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Chinese Journal of Polymer Science 2016年第7期34卷 830-837页

作者： si-hua guo fang-yuan zheng fang zeng 吴水珠 College of Materials Science and Engineering State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China

A simple and effective polymer fluorescent thermosensitive system was successfully developed based on the synergistic effect of excimer/monomer interconversion of pyrene derivatives and electrostatic interaction between polyelectrolyte and charged fluorophore. As for the system, the excimer-monomer conversion, thermosensitive behavior and thermo-responsive reversibility were investigated experimentally. Temperature variation and temperature-distribution induced fluorescence changes can be observed directly by naked eyes. Thus, this polymer system holds promise for serving as a fluorescent thermometer.

关键词： Polymer fluorescent thermometer Temperature-responsive Electrostatic interaction Aggregation Deaggregation

Asymptotic stability of solutions to the nonisentropic hydrodynamic model for semiconductors

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Applied Mathematics(A Journal of Chinese Universities) 2008年第2期23卷 151-167页

作者： XU Jiang fang Dao-yuan Dept. of Math. Nanjing Univ. of Aeronautics and Astronautics Nanjing 210016 China Dept. of Math. Zhejiang Univ. Hangzhou 310027 China

In this paper, the asymptotic stability of smooth solutions to the multidimensional nonisentropic hydrodynamic model for semiconductors is established, under the assumption that the initial data are a small perturbation of the stationary solutions for the thermal equilibrium state, whose proofs mainly depend on the basic energy methods.

关键词： asymptotic stability smooth solutions hydrodynamic model semiconductor.

A fast and reliable overset unstructured grids approach

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Acta Mechanica Sinica 2013年第2期29卷 149-157页

作者： Zhong-Liang Kang Chao Yan Jian Yu yuan-yuan fang Institute of Fluid Mechanics Beihang University Academy of Beijing Gas GroupCo. Ltd

A cell-centred overset unstructured grids approach is *** this approach,the intergrid boundary is initially established based on the wall distance from the cell centre,and is then *** accelerate the intergrid-boundary definition much more,a neighbor-toneighbor donor search algorithm based on advancing-front method is modified with the help of minimum cuboid *** simplify the communications between different grid cell types and to obtain second-order spatial accuracy,a new interpolation method is constructed based on linear reconstruction,which employs only one layer of fringe cells along the intergrid *** unsteady flows with relative motion,the intergrid boundary can be redefined fast and *** numerical results show that the present dynamic overset unstructured grids approach is accurate and reliable.

关键词： Overset unstructured grids·Dynamic grids·Intergrid-boundary definition·Interpolation

Oil-source correlation of Lower-Triassic oil seepages in Ni＇erguan village, Southern Guizhou Depression, China

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Acta Geochimica 2016年第1期35卷 50-63页

作者： fang yuan Yuhong Liao Yunxin fang Ansong Geng The State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Wushan Guangzhou 510640People's Republic of China University of Chinese Academy of Sciences Beijing 100039People's Republic of China The Key Laboratory of Marine Mineral Resources Guangzhou Marine Geological Survey Ministry of Land and Resources Guangzhou 510075 People's Republic of China

There are abundant bitumens and oil seepages stored in vugs in a Lower-Triassic Daye formation(T_1d)marlite in Ni'erguan village in the Southern Guizhou Depression. However, the source of those oil seepages has not been determined to date. Multiple suites of source rocks of different ages exist in the depression. Both the oil seepages and potential source rocks have undergone complicated secondary alterations, which have added to the difficulty of an oil-source correlation. For example, the main source rock, a Lower-Cambrian Niutitang Formation"(∈_1n) mudstone, is over mature, and other potential source rocks, both from the Permian and the Triassic, are still in the oil window. In addition, the T_1d oil seepages underwent a large amount of biodegradation. To minimize the influence of biodegradation and thermal maturation, special methods were employed in this oil-source correlation study. These methods included catalytic hydropyrolysis, to release covalently bound biomarkers from the over mature"kerogen of ∈_1n mudstone, sequential extraction, to obtain chloroform bitumen A and chloroform bitumen C from the T_1d marlite, and anhydrous pyrolysis, to release pyrolysates from the kerogen of T_1d marlite. Using the methods above, the biomarkers and n-alkanes releasedfrom the oil samples and source rocks were analysed by GC–MS and GC-C-IRMS. The oil-source correlation indicated that the T_1d oil seepage primarily originated from"the ∈_1n mudstone and was partially mixed with oil generated from the T_1d marlite. Furthermore, the seepage also demonstrated that the above methods were effective for the complicated oil-source correlation in the Southern Guizhou Depression.

关键词： Oil seepage Biomarker Carbon isotopic composition Catalytic hydropyrolysis Oil-source correlation

Fluorescence Microscopic Image Analysis of Nucleic Acids Based on The Capillary Flow Directed Assembly Ring of Neutral Red-nucleic Acid Supramolecular Complexes

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Chemical Research in Chinese Universities 2003年第3期19卷 275-279页

作者： LI yuan fang HUANG Cheng zhi Laboratory of Supramolecular Chemistry and Biomedical Analysis College of Chemistry and Chemical EngineeringSouthwest Normal UniversityChongqing 400715P.R.China

It is critical to establish a direct and precise method with a high sensitivity and selectivity in analytical chemistry. In this research, making use of a well known phenomenon of capillary flow, we have proposed an image analysis method of nucleic acids at the price of a small amount of sample. When a droplet of the supramolecular complex solution, formed by neutral red and nucleic acids(NA) under an approximate neutral condition, was placed on the hydrophobic surface of dimethyl dichlorosilane pretreated glass slides, and it was evaporated, the supramolecular complex exhibited the periphery of the droplet due to the capillary effect, and accumulated there to form a red capillary flow directed assembly ring(CFDAR). A typical CFDAR has an outer diameter of (2 r ) about 1.18 mm and a ring width(2 δ ) of about 41 μm. Depending on the experimental conditions, a variety of CFDAR can be assembled. The experimental results are in agreement with our former theoretical discussion. It was found that when a droplet volume is 0.1 μL, the fluorescence intensity of the CFDAR formed by the NR NA is in proportion to the content of calf thymus DNA in the range of 0-0.28 ng, fish sperm DNA of 0-0.24 ng and yeast RNA of 0-0.16 ng with the limit of detection(3 σ ) of 1 7, 1.4 and 0.9 pg, respectively for the three nucleic acids.

关键词： Nuclei acids(NA) Neutral red(NR) Ring assembly Solid support surface Fluorescence imaging analysis

INDIRECT ACCELERATED ADAPTIVE FUZZY CONTROLLER

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Chinese Journal of Mechanical Engineering 2008年第1期21卷 91-93页

作者： ZHU Liye fang yuan ZHANG Weidong Baosteel Research Institute Shanghai 201900 China Department of Automation Shanghai Jiaotong University Shanghai 200240 China

According to a type of normal nonlinear system, an indirect adaptive fuzzy （IAF） controller has been applied to those systems where no accurate mathematical models of the systems under control are available. To satisfy with system performance, an indirect accelerated adaptive fuzzy （IAAF） controller is proposed, and its general form is presented. The general form IAAF controller ensures necessary control criteria and system＇s global stability using Lyapunov Theorem. It has been proved that the close-loop system error converges to a small neighborhood of equilibrium point. The optimal IAAF controller is derived to guarantee the process＇s shortest settling time. Simulation results indicate the IAAF controller make the system more stable, accurate, and fast.

关键词： Indirect adaptive fuzzy controller Accelerated controller Stability System error Settling time

A New Method for Deriving High-Vertical-Resolution Wind Vector Data from the L-Band Radar Sounding System in China

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Advances in Atmospheric Sciences 2024年第11期41卷 2192-2202页

作者： fang yuan Zijiang ZHOU Jie LIAO National Meteorological Information Center China Meteorological AdministrationBeijing 100081China

High-vertical-resolution radiosonde wind data are highly valuable for describing the dynamics of the meso-and microscale atmosphere. However, the current algorithm used in China's L-band radar sounding system for calculating highvertical-resolution wind vectors excessively smooths the data, resulting in significant underestimation of the calculated kinetic energy of gravity waves compared to similar products from other countries, which greatly limits the effective utilization of the data. To address this issue, this study proposes a novel method to calculate high-vertical-resolution wind vectors that utilizes the elevation angle, azimuth angle, and slant range from L-band radar. In order to obtain wind data with a stable quality, a two-step automatic quality control procedure, including the RMSE-F(root-mean-square error F) test and elemental consistency test are first applied to the slant range data, to eliminate continuous erroneous data caused by unstable signals or radar malfunctions. Then, a wind calculation scheme based on a sliding second-order polynomial fitting is utilized to derive the high-vertical-resolution radiosonde wind vectors. The evaluation results demonstrate that the wind data obtained through the proposed method show a high level of consistency with the high-resolution wind data observed using the Vaisala Global Positioning System and the data observed by the new Beidou Navigation Sounding System. The calculation of the kinetic energy of gravity waves in the recalculated wind data also reaches a level comparable to the Vaisala observations.

关键词： L-band radar sounding system upper air high-vertical-resolution radiosonde wind vectors quality control polynomial fitting

Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy:advances and perspectives

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1253-1278页

作者： yuan fang Guochao Liao Bin Yu Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China International Institute for Translational Chinese MedicineGuangzhou University of Chinese MedicineGuangzhou 510006China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Blocking the MDM2/X-P53 protein-protein interaction has been widely recognized as an attractive therapeutic strategy for the treatment of *** small-molecule MDM2 inhibitors have been reported since the release of the structure of the MDM2-P53 interaction in 1996,SAR405838,NVP-CGM097,MK-8242,RG7112,RG7388,DS-3032 b,and AMG232 currently undergo clinical evaluation for cancer *** review is intended to provide a comprehensive and updated overview of MDM2 inhibitors and proteolysis targeting chimera(PROTAC)degraders with a particular focus on how these inhibitors or degraders are identified from starting points,strategies employed,structure-activity relationship(SAR)studies,binding modes or co-crystal structures,biochemical data,mechanistic studies,and preclinical/clinical ***,we briefly discuss the challenges of designing MDM2/X inhibitors for cancer therapy such as dual MDM2/X inhibition,acquired resistance and toxicity of P53 activation as well as future directions.

关键词： MDM2/X-P53 interaction MDM2/X inhibitors PROTAC degraders Cancer therapy

Comprehensive review of targeted therapy for colorectal cancer

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2155-2184页

作者： yuan-Hong Xie Ying-Xuan Chen Jing-yuan fang Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseaseState Key Laboratory for Oncogenes and Related GenesKey Laboratory of Gastroenterology&HepatologyMinistry of HealthRenji HospitalSchool of MedicineShanghai Jiao Tong University145 Middle Shandong Road200001 ShanghaiChina

Colorectal cancer(CRC)is among the most lethal and prevalent malignancies in the world and was responsible for nearly 881,000 cancer-related deaths in *** and chemotherapy have long been the first choices for cancer ***,the prognosis of CRC has never been satisfying,especially for patients with metastatic *** therapy is a new optional approach that has successfully prolonged overall survival for CRC *** successes with the anti-EGFR(epidermal growth factor receptor)agent cetuximab and the anti-angiogenesis agent bevacizumab,new agents blocking different critical pathways as well as immune checkpoints are emerging at an unprecedented *** worldwide are currently updating the recommended targeted drugs on the basis of the increasing number of high-quality clinical *** review provides an overview of existing CRC-targeted agents and their underlying mechanisms,as well as a discussion of their limitations and future trends.

关键词： Surgery drugs chemotherapy

Influence of the microbiota on epigenetics in colorectal cancer

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National Science Review 2019年第6期6卷 1138-1148页

作者： Danfeng Sun Yingxuan Chen Jing-yuan fang Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health State Key Laboratory for Oncogenes and Related GenesShanghai Institute of Digestive DiseaseRenji Hospital School of Medicine Shanghai Jiao Tong University

Colorectal cancer is one of the most common malignancies and is the second leading cause of cancer death worldwide. Generally, there are three categories of colorectal cancer development mechanism—genetic,epigenetic and aberrant immunological signaling pathways—all of which may be initiated by an imbalanced gut microbiota. Epigenetic modifications enable host cells to change gene expression without modifying the gene sequence. The microbiota can interact with the host genome dynamically through the interface presented by epigenetic modifications. In particular, bacterially derived short-chain fatty acids have been identified as one clear link in the interaction of the microbiota with host epigenetic pathways. This review discusses recent findings relating to the cross talk between the microbiota and epigenetic modifications in colorectal cancer.

关键词： colorectal cancer gut microbiota epigenetics short-chain fatty acids