检索结果-南通市图书馆

UPLC-MS/MS方法同时测定百咳宁颗粒中6种主要有效成分

在线全文

学校读者我要写书评

暂无评论

中草药 2016年第1期47卷 76-80页

作者：李瑞宏房桂珍安娜冯超祁金龙张海林河北省儿童医院河北石家庄050013 河北医科大学生物医学工程中心河北石家庄050017 河北医科大学药理学教研室河北石家庄050017

目的建立UPLC-MS/MS方法同时测定百咳宁颗粒中6种主要有效成分（靛玉红、贝母素甲、贝母素乙、银杏内酯A、银杏内酯B和银杏内酯C）。方法百咳宁颗粒经氯仿-甲醇溶剂索氏提取后进样,采用正负离子切换的多反应监测（MRM）模式同时测定百... 详细信息

目的建立UPLC-MS/MS方法同时测定百咳宁颗粒中6种主要有效成分（靛玉红、贝母素甲、贝母素乙、银杏内酯A、银杏内酯B和银杏内酯C）。方法百咳宁颗粒经氯仿-甲醇溶剂索氏提取后进样,采用正负离子切换的多反应监测（MRM）模式同时测定百咳宁颗粒中的靛玉红,2种贝母素和3种银杏内酯类成分。色谱柱为Inertsutain C_（18）（75 mm×3.0 mm,2μm）柱,流动相为甲醇-乙腈-2 mmol/L乙酸铵水溶液,梯度洗脱,分析时间为6 min。结果所测6种主要有效成分在测定浓度范围内线性关系良好,r均大于0.995 8;精密度、重复性和稳定性良好;平均加样回收率为96.5%~105.1%,RSD≤4.2%。结论本法简单快捷、灵敏度高、专属性好,可用于百咳宁颗粒中6中主要有效成分的定量控制,除靛玉红外,其他5种成分均为处方中首次测定,百咳宁颗粒中银杏内酯类成分的量较低。

关键词： UPLC-MS/MS 百咳宁颗粒靛玉红贝母素甲贝母素乙银杏内酯A 银杏内酯B 银杏内酯C

在线全文

学校读者我要写书评

暂无评论

从古典小说《七侠五义》看山西商人形象

宁波教育学院学报 2015年第3期17卷 46-49页

作者：方桂珍付洪伟西双版纳州第一中学云南景洪666100

与正史材料所载不同的是,在清末古典小说《七侠五义》中,作者对山西商人见利忘义、嗜财如命的负面形象作了充分刻画。小说中所反映的这种现象,既有山西商人自身的原因,同时也有说书艺人的片面认识,更重要的是,中国传统文化对经商的轻蔑... 详细信息

与正史材料所载不同的是,在清末古典小说《七侠五义》中,作者对山西商人见利忘义、嗜财如命的负面形象作了充分刻画。小说中所反映的这种现象,既有山西商人自身的原因,同时也有说书艺人的片面认识,更重要的是,中国传统文化对经商的轻蔑和对商人较低的社会地位认同都导致了这种负面刻画。

关键词：《七侠五义》山西商人负面刻画传统文化

在线全文

学校读者我要写书评

暂无评论

羧甲基纤维素-壳聚糖共混膜的性能表征

林产化学与工业 2010年第1期30卷 43-48页

作者：张锐方桂珍马英梅马艳丽东北林业大学生物质材料科学与技术教育部重点实验室黑龙江哈尔滨150040

通过共混的方法制备了3种不同质量比（1：2、1：1、2：1）的羧甲基纤维素一壳聚糖（CMC-CS）共混膜，利用IR和扫描电镜（SEM）对膜进行结构表征，用差示扫描量热法（DSC）考察了CMC-CS共混膜的热稳定性，研究了共混膜的均匀性、耐酸性... 详细信息

通过共混的方法制备了3种不同质量比（1：2、1：1、2：1）的羧甲基纤维素一壳聚糖（CMC-CS）共混膜，利用IR和扫描电镜（SEM）对膜进行结构表征，用差示扫描量热法（DSC）考察了CMC-CS共混膜的热稳定性，研究了共混膜的均匀性、耐酸性、拉伸强度和溶胀性，并对分子间的作用机理进行探讨。结果表明，CMC与CS混合时，存在静电作用与氢键作用，生成了聚电解质复合物；在170～330℃，共混膜分子间发生降解，在217．4℃时离子键断裂，静电作用消失；经分析当CMC与CS比例为1：1时，膜性能最好，共混膜的静电作用最大，拉伸强度可达34．44MPa，比CS单膜拉伸强度提高了64．47％；CMC的加入，使得酸性适用范围下限由CS膜的pH值5降至4，在pH值6中浸泡一段时间后，测得拉伸强度为25．71MPa；CMC—CS膜的吸水溶胀性显著降低。

关键词：羧甲基纤维素壳聚糖共混膜

在线全文

学校读者我要写书评

暂无评论

植物单宁的应用及研究进展

林产化工通讯 2005年第5期39卷 39-43页

作者：黄占华方桂珍东北林业大学生物质材料科学与技术教育部重点实验室黑龙江哈尔滨150040

植物单宁是自然界广泛分布的一类天然产物,具有结构类型的多样性和生物活性的广谱性,其在医药、食品、农业、材料、化工等多学科领域得到广泛的应用,已引起国内外研究者的普遍关注。本文就植物单宁近年来的研究与应用进展予以评述,旨在... 详细信息

植物单宁是自然界广泛分布的一类天然产物,具有结构类型的多样性和生物活性的广谱性,其在医药、食品、农业、材料、化工等多学科领域得到广泛的应用,已引起国内外研究者的普遍关注。本文就植物单宁近年来的研究与应用进展予以评述,旨在为新的活性成分研究及其资源的高效利用提供依据。

关键词：植物单宁生理活性应用

Inhibition of hepatitis B virus via selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第13期30卷 1911-1925页

作者： Fei-Lin Ge Yan Yang Lan-Lan Si Yuan-Hua Li Meng-zhen Cao Jun Wang Zhao-fang Bai Zhi-Gang Ren Xiao-He Xiao Yan Liu Department of Chinese Medicine State Key Laboratory of Antiviral DrugsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina The Fifth Medical Center of Chinese PLA General Hospital Beijing 100039China College of Traditional Chinese Medicine Chongqing Medical UniversityChongqing 400010China Beijing Key Laboratory of Emerging Infectious Diseases Peking University Ditan Teaching HospitalBeijing 100015China Department of Infectious Diseases State Key Laboratory of Antiviral Drugsthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Liuweiwuling Tablet(LWWL)is a Chinese patent medicine approved for the treatment of chronic inflammation caused by hepatitis B virus(HBV)*** studies have indicated an anti-HBV effect of LWWL,specifically in terms of antigen inhibition,but the underlying mechanism remains *** To investigate the potential mechanism of action of LWWL against *** In vitro experiments utilized three HBV-replicating and three non-HBV-replicating cell *** in vivo experiment involved a hydrodynamic injectionmediated mouse model with HBV *** and metabolomics were used to investigate the underlying mechanisms of action of *** In HepG2.1403F cells,LWWL(0.8 mg/mL)exhibited inhibitory effects on HBV DNA,hepatitis B surface antigen and pregenomic RNA(pgRNA)at rates of 51.36%,24.74%and 50.74%,*** inhibition rates of LWWL(0.8mg/mL)on pgRNA/covalently closed circular DNA in HepG2.1403F,HepG2.2.15 and HepG2.A64 cells were 47.78%,39.51%and 46.74%,*** of transcriptomics and metabolomics showed that the anti-HBV effect of LWWL was primarily linked to pathways related to apoptosis(PI3K-AKT,CASP8-CASP3 and P53 pathways).Apoptosis flow analysis revealed that the apoptosis rate in the LWWL-treated group was significantly higher than in the control group(CG)among HBV-replicating cell lines,including HepG2.2.15(2.92%±1.01%vs 6.68%±2.04%,P0.05),L02 cells(5.49%±0.80%vs 5.48%±1.01%,P>0.05)and LX2 cells(6.29%±1.54%vs 6.29%±0.88%,P>0.05).TUNEL staining revealed a significantly higher apoptosis rate in the LWWL-treated group than in the CG in the HBVreplicating mouse model,while no noticeable difference in apoptosis rates between the two groups

关键词： Hepatitis B virus Chinese patent medicine Antiviral activity Antiviral mechanism Selective apoptosis

Electric field dependence of spin qubit in a Si-MOS quantum dot

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第6期33卷 248-253页

作者：马荣龙倪铭周雨晨孔真真王桂磊刘頔罗刚曹刚李海欧郭国平 CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Beijing Superstring Academy of Memory Technology Beijing 100176China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Origin Quantum Computing Company Limited Hefei 230026China

Valley, the intrinsic feature of silicon, is an inescapable subject in silicon-based quantum computing. At the spin–valley hotspot, both Rabi frequency and state relaxation rate are significantly enhanced. With protection against charge noise, the valley degree of freedom is also conceived to encode a qubit to realize noise-resistant quantum ***, based on the spin qubit composed of one or three electrons, we characterize the intrinsic properties of valley in an isotopically enriched silicon quantum dot(QD) device. For one-electron qubit, we measure two electric-dipole spin resonance(EDSR) signals which are attributed to partial occupation of two valley states. The resonance frequencies of two EDSR signals have opposite electric field dependences. Moreover, we characterize the electric field dependence of the upper valley state based on three-electron qubit experiments. The difference of electric field dependences of the two valleys is 52.02 MHz/V, which is beneficial for tuning qubit frequency to meet different experimental requirements. As an extension of electrical control spin qubits, the opposite electric field dependence is crucial for qubit addressability,individual single-qubit control and two-qubit gate approaches in scalable quantum computing.

关键词： silicon-based quantum computing valley electric-dipole spin resonance

Temperature inversion enables superior stability for low-temperature Zn-ion batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 245-253页

作者： Fu-Da Yu Zhe-Jian Yi Rui-Yang Li Wei-Hao Lin Jie Chen Xiao-Yue Chen Yi-Ming Xie Ji-Huai Wu Zhang Lan Lan-fang Que Bao-Sheng Liu Hao Luo zhen-Bo Wang Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021FujianChina b2 School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Space Power-SourcesSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongChina

It is challenging for aqueous Zn-ion batteries(ZIBs)to achieve comparable low-temperature(low-T)performance due to the easy-frozen electrolyte and severe Zn ***,an aqueous electrolyte with a low freezing point and high ionic conductivity is *** with molecular dynamics simulation and multi-scale interface analysis(time of flight secondary ion mass spectrometry threedimensional mapping and in-situ electrochemical impedance spectroscopy method),the temperature independence of the V_(2)O_(5)cathode and Zn anode is observed to be ***,dominated by the solvent structure of the designed electrolyte at low temperatures,vanadium dissolution/shuttle is significantly inhibited,and the zinc dendrites caused by this electrochemical crosstalk are greatly relieved,thus showing an abnormal temperature inversion *** the disclosure and improvement of the above phenomena,the designed Zn||V_(2)O_(5)full cell delivers superior low-T performance,maintaining almost 99%capacity retention after 9500 cycles(working more than 2500 h)at-20°*** work proposes a kind of electrolyte suitable for low-T ZIBs and reveals the inverse temperature dependence of the Zn anode,which might offer a novel perspective for the investigation of low-T aqueous battery systems.

关键词： Aqueous Zn-ion batteries Low-temperature performance Opposite temperature dependence Zndendrite growth Vanadium dissolution

Association between luteinizing hormone level decrease on the triggering day and pregnancy outcome for in vitro fertilization/intracytoplasmic sperm injection patients following gonadotropin-releasing hormone antagonist protocol: a retrospective cohor

在线全文

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2024年第1期8卷 8-17页

作者： Qing-fang Li Min-Yue Tang gui-Quan Wang Xi-Jing Chen Guo-fang Feng Yi-Min Zhu Women's Hospital School of MedicineZhejiang University1 Xueshi RoadHangzhou 310006China Key Laboratory of Reproductive Genetics Ministry of Education Zhejiang UniversityHangzhou 310006China

Objective:Optimal luteinizing hormone(LH)levels forin vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)patients following the gonadotropin-releasing hormone(GnRH)antagonist protocol remain *** study aimed to estimate the association between serum LH levels on the triggering day(LHLOT)and clinical pregnancy outcomes in IVF/ICSI patients following the GnRH antagonist ***:We enrolled 4743 IVF/ICSI cycles using flexible or fixed GnRH antagonist protocols between January 2017 and June *** patients were stratified into four groups according to the LHLOT quartiles(Q1–Q4).Each group was further divided into two subgroups according to the median basal LH/*** main outcomes were clinical pregnancy,birth,and miscarriage *** outcomes were oocyte yield,number of MII,fertilized oocytes(2PN),and high-quality ***:Serum LHLOT levels were negatively correlated with oocyte yield and the numbers of MII,2PN,and high-quality *** outcomes were compared among the different quartiles and *** absolute difference in the clinical pregnancy rates between the Q4 and Q1 groups was 6.4%(47.2%vs.40.8%,P3.04 and≤3.04 were 32.7%and 48.6%(P2.14 and≤2.14 were 50.2%and 41.9%,respectively(P<0.05).The greater the decrease in LH levels,the lower the oocyte maturation rate across all ***:According to the LHLOT quartiles,the Q1 of serum LHLOT<1.43 IU/L may result in a higher number of oocytes but reduced oocyte maturation and lower clinical pregnancy rates.A decrease in LH levels by approximately 2.14 to 3.04 times compared to basal LH levels may lead to higher clinical pregnancy rates in IVF/ICSI patients following the GnRH antagonist protocol.

关键词： GnRH antagonist IVF/ICSI Luteinizing hormone Ovarian stimulation Reproductive outcomes

YXA2.3吸附剂对尿素氮肌酐及砷(Ⅲ)的静态吸附和吸附动力研究

在线全文

学校读者我要写书评

暂无评论

黑龙江大学自然科学学报 2011年第2期28卷 218-222页

作者：陈超远崔杉高坡杨宇方桂珍黑龙江大学化学化工与材料学院哈尔滨150080 东北林业大学材料科学与工程学院哈尔滨150040

二乙烯基三胺基氧化纤维素(YXA2.3)的主链结构中的醛基官能团及长链多胺基基团,在透析液中可对一定浓度的肌酐和砷(Ⅲ)溶液分别具有化学吸附能力。为此对肌酐和砷(Ⅲ)进行了静态吸附实验及吸附动力学实验。结果实验温度为37℃,pH值为7... 详细信息

二乙烯基三胺基氧化纤维素(YXA2.3)的主链结构中的醛基官能团及长链多胺基基团,在透析液中可对一定浓度的肌酐和砷(Ⅲ)溶液分别具有化学吸附能力。为此对肌酐和砷(Ⅲ)进行了静态吸附实验及吸附动力学实验。结果实验温度为37℃,pH值为7的透析液中,肌酐浓度为100 mg.L-1,吸附时间为5.0 h时,其静态吸附容量为3.04 mg.g-1;当选择肌酐浓度分别为40 mg.L-1、70 mg.L-1、90 mg.L-1、100 mg.L-1、130 mg.L-1,吸附时间为5.0 h时,吸附容量分别为2.45 mg.g-1、2.81 mg.g-1、2.94 mg.g-1、3.04 mg.g-1、3.12 mg.g-1。由此建立吸附动力学吸附容量曲线结果表明,在吸附质用量固定时,随着透析液中肌酐含量的增加,吸附容量逐渐增大。在砷(Ⅲ)浓度为0.2μ***-1的透析液中,吸附时间为5.0 h时,其静态吸附容量为8.9μg.g-1;当选择砷(Ⅲ)浓度为0.2μ***-1、2.0μ***-1、10.0μ***-1、15.0μ***-1、20.0μ***-1,吸附时间为5.0 h时,静态吸附容量为8.9μg.g-1、68.4μg.g-1、210.4μg.g-1、311.8μg.g-1、415.0μg.g-1。实验表明,该吸附剂在一定条件下对肌酐溶液和砷(Ⅲ)溶液具有一定的吸附性能。

关键词：二乙烯基三胺基氧化纤维素肌酐砷(Ⅲ) 吸附性能吸附动力研究