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Acute pancreatitis:Etiology and common pathogenesis

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World Journal of Gastroenterology 2009年第12期15卷 1427-1430页

作者： Guo-Jun Wang chun-fang Gao Dong Wei Cun Wang Si-Qin Ding Institute of Digestive Surgery and Department of General Surgery 150 Hospital of Chinese PLA Gaoxin District Luoyang 471031 Henan Province China

Acute pancreatitis is an inflammatory disease of the *** etiology and pathogenesis of acute pancreatitis have been intensively investigated for centuries *** causes of acute pancreatitis have been discovered,but the pathogenetic theories are *** most common cause of acute pancreatitis is gallstone impacting the distal common bile-pancreatic *** majority ofinvestigators accept that the main factors for acute billiary pancreatitis are pancreatic hyperstimulation and bile-pancreatic duct obstruction which increase pancreatic duct pressure and active trypsin *** pancreatitis occurs when intracellular protective mechanisms to prevent trypsinogen activation or reduce trypsin activity are ***,little is known about the other acute *** hypothesize that acute biliary pancreatitis and other causes of acute pancreatitis possess a common *** hyperstimulation and pancreatic duct obstruction increase pancreatic duct pressure,active trypsin reflux,and subsequent unregulated activation of trypsin within pancreatic acinar *** activation within the pancreas leads to auto-digestion of the gland and local *** the hypothesis is confirmed,traditional therapeutic strategies against acute pancreatitis may be *** of pancreatic duct pressure should be advocated in the treatment of acute pancreatitits which may greatly improve its outcome.

关键词： Acute pancreatitis Pathogenesis Etiology Pancreatic duct obstruction Pancreatichyperstimulation Pancreatic duct pressure

Source Apportionment of Ambient PM_(10) in the Urban Area of Longyan City,China:a Comparative Study Based on Chemical Mass Balance Model and Factor Analysis Method

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Chemical Research in Chinese Universities 2012年第2期28卷 204-208页

作者： QIU Li-min LIU Miao WANG Ju ZHANG Sheng-nan fang chun-sheng Environmental Science Department College of Environment and ResourcesJilin UniversityChangchun 130012P.R.China Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun 130021P.R.China

In order to identify the day and night pollution sources of PM10 in ambient air in Longyan City,the authors analyzed the elemental composition of respirable particulate matters in the day and night ambient air samples and various pollution sources which were collected in January 2010 in Longyan with inductivity coupled plasma-mass spectrometry（ICP-MS）.Then chemical mass balance（CMB） model and factor analysis（FA） method were applied to comparatively study the inorganic components in the sources and receptor *** results of factor analysis show that the major sources were road dust,waste incineration and mixed sources which contained automobile exhaust,soil dust/secondary dust and coal dust during the daytime in Longyan City,*** are two major sources of pollution which are soil dust and mixture sources of automobile exhaust and secondary dust during the night in *** results of CMB show that the major sources are secondary dust,automobile exhaust and road dust during the daytime in *** major sources are secondary dust,soil dust and automobile exhaust during the night in *** results of the two methods are similar to each other and the results will guide us to plan to control the PM10 pollution sources in Longyan.

关键词： Factor analysis(FA) method Chemical mass balance(CMB) model Source apportionment Atmospheric particle PM10

Can mean platelet volume play a role in evaluating the severity of acute pancreatitis?

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World Journal of Gastroenterology 2017年第13期23卷 2404-2413页

作者： Jing-Jing Lei Li Zhou Qi Liu Can Xiong chun-fang Xu Department of Gastroenterology The First Affiliated Hospital of Soochow University Department of Gastroenterology The Affiliated Baiyun Hospital of Guizhou Medical University

AIM To investigate serum mean platelet volume(MPV) levels in acute pancreatitis(AP) patients and assess whether MPV effectively predicts the disease severity of *** We included 117 consecutive patients with AP as the AP group and 34 consecutive patients with colorectal polyps(before endoscopic treatment) as the control group. Complete blood counts, liver function, platelet indices(MPV), coagulation parameters, lactate dehydrogenase(LDH) and C-reactive protein(CRP) were measured on days 1, 2, 3 and 7 after admission. Receiver operating characteristic curves were used to compare the sensitivity and specificity of MPV, white blood cell(WBC), LDH and CRP in predicting AP severity. The Modified Glasgow Prognostic Score(m GPS) and the 2012 revised Atlanta criteria were used to evaluate disease severity in *** MPV levels were significantly lower in the AP group than in the control group on day 1(P = 0.000), day 2(P = 0.029) and day 3(P = 0.001) after *** addition, MPV values were lower on day 1 after admission than on day 2(P = 0.012), day 3(P = 0.000) and day 7(P = 0.002) in all AP patients. Based on the m GPS, 78 patients(66.7%) were diagnosed with mild and 39 patients(33.3%) with severe AP. There was no significant difference in mean MPV levels between patients diagnosed with mild and severe AP based on the m GPS(P = 0.424). According to the 2012 revised Atlanta criteria, there were 98 patients(83.8%) without persistent organ failure(OF) [non-severe acute pancreatitis(non-SAP) group] and 19 patients(16.2%) with persistent OF(SAP group). MPV levels were significantly lower in the SAP group than in the non-SAP group on day 1 after admission(P = 0.002). On day 1 after admission using a cut-off value of 6.65 f L, the overall accuracy of MPV for predicting SAP according to the 2012 revised Atlanta criteria(AUC = 0.716) had a sensitivity of 91.8% and a specificity of 47.4% and was superior to the accuracy of the traditional markers WBC(AUC = 0.700) and

关键词： Persistent organ failure Acute pancreatitis Mean platelet volume White blood cell C-reactive protein Lactate dehydrogenase

延时的间歇性肾脏替代治疗用于维持性血液透析替代治疗的临床观察

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中国血液净化 2024年第4期23卷 282-285页

作者：席春生王谨涵蔡蕊莲方春天肖燎原刘飞高健中国人民解放军联勤保障部队第九四〇医院肾脏病科兰州730050

目的观察延时的间歇性肾脏替代治疗(prolonged intermittent renal-replacement therapy,PIRRT)用于维持性血液透析(maintenance hemodialysis,MHD)替代治疗的可行性和安全性。方法回顾性评估2022年10月—2023年3月中国人民解放军联勤保障部队第九四〇医院的MHD患者因疫情管控需行肾脏替代治疗的临床资料。治疗模式选用前后联合稀释的加速静脉-静脉血液滤过(accelerated venovenous hemofiltration,AVVH),按治疗剂量分为25~30 ml/(kg·h)组(低剂量组)和50~60 ml/(kg·h)组(高剂量组)。从电子病历收集评估入院首次PIRRT治疗参数、治疗开始时和结束时血清尿素、钾、磷、二氧化碳,计算尿素下降率(URR)、单室模型尿素清除率(spKt/V)以及治疗期间和结束后不良反应等,比较2组上述指标。结果低剂量组(n=31)和高剂量组(n=36)患者年龄、男性比例、干体质量、血红蛋白水平比较均无统计学差异(t=1.388、0.459、0.479、0.913,P=0.085、0.498、0.683、0.818)。高剂量组PIRRT血流量、治疗剂量、滤过分数均高于低剂量组(t=14.535、39.358、7.304,均P<0.001)。2组患者总净超滤量比较无统计学差异(t=1.076,P=0.857)。治疗结束时,2组患者血钾、磷、二氧化碳水平均达正常范围。高剂量组URR及spKt/V均高于低剂量组,差异有统计学意义(t=12.039、5.145,均P<0.001)。2组患者PIRRT期间均未发生明显不良反应。结论PIRRT能够有效纠正MHD患者容量超负荷、电解质和酸碱紊乱;与低剂量PIRRT相比,高剂量PIRRT更能有效降低尿毒症毒素水平,且患者耐受性良好,更适用于MHD的替代治疗。

关键词：延时的间歇性肾脏替代治疗维持性血液透析替代治疗

Clinical values of Barcelona Clinic Liver Cancer subgroup and up-to-7 criteria in intermediate stage hepatocellular carcinoma with transcatheter arterial chemoembolization

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World Journal of Clinical Cases 2022年第21期10卷 7275-7284页

作者： Shou-Wu Lee Yen-chun Peng Han-chung Lien chung-Wang Ko chun-fang Tung Chi-Sen Chang Division of Gastroenterology and Hepatology Department of Internal MedicineTaichung Veterans General HospitalTaichung 40705Taiwan Department of Internal Medicine Yang Ming Chiao Tung UniversityTaipei 112304Taiwan Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichung 40227Taiwan Department of Internal Medicine Chung Shan Medical UniversityTaichung 40201Taiwan

BACKGROUND Transarterial chemoembolization(TACE)is a recommended treatment for patients with intermediate stage hepatocellular carcinoma(HCC)but with variable treatment *** To determine factors for predicting outcomes of TACE in patients with intermediate stage B *** Patients with Barcelona Clinic Liver Cancer(BCLC)stage B HCC who underwent TACE as the primary treatment were enrolled at Taichung Veterans General Hospital from January 2005 to December *** were assigned to either the objective responder(OR)group or the non-OR group according to mRECIST *** and radiological characteristics were compared between the 2 *** overall survival of enrolled subjects was *** In 128 enrolled patients,66(51.6%)were in the OR group and 62(48.4%)in the non-OR *** with the non-OR group,the OR group had a significantly smaller HCC size(6.55 cm vs 9.50 cm,P=0.001)and was within the up-to-7 criteria(50%vs 26.7%,P=0.001).After multivariable analyses,these significant associations still *** survival rate of all the subjects averaged 20.65±13.26 *** survival rate at 1-year was 64.8%,2-year was 46.9%,and 3-year was 31.2%.For those patients with OR to TACE,smaller tumor size and within up-to-7 criteria were associated with significantly better overall *** patients with subgroup B1 had the highest OR ratio(75%)and better overall survival(26.70±12.07 mo)after *** BCLC stage B HCC patients with smaller tumor size or within up-to-7 criteria had better survival outcomes to *** stage B subgroup is useful to predict refractoriness to TACE.

关键词： Hepatocellular carcinoma Objective response Overall survival Transcatheter arterial chemoembolization Barcelona Clinic Liver Cancer

Study on State of Terbium Ion in Liposome by One order Derivative Fluorescence Quenching Method

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Wuhan University Journal of Natural Sciences 1999年第4期4卷 469-472页

作者： Mu Xiao-jing fang Guo-chun Yao Song-nian Wuhan University College of Chemistry and Environmental Science Wuhan China (GRID:grid.49470.3e) (ISNI:***)

The state of Tb3+ is investigated in liposome. When the concentration of PC is below CMC (critical micell concentration), most of Tb3+ is associated with PC, the binding constant is about 3.35×103 L/mol. When the concentration of PC is beyond CMC, most of Tb3+ is dimerized, the dimerization constant is about 3.92×104L/mol. In PC?CH?H2O system, the binding constant of Tb3+?CH complex 2.93×104L/mol is obtained.

关键词： one-order derivative fluorescence quenching method liposome PC-Tb binding constant

Effects of hot compression deformation temperature on the microstructure and properties of Al–Zr–La alloys

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International Journal of Minerals,Metallurgy and Materials 2018年第2期25卷 236-243页

作者： Xian-hua Yue chun-fang Liu Hui-hua Liu Su-fen Xiao Zheng-hua Tang Tian Tang College of Materials Science and Engineering Sichuan University TBEA Deyang Cable Stock Co. Ltd.

The main goal of this study is to investigate the microstructure and electrical properties of Al–Zr–La alloys under different hot compression deformation temperatures. In particular, a Gleeble 3500 thermal simulator was used to carry out multi-pass hot compression tests. For five-pass hot compression deformation, the last-pass deformation temperatures were 240, 260, 300, 340, 380, and 420°C, respectively, where the first-pass deformation temperature was 460°C. The experimental results indicated that increasing the hot compression deformation temperature with each pass resulted in improved electrical conductivity of the alloy. Consequently, the flow stress was reduced after deformation of the samples subjected to the same number of passes. In addition, the dislocation density gradually decreased and the grain size increased after hot compression deformation. Furthermore, the dynamic recrystallization behavior was effectively suppressed during the hot compression process because spherical Al;Zr precipitates pinned the dislocation movement effectively and prevented grain boundary sliding.

关键词： microstructure Al–Zr–La alloys hot compression deformation dislocation

Beam Splitting in Induced Inhomogeneous Media

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Chinese Physics Letters 2012年第6期29卷 155-158页

作者： WANG chun-fang BAI Yan-Feng GUO Hong-Ju CHENG Jing College of Science University of Shanghai for Science and TechnologyShanghai 200093 Department of Physics Southeast UniversityNanjing 211189 Shanghai Publishing and Printing College Shanghai 200093 School of Physical Science and Technology South China University of TechnologyGuangzhou 510640

We study the spatial behavior of a deflected beam in a coherent A-type three-level atomic medium with an inhomogeneous control *** the Rabi coupling by the control laser is in a Gaussian profile,the spatialdependent refraction index of the atomic medium will result in a beam splitting as well as the deflection of the slow probe light under electromagnetically induced *** terms of the phase difference between the two splitting beams and the position of the splitting,the possible interpretation of the splitting is given in theory.

关键词： theory splitting beam

Endoscopic diagnosis of gastrointestinal graft-versus-host disease

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World Journal of Gastroenterology 2008年第14期14卷 2262-2267页

作者： chun-fang Xu Lan-Xiang Zhu Xiao-Ming Xu Wei-Chang Chen De-Pei Wu Department of Gastroenterology The First Affiliated Hospital of SooChow University 188 Shizi Street Suzhou 215006 Jiangsu Province China

AIM:To evaluate the diagnostic value of endoscopy in patients with gastrointestinal graft-versus-host disease (GI GVHD). METHODS:We identified 8 patients with GI GVHD following allogeneic hematopoietic stem cell trans-plantation (HSCT). GVHD was defined histologically as the presence of gland apoptosis, not explained by other inflammatory or infectious etiologies. RESULTS:The symptoms of GI GVHD included anorexia, nausea, vomiting, watery diarrhea, abdominal pain, GI bleeding, etc. Upper endoscopic appearance varied from subtle mucosal edema, hyperemia, erythema to obvious erosion. Colonoscopic examination showed diffuse edema, hyperemia, patchy erosion, scattered ulcer, sloughing and active bleeding. Histological changes in GI GVHD included apoptosis of crypt epithelial cells, dropout of crypts, and lymphocytic infiltration in epithelium and lamina propria. The involvement of stomach and rectocolon varied from diffuse to focal. CONCLUSION:Endoscopy may play a significant role in early diagnosis of GI GVHD patients following allogeneic HSCT, and histologic examination of gastrointestinal biopsies is needed to confirm the final diagnosis.

关键词： Gastrointestinal graft-versus-host disease Endoscopy Diagnosis Allogeneic hematopoietic stem cell transplantation