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Microseism Variations in Response to Antarctic Seasonal Changes in Sea Ice Extent

Earthquake Research in China 2020年第2期34卷 264-284页

作者： XU Xiaoqing LIN Jianmin fang sunke Marine Acoustics and Remote Sensing Laboratory Zhejiang Ocean UniversityZhoushan 316021China Key Laboratory of Ocean Observation-Imaging Testbed of Zhejiang Province Ocean CollegeZhejiang UniversityZhoushan 316021China State Key Laboratory of Marine Geology School of Ocean and Earth ScienceTongji UniversityShanghai 200092China

The temporal and spatial distributions of Antarctic sea ice play important roles in both the generation mechanisms and the signal characteristics of microseisms. This link paves the way for seismological investigations of Antarctic sea ice. Here we present an overview of the current state of seismological research about microseisms on Antarctic sea ice. We first briefly review satellite remote-sensing observations of Antarctic sea ice over the past 50 years. We then systematically expound upon the generation mechanisms and source distribution of microseisms in relation to seismic noise investigations of sea ice, and the characteristics of Antarctic microseisms and relationship with sea ice variations are further analyzed. We also analyze the continuous data recorded at seismic station BEAR in West Antarctica from 2011 to 2018 and compare the microseism observations with the corresponding satellite remotesensing observations of Antarctic sea ice. Our results show that:(1) the microseisms from the coastal regions of West Antarctica exhibit clear seasonal variations,SFM with maximum intensities every April-May and minimum intensities around every October-November;while DFM intensities peak every February-March,and reach the minimum around every October. Comparatively,the strong seasonal periodicity of Antarctic sea ice in better agreement with the observed DFM;and(2) microseism decay is not synchronous with sea ice expansion since the microseism intensity is also linked to the source location,source intensity(e. g.,ocean storms,ocean wave field),and other factors. Finally, we discuss the effect of Southern Annular Mode on Antarctic sea ice and microseisms,as well as the current limitations and potential of employing seismological investigations to elucidate Antarctic sea ice variations and climate change.

关键词： Antarctic sea ice Microseism Climate change Southern annular Mode

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台风“海鸥”激发地脉动源区的联合台阵定位研究

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地球物理学报 2021年第12期64卷 4341-4354页

作者：林建民方孙珂倪四道浙江省海洋观测-成像试验区重点实验室浙江大学浙江舟山316021 浙江大学海洋学院浙江舟山316021 大地测量与地球动力学国家重点实验室中科院精密测量科学与技术创新研究院武汉430071

利用台风所激发的P波地脉动信号,地震学家近年来开始尝试通过地震学方法定位、监测台风.由于单台阵定位精度的局限性(主要取决于台站数目、孔径和结构等),本文提出了将台阵至源区的距离作为归一化权重因子、结合反卷积技术的双台阵联合... 详细信息

利用台风所激发的P波地脉动信号,地震学家近年来开始尝试通过地震学方法定位、监测台风.由于单台阵定位精度的局限性(主要取决于台站数目、孔径和结构等),本文提出了将台阵至源区的距离作为归一化权重因子、结合反卷积技术的双台阵联合定位方法,并利用中国喜马拉雅二期台阵(ChinArray II)和日本高灵敏度地震台网(Hi\|net)的连续波形数据,对2014年西北太平洋强台风“海鸥”所激发的P波地脉动源区进行了定位测试.联合定位结果与理论模拟源区具有较好一致性:台风“海鸥”位于菲律宾海时,其激发海浪与台风“风神”遗留涌浪相互作用而激发的P波地脉动源区偏离“海鸥”移动轨迹;而当“海鸥”进入南海后,其激发的P波源区则紧随台风中心.与单台阵定位结果的对比分析表明,本文所提出的方法能够有效降低以下方面影响:(1)单台阵响应函数强旁瓣导致定位结果出现“伪影”、不聚焦;(2)台阵至源区距离小于~26°时,P波沿复杂浅地层传播时实际走时与基于理想地球模型的理论预测走时存在较大偏差导致近场定位误差增大;以及(3)上地幔三重震相的干扰等.因此,该方法有效提升了定位结果的聚焦性与稳定性,实现对“海鸥”激发P波地脉动源区的全程、稳定定位追踪,为发展基于地震学的台风监测新方法提供支持.

关键词：台风地脉动地震台阵定位

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基于地震学的台风监测研究

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地震学报 2023年第3期45卷 411-430页

作者：朱昕晖方孙珂林建民浙江海洋大学海洋科学与技术学院浙江舟山316021 浙江大学海洋学院浙江舟山316021 浙江大学浙江省海洋观测-成像试验区重点实验室浙江舟山316021

台风是全球最具破坏力的气象灾害之一,由于台风过境时现场海洋观测资料相对匮乏,与目前对台风的监测、预报和防灾减灾的迫切需求尚不相匹配。近年来,利用地震学观测资料与技术手段,通过台风激发的地震背景噪声,对台风进行监测的新方法... 详细信息

台风是全球最具破坏力的气象灾害之一,由于台风过境时现场海洋观测资料相对匮乏,与目前对台风的监测、预报和防灾减灾的迫切需求尚不相匹配。近年来,利用地震学观测资料与技术手段,通过台风激发的地震背景噪声,对台风进行监测的新方法逐渐兴起。本文对近年来有关台风激发地震背景噪声机理、源区分布以及基于地震背景噪声的台风定位追踪、海浪参数反演等研究进展进行综述,分析已取得的研究成果及可能存在的问题,讨论并展望基于地震学的台风监测研究思路与热点。基于地震学的台风监测有望为传统台风观测与研究提供跨学科的观测资料与技术支持。

关键词：台风地震背景噪声地脉动地震台阵聚束

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Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-Rong Wu Xiao-Hong He Yong-fang Xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： Wei-Tong Cui Hua-Ru Xue Dian-fang Wei Xiao-Yu Feng Kai Wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao fang Junfan fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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习近平关于新质生产力重要论述的理论体系和实践指向研究

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 60-68页

作者：方世南苏州大学东吴智库苏州大学马克思主义学院江苏省习近平新时代中国特色社会主义思想研究中心苏州大学基地江苏苏州215006

习近平总书记关于新质生产力重要论述深刻阐明了新质生产力的基本内涵、本质特征、鲜明标志、核心要素、形成规律以及实现路径等重大理论和实践问题,是具有重大原创性、标识性、系统性、实践性的理论创新成果,是习近平新时代中国特色社... 详细信息

习近平总书记关于新质生产力重要论述深刻阐明了新质生产力的基本内涵、本质特征、鲜明标志、核心要素、形成规律以及实现路径等重大理论和实践问题,是具有重大原创性、标识性、系统性、实践性的理论创新成果,是习近平新时代中国特色社会主义思想的重要组成部分。习近平总书记关于新质生产力重要论述是在推进中国式现代化进程中形成的新的生产力理论,是指导我国经济社会高质量发展的学理化、体系化的理论体系,是具有深邃而丰富辩证法则的实践指向。

关键词：中国式现代化新质生产力重要论述理论体系实践指向

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