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通智测试——基于动态具身物理社会交互环境的通用人工智能测试

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Engineering 2024年第3期34卷 12-22页

作者： Yujia peng Jiaheng Han Zhenliang Zhang Lifeng fan Tengyu Liu Siyuan Qi Xue Feng Yuxi Ma Yizhou Wang Song-Chun Zhu National Key Laboratory of General Artificial Intelligence Beijing Institute for General Artificial IntelligenceBeijing 100086China Institute for Artificial Intelligence Peking UniversityBeijing 100871China Beijing Key Laboratory of Behavior and Mental Health School of Psychological and Cognitive SciencesPeking UniversityBeijing 100871China School of Intelligence Science and Technology Peking UniversityBeijing 100871China School of Computer Science Peking UniversityBeijing 100871China

The release of the generative pre-trained transformer(GPT)series has brought artificial general intelligence(AGI)to the forefront of the artificial intelligence(AI)field once ***,the questions of how to define and evaluate AGI remain *** perspective article proposes that the evaluation of AGI should be rooted in dynamic embodied physical and social interactions(DEPSI).More specifically,we propose five critical characteristics to be considered as AGI benchmarks and suggest the Tong test as an AGI evaluation *** Tong test describes a value-and ability-oriented testing system that delineates five levels of AGI milestones through a virtual environment with DEPSI,allowing for infinite task *** contrast the Tong test with classical AI testing systems in terms of various aspects and propose a systematic evaluation system to promote standardized,quantitative,and objective benchmarks and evaluation of AGI.

关键词： Artificial general intelligence Artificial intelligence benchmark Artificial intelligence evaluation Embodied artificial intelligence Value alignment Turing test Causality

Unveiling of Terahertz Emission from Ultrafast Demagnetization and the Anomalous Hall Effect in a Single Ferromagnetic Film

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Chinese Physics Letters 2024年第4期41卷 45-50页

作者：蓝志强李章顺徐浩然刘凡金钻明彭滟朱亦鸣 Terahertz Technology Innovation Research Institute Terahertz Spectrum and Imaging Technology Cooperative Innovation CenterShanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai 200093China

Using THz emission spectroscopy,we investigate the elementary spin dynamics in ferromagnetic single-layer Fe on a sub-picosecond *** demonstrate that THz radiation changes its polarity with reversal of the magnetization applied by the external magnetic *** addition,it is found that the sign of THz polarity excited from different sides is defined by the thickness of the Fe layer and Fe/dielectric *** on the thickness and symmetry dependences of THz emission,we experimentally distinguish between the two major contributions:ultrafast demagnetization and the anomalous Hall *** experimental results not only enrich understanding of THz electromagnetic generation induced by femtosecond laser pulses but also provide a practical way to access laser-induced ultrafast spin dynamics in magnetic structures.

关键词： magnetic magnetization polarity

Mutation of EJC Binding Domain of ZmeIF4A3Enhances Sugarcane Mosaic Virus Infection

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Mutation of EJC Binding Domain of ZmeIF4A3Enhances Sugarcane...

Integration of serum pharmacochemistry with network pharmacology to reveal the potential mechanism of Yangqing Chenfei formula(养清尘肺方) for the treatment of silicosis

中国植物病理学会2024年学术年会

作者： peng Dezhi DU Kaitong fan Zaifeng ZHOU Tao Department of Plant Pathology China Agricultural University

Eukaryotic initiation factor 4 A-Ⅲ(eIF4 A-Ⅲ) is a pivotal RNA-binding protein within the exon junction complex(EJC),which is crucial for numerous post-transcriptional regulatory *** EJC interacts with Up-frame shift protein 3(UPF3),a key factor in nonsense-mediated mRNA decay(NMD),thereby mediating the EJC-NMD *** previously showed that the silencing of ZmUPF3 expression enhances susceptibility to sugarcane mosaicvirus(SCMV),suggesting that the NMD pathway can contribute to antiviral defense against ***,we hypothesized that a mutation within the EJC binding domain of ZmeIF4 A3 could disrupt the NMD pathway,thereby potentially increasing the susceptibility of plants to SCMV *** findings from agroinfiltration with SCMV-GFP infectious clone into Nicotiana benthamiana leaves support this ***,we observed a significant increase in the accumulation of SCMV-GFP RNA and coat protein(CP) in cells with mutated EJC-binding sites compared to those expressing wild-type ZmeIF4 ***,these results indicate that the mutation of EJC binding sites in ZmeIF4 A3 promotes SCMV infection,further implicating the EJC-mediated NMD pathway in the plant's resistance to SCMV.

关键词： Eukaryotic initiation factor 4A-Ⅲ(eIF4A3) nonsense-mediated mRNA decay(NMD) sugarcane mosaic virus(SCMV) Exon junction complex(EJC)

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Journal of Traditional Chinese Medicine 2024年第4期44卷 784-793页

作者： HU Yuanyuan LIU Xinguang ZHAO peng WU Jinyan YAN Xinhua HOU Runsu WANG Xiangcheng YANG fan TIAN Xinrong LI Jiansheng Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200032China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R.China.Zhengzhou 450046China Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046China

OBJECTIVE:To explore the mechanisms of Yangqing Chenfei formula(养清尘肺方,YCF)in the treatment of silicosis through a comprehensive strategy consisting of serum pharmacochemistry,network pharmacology analysis,and in vitro ***:An ultrahigh-performance liquid chromatography-tandem mass spectrometry method was used to confirm the active components in YCF-medicated ***,we obtained targets for active components and genes for silicosis from multiple ***,a protein-protein interaction network was constructed,and Kyoto Encyclopedia of Genes and Genomes pathway and biological process analyses were conducted to elucidate the mechanisms of YCF for the treatment of ***,we validated the important components and mechanisms in ***:Altogether,19 active components were identified from rat serum after YCF *** identified 724 targets for 19 components,which were mainly related to inflammation[phosphatidy linositol 3 kinase/protein kinase B,forkhead box O,hypoxia inducible factor,and T-cell receptor signaling pathway,nitric oxide biosynthetic process],fibrotic processes[vascular endothelial growth factor signaling pathway,extracellular signal regulated kinase(ERK)1 and ERK2 cascade,smooth muscle cell proliferation],and apoptosis(negative regulation of apoptotic process).In addition,218 genes for silicosis were identified and were mainly associated with the inflammatory response and immune process[cytokine-cytokine receptor interaction,tumor necrosis factor alpha(TNF-α),toll-like receptor,and nucleotide binding oligomerization domain-like receptor signaling pathway].Taking an intersection of active component targets and silicosis genes,we obtained 61 common genes that were mainly related to the inflammatory response and apoptosis,such as the phosphatidylinositol-3-kinase/protein kinase B signaling pathway,mitogen activated protein kinases signaling pathway,TNF signaling pathway,toll-like receptor signaling pathway,b

关键词： silicosis network treatment

基于有限谓词追踪的民机系统需求一致性检查方法

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系统工程与电子技术 2024年第1期46卷 205-218页

作者：王鹏岳舒婷张帆董磊中国民航大学民航航空器适航审定技术重点实验室天津300300 中国民航大学安全科学与工程学院天津300300

针对民机安全关键系统在正向研发过程中,系统级需求的正确性难以在设计早期全部完成确认的问题,提出一种基于有限谓词追踪的功能需求一致性检查体系。首先,引入一阶逻辑中的谓词追踪,建立系统内部功能需求与交互功能需求形式化规约方法... 详细信息

针对民机安全关键系统在正向研发过程中,系统级需求的正确性难以在设计早期全部完成确认的问题,提出一种基于有限谓词追踪的功能需求一致性检查体系。首先,引入一阶逻辑中的谓词追踪,建立系统内部功能需求与交互功能需求形式化规约方法。其次,针对单条、多条需求内容正确性以及需求关系一致性,构建需求一致性检查形式化规约,开展需求自冲突、集冲突与需求关系一致性检验,并生成可解释的检查反例进行需求迭代。最后,以机载平视显示(head-up display,HUD)系统飞行信息符号生成与显示功能为例,验证该方法的正确性与有效性。研究结果表明,基于有限谓词追踪的功能需求一致性检查方法能够提高需求一致性检查效率、降低研发成本,为民机系统级需求确认提供支持。

关键词：需求一致性定理证明功能需求正确性一阶逻辑需求冲突

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di fan Wan Wang Bin Wang Ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2024年

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli fan Xiaojun peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Black holes as the source of dark energy:A stringent test with high-redshift JWST AGNs

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 181-188页

作者： Lei Lei Lei Zu Guan-Wen Yuan Zhao-Qiang Shen Yi-Ying Wang Yuan-Zhu Wang Zhen-Bo Su Wen-Ke Ren Shao-peng Tang Hao Zhou Chi Zhang Zhi-Ping Jin Lei Feng Yi-Zhong fan Da-Ming Wei Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China

Studies have proposed that there is evidence for cosmological coupling of black holes(BHs)with an index of k≈3;hence,BHs serve as the astrophysical source of dark ***,the data sample is limited for the redshifts of≤*** recent years,the James Webb Space Telescope(JWST)has detected many high-redshift active galactic nuclei(AGNs)and *** the JWST NIRSpec-/NIRCam-resolved AGNs,three are determined to be in early-type host galaxies with a redshift of z~***,their M_(*)and MBH are in tension with the predicted cosmological coupling of black holes with k=3 at a confidence level of~2σ,which challenges the hypothesis that BHs serve as the origin of dark *** work on high-redshift AGNs using the JWST will further assess such a hypothesis by identifying more early-type host galaxies in the higher mass range.

关键词： dark energy supermassive black hole active galactic nuclei James Webb Space Telescope

Screening of colorectal cancer: Methods and strategies

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World Journal of Clinical Oncology 2024年第7期15卷 799-805页

作者： Zhen Liao Jin-Tao Guo fan Yang Shu-peng Wang Si-Yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

Colorectal cancer(CRC)has high incidence and mortality rates,and the em-ergence and application of CRC screening have helped us effectively control the occurrence and development of ***,common international screening methods include tests based on feces and blood,and examination methods that allow for visualization,such as sigmoidoscopy and *** methods have been widely used,whereas others such as multi-target stool RNA test are still being explored and developed,and are expected to become front-line screening methods for CRC in the *** choice of screening method is affected by external conditions and the patients'situation,and the clinician must choose an appropriate strategy according to the actual situation and the patient's *** article introduces various CRC screening methods and analyzes the factors relevant to the screening strategy.

关键词： Colorectal cancer Screening Stool-based test Endoscopic examination Computed tomography colonography Blood-based test