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红前期疟疾疫苗研究进展

中国热带医学 2024年第4期24卷 400-406,421页

作者：方强曹玉洁夏惠蚌埠医科大学安徽蚌埠233030

疟疾是一种危害严重的全球性传染疾病,曾在我国严重肆虐。近年来全球疟疾防控形势停滞不前,我国也面临巨大输入性疟疾威胁,亟需有效的疟疾疫苗作为现有防控措施之外的新增手段。相对于红内期疫苗和传播阻断疫苗,以预防感染为主要目标的... 详细信息

疟疾是一种危害严重的全球性传染疾病,曾在我国严重肆虐。近年来全球疟疾防控形势停滞不前,我国也面临巨大输入性疟疾威胁,亟需有效的疟疾疫苗作为现有防控措施之外的新增手段。相对于红内期疫苗和传播阻断疫苗,以预防感染为主要目标的红前期疫苗一直受到更多的关注,并在近年取得一系列进展。目前仅有的2款获WHO推荐使用的疟疾疫苗均为红前期疫苗。本文简要综述红前期疟疾疫苗研发现状和趋势,以期为后续疟疾疫苗研发与应用提供参考。

关键词：疟疾红前期疫苗疟原虫

基于技术接受模型的双语直播带货中英汉语使用研究:以东方甄选为例

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湖州师范学院学报 2024年第3期46卷 98-105页

作者：方强燕山大学外国语学院河北秦皇岛066000

应用技术接受模型分析东方甄选双语直播间英汉语在时长、频率、编码的信息类型和语境等方面的异同。研究发现:英汉语均可用于编码技术信息模型中的商品信息介绍、信息接受和直播趣味性提高等方面,而场景信息和商品背景信息一般只编码为... 详细信息

应用技术接受模型分析东方甄选双语直播间英汉语在时长、频率、编码的信息类型和语境等方面的异同。研究发现:英汉语均可用于编码技术信息模型中的商品信息介绍、信息接受和直播趣味性提高等方面,而场景信息和商品背景信息一般只编码为汉语。直播初期和直播火爆后,直播的交际目的不同。直播初期,直播目的是提升直播间和主播的信任度,故而英语是重要的人气提升手段;直播火爆后,商品销售(信息接受)是直播的目的,英语的使用量、地位和作用等明显降低。

关键词：双语直播技术接受模型交际目的东方甄选

Complications associated with the apnea test in the determination of the brain death

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Chinese Medical Journal 2008年第13期121卷 1169-1172页

作者： WU Xiao-liang fang qiang LI Li QIU Yun-qing LUO Ben-yan Department of Intensive Care Unit First Affiliated Hospital of College of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Infectious Disease First Affiliated Hospital of College of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Neurology First Affiliated Hospital of College of Medicine Zhejiang University Hangzhou Zhejiang 310003 China

Background An apnea test is essential in the clinical determination of brain death. This study was conducted to analyse complications associated with the apnea test in the determination of the brain death. Methods On 93 adult patients in coma in Zhejiang Province of China from January 2003 to December 2006, 179 apnea tests were performed as a part of the determination of brain death. Potential risk conditions and complications were analysed during apnea tests. Results During apnea, serious cardiac arrhythmia did not occur in all patients. Complications occurred in 37 of 179 （21%） apnea tests. Hypotension occurred in 30 patients （17%） and it was observed in 8/94 （9%） tests with baseline value of systolic arterial blood pressure not less than 120 mmHg, and 22/85 （26%） less than 120 mmHg （P 〈0.05）. Severe hypoxaemia occurred in 10 patients （6%） of which 3/138 （2%） tests with baseline value of arterial oxygen pressure not less than 200 mmHg, and 7/41 （17%） less than 200 mmHg （P 〈0.05）. Conclusions This study demonstrated that complications occurred mostly in patients with inadequate baseline systolic arterial blood pressure and preoxygenation. Adequate precautions during the apnea tests may reduce the risk of cardiovascular and oxygenation complication.

关键词： apnea test brain death complications

基于ITS2序列及其二级结构对矩镰荚苜蓿和近缘种的分子鉴定

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西北农业学报 2024年第3期33卷 397-405页

作者：王霞刘艳贾秀秀方强恩甘肃农业大学草业学院草业生态系统教育部重点实验室中-美草地畜牧业可持续发展研究中心兰州730070

为准确鉴定矩镰荚苜蓿(Medicagoarchiducis-nicolai)及其近缘种花苜蓿(M.ruthenica)、阔荚苜蓿(M.platycarpos)和毛荚苜蓿(M.edgeworthii),利用DNA条形码技术对4个物种的ITS2序列进行注释、比对、检验,计算种内种间遗传距离,邻接法(neighbor-joining, NJ)构建系统发育树,通过RNAfoldwebserver预测4个近缘种的ITS2二级结构。结果显示,矩镰荚苜蓿及其近缘种的ITS2序列长度为220~221 bp,稳定性好;种间遗传距离(0.004 55~0.022 73)明显大于种内遗传距离(均为0),存在明显的“BarcodingGap”区域;NJ系统发育树显示,毛荚苜蓿聚为一支,矩镰荚苜蓿、花苜蓿和阔荚苜蓿聚为另一支,然后矩镰荚苜蓿与阔荚苜蓿又各自形成单系;在二级结构中,矩镰荚苜蓿与阔荚苜蓿、毛荚苜蓿存在明显差异,但与花苜蓿极为相似,难以区分。分析表明:除花苜蓿外,以ITS2序列作为条形码并辅以二级结构,可以达到对矩镰荚苜蓿、阔荚苜蓿和毛荚苜蓿准确、快速鉴定的目的。

关键词：矩镰荚苜蓿 ITS2序列二级结构分子鉴定

A Floating Astronomical Time Scale for the Early Late Cretaceous Continental Strata in the Songliao Basin, Northeastern China

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Acta Geologica Sinica(English Edition) 2020年第1期94卷 27-37页

作者： MA Xiaojuan WU Huaichun fang qiang SHI Meinan ZHANG Shihong YANG Tianshui LI Haiyan WANG Chengshan Schoolof Ocean Sciences China University of GeosciencesBeijing 100083China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China

A continuous terrestrial succession was recovered from the Songke-2(SK-2)borehole in the Songliao Basin,Northeastern China.This borehole provides a unique material for further research on the continental paleoclimate during Cretaceous greenhouse period,following a series of achievements of the Songke-1(SK-1)core.In this study,thorium(Th)logging data were chosen as a paleoclimate proxy to conduct a detailed cyclostratigraphic analysis.The Th series varies quasi-periodically;power spectra and evolutionary fast Fourier transformation(FFT)analysis reveal significant cycles in the Quantou(K2 q),Qingshankou(K2 qn),Yaojia(K2 y)and Nenjiang(K2 n)formations.The ratio of cycle wavelengths in these stratigraphic units is approximately 20:5:2:1,corresponding to long orbital eccentricity(405 kyr),short orbital eccentricity(100 kyr),obliquity(37 kyr),and precession cycles(22.5 kyr and 18.4 kyr).The durations of the K2 n,K2 y,K2 qn and K2 q are estimated as 6.97,1.83,5.30 and 4.52 Myr,respectively,based on the constructed^18.62 Myr"floating"astronomical time scale(ATS).Comparison of the durations between the SK-1 s and SK-2 boreholes exhibits a slight difference of 0.06 Myr and 0.459 Myr for K2 qn and K2 y.Nevertheless,our ATS of K2 n supports the chronostratigraphic frame constructed by the CA-ID-TIMS data of the SK-1 s borehole.This new"floating"ATS provides precise numerical ages for stratigraphic boundaries,biozones and geological events in the Songliao Basin,and can serve as a basis for correlation of strata and events between marine and terrestrial systems.

关键词： Late Cretaceous SK-2 borehole cyclostratigraphy astronomical time scale Songliao Basin northeastern China

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聚丙烯非均相阳离子交换膜制备工艺的优化

能源研究与管理 2024年第2期16卷 79-85页

作者：袁冶刘隽方强武汉工程大学材料科学与工程学院武汉430205 武汉力强复合材料有限公司武汉430223

为提高电去离子(EDI)设备中离子交换膜的性能,探讨了采用热压工艺代替传统压延工艺制备聚丙烯非均相离子交换膜的方法。将聚丙烯作为基础骨架材料与离子交换树脂混合,将材料放置在模具中,并通过热压机热压成型。这种方法旨在增加膜内离... 详细信息

为提高电去离子(EDI)设备中离子交换膜的性能,探讨了采用热压工艺代替传统压延工艺制备聚丙烯非均相离子交换膜的方法。将聚丙烯作为基础骨架材料与离子交换树脂混合,将材料放置在模具中,并通过热压机热压成型。这种方法旨在增加膜内离子交换树脂含量,以提升离子交换效率,同时减少生产过程中的边角料浪费,降低成本。通过实验对比得到阳离子交换树脂含量为64%时为最佳配方,在此配方下进一步优化得到最佳制备条件为热压温度230℃、压力30 MPa,该条件下制备出的阳离子交换膜的离子交换容量提升至2.351 mmol/g,离子迁移率可以保持在0.895。研究表明通过调整热压条件——温度、压力及离子交换树脂的含量,最终制备出的阳离子交换膜性能获得了显著提升。

关键词：离子交换膜聚丙烯连续电除盐技术非均相阳离子交换膜

INCORPERATING ARTICULATORY VELOCITY INFORMATION IN ACOUSTIC-TO-ARTICULATORY INVERSION

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中国语音学报 2021年第1期 147-153页

作者： fang qiang Institute of Linguistics Chinese Academy of Social Sciences

Conventional acoustic-to-articulatory inversion methods usually train mappings by using maximum likelihood or least square criterion,which assume that all the articulatory channels are equally important.However,different articulatory channels play different roles in speech production.In this paper,to account for this in acoustic-to-articulatory inversion,the importance of each articulatory channel is modeled as an exponential function of its corresponding velocity profile,and incorporated into the conventional least square loss function.The proposed loss function is applied to optimize a batch normalized Deep Neural Network(DNN)for acoustic-to-articulatory inversion.The result indicates that the DNN trained with the proposed cost function outperforms the DNN trained with traditional cost function for most articulatory channels.

关键词： Batch normalized DNN Acoustic-to-articulatory inversion Critical articulator

A Robust Algorithm Based on Object Contours and Order Matching for Disparity Map Post-Processing

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The Journal of China Universities of Posts and Telecommunications 2002年第1期9卷 13-17页

作者： Wu Yong-jun Wu Yan fang qiang School of Electronics &Information Engineering Xi'an Jiaotong University Xi'an 710049 P.R. China Xi'an Institute of Post &Telecommunications Xi'an 710061 P.R. China

Based on the feature of stereo images' content and the property of natural objects, we redefine the general order matching constraint with object contour restriction. According to the modified order matching constraint, we propose a robust algorithm for disparity map post processing. Verified by computer simulations using synthetic stereo images with given disparities, our new algorithm proves to be not only efficient in disparity error detection and correction, but also very robust, which can resolve the severe problem in the algorithm proposed in Ref. that if there are large differences among the depths of objects in a scene, the algorithm will make mistakes during the process of disparity error detection and correction.

关键词： object contour global order matching constraint disparity map post processing

缺陷CuAg催化剂的构筑及电催化CO_(2)还原制备C_(2+)产物

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高等学校化学学报 2024年第7期45卷 156-165页

作者：井慧芳刘毅房强郎学磊郝根彦钟达忠李晋平赵强太原理工大学化学工程与技术学院气体能源高效清洁利用山西省重点实验室太原030024 山西工学院能源工程学院朔州036000

通过电化学还原Ag/Cu(OH)2构筑得到了富含缺陷位点的Ag/Cu-OH催化剂,与Ag/CuO前驱体电化学还原获得的Ag/Cu-O相比,其表现出更好的电催化二氧化碳还原反应(CO_(2)RR)制备C_(2+)产物的选择性.在H型电解槽(H-cell)中评估了催化剂的电催化性... 详细信息

通过电化学还原Ag/Cu(OH)2构筑得到了富含缺陷位点的Ag/Cu-OH催化剂,与Ag/CuO前驱体电化学还原获得的Ag/Cu-O相比,其表现出更好的电催化二氧化碳还原反应(CO_(2)RR)制备C_(2+)产物的选择性.在H型电解槽(H-cell)中评估了催化剂的电催化性能,Ag2%/Cu-OH表现出比Ag2%/Cu-O高1.5倍的乙烯(C_(2)H_(4))法拉第效率(FE)和高1.3倍的C_(2+)法拉第效率.在接近实际应用的膜电极组件(MEA)中,Ag2%/Cu-OH在高达375 mA/cm^(2)的电流密度下,表现出高达56.2%的C_(2)H_(4)法拉第效率.Ag2%/Cu-OH性能的提高不仅归因于Cu和Ag之间的协同作用,还归因于具有更多的低配位Cu缺陷位点,低配位Cu有利于*CO的吸附,进一步促进了^(*)CO二聚为C_(2+)产物.

关键词：二氧化碳还原反应电催化缺陷位点乙烯产物 C_(2+)产物