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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang Hao Nian Yan-fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Validation method for simulation models with cross iteration

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Journal of Systems Engineering and Electronics 2019年第3期30卷 555-563页

作者： fang ke ZHAO Kaibin ZHOU Yuchen Control and Simulation Center Harbin Institute of Technology

Cross iteration often exists in the computational process of the simulation models, especially for control models. There is a credibility defect tracing problem in the validation of models with cross iteration. In order to resolve this problem, after the problem formulation, a validation theorem on the cross iteration is proposed, and the proof of the theorem is given under the cross iteration circumstance. Meanwhile, applying the proposed theorem, the credibility calculation algorithm is provided, and the solvent of the defect tracing is explained. Further, based on the validation theorem on the cross iteration, a validation method for simulation models with the cross iteration is proposed, which is illustrated by a flowchart step by step. Finally, a validation example of a sixdegree of freedom (DOF) flight vehicle model is provided, and the validation process is performed by using the validation method. The result analysis shows that the method is effective to obtain the credibility of the model and accomplish the defect tracing of the validation.

关键词： validation method simulation model cross iteration validation theorem validation example

Generalized bounds on the partial periodic correlation of complex roots of unity sequence set

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 207-210页

作者： Li-fang feng Institute of Mobile Communication Southwest Jiaotong University Chengdu 610031 China

In this paper,the generalized bounds are derived on the partial periodic correlation of complex roots of unity sequence set with zero or low correlation zone(ZCZ/LCZ)as the important criteria of the sequence design and *** derived bounds are with respect to family size,subsequence length,maximum partial autocorrelation sidelobe,maximum partial cross-correlation value and the ZCZ/*** results show that the derived bounds include the previous periodic bounds,such as Sarwate bound,Welch bound,Peng-Fan bound and Paterson-Lothian bound,as special cases.

关键词： Partial correlation Zero correlation zone (ZCZ) Low correlation zone (LCZ) CDMA

INVESTIGATION OF THE FLOW IN FRACTAL RESERVOIR INCLUDING THE EFFECTS OF QUADRATIC GRADIENT TERM

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Journal of Hydrodynamics 2004年第4期16卷 474-480页

作者： YAOYue-dong LIXiang-fang TONGDeng-ke InstituteofPetroleumandGasEngineering UniversityofPetroleumBeijing102249China DepartmentofAppliedMathematics UniversityofPetroleumDongying257062China

According to the assumption of slightly compressible fluid, the quadraticgradient term in the nonlinear partial differential equations for the traditional well-test model isusually neglected. The linear partial differential equation is thus established. It is known thatneglecting the quadratic gradient term results in errors for long-time well tests. A nonlinear flowmodel for fractal medium is constructed and the quadratic gradient term is considered. The exactsolutions of the fractal reservoir models are obtained by Laplace transform and Weber transform in aconstant-rate and constant-pressure production for an infinitely large system. This paper addressesthe variation of pressure with fluid compressibility coefficient and fractal reservoir *** plots of the typical pressure curves are constructed, and the results can be applied towell-test analysis.

关键词： fractal model nonlinear exact solution typical curve plots well test

Simulation of Horizontal-Two-Dimension Focused Waves Using A Two-Layer Boussinesq-Type Model

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China Ocean Engineering 2023年第5期37卷 725-737页

作者： ZOU Wen-feng WANG Ping LIU Zhong-bo fang ke-zhao SUN Jia-wen ZHANG Ning-chuan key Laboratory of coastal and offshore engineering Dalian University of TechnologyDalian 116024China State Environmental Protection key Laboratory of Marine Ecosystem Restoration National Marine Environmental Monitoring CenterDalian 116023China Dalian Maritime University College of Transportation EngineeringDalian 116024China

Accurate simulation of the horizontal-two-dimension(H2D)focused wave group in deep water requires high accuracy of a numerical *** two-layer Boussinesq-type model(Liu and fang,2016;Liu et al.,2018)with the highest spatial derivative of 2 has high accuracy in both linear and nonlinear *** on the further development of the velocity equations(Liu et al.,2023),the H2D numerical model for water waves is established with the prediction-correction-iteration model in the finite difference method,and a composite fourth-order Adams-Bashforth-Moulton scheme is used for time *** wave generation method proposed by Hsiao et al.(2005)is applied and calibrated in this H2D *** numerical calculations lead to the following three main conclusions:First,compared with the analytical solution of Stokes linear waves,the calculated velocity profiles show higher accuracy by using the improved velocity ***,the simulations of the focused multidirectional wave group are carried out,and good agreements are found,demonstrating that the present H2D numerical model shows high accuracy in simulating focused multidirectional wave groups,and the effectiveness of the improved velocity formulas is also ***,the velocity profiles throughout the computational domain at the time of maximum wave crest are ***,the FFT method is used to obtain the amplitude with different frequencies for several locations,and the changes of the wavelet energy spectrum at different locations are presented for several cases.

关键词： focused wave horizontal-two-dimension model finite difference method nonlinear property

Authenticating Tripartite key Agreement Protocol with Pairings

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Journal of Computer Science & Technology 2004年第2期19卷 169-176页

作者： Sheng-LiLiu fang-GuoZhang ke-FeiChen DepartmentofComputerScienceandEngineering ShanghaiJiaoTongUniversityShanghai200030P.R.China SchoolofInformationScienceandTechnology ZhongshanUniversityGuangzhou510275P.R.China

In this paper, an authenticated tripartite key agreement protocol is proposed, which is an ID-based one with pairings. This protocol involves only one round. The authenticity of the protocol is assured by a special signature scheme, so that messages carrying the information of two ephemeral keys can be broadcasted authentically by an entity. Consequently, one instance of the protocol results in eight session keys for three entities. In other word, one instance of the protocol generates a session key, which is eight times longer than those obtained from traditional key agreement protocols. Security attributes of the protocol are presented, and the computational overhead and bandwidth of the broadcast messages are analyzed as well.

关键词： key agreement bilinear pairing identity-based cryptography

Analysis and Inverse Substructuring Computation on Dynamic Quality of Mechanical Assembly

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 539-548页

作者： Lü Guangqing YI Chuijie fang ke key Lab of Disasters Forecast and Control in Engineering of Ministry of Education Jinan University Research Center of Equipment Energy & Environment Qingdao Technological University

Mechanical assembly has its own dynamic quality directly affecting the dynamic quality of whole product and should be considered in quality inspection and estimation of mechanical assembly. Based on functional relations between dynamic characteristics involved in mechanical assembly, the effects of assembling process on dynamic characteristics of substructural components of an assembly system are investigated by substructuring analysis. Assembly-coupling dynamic stiffness is clarified as the dominant factor of the effects and can be used as a quantitative measure of assembly dynamic quality. Two computational schemes using frequency response functions（FRFs） to determine the stiffness are provided and discussed by inverse substructuring analysis, including their applicable conditions and implementation procedure in application. Eigenvalue analysis on matrix-ratios of FRFs before and after assembling is employed and well validates the analytical outcomes and the schemes via both a lumped-parameter model and its analogic experimental counterpart. Applying the two schemes to inspect the dynamic quality provides the message of dynamic performance of the assembly system, and therefore improves conventional quality inspection and estimation of mechanical assembly in completeness.

关键词： mechanical assembly dynamic quality substructuring analysis inverse substructuring assembly-coupling dynamic stiffness

Effect of Ag and Ni on the melting point and solderability of SnSbCu solder alloys

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International Journal of Minerals,Metallurgy and Materials 2009年第6期16卷 691-695页

作者： Yan-fu Yan Yan-sheng Wang Li-fang feng ke-xing Song Jiu-ba Wen Henan key Laboratory of Advanced Non-ferrous Metals Luoyang 471003 China Architecture and Civil Engineering Institute Henan University of Science and Technology Luoyang 471003 China

To improve the properties of Sn10Sb8Cu solder alloy, two new solders （SnSbCuAg and SnSbCuNi） were formed by adding small amounts of Ag or Ni into the solder alloy. The results show that the melting point of the SnSbCuAg solder alloy decreases by 14.1℃ and the spreading area increases by 16.5% compared to the matrix solder. The melting point of the SnSbCuNi solder alloy decreases by 5.4℃ and the spreading area is slightly less than that of the matrix solder. Microstructure analysis shows that adding trace Ag makes the melting point decline due to the dispersed distribution of SnAg phase with low melting point. Adding trace Ni, Cu6Sn5 and （Cu, Ni）6Sn5 with polyhedron shape on the copper substrate can be easily seen in the SnSbCuNi solder alloy, which makes the viscosity of the melting solder increase and the spreading property of the solder decline.

关键词： solder alloy Ag Ni melting point solderability