentiation, migration and invasion of SK-HEPI cells were observed through in vitro cell culture, MTT, flow cytometry and transwell assays. Results:In response to the action of regenerated tissue extracts after liver injury, SK-HEP1 cells were blocked in G_0/G_1 phase, their growth rate was distinctly reduced. The number of SK-HEP1^(-fj)colonies decreased. The migration ability of SK-HEPI cells showed a decreased trend on day7 and day 11 after induction. SK-HEPl's invasion ability clearly decreased on days 7 and11 after induction, especially on day 7. Conclusions: To a certain extent, regenerated tissue extracts after liver injury can inhibit the proliferation, differentiation, migration and invasion of hepatoma cells, showing an important potential of being a differentiating agent for the treatment of liver cancer.

关键词： SK-HEPI hepatoma cell Regenerated tissue extracts of liver injury Differentiation-inducing therapy SK-HEPI cell enrichment(SK-HEP1-fjr)

An association study of HFEgene mutation with idiopathic male infertility in the Chinese Han population

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Asian Journal of Andrology 2012年第4期14卷 599-603页

作者： Xiao-Ying Yu Bin-Bin Wang Zhong-Cheng Xin Tao Liu ke Ma Jian Jiang Xiang fang Li-Hua Yu Yi-Feng Peng Xu Ma Institute of Reproductive Medicine Yijishan HospitalWannan Medical CollegeWuhu 241001China National Research Institute for Family Planning Beijing 100081China peking Union Medical College Beijing 100081China Andrology Center Peking University First HospitalBeijing 100034China World Health Organization Collaborating Centre for Research in Human Reproduction Beijing 100081China

Mutations in the haemochromatosis gene （HFE） influence iron status in the general population of Northern Europe, and excess iron is associated with the impairment of spermatogenesis. The aim of this study is to investigate the association between three mutations （C282Y, H63D and S65C） in the HFEgene with idiopathic male infertility in the Chinese Han population. Two groups of Chinese men were recruited： 444 infertile men （including 169 with idiopathic azoospermia） and 423 controls with proven fertility. The HFEgene was detected using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） technique. The experimental results demonstrated that no C282Y or $65C mutations were detected. Idiopathic male infertility was not significantly associated with heterozygous H63D mutation （odds ratio=O.801, 95% confidence interval=0.452-1.421, X2=0.577, P=0.448）. The H63D mutation frequency did not correlate significantly with the serum luteinizing hormone （LH）, follicle-stimulating hormone （FSH） and testosterone （T） levels in infertile men （P=0.896, P=0.404 and P=O.05, respectively）. Our data suggest that the HFEH63D mutation is not associated with idiopathic male reproductive dysfunction.

关键词： gene mutation gonadotropic hormone HFE male infertility

诱导多潜能干细胞在精子发生过程中的研究进展

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中华男科学杂志 2015年第10期21卷 925-930页

作者：方芳倪柯熊承良华中科技大学同济医学院计划生育研究所/生殖医学中心湖北武汉430030 华中科技大学附属同济医院外科学系湖北武汉430030

精子发生是一个复杂的过程,目前关于人类精子发生的认知主要来源于动物模型,而对于人类精子发生的早期阶段,仍不是非常了解。体外精子发生模型的建立不仅能促进深入了解精子发生过程及不育症发病机制,而且有助于男性不育症的临床治疗。... 详细信息

精子发生是一个复杂的过程,目前关于人类精子发生的认知主要来源于动物模型,而对于人类精子发生的早期阶段,仍不是非常了解。体外精子发生模型的建立不仅能促进深入了解精子发生过程及不育症发病机制,而且有助于男性不育症的临床治疗。本文将对多潜能干细胞(i PSCs)在诱导精子发生过程中的相关研究进行综述,并探讨诱导i PSCs应用于男性不育症临床治疗所面临的问题以及发展前景。

关键词：精子发生无精子症原始生殖细胞胚胎干细胞诱导多潜能干细胞

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重构本草——决明子

长春中医药大学学报 2024年第1期40卷 20-22页

作者：谢伟楠段莹莹刘珂王昭博赵锡艳李丽静中国中医科学院广安门医院北京100053 北京中医药大学北京100029 西安交通大学第二附属医院西安710004 长春中医药大学药学院长春130117

通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出决明子:功效主要为清热明目,润肠通便。症靶为肥胖、便秘和目赤肿痛。标靶为血脂升高和血压升高。现代药理研究发现... 详细信息

通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出决明子:功效主要为清热明目,润肠通便。症靶为肥胖、便秘和目赤肿痛。标靶为血脂升高和血压升高。现代药理研究发现决明子及其有效成分具有降血压、降血脂、保护视网膜、通便、护肝、抗菌等作用。决明子主要化学成分大黄素型蒽醌类化合物具有肝肾毒性,临床使用中应注意用量配伍,以免造成或加重肝肾损伤。临床使用剂量为3~60 g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索决明子用量与症靶、标靶的量效关系构建。

关键词：决明子症靶标靶重构本草临床回归