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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu chao fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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First-principle studies of radioactive fission productions Cs/Sr/Ag/I adsorption on chrome-molybdenum steel in Chinese 200 MW HTR-PM

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Nuclear Science and Techniques 2017年第6期28卷 123-132页

作者： Chuan Li chao fang Chen Yang Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy TechnologyKey Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua University

Chrome-molybdenum steel(2·1/4Cr1Mo) is one of the main products of steam *** adsorption behaviors of radioactive fission products on2·1/4Cr1Mo surface are critical in the analysis of ***,the adsorption behavior of cesium,strontium,silver and iodine on 2·1/4Cr1Mo was investigated with first-principle calculations that the Ag and I atoms prefer to be adsorbed at the square hollow site of the face-centered cubic iron cell with a binding energy of about 1 and 3 eV,*** contrast,Cs and Sr atoms are not adsorbed on the surface of the 2·1/*** results are again confirmed via analysis of charge density differences and the densities of ***,the adsorption rates of these fission products show that only I and Ag have significant adsorption on the metal *** adsorption results explain the amount of adsorbed radionuclides for an evaluation of nuclear safety in *** micro-pictures of the interaction between fission products and materials are a new and useful way to analyze the source term.

关键词： First-principle calculation Fission product Adsorption behavior HTR-PM

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Reentry Trajectory Optimization for Hypersonic Vehicles Using Fuzzy Satisfactory Goal Programming Method

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International Journal of Automation and computing 2015年第2期12卷 171-181页

作者： chao-fang Hu Yue Xin School of Electrical Engineering and Automation Tianjin University

Constrained reentry trajectory optimization for hypersonic vehicles is a challenging job. In particular, this problem becomes more difficult when several objectives with preemptive priorities are expected for different purposes. In this paper, a fuzzy satisfactory goal programming method is proposed to solve the multi-objective reentry trajectory optimization problem. Firstly, direct collocation approach is used to discretize the reentry trajectory optimal-control problem with nonlinear constraints into nonlinear multiobjective programming problem with preemptive priorities, where attack angles and bank angles at nodes and collocation nodes are selected as control variables. Secondly, the preemptive priorities are transformed into the relaxed order of satisfactory degrees according to the principle that the objective with higher priority has higher satisfactory degree. Then the fuzzy satisfactory goal programming model is proposed. The balance between optimization and priorities is realized by regulating parameter λ, such that the satisfactory reentry trajectory can be acquired. The simulation demonstrates that the proposed method is effective for the multi-objective reentry trajectory optimization of hypersonic vehicles.

关键词： Reentry trajectory optimization direct collocation method multi-objective optimization fuzzy satisfactory method goal programmin

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Relations of Microstructural Attributes and Strength-Ductility of Zirconium Alloys with Hydrides

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Chinese Journal of Mechanical Engineering 2023年第4期36卷 407-419页

作者： chao fang Xiang Guo Jianghua Li Gang Chen School of Mechanical Engineering Tianjin UniversityTianjin 300354China Tianjin Key Laboratory of Nonlinear Dynamics and Control Tianjin 300072China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

As the first safety barrier of nuclear reactors,zirconium alloy cladding tubes have attracted extensive attention because of its good mechanical *** strength and ductility of zirconium alloy are of great significance to the service process of cladding tubes,while brittle hydrides precipitate and thus deteriorate the overall *** on the cohesive finite element method,the effects of cohesive strength,interfacial characteristics,and hydrides geometric characteristics on the strength and ductility of two-phase material(zirconium alloy with hydrides)are numerically *** results show that the fracture behavior is significantly affected by the cohesive strength and that the overall strength and ductility are sensitive to the cohesive strength of the zirconium ***,the interface is revealed to have prominent effects on the overall fracture *** the cohesive strength and fracture energy of the interface are higher than those of the hydride phase,fracture initiates in the hydrides,which is consistent with the experimental *** addition,it is found that the number density and arrangement of hydrides play important roles in the overall strength and *** simulation provides theoretical support for the performance analysis of hydrogenated zirconium alloys during nuclear reactor operation.

关键词： Zirconium alloy Hydride Strength and ductility Cohesive finite element method Microcrack initiation and propagation

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Cu/Picolinamides-Catalyzed Coupling of (Hetero) aryl Halides with Secondary Phosphine Oxides and Phosphite

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Chinese Journal of Chemistry 2021年第11期39卷 2957-2961页

作者： chao fang Bangguo Wei Dawei Ma Department of Natural Medicine School of PharmacyFudan University826 Zhangheng RoadShanghai201203 China State Key Laboratory of Bioorganic&Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling LuShanghai200032 China

Some 4-hydroxy-picolinic acid derived amides were revealed as more efficient ligands for Cu-catalyzed coupling of(hetero)aryl halides with secondary phosphine oxides and *** 3—5 mol%CuI and ligands were required to e... 详细信息

关键词： Synthetic methods Cross-Coupling Aryl halides Copper Aryl phosphine oxides

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Temporal Electronic Structures of Nonresonant Raman Excited Virtual States of P-Hydroxybenzoic Acid

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Chinese Physics Letters 2012年第8期29卷 73-76页

作者： fang chao SUN Li-Feng Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084

An algorithm is employed to calculate molecular bond polarizabilities of p-hydroxybenzoic acid,which supplies essential electronic information of the nonresonant Raman excited virtual *** main dynamical behavior of the excited virtual states of p-hydroxybenzoic acid with 514.5 nm excitation is such that the Raman excited electrons tend to flow to the C–C connected with–OH and–COOH from the benzene ring because of the electronic repulsion *** distribution of the electrons at the final stage of relaxation is given out through the comparison between the bond electronic densities of the ground states and the bond polarizabilities after ***,the relaxation characteristic times of bond polarizabilities shows that the transport of electrons on–COOH is distinct.

关键词： effect excited relaxation

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Synthesis of 2,4-Diarylcyclooctenopyridines with One-pot Four-component Reactions

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Chemical Research in Chinese Universities 2009年第3期25卷 338-342页

作者： WANG Qi-fang YAN chao-guo College of Chemistry ＆ Chemical Engineering Yangzhou University Yangzhou 225002 P. R. China

An efficient one-pot four-component reaction has been developed for the synthesis of 2,4-diarylcyclooctenopyridines, in moderate yields. This route is an effective modified two-step synthesis of Krohnke pyridine and involves a four-component tandem reaction of pyridinium bromide with aromatic aldehydes and cyclooctanone in a system of NHaOAc/HOAc under microwave irradiation.

关键词： Pyridine Cycloalkenopyridine Multicomponent reaction Microwave irradiation

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Study on the passive film formed on 2205 stainless steel in acetic acid by AAS and XPS

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 170-176页

作者： Xue-qun Cheng Xiao-gang Li chao-fang Dong Corrosion and Protection Center University of Science and Technology Beijing Beijing 100083 China

The properties of the passive film formed on 2205 stainless steel in acetic acid at high temperature that contained chloride ions were studied by atomic absorption spectrometry （AAS）, X-ray photoelectron spectroscopy （XPS）, and electrochemical polarization measurements. AAS results show that molybdenum is enriched on the surface as the passive film is dissolved. This enrichment decreases the corrosion resistance because it hinders chloride adsorption and Fe ion dissolution, and acts as a local pH buffer because it consumes protons. The dissolution ratio of Fe/Cr is approximately 10 during the active dissolution of the passive film. XPS results indicate that when the potential is in the passivation region, Cr comprises about 50% of the metal cations in the near-surface region of the passive film and is the main metal constituent in this region. When the polarization potential is much greater than the transpassivation potential, the Mo content accounts for approximately 45% of the metal cations in the nearurface region; Fe and Ni have no obvious influence on the formation, dissolution, or puncture of the passive film.

关键词： acetic acid corrosion electrochemical behavior stainless steel passive film

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Natural variation and artificial selection of photoperiodic flowering genes and their applications in crop adaptation

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aBIOTECH 2021年第2期2卷 156-169页

作者： Xiaoya Lin chao fang Baohui Liu Fanjiang Kong Innovative Center of Molecular Genetics and Evolution School of Life SciencesGuangzhou UniversityGuangzhouChina

Flowering links vegetative growth and reproductive growth and involves the coordination of local environmental cues and plant genetic *** timing of floral initiation and maturation in both wild and cultivated plants is important to their fitness and productivity in a given growth *** domestication of plants into crops,and later crop expansion and improvement,has often involved selection for early *** this review,we analyze the basic rules for photoperiodic adaptation in several economically important and/or well-researched crop *** ancestors of rice(Oryza sativa),maize(Zea mays),soybean(Glycine max),and tomato(Solanum lycopersicum)are short-day plants whose photosensitivity was reduced or lost during domestication and expansion to high-latitude ***(Triticum aestivum)and barley(Hordeum vulgare)are long-day crops whose photosensitivity is influenced by both latitude and vernalization ***,we summarize recent studies about where these crops were domesticated,how they adapted to photoperiodic conditions as their growing area expanded from domestication locations to modern cultivating regions,and how allelic variants of photoperiodic flowering genes were selected during this process.A deeper understanding of photoperiodic flowering in each crop will enable better molecular design and breeding of high-yielding cultivars suited to particular local environments.

关键词： Adaptation Photoperiodic flowering Crops Artificial selection

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NUMERICAL MODEL FOR FLOW THROUGH SUBMERGED VEGETATION REGIONS IN A SHALLOW LAKE

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Journal of Hydrodynamics 2011年第2期23卷 170-178页

作者： WANG Pei-fang WANG chao Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry ot Education College of Environment Hohai University Nanjing 210098 China

Aquatic vegetation has a significant impact on water currents. To evaluate the effects of changes in the aquatic vegetation on water currents of different velocity, a 3-D hydrodynamic model was then developed by taking into consideration of the additional hydraulic resistance of the aquatic plants. The Navier- Stokes equations were then solved using the SIMPLE method and the k - e＂ turbulence model. Calculations using the established models were used to forecast the vertical distribution of the horizontal velocity and horizontal flow under the transmission conditions of the South-North Water Diversion in the Nansi Lake. And comparative calculation for the flow velocity was also performed using the simplified method of assigning a high roughness coefficient to the lake bed in the same area. Results suggest that adding additional hydraulic resistance of the aquatic plants is feasible. The calculation errors between simulation result and the field observed data are smaller than 15%, while, those errors are up to 35% if the influence of aquatic vegetation is dealt with the simplified method.

关键词： lakes numerical models hydraulic resistance aquatic vegetation

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