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Antibacterial and cytotoxic metabolites produced by Streptomyces tanashiensis BYf.112 isolated f.om Odontotermes f.rmosanus

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Chinese Journal of.Natural Medicines 2024年第9期22卷 822-830页

作者： WU Jun SONG Tao z.ANG Le HUANG z.ongdi HUANG fang YIN Caiping z.ANG Shuxiang LIU Xinhua z.ANG Yinglao School of.Lif. Science Anhui Agricultural UniversityHefei 230036China School of.Pharmacy Anhui Medical UniversityHefei 230036China

Chemical investigations of.the termite-associated Streptomyces tanashiensis BYf.112 resulted in the discovery of.f.ur novel alkaloid derivatives: vegf.ecines A and B(1 and 2), exf.liaz.ne A(3), and venez.eline H(7), in addition to nine known metabolites(4-6, 8-13). The structures of.these compounds were elucidated through comprehensive spectroscopic analysis and comparison with existing literature data. Antibacterial assays revealed that viridomycin A(11) exhibited potent antibacterial activity against Staphylococcus aureus, with a z.ne of.inhibition(z.I) of.12.67 mm, in comparison to a z.I of.17.67 mm f.r the positive control gentamicin sulf.te. Viridomycin A(11) showed moderate activity against Micrococcus tetragenus and Pseudomonas syringae pv. actinidae, with z.I values of.15.50 and 14.33 mm, respectively, which were inf.rior to those of.gentamicin sulf.te(34.67 and 24.00mm). Viridomycin f.12) also exhibited moderate antibacterial ef.ects against S. aureus, M. tetragenus, and P. syringae pv. actinidae,with z.I values of.8.33, 16.50, and 10.83 mm, respectively. Cytotoxicity assays demonstrated that viridobruunine A(5), exf.liaz.ne(6), viridomycin A(11), and X-14881E(13) exhibited signif.cant cytotoxicity against human malignant melanoma(A375), ovarian cancer(SKOV-3), and gastric cancer(MGC-803) cell lines, with IC_(50) values ranging f.om 4.61 to 19.28 μmol·L^(-1). f.rthermore, bioinf.rmatic analysis of.the complete genome of.S. tanashiensis suggested a putative biosynthetic gene cluster(BGC) responsible f.r the production of.compounds 1-12. These f.ndings indicate that the secondary metabolites of.insect-associated S. tanashiensis BYf.112hold promise as potential sources of.novel antibacterial and anticancer agents.

关键词： Odontotermes f.rmosanus Streptomyces tanashiensis Alkaloid Cytotoxic activity Antibacterial activity Biosynthetic pathway

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Alcohol-dispersed polymer complex as an ef.ective and durable interf.ce modif.er f.r n-i-p perovskite solar cells

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Journal of.Energy Chemistry 2024年第6期93卷 243-252,I0007页

作者： Chang Shi Jiangling Li Shuping Xiao z.yi Wang Wuchen Xiang Rui Wu Yang Liu Yinhua z.ou Weijun Ke Guojia fang Pingli Qin Hubei Key Laboratory of.Optical Inf.rmation and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205HubeiChina Wuhan National Laboratory f.r Optoelectronics Huazhong University of Science and TechnologyWuhan 430074HubeiChina School of.Physics and Technology Key Laboratory of Artificial Micro-and Nano-structures of the Ministry of Education and School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina

Abundant interf.cial def.cts remain a signif.cant challenge that hampers both the ef.iciency and stability of.perovskite solar cells(PSCs).Herein,an alcohol-dispersed conducting polymer complex,denoted as PEDOT:f.Poly(3,4-ethylene dioxythiophene):Perf.uorinated sulf.nic acid ionomers),is introduced into the interf.ce between perovskite and hole transporting layer in regular-structured ***:f.serves as a multi-f.nctional interf.ce layer(f.lling grain boundaries and covering perovskite's grain-surf.ce)to achieve a robust interaction with organic groups within perovskites,which could induce a structural transf.rmation of.PEDOT to increase its conductivity f.r the ef.icient ***,the strong interaction between PEDOT and perovskites could promote an ef.ective coupling of.undercoordinated Pb~(2+)ions with the lone electron pairs near O&S atoms in PEDOT molecules,thereby enhancing def.ct ***,PEDOT:f.with inherent hydrophobic properties prevents ef.ectively moisture invasion into perovskites f.r the improved long-term stability of.the ***,the PEDOT:f.based PSCs achieved a champion ef.iciency of.24.81%,and maintained ca.92%of.their initial ef.iciency af.er 7680 h of.storage in a dry air environment,accompanied by the enhanced photothermal stability.

关键词： Alcohol-dispersed conducting polymer complex Interf.ce passivation Grain boundaries Device stability Perovskite solar cells

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Adenine nucleotide translocase 2(Ant2)is required f.r individualiz.tion of.spermatogenesis of.Drosophila melanogaster

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Insect Science 2024年第4期31卷 1055-1072页

作者： z.en He Yang fang f.ngchao z.ang Yang Liu Xinkai Cheng Jiajia Wang Dechen Li Dengsong Chen f.n Wu Industrial Crops Institute Hubei Academy of Agriculture SciencesWuhanChina Institute of.Evolution&Marine Biodiversity Ocean University of ChinaQingdaoShandong ProvinceChina

Successf.l completion of.spermatogenesis is crucial f.r the perpetuation of.the *** Drosophila,spermatid individualiz.tion,a process involving changes in mitochondrial structure and f.nction is critical to produce f.nctional mature ***2,encoding a mitochondrial adenine nucleotide translocase,is highly expressed in male testes and plays a role in energy metabolism in the ***,its molecular f.nction remains ***,we identif.ed an important role of.Ant2 in spermatid *** Ant2 knockdown testes,spermatid individualiz.tion complexes composed of.f.actin cones exhibited a dif.use distribution,and mature sperms were absent in the seminal vesicle,thus leading to male *** most striking ef.ects in Ant2-knockdown spermatids were decrease in tubulin polyglycylation and disruption of.proper mitochondria derivatives *** apoptotic cells were also observed in Ant2-knockdown *** f.rther investigate the phenotype of.Ant2 knockdown in testes at the molecular level,complementary transcriptome and proteome analyses were *** the mRNA level,868 dif.erentially expressed genes were identif.ed,of.which 229 genes were upregulated and 639 were downregulated induced via Ant2 ***-labeling proteome analysis revealed 350 dif.erentially expressed proteins,of.which 117 proteins were upregulated and 233 were *** expression of.glutathione transf.rase(GstD5,GstE5,GstE8,and GstD3),proteins involved in reproduction were signif.cantly regulated at both the mRNA and protein *** results indicate that Ant2 is crucial f.r spermatid maturation by af.ecting mitochondrial morphogenesis.

关键词： adenine nucleotide translocase Drosophila melanogaster individualiz.tion complexes mitochondria spermatogenesis tubulin polyglycylation

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Serum 25-Hydroxyvitamin D Level Might Be a Usef.l Indicator of.Disease Severity in Obese Children With Atopic Dermatitis:A Case-Control Study

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International Journal of.Dermatology and Venereology 2024年第1期7卷 6-11页

作者： Jing-Jing Chen Xiao-Kai fang Xiu-Mei Liu Xiao-Chun Liu Xu Yao Department of.Allergy and Rheumatology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:To assess the relationship between the severity of.atopic dermatitis(AD)in children of.varying weight categories and their serum 25-hydroxyvitamin D[25(OH)D]***:The study population comprised 899 patients with AD and 854 age-and sex-matched *** Mann-Whitney U test and Kruskal-Wallis H tests were used to assess dif.erences between groups,and Spearman correlation analysis was used to test ***:The 25(OH)D level in the AD group was M(Q_(25),Q_(75)),24.0(19.7,28.4)ng/mL,which was signif.cantly lower than the control group(26.4[23.6,29.9]ng/mL;z.-3.34,P=0.001).25(OH)D levels in children with AD were negatively correlated with body mass index(r=-0.30,Pf.Atopic Dermatitis(SCORAD;r=-0.14,Pf.cant dif.erences in 25(OH)D(H=18.46,Pf.erent body mass index *** 25(OH)D levels were 22.3(17.5,27.1)ng/mL in the overweight AD group and 22.3(17.6,25.7)ng/mL in the obese AD group,which were signif.cantly lower than those in the normal-weight AD group(24.7[20.4,25.5]ng/mL;P=0.003,P=0.004).25(OH)D levels were negatively correlated with SCORAD in obese AD patients(r=-0.25,P=0.010).Conclusion:Vitamin D insuf.icient or def.cient is obvious in children AD *** 25(OH)D levels in the overweight/obese AD group are signif.cantly lower than those in the normal-weight AD *** D level is negatively correlated with SCORAD in obese children with AD.

关键词： atopic dermatitis vitamin D disease severity index immunoglobulin E body mass index eosinophil children overweight/obese

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SRY-Box transcription f.ctor 9 triggers YAP nuclear entry via direct interaction in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong Ding fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-Lu Hong Ming-Chen Wang fang-z.i Yan Kai Ding Ya-Lu Cui Bai-Nan z.eng Jin Ding Cheng Luo Xin z.ang Wei-f.n Xie Department of.Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of.Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of.Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of.YAP f.om the cytoplasm to the nucleus is critical f.r its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of.YAP are not f.lly *** this study,we have uncovered a crucial role of.SOX9 in the activation of.***9 promotes the nuclear translocation of.YAP by direct ***,we have identif.ed that the binding between Asp-125 of.SOX9 and Arg-124 of.YAP is essential f.r SOX9-YAP interaction and subsequent nuclear entry of.***,we have discovered a novel asymmetrical dimethylation of.YAP at Arg-124(YAP-R124me2a)catalyz.d by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of.SOX9 containing Asp-125.S-A1 signif.cantly inhibits YAP nuclear translocation and ef.ectively suppresses tumor *** study provides the f.rst evidence of.SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy f.r YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

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Beyond network centrality: individual-level behavioral traits f.r predicting inf.rmation superspreaders in social media

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National Science Review 2024年第07期 148-157页

作者： fang z.ou Linyuan Lü Jianguo Liu Manuel Sebastian Mariani Institute of.f.ndamental and f.ontier Sciences University of Electronic Science and Technology of China Yangtz. Delta Region Institute(Huz.ou) University of Electronic Science and Technology of China School of.Cyber Science and Technology University of Science and Technology of China Department of.Digital Economics Shanghai University of Finance and Economics URPP Social Networks Universit?t Zürich

Understanding the heterogeneous role of.individuals in large-scale inf.rmation spreading is essential to manage online behavior as well as its potential of.line consequences. To this end, most existing studies f.om diverse research domains f.cus on the disproportionate role played by highly connected ‘hub’ ***, we demonstrate here that inf.rmation superspreaders in online social media are best understood and predicted by simultaneously considering two individual-level behavioral traits: inf.uence and susceptibility. Specif.cally, we derive a nonlinear network-based algorithm to quantif. individuals' inf.uence and susceptibility f.om multiple spreading event data. By applying the algorithm to large-scale data f.om Twitter and Weibo, we demonstrate that individuals' estimated inf.uence and susceptibility scores enable predictions of.f.ture superspreaders above and beyond network centrality, and reveal new insights into the network positions of.the superspreaders.

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SSL Depth: self.supervised learning enables 16× speedup in conf.cal microscopy-based 3D surf.ce imaging [Invited]

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Chinese Optics Letters 2024年第6期22卷 3-7页

作者： z.-Hao Wang Tong-Tian Weng Xiang-Dong Chen Li z.ao fang-Wen Sun CAS Key Laboratory of.Quantum Inf.rmation University of Science and Technology of ChinaHefei 230026China CAS Center f.r Excellence in Quantum Inf.rmation and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hef.i National Laboratory University of Science and Technology of ChinaHefei 230088China Anhui Golden-Shield 3D Technology Co. Ltd.Hefei 230011China

In scientif.c and industrial research, three-dimensional (3D) imaging, or depth measurement, is a critical tool that provides detailed insight into surf.ce properties. Conf.cal microscopy, known f.r its precision in surf.ce measurements, plays a key role in this f.eld. However, 3D imaging based on conf.cal microscopy is of.en challenged by signif.cant data requirements and slow measurement speeds. In this paper, we present a novel self.supervised learning algorithm called SSL Depth that overcomes these challenges. Specif.cally, our method exploits the f.ature learning capabilities of.neural networks while avoiding the need f.r labeled data sets typically associated with supervised learning approaches. Through practical demonstrations on a commercially available conf.cal microscope, we f.nd that our method not only maintains higher quality, but also signif.cantly reduces the f.equency of.the z.axis sampling required f.r 3D imaging. This reduction results in a remarkable 16×measurement speed, with the potential f.r f.rther acceleration in the f.ture. Our methodological advance enables highly ef.icient and accurate 3D surf.ce reconstructions, thereby expanding the potential applications of.conf.cal microscopy in various scientif.c and industrial f.elds.

关键词： conf.cal microscopy 3D surf.ce imaging self.supervised learning

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Predef.ned-time repetitive learning control of.robotic manipulators

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Kongz.i yu Juece/Control and Decision 2024年第11期39卷 3719-3726页

作者： Li Y.-Q. Chen Q. Shi H.-H. z.ang z.-H. Chen P. College of.Inf.rmation Engineering Zhejiang University of Technology Hangzhou 310023 China

A backstepping-based predef.ned-time repetitive learning control scheme is proposed f.r uncertain robot manipulators to achieve rapid and high-precision tracking control perf.rmance. A non-singular predef.ned-time virtual controller is constructed to ef.ectively avoid the singularity issues caused by the dif.erentiation of.the virtual controller in conventional f.nite-time backstepping design. It ensures that the tracking error of.the robot manipulators joint positions converges to a neighborhood of.the origin within the predef.ned time. Then, the lumped uncertainty of.the manipulator is separated into periodic and non-periodic parts by considering the periodic characteristics of.the desired trajectory. A f.lly saturated repetitive learning law is constructed to accurately estimate and compensate f.r the periodic uncertainty. Meanwhile, a robust control law is developed and the terminal attracting technique is applied to guarantee the ef.ective compensation of.the non-periodic uncertainty including external disturbances, such that the high-precision tracking of.the robot manipulators joint positions is achieved. f.nally, the stability of.the closed-loop system and the error convergence perf.rmance of.the proposed scheme are analyz.d through the Lyapunov stability synthesis. The ef.ectiveness of.the proposed control method is verif.ed by comparative simulations. © 2024 Northeast University. All rights reserved.

关键词： backstepping recursive algorithm periodic uncertainty predef.ned-time control repetitive learning law robot manipulator tracking control

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f.iction and wear behaviors of.a gradient nano-grained AISI 316L stainless steel under dry and oil-lubricated conditions

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Journal of.Materials Science & Technology 2018年第10期34卷 1835-1842页

作者： P.f. Wang z. Han Shenyang National Laboratory f.r Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China University of.Chinese Academy of.Sciences Beijing 100049 China

A gradient nano-grained （GNG） surf.ce layer was f.bricated on an AIS1316L stainless steel （SS） by using the surf.ce mechanical rolling treatment （SMRT）. Reciprocating dry and oil-lubricated sliding tests of.the GNG 316L SS in air at room temperature were conducted in comparison with the coarse-grained （CG） counterpart. Worn surf.ce morphologies and subsurf.ce microstructures were investigated f.r both 316L SS samples. 316L SS with a GNG surf.ce layer shows a signif.cantly improved wear resistance, especially under oil-lubricated condition. The notably wear resistance enhancement of.the GNG 316L SS is attributed to the GNG surf.ce layer with high strain accommodation ability and high hardness, which can reduce the wear volume in the running-in stage ef.ectively.

关键词： Austenitic stainless steel Gradient nano-grained surf.ce layer f.iction and wear Running-in

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A 1-bp deletion in the MC04g1399 is highly associated with f.ilure to produce f.uit wart in bitter gourd

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Horticultural Plant Journal 2024年第1期10卷 171-180页

作者： Jia Liu Junjie Cui Jichi Dong Jian z.ong Chunf.ng z.ong f.nchong Yuan Wendong Guan fang Hu Jiaowen Cheng Kailin Hu College of.Horticulture South China Agricultural UniversityGuangzhouGuangdong 510642China Key Laboratory of.Biology and Genetic Improvement of.Horticultural Crops(South China) Ministry of Agriculture and Rural AffairsGuangzhouGuangdong 510642China Guangdong Vegetables Engineering Research Center GuangzhouGuangdong 510642China Department of.Horticulture Foshan UniversityFoshanGuangdong 528225China Henry f.k School of.Biology and Agricultural Shaoguan UniversityShaoguanGuangdong 512023China

f.uit wart is an important appearance trait inf.uencing consumer pref.rences of.bitter gourd(Momordica charantia L.).The molecular genetic mechanisms underlying f.uit wart f.rmation in bitter gourd are largely *** this study,genetic analysis based on f.ur generations showed that f.uit wart f.rmation in bitter gourd was controlled by a single dominant locus named as *** f.a locus was initially mapped into a 4.82 Mb region on pseudochromosome 4 by BSA-seq analysis and subsequently narrowed down to a 286.30 kb region by linkage analysis.A large f.population consisting of.2360 individuals was used to screen recombinants,and the f.a locus was f.nally f.ne mapped into a 22.70 kb region harboring f.ur protein-coding genes through recombination ***04g1399,encoding an epidermal patterning f.ctor 2-like protein,was proposed as the best candidate gene f.r f.a via sequence variation and expression *** addition,a 1-bp insertion and deletion(InDel)variation within MC04g1399 was converted to a cleaved amplif.ed polymorphic sequence(CAPS)marker that could precisely distinguish between the warty and non-warty types with an accuracy rate of.100%among a wide panel of.126 bitter gourd germplasm *** results not only provide a scientif.c basis f.r deciphering the molecular mechanisms underlying f.uit wart f.rmation but also provide a powerf.l tool f.r ef.icient genetic improvement of.f.uit wart via marker-assisted selection.

关键词： Bitter gourd f.uit wart Bulk segregant analysis f.ne-mapping Candidate gene

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