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Protective Mechanism of Electroacupuncture on Peripheral Neurotoxicity Induced by Oxaliplatin in Rats

Chinese Journal of Integrative Medicine 2022年第9期28卷 833-839页

作者： WANG Feng-jiao SHI She WANG Yong-qiang WANG Ke fan shen-dong ZHANG Ya-nan FENG Chen-chen JU Zi-yong College of Acumox and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Anesthesiology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200120China Acupuncture Anesthesia Clinical Research Institute Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China

Objective:To study the effect of electroacupuncture(EA)on oxaliplatin-induced peripheral neuropathy(OIPN)in rats.Methods:Male Sprague-Dawley rats were equally divided into 3 groups using a random number table:the control group,the OIRN group,and the EA(OIPN+EA)group,with 10 rats in each.The time courses of mechanical,cold sensitivity,and microcirculation blood flow intensity were determined.The morphology of the dorsal root ganglion(DRG)was observed by electron microscopic examination.The protein levels of nuclear factor E2-related factor 2(Nrf2),heme oxygenase-1(HO-1),and the transient receptor potential(TRP)protein family in DRGs were assayed by Western blot.Results:EA treatment significantly reduced mechanical allodynia and cold allodynia in OIPN rats(P<0.01).Notably,oxaliplatin treatment resulted in impaired microcirculatory blood flow and pathomorphological defects in DRGs(P<0.01).EA treatment increased the microcirculation blood flow and attenuated the pathological changes induced by oxaliplatin(P<0.01).In addition,the expression levels of Nrf2 and HO-1 were down-regulated,and the TRP protein family was over-expressed in the DRGs of OIPN rats(P<0.01).EA increased the expression levels of Nrf2 and HO-1 and decreased the level of TRP protein family in DRG(P<0.05 or P<0.01).Conclusion:EA may be a potential alternative therapy for OIPN,and its mechanism may be mainly mediated by restoring the Nrf2/HO-1 signaling pathway.

关键词： electroacupuncture oxaliplatin peripheral neuropathy dorsal root ganglion nuclear factor-erythroid-2-related factor 2

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Linear-fitting-based recursive filtering for nonlinear systems under encoding-decoding mechanism

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Science China(Information Sciences) 2024年第5期67卷 183-196页

作者： Bo JIANG Hongli dong Zhiwei GAO Yuxuan shen fan YANG Artificial Intelligence Energy Research Institute Northeast Petroleum University Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Sanya Offshore Oil & Gas Research Institute Northeast Petroleum University School of Electrical & Information Engineering Northeast Petroleum University

This paper deals with a recursive filtering problem for a class of discrete time-varying nonlinear networked systems with the encoding-decoding mechanism. The linear fitting method is introduced to handle the nonlinearity. An encoding-decoding mechanism is constructed to describe the data transmission process in wireless communication networks(WCNs). To be specific, the measurement outputs are mapped by a quantizer to unique codewords for transmission in WCNs. Then, the codewords are decoded by the decoder to recover the measurement outputs which are sent to the filter. The processing/encoding delay and network delay have been considered. Firstly, on the premise that the upper bound of the filtering error covariance is minimum, the appropriate filtering gain is calculated. Then, the mean square exponential boundedness of the filtering error is analyzed. Finally, two simulation examples are presented to verify the effectiveness of the proposed algorithm.

关键词： encoding-decoding mechanism uniform quantizer linear fitting networked systems recursive filtering

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Protocol-Based Non-Fragile State Estimation for Delayed Recurrent Neural Networks Subject to Replay Attacks

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 249-251页

作者： fan Yang Hongli dong Yuxuan shen Xuerong Li dongyan Dai the Artificial Intelligence Energy Research Institute Northeast Petroleum UniversityDaqing 163318 the Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Northeast Petroleum UniversityDaqing 163318 the Sanya Offshore Oil&Gas Research Institute Sanya 572025China IEEE

Dear Editor, This letter focuses on the protocol-based non-fragile state estimation problem for a class of recurrent neural networks(RNNs). With the development of communication technology, the networked systems have ... 详细信息

关键词： network communication estimation

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Plant RNA-binding proteins:Phase separation dynamics and functional mechanisms underlying plant development and stress responses

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Molecular Plant 2024年第4期17卷 531-551页

作者： sheng fan Yu Zhang Shaobo Zhu Lisha shen Temasek Life Sciences Laboratory 1 Research LinkNational University of Singapore1 Research LinkSingapore 117604Singapore Department of Biological Sciences National University of Singapore14 Science Drive 4Singapore 117543Singapore

RNA-binding proteins(RBPs)accompany RNA from synthesis to decay,mediating every aspect of RNA metabolism and impacting diverse cellular and developmental processes in eukaryotes.Many RBPs undergo phase separation along with their bound RNA to form and function in dynamic membraneless biomolecular condensates for spatiotemporal coordination or regulation of RNA metabolism.Increasing evidence suggests that phase-separating RBPs with RNA-binding domains and intrinsically disordered regions play important roles in plant development and stress adaptation.Here,we summarize the current knowledge about how dynamic partitioning of RBPs into condensates controls plant development and enables sensing of experimental changes to confer growth plasticity under stress conditions,with a focus on the dynamics and functional mechanisms of RBP-rich nuclear condensates and cytoplasmic granules in mediating RNA metabolism.We also discuss roles of multiple factors,such as environmental signals,protein modifications,and N6-methyladenosine RNA methylation,in modulating the phase separation behaviors of RBPs,and highlight the prospects and challenges for future research on phase-separating RBPs in crops.

关键词： RNA-binding proteins phase separation biomolecular condensates RNA metabolism development stress resilience

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Sustainable management of campus fallen leaves through low-temperature pyrolysis and application in Pb immobilization

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Journal of Environmental Sciences 2024年第5期139卷 281-292页

作者： Rongli Tan Ke Li Yue Sun Xiaoliang fan Zhengtao shen Lingyi Tang School of Environment Nanjing UniversityNanjing 210023China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China School of Earth and Engineering Sciences Nanjing UniversityNanjing 210023China Department of Earth and Atmospheric Sciences University of AlbertaEdmonton T6G 2E3Canada

Realizing campus sustainability requires the environmental-friendly and economical treatment of tremendous fallen leaves.Producing fallen leaf biochar at a low temperature is a candidate approach.In this study,six common types of fallen leaves on the campus were pyrolyzed at 300℃.The obtained biochars were characterized and the adsorption mechanisms of lead(Pb)by the fallen leaf biochars were investigated.The adsorption capacity of leaf biochar for Pb was relatively high,up to 209 mg/g(Yulania denudata leaf biochar).Adsorption of Pb onto active sites was the rate-limiting step for most leaf biochars.But for Platanus leaf biochar,intraparticle diffusion of Pb^(2+)dominated owing to the lowest adsorption capacity.However,the highest exchangeable Pb fraction(27%)indicated its potential for removing aqueous Pb^(2+).Ginkgo and Prunus cerasifera leaf biochar immobilized Pb by surface complexation and precipitation as lead oxalate.Hence,they were suitable for soil heavy metal remediation.This study shed the light on the sustainable utilization of campus fallen leaves and the application of fallen leaf biochars in heavy metal remediation.

关键词： Fallen leaves Waste management Biochar Lead removal Sorption Circular campus

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Experimental and numerical study regarding H-steel all-bolted connection steel frame with composite wall boards

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 427-443页

作者： fan Min Guo Hongchao Li shen Wang Zhenshan Wang Huaqiang School of Civil Engineering and Architecture Xi’an University of TechnologyXi’an 710048China State Key Laboratory Base of Eco-Hydraulic Engineering in Arid Area Xi’an University of TechnologyXi’an 710048China

H-steel all-bolted connection steel frame structures with heat preservation and decoration composite wall boards were investigated and the seismic performances of three scaled specimens were studied.The failure modes,hysteresis curves,bearing capacity,ductility,energy dissipation capacity,stiffness degradation and strain distribution were discussed.The calculation method of structural theoretical internal force was presented.The results showed that the overall structural seismic performance was better,and the structural ductility met the demands of elastic-plastic inter-story drift angle for seismic design.The H-steel weak-axis connection structure obtained better energy dissipation capacity,and its bearing capacity and stiffness were slightly different from the strong-axis connection.The heat preservation and decoration performance of composite wallboard and the all-bolted connection of the steel frame realized prefabrication during the whole construction period.The plastic hinge of the steel beam can be moved outwards because of the L-angles,which effectively avoids stress concentration in joint areas and expands the plastic hinge range.The errors between the theoretical structural capacity calculated by the plastic analysis method and the test results were within 2.44%.In addition,structural failure mechanisms and bearing capacities were verified by the finite element(FE)analysis,and the effects of the main parameters on the structures were investigated.The FE verification results were the same as in the test.The research results provide theoretical support and technical guidance for the application of thermal insulation and decorative composite wall panels in H-shaped steel all-bolted steel frames.

关键词： composite wall boards all-bolted steel frame H-steel low-cyclic loading failure modes

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Cobalt-Catalyzed Switchable[4+1]and[4+1+1]Spirocyclization of Aromatic Amides with 2-Diazo-1H-indene-1,3(2H)-dione:Access to Spiro Indene-2,1'-isoindolinones and Spiro Isochroman-3,1'-isoindolinones

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Chinese Journal of Chemistry 2024年第4期42卷 363-369页

作者： Bin Li Mengmeng Xie Jingyu Li Nana shen Xinying Zhang Xuesen fan State Key Laboratory of Antiviral Drugs Pingyuan LaboratoryKey Laboratory of Green Chemical Media and ReactionsKey Laboratory for Yellow River and Huai River Water Environmental Pollution ControlMinistry of EducationSchool of EnvironmentSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan453007 China

Herein,we report a condition-controlled divergent synthesis of spiro indene-2,1'-isoindolinones and spiro isochroman-3,1'-isoindolinones through cobalt-catalyzed formal[4+1]and[4+1+1]spirocyclization of aromatic amides with 2-diazo-1H-indene-1,3(2H)-dione.When the reaction is carried out under air in ethyl acetate,spiro indene-2,1'-isoindolinones are formed through Co(II)-catalyzed C—H/N—H[4+1]spirocyclization.When the reaction is run under O2 in CH3CN,on the other hand,spiro isochroman-3,1'-isoindolinones are generated through Baeyer-Villiger oxidation of the in situ formed spiro indene-2,1'-isoindolinones with O2 as a cheaper and environmental-friendly oxygen source.In general,these protocols have advantages such as using non-precious and earth-abundant metal catalyst,no extra additive,high efficiency and regioselectivity.A gram-scale synthesis and the removal of the directing group further highlight its utility.

关键词： Spiro indene-2,1'-isoindolinones Spiro isochroman-3,1'-isoindolinones 3d Transition metals Cobalt-catalyzed C-H Activation Switchable[4+1]and[4+1+1]spirocyclization Aromatic amides 2-Diazo-1H-indene-1,3(2H)-dione

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Therapeutic cancer vaccines:advancements,challenges,and prospects

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Signal Transduction and Targeted Therapy 2024年第1期9卷 150-172页

作者： Ting fan Mingna Zhang Jingxian Yang Zhounan Zhu Wanlu Cao Chunyan dong Department of Oncology East Hospital Affiliated to Tongji UniversityTongji University School of MedicineShanghaiChina Postgraduate Training Base Shanghai East HospitalJinzhou Medical UniversityShanghai 200120China

With the development and regulatory approval of immune checkpoint inhibitors and adoptive cell therapies,cancer immunotherapy has undergone a profound transformation over the past decades.Recently,therapeutic cancer vaccines have shown promise by eliciting de novo T cell responses targeting tumor antigens,including tumor-associated antigens and tumor-specific antigens.The objective was to amplify and diversify the intrinsic repertoire of tumor-specific T cells.However,the complete realization of these capabilities remains an ongoing pursuit.Therefore,we provide an overview of the current landscape of cancer vaccines in this review.The range of antigen selection,antigen delivery systems development the strategic nuances underlying effective antigen presentation have pioneered cancer vaccine design.Furthermore,this review addresses the current status of clinical trials and discusses their strategies,focusing on tumor-specific immunogenicity and anti-tumor efficacy assessment.However,current clinical attempts toward developing cancer vaccines have not yielded breakthrough clinical outcomes due to significant challenges,including tumor immune microenvironment suppression,optimal candidate identification,immune response evaluation,and vaccine manufacturing acceleration.Therefore,the field is poised to overcome hurdles and improve patient outcomes in the future by acknowledging these clinical complexities and persistently striving to surmount inherent constraints.

关键词： breakthrough approval overcome

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Doppler-resilient waveform design in integrated MIMO radar-communication systems

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Science China(Information Sciences) 2024年第1期67卷 187-202页

作者： Zhengchun ZHOU Bing LIU Bingsheng shen Avik Ranjan ADHIKARY Pingzhi fan Institute of Mobile Communications Southwest Jiaotong University Department of Mathematics Southwest Jiaotong University

In recent years,the increased high-rate wireless services(5G and 6G) and reliable sensing capabilities(automotive radar,air traffic control,geophysical monitoring),have led to more serious spectrum congestion.Conventionally,radars and communication systems are often seen to be “competing” for the same resources.In this scenario,an integrated platform for radar and communication systems seems to be an optimal solution to address the problem.In this paper,we propose a preamble waveform design based on zero-correlation zone(ZCZ) and zero odd-correlation zone(ZOCZ) sequence sets,which are Doppler resilient in multiple-input,multiple-output(MIMO) radar.The preamble waveforms can be simultaneously used for channel estimation and radar sensing in RadCom systems.The ambiguity function of the proposed waveforms displays low/zero sidelobes within a time-delay correlation zone.Finally,we give some numerical results to show the efficiency of the proposed waveforms in radar sensing and channel estimation.

关键词： ambiguity function correlation channel estimation integrated radar and communication (RadCom) systems MIMO radar zero correlation zone (ZCZ) sequence set zero odd-correlation zone (ZOCZ) sequence set

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Current landscape of preoperative neoadjuvant therapies for initial resectable colorectal cancer liver metastasis

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World Journal of Gastroenterology 2024年第7期30卷 663-672页

作者： Xiao-Fei Cheng Feng Zhao dong Chen fan-Long Liu Department of Colorectal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Radiation Oncology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

Colorectal cancer liver metastasis(CRLM)presents a clinical challenge,and optimizing treatment strategies is crucial for improving patient outcomes.Surgical resection,a key element in achieving prolonged survival,is often linked to a heightened risk of recurrence.Acknowledging the potential benefits of preoperative neoadjuvant chemotherapy in managing resectable liver metastases,this approach has gained attention for its role in tumor downsizing,assessing biological behavior,and reducing the risk of postoperative recurrence.However,the use of neoadjuvant chemotherapy in initially resectable CRLM sparks ongoing debates.The balance between tumor reduction and the risk of hepatic injury,coupled with concerns about delaying surgery,necessitates a nuanced approach.This article explores recent research insights and draws upon the practical experiences at our center to address critical issues regarding considerations for initially resectable cases.Examining the criteria for patient selection and the judicious choice of neoadjuvant regimens are pivotal areas of discussion.Striking the right balance between maximizing treatment efficacy and minimizing adverse effects is imperative.The dynamic landscape of precision medicine is also reflected in the evolving role of gene testing,such as RAS/BRAF and PIK3CA,in tailoring neoadjuvant regimens.Furthermore,the review emphasizes the need for a multidisciplinary approach to navigate the comp-lexities of CRLM.Integrating technical expertise and biological insights is crucial in refining neoadjuvant strategies.The management of progression following neoadjuvant chemotherapy requires a tailored approach,acknowledging the diverse biological behaviors that may emerge.In conclusion,this review aims to provide a comprehensive perspective on the considerations,challenges,and advancements in the use of neoadjuvant chemotherapy for initially resectable CRLM.By combining evidencebased insights with practical experiences,we aspire to contribute to the ongoing discourse on refining treatment

关键词： Neoadjuvant therapy Colorectal cancer liver metastasis Multidisciplinary teams Chemotherapeutic regimens Resectability criteria

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