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Prognostic factors of recurrent intrahepatic cholangiocarcinoma after hepatectomy:A retrospective study

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World Journal of Gastroenterology 2022年第15期28卷 1574-1587页

作者： Zi-bo Yuan Hong-bo fang Quan-Kai Feng Tao Li Jie Li Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Henan Research Centre for Organ Transplantation the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a highly malignant *** is an effective treatment for early ICC,but postoperative recurrence greatly affects patient *** on recurrent ICC after hepatectomy are *** To investigate the clinical characteristics of patients with recurrent ICC after hepatectomy,analyse prognostic factors and explore diagnosis and treatment *** A retrospective analysis was performed on all ICC patients undergoing hepatectomy from January 2013 to August *** with postoperative recurrence were selected according to the inclusion and exclusion *** overall survival was plotted by the Kaplan-Meier method,and differences were assessed by univariate survival analysis using the log-rank *** analysis of cumulative survival was performed using the Cox proportional risk *** During the 8-year study period,103 patients underwent ICC-related hepatectomy,and 54 exhibited postoperative *** median disease-free survival(DFS)was 6 mo,the median overall survival(OS)was 9 mo,and the cumulative OS rates at 1,2 and 3 years after the operation were 40.7%,14.8%and 7.4%,*** median OS after recurrence was 4 mo,and the cumulative OS rates at 1,2 and 3 years after recurrence were 16.1%,6.7%and 3.4%,*** analysis showed that alcohol consumption[hazard ratio(HR)=4.64,95%confidence interval(CI):1.53-14.04,P=0.007]and DFS<6 mo(HR=3.47,95%CI:1.59-7.60,P=0.002)were independent risk factors for the cumulative survival of patients with recurrence,while treatment after recurrence(HR=0.21,95%CI:0.08-0.55,P=0.001)was an independent protective *** median OS time of patients receiving multimodality therapy after recurrence of ICC was 7 mo,which was significantly higher than that of patients receiving only local therapy(3 mo),patients receiving systematic therapy(4 mo)and patients receiving the best supportive therapy(1 mo).Patients

关键词： Intrahepatic cholangiocarcinoma Hepatectomy Recurrence Multimodality therapy Prognosis

Mode characteristics of silver-coated inverted-wedge silica microdisks

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Science China(Physics,Mechanics & Astronomy) 2015年第11期58卷 40-44页

作者： bo fang WANG XiaoOu LI Ying GAO Feng ZHANG GuoQuan XU JingJun The Key Laboratory of Weak-Light Nonlinear Photonics Ministry of Education TEDA Applied Physics Institute and School of PhysicsNankai University

The characteristics of whispering gallery modes(WGM) in silver-coated inverted-wedge silica microdisks are theoretically investigated by using finite element method. Dielectric TE mode always exists in silver-coated inverted-wedge resonators; dielectric TM mode tends to couple with SPP modes; only pure interior surface plasmonic polariton(SPP) mode but not pure exterior SPP mode is observed in contrast to the metal-coated cylindrical and toroidal resonators. The dependence of quality factor of different kinds of WGMs on the radius of the resonator and the thickness of the coated silver layer are systematically analyzed. We find that the quality factors of the hybrid WGMs associated with SPP mode can reach 104. The maximum light intensity enhancement in ambient for a hybrid mode consisting of a dielectric TM mode and an exterior SPP mode can be obtained when a silver film of thickness ~40 nm is deposited. The silver-coated inverted-wedge silica resonators may be widely applied in sensing and surface enhanced Raman scattering.

关键词： microcavity whispering gallery mode surface plasmonic polariton

Structural and Electrical Characteristics of Amorphous ErAlO Gate Dielectric Films

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Chinese Physics Letters 2012年第8期29卷 244-246页

作者： ZHU Yan-Yan fang Ze-bo TAN Yong-Sheng Department of Physics Shaoxing UniversityShaoxing 312000 Department of Mathematics and Physics Shanghai University of Electric PowerShanghai 200090

Ultrathin high-k dielectric ErAlO films were deposited on Si(100)substrates by using radio-frequency magnetron *** very flat surface of the annealed film with a rms roughness less than 0.25 nm was observed by using an atomic force *** film shows good thermal stability when annealing at 900℃ for 30 s in the O_(2) *** effective dielectric constant of the film is around 15.2,and a low leakage current of 8.4×10^(-5) A/cm^(2) at an electric field of 1 MV/cm was achieved for the film with the equivalent oxide thickness of 2.0 nm after annealing.

关键词： film roughness annealed

慢性牙周炎患者血清NfL以及HE4的表达与诊断价值研究

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临床口腔医学杂志 2024年第10期40卷 614-618页

作者：李方波石珊田银平李森森杨再波恩施土家族苗族自治州中心医院口腔诊疗中心

目的:探究慢性牙周炎(chronic periodontitis, CP)患者血清神经丝轻链(neurofilament light chain, NfL),附睾蛋白4(human epididymal protein 4,HE4)的表达与诊断价值。方法:选择2022年1月～2024年2月在本院诊治的51例CP患者，同期体检的健康志愿者51例为对照组。ELISA检测炎症因子肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein, CRP)、IL-1β以及NfL、HE4水平。检测免疫球蛋白A(immunoglobulin A,IgA)、IgM、IgG水平。检查并记录牙周临床指标探诊深度(probing depth, PD)、附着丧失(loss of attachment, AL)、龈沟出血指数(gingival sulcus bleeding index, SBI)、牙龈指数(gingival index, GI)。Pearson相关性分析NfL、HE4水平与实验室指标以及牙周临床指标(PD、AL、SBI、GI)之间的相关性；多因素Logistic回归分析CP发生的影响因素；ROC曲线分析NfL、HE4对CP发生的诊断价值。结果:CP组牙龈出血、牙面菌斑例数、免疫因子IgG,炎症因子IL-6、IL-1β、CRP、TNF-α,牙周临床指标GI、SBI、PD、AL以及血清NfL,HE4水平高于对照组(P<0.05);血清NfL,HE4水平与免疫因子IgG,炎症因子IL-6、IL-1β、CRP、TNF-α,牙周临床指标GI、SBI、PD、AL均呈正相关(P<0.05);存在龈下菌斑以及血清NfL,HE4水平升高是CP发生的独立危险因素(P<0.05);NFL、HE4单独诊断CP发生的AUC分别为0.830、0.821,联合诊断的AUC为0.908,优于各自单独诊断(均P<0.05)。结论:CP患者NfL,HE4水平升高，并与牙周临床指标、免疫因子、炎症因子指标呈正相关，两者联合诊断CP发生具有一定的临床意义。

关键词：慢性牙周炎神经丝轻链附睾蛋白4 牙周指标炎症反应诊断价值

Effects of Different Dietary Lipid Contents on Growth and Lipase Activity of Eriocheir sinensis Larvae

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Journal of Ocean University of China 2011年第1期10卷 55-60页

作者： ZHENG Debin PAN Luqing fang bo The Key Laboratory of Mariculture Ministry of Education Ocean University of China Qingdao 266003 P. R. China

The effects of different dietary lipid content on the growth and lipase activity ofEriocheir sinensis larvae were studied in the paper. The results showed that the survival, metamorphic rate and weight gain of E. sinensis larvae at different stages of growth all varied significantly with lipid content （P〈0.05）. Further, the survival and metamorphosis rates were the highest during the larval phases Z3 to Z4, and the weight gain was the highest during the larval phases Z5 to M. During the first 20h after metamorphosis of every larval stage, the lipase activity increased over time at Z1, Z2, Z3 and M and declined at Z4 and Zs, and was influenced significantly by lipid content （P〈0.05）. In addition, lipase activity at each larval stage began to respond to dietary lipid contents 4h after the larvae were fed, and tended to be stable after 12 h. The diets with higher lipase activity and lower lipid content were selected to give the suitable recipe of lipid requirements at each larval stage. It was concluded that the suitable lipid requirements at Zb Z2, Z3, Z4, Z5 and M were 6%, 4% 6%, 8%, 8% and 10%, respectively.

关键词： lipid content Eriocheir sinensis larvae growth lipase

双斑东方鲀鱼头美拉德反应工艺优化及挥发性风味物质分析

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中国调味品 2024年第4期49卷 109-115页

作者：刘瑞刘智禹陈贝方旭波张瑞娟陈小娥浙江海洋大学食品与药学学院浙江舟山316022 福建省海洋生物增养殖与高值化利用重点实验室福建厦门361013 浙江国际海运职业技术学院浙江舟山316024

为了提高双斑东方鲀鱼头的附加值,制备了河鲀鱼风味基料。以鱼头为原料,酶解后利用美拉德反应对其进行增香、呈色,采用正交试验优化工艺条件,并利用气相色谱-质谱(gas chromatography-mass spectrometry, GC-MS)联用技术和电子鼻分析美... 详细信息

为了提高双斑东方鲀鱼头的附加值,制备了河鲀鱼风味基料。以鱼头为原料,酶解后利用美拉德反应对其进行增香、呈色,采用正交试验优化工艺条件,并利用气相色谱-质谱(gas chromatography-mass spectrometry, GC-MS)联用技术和电子鼻分析美拉德反应前、后挥发性物质的变化。结果表明,双斑东方鲀鱼头酶解液美拉德反应的最适条件为木糖-氨基葡萄糖配比1∶2、还原糖添加量3.5%、反应时间65 min、反应温度115℃。GC-MS结果显示,美拉德反应改善了酶解液的整体风味,醛类是美拉德反应产物中最主要的挥发性物质,其他化合物则使其风味更加丰富。电子鼻雷达图分析结果与GC-MS数据结果基本保持一致。该研究结果为以双斑东方鲀鱼头为原料开发海鲜风味基料提供了理论基础。

关键词：双斑东方鲀鱼头美拉德反应正交试验风味 GC-MS 电子鼻

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广东省绿色发展水平评价与空间异质性

广州大学学报（自然科学版） 2024年第1期23卷 49-59页

作者：方应波廖慧娟蔡宗朝清远职业技术学院旅游家政与艺术学院广东清远511510 广州南洋理工职业学院经济管理学院广东广州510925

基于空间异质性视角,评判和诊断广东省绿色发展状态并揭示其演变规律,旨在为强化靶向施策提供参考,运用熵值法对2006—2019年广东全域和“一核一带一区”绿色发展水平及速率差异展开评价并进行空间分析。研究表明:(1)广东省绿色发展平... 详细信息

基于空间异质性视角,评判和诊断广东省绿色发展状态并揭示其演变规律,旨在为强化靶向施策提供参考,运用熵值法对2006—2019年广东全域和“一核一带一区”绿色发展水平及速率差异展开评价并进行空间分析。研究表明:(1)广东省绿色发展平均水平整体呈持续上升趋势,沿海经济带和北部生态区绿色发展水平低于全省平均值,绿色发展支撑结构中社会公平指数增长最为迅速。(2)珠三角地区绿色发展支撑结构维持绿色生产、绿色生活和社会公平“三轮驱动”的特征,但增长速度均明显放缓,尤以绿色生产维度增幅减缓突出;沿海经济带和北部生态区形成绿色生产和绿色生活增幅均衡、社会公平强劲增长、绿色生产波动增长的支撑结构。(3)广东省绿色发展水平区域间差异明显但区域集聚程度增加,高水平地区趋于集中;区域内部趋于分化,北部生态区势头向好但清远和韶关尚需发力,沿海经济带的茂名稳居高水平发展态势。由此提出推动广东绿色发展的建议:在巩固社会公平取得进展的同时依然要正视绿色发展水平的地域差异,提升沿海经济带和北部生态区绿色生产的稳定性,发挥珠三角和茂名在绿色发展中的空间溢出效应。

关键词：绿色发展绿色生产绿色生活社会公平

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上海市重症出生缺陷儿童巢式病例对照研究

上海预防医学 2024年第5期36卷 463-468页

作者：钱耐思晋珊郑文蔚陈蕾方博王春芳夏天虞慧婷上海市疾病预防控制中心上海200336 上海市长宁区疾病预防控制中心上海200051

【目的】基于上海市全人群出生队列,设计重症出生缺陷儿童的巢式病例对照研究,了解重症出生缺陷儿童的健康状况,探索出生缺陷发生的影响因素。【方法】应用巢式病例对照研究方法,在全人群出生队列的基础上,以重症出生缺陷儿童为病例组,... 详细信息

【目的】基于上海市全人群出生队列,设计重症出生缺陷儿童的巢式病例对照研究,了解重症出生缺陷儿童的健康状况,探索出生缺陷发生的影响因素。【方法】应用巢式病例对照研究方法,在全人群出生队列的基础上,以重症出生缺陷儿童为病例组,匹配健康儿童作为对照组,通过病史核查和入户随访收集儿童基本信息、健康状况、母亲孕史情况和生存追踪情况。应用多因素logistic回归模型探索出生缺陷的危险因素。【结果】共纳入2011年1月1日—2021年12月31日出生的婴儿18875例,其中重症出生缺陷儿童11500例(60.93%),健康对照儿童7375例(39.07%)。多因素logistic回归分析显示,男性(OR=1.20,95%CI:1.13~1.29)、非沪籍(OR=1.16,95%CI:1.06~1.25)、多胎(OR=8.41,95%CI:6.25~11.30)、人工授精(OR=2.31,95%CI:1.34~3.99),试管婴儿(OR=1.85,95%CI:1.44~2.38)、母亲放射暴露(OR=1.83,95%CI:1.07~3.14)、母亲妊娠期疾病(OR=1.61,95%CI:1.49~1.74)、妊娠期负性事件(OR=2.34,95%CI:1.88~2.92)、父亲化学暴露(OR=1.88,95%CI:1.32~2.69)、父亲放射暴露(OR=1.65,95%CI:1.18~2.33)、出生缺陷家族史(OR=8.18,95%CI:3.96~16.89)、母亲孕前超重(OR=1.16,95%CI:1.07~1.27)、肥胖(OR=1.15,95%CI:1.03~1.30)、过度肥胖(OR=1.52,95%CI:1.26~1.83)是出生缺陷发生的危险因素。按畸形种类分析发现早产(OR=27.87,95%CI:20.84~37.27)是心脏畸形和唇腭裂畸形的危险因素,尤其在心脏畸形中居于首位。【结论】在控制影响因素后,母亲妊娠前超重、肥胖和过度肥胖是出生缺陷发生的独立危险因素,人工授精和试管婴儿也是出生缺陷发生的独立危险因素。选择健康生活方式、加强妊娠期身心健康、控制体重指数(BMI),有利于降低出生缺陷发生风险。

关键词：出生队列出生缺陷巢式病例对照影响因素

水性单组分浸涂漆在汽车发动机缸体上的应用研究

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涂料工业 2024年第11期54卷 63-69,75页

作者：王荣芳姚煌许奕祥谢唯吴炳贤王从国方博擎天材料科技有限公司广东东莞523988 中国电器科学研究院股份有限公司广州510300

针对汽车发动机缸体上涂装的防护涂层经超声波-化学清洗工艺容易被破坏和剥离的难题,研制了一种高性能水性单组分浸涂漆并研究其应用效果;探讨了浸涂漆的成膜物、润湿剂、催干剂和附着力促进剂对漆膜的附着力、耐水性、耐盐雾性和耐超声... 详细信息

针对汽车发动机缸体上涂装的防护涂层经超声波-化学清洗工艺容易被破坏和剥离的难题,研制了一种高性能水性单组分浸涂漆并研究其应用效果;探讨了浸涂漆的成膜物、润湿剂、催干剂和附着力促进剂对漆膜的附着力、耐水性、耐盐雾性和耐超声波-化学清洗性能的影响。结果表明:选择水性丙烯酸改性环氧酯树脂TH-8180和改性水性环氧分散体H-502-42W按照质量比6∶4作为成膜物,选择润湿剂BW-104E和HOS 2413按照质量比2∶3进行复配,同时,添加5%无钴环保催干剂OXY-Coat1101和1.5%附着力促进剂MOAP 1880,制备的水性单组分浸涂漆对发动机缸体的润湿性良好,漆膜的干燥速度快,耐水性、耐盐雾性和耐超声波-化学清洗性优异。

关键词：水性单组分浸涂漆超声波-化学清洗工艺汽车发动机浸涂工艺

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