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从中西医结合的角度探讨结肠透析治疗慢性肾脏病

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中国中西医结合杂志 2019年第7期39卷 773-775页

作者：方敬爱山西医科大学第一医院肾内科

慢性肾脏病( chronic kidney disease,CKD)已经成为全球性公共健康问题,对患者的致残率及死亡率具有重要影响。研究显示,中国大陆成年人CKD 的患病率为10. 8%,且死亡率逐年增加[1,2 ],积极防治CKD 已成为目前肾脏病的研究热点。在我国,... 详细信息

慢性肾脏病( chronic kidney disease,CKD)已经成为全球性公共健康问题,对患者的致残率及死亡率具有重要影响。研究显示,中国大陆成年人CKD 的患病率为10. 8%,且死亡率逐年增加[1,2 ],积极防治CKD 已成为目前肾脏病的研究热点。在我国,中西医结合治疗 CKD 具有悠久的历史。经过长期的积淀与淬炼,形成了独具特色的中西医结合治疗模式,而结肠透析正是其中最具潜力的治疗方法。

关键词：中西医结合治疗慢性肾脏病结肠透析透析治疗 CKD 健康问题中国大陆治疗方法

中西医结合防治慢性肾脏病3~4期的现状及思考

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中国中西医结合杂志 2021年第4期41卷 427-429页

作者：方敬爱山西医科大学第一医院肾内科太原030001

随着人民生活水平的提高及环境生态的改变,慢性肾脏病(chronic kidney disease,CKD)已成为全球重要的公共卫生问题。据不完全统计,全球患病率逐年上升,已高达9.1%[1]。我国大陆地区18岁以上人群患病率约10.8%,但CKD病情隐匿,知晓率仅为1... 详细信息

随着人民生活水平的提高及环境生态的改变,慢性肾脏病(chronic kidney disease,CKD)已成为全球重要的公共卫生问题。据不完全统计,全球患病率逐年上升,已高达9.1%[1]。我国大陆地区18岁以上人群患病率约10.8%,但CKD病情隐匿,知晓率仅为12.5%[2]。病情发展至3~4期后,并发症显著增多,医疗费用高昂,严重影响患者的生活质量,进而导致死亡率明显升高。

关键词：慢性肾脏病人群患病率医疗费用公共卫生问题 CKD 中西医结合防治知晓率现状及思考

基于肠道菌群探讨中西医结合防治糖尿病肾脏疾病的新靶点

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中国中西医结合杂志 2023年第2期43卷 133-136页

作者：方敬爱山西医科大学第一医院肾内科太原030001

糖尿病肾脏疾病(diabetic kidney disease,DKD)是糖尿病严重的慢性并发症之一,已成为慢性肾脏病(chronic kidney disease,CKD)患者进入终末期肾脏病的主要原因[1]。目前,DKD治疗方法大多数仅限于降低血压、控制血糖和减少蛋白尿[2],但... 详细信息

糖尿病肾脏疾病(diabetic kidney disease,DKD)是糖尿病严重的慢性并发症之一,已成为慢性肾脏病(chronic kidney disease,CKD)患者进入终末期肾脏病的主要原因[1]。目前,DKD治疗方法大多数仅限于降低血压、控制血糖和减少蛋白尿[2],但这些传统的治疗方法并不能绝对延缓DKD患者肾脏损害的进展,进一步开发更有效的治疗策略一直是本领域的研究热点。肠道菌群是人类最大的“免疫器官”,与人类宿主共生互利,在维持代谢平衡等方面起着举足轻重的作用。

关键词：终末期肾脏病慢性肾脏病糖尿病肾脏疾病控制血糖肠道菌群治疗策略慢性并发症新靶点

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie jing Zhang Xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

还原型谷胱甘肽联合洛汀新对早期糖尿病肾病的疗效观察

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临床医药实践 2007年第3期16卷 166-168页

作者：孙艳艳方敬爱山西医科大学第一医院山西太原030001

目的观察还原型谷胱甘肽联合洛汀新治疗早期糖尿病肾病的临床疗效。方法选择符合1999年WHO诊断2型糖尿病的标准及Mogensen诊断分期标准的早期糖尿病肾病患者62例,分为两组洛汀新治疗组及还原型谷胱甘肽联合洛汀新治疗组。用药3个月后检... 详细信息

目的观察还原型谷胱甘肽联合洛汀新治疗早期糖尿病肾病的临床疗效。方法选择符合1999年WHO诊断2型糖尿病的标准及Mogensen诊断分期标准的早期糖尿病肾病患者62例,分为两组洛汀新治疗组及还原型谷胱甘肽联合洛汀新治疗组。用药3个月后检测血压(BP)、血脂、微量白蛋白尿(UAER)、血肌酐(SCr)、尿素氮(BUN)、C-反应蛋白(CRP)、糖化血红蛋白(GHbAl)及尿β2微球蛋白(β2-MG)的变化,了解还原型谷胱甘肽对肾脏的保护作用。结果两组治疗后均对BP、血脂、UAER、CRP、糖化血红蛋白及尿β2微球蛋白有明显改善,P<0.05,还原型谷胱甘肽联合洛汀新治疗组在微量白蛋白尿、CRP、GHbAl及β2-MG方面作用更显著,两组差异有显著性P<0.05,治疗前后SCr、BUN均在正常范围内。结论还原型谷胱甘肽联合洛汀新能通过减少UAER、CRO、GHbAl、β2-MG水平,延缓糖尿病肾病的进展。

关键词：糖尿病肾病洛汀新还原型谷胱甘肽

活性维生素D对慢性肾脏病患者代谢及肾脏细胞功能的影响

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中国血液净化 2024年第4期23卷 286-289页

作者：郭子仪张紫媛方敬爱山西医科大学第一临床医学院太原030001 山西医科大学第一医院肾内科太原030001

维生素D(vitamin D,VD)是一种脂溶性类固醇衍生物,其不足或缺乏影响慢性肾脏病(chronic kidney disease,CKD)患者的钙磷稳态、甲状旁腺激素水平及血糖血脂代谢,从而导致一系列并发症的发生,降低CKD患者的生活质量及生存率。本文将围绕... 详细信息

维生素D(vitamin D,VD)是一种脂溶性类固醇衍生物,其不足或缺乏影响慢性肾脏病(chronic kidney disease,CKD)患者的钙磷稳态、甲状旁腺激素水平及血糖血脂代谢,从而导致一系列并发症的发生,降低CKD患者的生活质量及生存率。本文将围绕维生素D对慢性肾脏病患者代谢及肾脏细胞功能的作用机制进行综述,为CKD及其并发症的防治提供思路。

关键词：维生素D 慢性肾脏病钙磷稳态甲状旁腺激素糖脂代谢

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黄芪甲苷延缓肾脏衰老的作用及其机制

中国应用生理学杂志 2022年第5期38卷 448-452,457页

作者：张紫媛方敬爱李苏芬胡雅玲刘文媛刘学军山西医科大学第一医院肾内科太原030001 山西医科大学太原030001 山西医科大学第一医院病理科太原030001 山西医科大学第一医院老年科太原030001

目的:探讨黄芪甲苷是否通过调控SIRT1/p53信号通路而发挥抑制细胞凋亡,延缓大鼠肾脏衰老的作用。方法:SPF级健康雄性SD大鼠,随机分为正常对照组(生理盐水5 ml/(kg·d)灌胃)、衰老模型组(生理盐水5 ml/(kg·d)灌胃)、黄芪甲苷组和SRT1720... 详细信息

目的:探讨黄芪甲苷是否通过调控SIRT1/p53信号通路而发挥抑制细胞凋亡,延缓大鼠肾脏衰老的作用。方法:SPF级健康雄性SD大鼠,随机分为正常对照组(生理盐水5 ml/(kg·d)灌胃)、衰老模型组(生理盐水5 ml/(kg·d)灌胃)、黄芪甲苷组和SRT1720组(在造模基础上分别施于黄芪甲苷40 mg/(kg·d)和SRT172020 mg/(kg·d)灌胃),每组各10只。饲养8周后收集大鼠血清、肾脏组织标本。ELISA法检测血清中肾功能(肌酐、尿素氮)和衰老相关分泌表型(TGF-β、IL-6)的水平;肾脏组织进行HE染色、Masson染色;RT-PCR及Western blot分别检测SIRT1、p53、Bcl-2、Bax、p21、pRb基因和蛋白水平表达。结果:衰老模型组大鼠血清肌酐、尿素氮水平较正常组升高,但各组之间比较差异无统计学意义(P>0.05);衰老模型组大鼠血清中TGF-β、IL-6水平较正常组显著升高(P0.05)。与正常组相比,衰老模型组大鼠的肾小管扩张,局部萎缩,肾间质炎性细胞浸润,胶原纤维增生;黄芪甲苷组及SRT1720组较模型组减轻。与正常组相比,衰老模型组大鼠肾脏组织中SIRT1、pRb蛋白及mRNA表达均显著下降,Bcl-2蛋白表达显著下降(P<0.05),p53、p21蛋白及mRNA表达显著升高,Bax蛋白表达显著升高(P<0.05)。与衰老模型组相比,黄芪甲苷组及SRT1720组上述指标的水平均有显著逆转(P<0.05)。结论:黄芪甲苷可能通过调控SIRT1/p53信号通路延缓大鼠肾脏衰老。

关键词：黄芪甲苷 SIRT1/p53信号通路肾脏衰老细胞凋亡

Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu Wen-Chang Jia jing Wen Xue-Lin Cheng Yan Han Ming-Hui Peng jing Zhou Yao Liu Sun-fang Jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

Assessment and Mapping of Potential Storm Surge Impacts on Global Population and Economy

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International Journal of Disaster Risk Science 2014年第4期5卷 323-331页

作者： Jiayi fang Shao Sun Peijun Shi jing’ai Wang State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China Academy of Disaster Reduction and Emergency Management Ministry of Civil Affairs and Ministry of EducationBeijing 100875China Key Laboratory of Environmental Change and Natural Disasters of Ministry of Education Beijing Normal UniversityBeijing 100875China School of Geography Beijing Normal UniversityBeijing 100875China Key Laboratory of Regional Geography Beijing Normal UniversityBeijing 100875China

With global climate change, population growth,and economic development in the twenty-first century,large cyclonic storm surges may result in devastating effects in some coastal areas of the world. However, due to the deficiency of global data and large-scale modeling efforts, the assessment and mapping of potential storm surge impacts at the global level are limited. In this article,the potential inundated area of global coastal zones is projected using information diffusion theory, based on the historical hourly sea-level observation records from the University of Hawaii Sea Level Center(UHSLC), considering variations in coastal morphology and tropical cyclone tracks. Combined with global demographic and GDP data,population and GDP at risk of storm surge impacts are calculated, mapped, and validated through the comparison with historical losses. The resulting potential impact maps provide a preliminary outlook on risks that may help governments of countries to make storm surge disaster prevention and reduction plans.

关键词： Global coastal zone Information diffusion Potential impact assessment Storm surge