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Preliminary single-arm study of brain effects during transcutaneous auricular vagus nerve stimulation treatment of recurrent depression by resting-state functional magnetic resonance imaging

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Journal of Traditional Chinese Medicine 2022年第5期42卷 818-824页

作者： CHEN Limei SUN Jifei GUO Chunlei LI Xiaojiao WANG Zhi Hong Yang fang jiliang Radiology Department Guang'anmen Hospital of China Academy of Chinese Medical SciencesBeijing 10003China

OBJECTIVE:To examine the brain effects of transcutaneous auricular vagus nerve stimulation(ta VNS)treatment of recurrent depression based on the functional brain network by using resting-state functional magnetic resonance imaging(f MRI).METHODS:Twenty-five patients with recurrent depression were enrolled in a single-arm trial of ta VNS treatment for eight *** results were assessed by 17-item Hamilton Depression Rating Scale(HAMD-17),Hamilton Anxiety Scale(HAMA),Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS),and Ruminative Response Scale(RRS)***-state f MRI was conducted to explore the brain effects before and after *** the functional connectivity(FC)analysis,the bilateral nucleus accumbens,globus pallidus,caudate,and putamen were selected as ***,the correlations between FC and the clinical scale scores were ***:After treatment,the patients’scores of HAMD-17,HAMA,SDS,SAS,and RRS were significantly decreased(P<0.05).FC was considerably decreased between the following areas:the left globus pallidus and the right postcentral gyrus,inferior parietal gyrus,the right globus pallidus and the left superior marginal gyrus,postcentral gyrus,superior parietal gyrus,inferior parietal gyrus,precuneus,right postcentral gyrus,superior marginal gyrus,and inferior parietal gyrus,between the right caudate and the right lingual gyrus,calcarine gyrus,and *** in FC between the right globus pallidus and the left inferior parietal gyrus,between the left globus pallidus and the right postcentral gyrus were negatively correlated with HAMD-17 scores change before and after treatment(before,P=0.003,r=-0.6;after,P=0.009,r=-0.54).The change of FC between the right globus pallidus and the right postcentral gyrus was negatively correlated with the change in SDS(P=0.026,r=-0.474).The difference in FC between the right globus pallidus and the right postcentral gyrus was negatively correlated with the change in

关键词： recurrence depression magnetic resonance imaging basal ganglia default mode network transcutaneous auricular vagus nerve stimulation

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Transcutaneous auricular vagus nerve stimulation would be an alternative to implantable cervical vagus nerve stimulation in some situation

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Journal of Traditional Chinese Medicine 2023年第3期43卷 627-630页

作者： HE Jiakai ZHANG Jinling WANG Yu LI Shaoyuan fang jiliang ZHANG Shuai ZHAO Yanan ZHAI Weihang GAO Deqiang LI Ran JIANG Yuhang CHEN Zehao JIA Baohui RONG Peijing Department of Physiology Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China Department of Physical Medicine and Rehabilitation Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

Implantable cervical vagus nerve stimulation(i VNS) is a representative and promising ***,the invasive nature restricts its *** auricular acupuncture treatment has a long *** auricular branch of the vagus nerve(ABVN) is a branch on the surface of the *** studies demonstrates that transcutaneous auricular vagus nerve stimulation(ta VNS) would achieve similar effects as i *** VNS and i VNS share a common anatomical basis and acting *** this article,we made a comparison between i VNS and ta VNS in indications and *** recent studies have revealed similar clinical efficacy of ta VNS,ta VNS would expand the indication of i *** clinical evidences are needed before ta VNS become be an alternative of i VNS.

关键词： transcutaneous auricular vagus nerve stimulation auricular branch of vagus nerve neuromodulation efficacy

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Effects of three needling manipulations of the right-side Zusanli(ST 36) on brain using functional magnetic resonance imaging

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Journal of Traditional Chinese Medicine 2017年第3期37卷 298-307页

作者： Lu Fengyan Gao Junhong Wang Yuanyuan Dai Qiufu Bao Yan Hong Yang Zhang Guolei Xin Juanjuan Zhao Yuxue Wu Shuyang Chen Yuanyuan Li Xiaojiao fang jiliang Yu Xiaochun Department of Needling Manipulation Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Department of medical imaging Guang An Men Hospital China Academy of Chinese Medical Sciences

OBJECTIVE: To investigate the effects on the brain using three needling manipulations(twirling, lifting-thrusting, and twirling plus lifting-thrusting)when the right-side Zusanli(ST 36) acupoint was stimulated with ***: Seventeen healthy subjects accepted three needling manipulations stimulating the right Zusanli(ST 36) over separate days. Functional magnetic resonance imaging was used to detect changes in the brain during the manipulations, and then the needling sensations were recorded using the MGH acupuncture sensation scale(MASS) after each scan. f MRI data were processed using Statistical Parametric Mapping 8 to analyze the positiveand negative activation in the brain induced by different acupuncture ***: The individual needling sensations showed no statistically significant differences among the three manipulations. However, the MASS index showed that lifting-thrusting > twirling plus lifting-thrusting > twirling. Lifting-thrusting activated left premotor cortex, left postcentral,right middle frontal gyrus, left inferior frontal gyrus,right lingual gyrus, left insula, right putamen, bilateral cingulate gyrus and right cerebellum; and deactivated bilateral hippocampus and left *** activated bilateral orbital middle frontal gyrus, left opercular and triangular inferior frontal gyrus, and right middle occipital gyrus; and deactivated bilateral precuneus, right amygdala, left anterior cingulate gyrus, right inferior temporal gyrus,right middle frontal gyrus, right supplementary motor gyrus, and left postcentral. Twirling plus lifting-thrusting activated bilateral postcentral, left inferior occipital gyrus, left insula, left thalamus, left cingulate gyrus, and right putamen; and deactivated right superior frontal gyrus, right superior parietal gyrus, right temporal gyrus, right middle occipital gyrus, right insula, and left lingual gyrus. Pairwise comparisons of the three manipulations showed that signals induced by lifti

关键词： Needling methods Point ST 36 (Zusan-li) Magnetic resonance imaging Limbic system Neocortex

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Design of Embedded High-Speed Data Sapmling System Based on ARM And DSP

Design of Embedded High-Speed Data Sapmling System Based on ...

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第一届国际测量仪器与测试自动化学术会议

作者： Liang Yongfeng fang Dawei (China jiliang University Hangzhou 310018 China)

＜正＞A embedded high-speed data sampling system based on ARM and DSP was presented in this paper. The import, export and display in the system were controlled by S3C44B0X whose kernel was *** data which had been converted by AD Converter was processed by DSP *** of the FIFO as a buffer between AD Converter and TMSC6713. data sampling and processing can run at high speed. After having been processed by TMSC6713. the data was send to S3C44B0X for saving and displaying through HPI channels. Besides, the system migrated real-time embedded operating system（uC/OS II ）.and all tasks of the system was given. The design is fit for high-speed data sampling system and it can be helpful in structure for instrument.

关键词： ARM DSP data sampling.

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A GEOLOGICAL STUDY ON STONE ANCHORS FOUND IN THE WESTERN COAST OFFSHORE OF CALIFORNIA

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Scientia Geologica Sinica 1998年第1期 65-73页

作者： fang Aimin, Li jiliang, Liu Xiaohan and Xu Wenli Laboratory of Lithosphere Tectonic Evolution, Institute of Geology, Chinese Academy of Sciences, Beijing, 100029

ＡＧＥＯＬＯＧＩＣＡＬＳＴＵＤＹＯＮＳＴＯＮＥＡＮＣＨＯＲＳＦＯＵＮＤＩＮＴＨＥＷＥＳＴＥＲＮＣＯＡＳＴＯＦＦＳＨＯＲＥＯＦＣＡＬＩＦＯＲＮＩＡＦａｎｇＡｉｍｉｎ，ＬｉＪｉｌｉａｎｇ，ＬｉｕＸｉａｏｈａｎａｎｄＸｕＷ... 详细信息

ＡＧＥＯＬＯＧＩＣＡＬＳＴＵＤＹＯＮＳＴＯＮＥＡＮＣＨＯＲＳＦＯＵＮＤＩＮＴＨＥＷＥＳＴＥＲＮＣＯＡＳＴＯＦＦＳＨＯＲＥＯＦＣＡＬＩＦＯＲＮＩＡＦａｎｇＡｉｍｉｎ，ＬｉＪｉｌｉａｎｇ，ＬｉｕＸｉａｏｈａｎａｎｄＸｕＷｅｎｌｉＬａｂｏｒａｔｏｒｙｏｆＬ...

关键词： FOUND

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THE BRAIN NETWORK INVOLVING IN ACUPUNCTURE IN TREATING FUNCTIONAL DYSPEPSIA — A RESTING STATE fMRI STUDY

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Journal of Integrative Medicine 2014年第3期 244-244页

作者： jiliang fang Guang ’anmen Hospital China Academy of Chinese Medical Sciences

Background: Acupuncture has been used to treat GI symptoms by altering acid secretion, GI motility, and visceral ***,the mechanism behind the beneficial effects remains *** this study, effects of acupuncture on the brain in treating functional dyspepsia(FD) are investigated by ***: Eight FD patients were recruited according to the Rome III criteria, with 8 healthy volunteers as *** resting fMRI was conducted in patients as well as the healthy subjects before and after one-month ***, the Symptom Index of Dyspepsia was scored, and the gastric motility barium meal dynamic radiography was monitored in one-minute video,and the serum gastrin(GS) was tested before and after *** clinical data were analyzed with SPSS *** resting fMRI data, the degree of local connectivity(LC) at each voxel of the brain and the functional connectivity(FC) maps based on a set of seeds were computed, then the comparison between patients and the control was conducted, the regions showing patient/control difference were then masked with the regions showing changes before/after ***: LC and FC were reduced in FD patients, and were improved after acupuncture *** score of Symptom Index of Dyspepsia in FD was significantly higher than healthy subjects before treatment, while it was decreased after *** imaging indices of gastric motility and GAS were close to the normal level after acupuncture, including the height of gastric retention liquid, the width of midgastric transverse band, the frequency of peristole and the time of ***: Acupuncture improved the brain network of FD involving the attention, emotion, cognition, control and default *** is consistent with the acupuncture effects for relieving clinical symptoms, enhancing gastric motility and increasing the level of gastrin.

关键词： fMRI A RESTING STATE fMRI STUDY THE BRAIN NETWORK INVOLVING IN ACUPUNCTURE IN TREATING FUNCTIONAL DYSPEPSIA

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CT定位下风府穴安全进针深度研究

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中国针灸 2000年第12期20卷 729-730页

作者：方继良张民王映辉中国中医研究院广安门医院北京100053

本文初步研究了CT定位下风府穴安全进针深度 ,说明其与颈围、体重有较好的直线相关性 ,可利用此两指标求得相应个体的安全深度。结果显示 :鼻尖方向针刺风府穴可损伤延髓 ,针刺安全深度男性为 5 5 71± 7 1 8mm ,女性为 43 83± 5 81m... 详细信息

本文初步研究了CT定位下风府穴安全进针深度 ,说明其与颈围、体重有较好的直线相关性 ,可利用此两指标求得相应个体的安全深度。结果显示 :鼻尖方向针刺风府穴可损伤延髓 ,针刺安全深度男性为 5 5 71± 7 1 8mm ,女性为 43 83± 5 81mm ,有显著差异。

关键词：针刺深度 CT定位风府穴安全深度

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从针灸影像研究到针灸治疗脑病新技术实践体会

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中国中西医结合影像学杂志 2019年第4期17卷 331-333页

作者：许可方继良中国中医科学院广安门医院

针灸脑效应已成为中西医结合影像学研究热点,目前在穴位特异性、针刺模式、针灸治疗疾病机制等方面均有较大进展.针灸治疗疾病机制研究中对抑郁症的研究较深入.探寻脑网络与临床疗效关系是机制研究的重点,影像学特征标签预测针灸疗效是... 详细信息

针灸脑效应已成为中西医结合影像学研究热点,目前在穴位特异性、针刺模式、针灸治疗疾病机制等方面均有较大进展.针灸治疗疾病机制研究中对抑郁症的研究较深入.探寻脑网络与临床疗效关系是机制研究的重点,影像学特征标签预测针灸疗效是研究的新方向.

关键词：针刺脑功能影像抑郁症经皮耳迷走神经刺激术

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Auricular vagus nerve acupressure for patients with emotional distress under the COVID-19 pandemic:A smartphone-based,randomized controlled trial

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TMR Modern Herbal Medicine 2021年第2期4卷 1-14页

作者： Peijing Rong Lei Wang Lingling Yu Junying Wang Yan Ma Liting Wang Suxia Li Chunzhi Tang Liming Lu Liang Li Jiazi Dong jiliang fang Liwei Hou Zongshi Qin Xiaolan Su Zhangjin Zhang Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijingChina.2 Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Rehabilitation Wuhan No.1 HospitalWuhanHubeiChina Department of Electronic Engineering Tsinghua UniversityBeijingChina National Institute of Drug Dependence Peking UniversityBeijingChina Medical College of Acu-Moxi and Rehabilitation Guangzhou University of Chinese MedicineGuangzhouChina School of Acupuncture Moxibustion and TuinaLiaoning University of Traditional Chinese MedicineShenyangChina Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijingChina School of Chinese Medicine LKS Faculty of Medicinethe University of Hong KongHong KongChina Wangjing Hospital China Academy of Chinese Medical SciencesBeijingChina National Data Center of Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijingChina.

Objective: To confirm whether self-administered AVNA treatment is effective in improving emotional distressunder the COVID-19 ***: A smartphone-based online, randomized, controlled trial was designed from 26 February 2020 to 28April 2020 in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China. Local residentswho had considerable emotional distress with a score of the Hospital Anxiety and Depression Scale (HADS) ≥9 were recruited. Participants were randomly assigned to three times of AVNA (n = 191) per day, in morning,around noon, and in evening or usual care (UC, n = 215) once daily for 14 days. The primary outcome was theresponse rate, which was the proportion of participants whose Hospital Anxiety and Depression Scale (HADS)score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 ***: The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%,P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reductionin scores of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effectsize of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep qualitybeing remarkably higher than those with UC at ***: During COVID-19 pandemic period, treatment with self-administrated AVNA was more effectivethan UC in reducing emotional distress of isolated populations. These findings support self-administered AVNAas a treatment option for patients with emotional distress under the COVID-19 pandemic or other emergentevents.

关键词： Neurology,Psychiatry Emotional distress Auricular vagus nerve stimulation COVID-19

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现代脑功能磁共振诠释传统针刺机制

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磁共振成像 2020年第2期11卷 81-83页

作者：方继良荣培晶刘波中国中医科学院广安门医院放射科北京100053 中国中医科学院针灸研究所北京100700 广东省中医院放射科广州510120

功能磁共振成像(functional MRI,fMRI)近年在针灸脑效应、针灸治病脑机制研究的应用逐渐增多,取得了新的进展。研究在健康受试者及患者的治疗前后进行,采用任务态、静息态、脑结构等多模态成像方法,观察针刺后的脑形态、功能激活及网络... 详细信息

功能磁共振成像(functional MRI,fMRI)近年在针灸脑效应、针灸治病脑机制研究的应用逐渐增多,取得了新的进展。研究在健康受试者及患者的治疗前后进行,采用任务态、静息态、脑结构等多模态成像方法,观察针刺后的脑形态、功能激活及网络的变化,初步发现了人体经穴针刺的脑效应特征,特别是针灸疗效相关的脑功能及网络变化规律,丰富了针灸脑科学的内涵。

关键词：功能磁共振成像针刺脑机制针灸疗法

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