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Science China Life Sciences 2025年第1期68卷 297-299页

作者： Junbin zhou Rongli Wei Guanghan fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo qi Haiyang Xie Shusen Zheng qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Detection using mask adaptive transformers in unmanned aerial vehicle imagery

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Optoelectronics Letters 2025年第2期21卷 113-120页

作者： YE Huibiao fan Weiming GUO Yuping WANG Xuna zhou Dalin China Telecommunication Corporation Zhejiang Branch Innovation Center for Smart Medical Technologies & Devices Binjiang Institute of Zhejiang University School of Computing University of Portsmouth

Drone photography is an essential building block of intelligent transportation,enabling wide-ranging monitoring,precise positioning,and rapid ***,the high computational cost of transformer-based methods in object detection tasks hinders real-time result transmission in drone target detection ***,we propose mask adaptive transformer (MAT) tailored for such ***,we introduce a structure that supports collaborative token sparsification in support windows,enhancing fault tolerance and reducing computational *** structure comprises two modules:a binary mask strategy and adaptive window self-attention (A-WSA).The binary mask strategy focuses on significant objects in various complex *** A-WSA mechanism is employed to self-attend for balance perfomance and computational cost to select objects and isolate all contextual *** experiments on the challenging CarPK and VisDrone datasets demonstrate the effectiveness and superiority of the proposed ***,it achieves a mean average precision (mAP@0.5) improvement of 1.25%over car detector based on you only look once version 5 (CD-YOLOv5) on the CarPK dataset and a 3.75%average precision(AP@0.5) improvement over cascaded zoom-in detector (CZ Det) on the VisDrone dataset.

关键词： Drones

Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang fan Zhang Xingyu zhou qian Wang Changyu Liu Yangyang Liu Hui Wang Xiaojie Liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

Flexible Strain Sensors with Ultra‑High Sensitivity and Wide Range Enabled by Crack‑Modulated Electrical Pathways

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Nano-Micro Letters 2025年第3期17卷 246-264页

作者： Yunzhao Bai Yunlei zhou Xuanyu Wu Mengfei Yin Liting Yin Shiyuan Qu fan Zhang Kan Li YongAn Huang State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Flexible Electronics Research Center Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200People’s Republic of China School of Mechano‑Electronic Engineering Xidian UniversityXi’an 710071People’s Republic of China Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reconciling sensitivity with measurement *** by the structure of bamboo slips,we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric *** resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%.The integration of patterned liquid metal enables customisable tuning of the sensor’s response,while the porous fabric structure ensures superior comfort and air permeability for the *** design not only optimises the sensor’s performance but also enhances the electrical stability that is essential for practical *** systematic investigation,we reveal the intrinsic mechanisms governing the sensor’s response,offering valuable insights for the design of wearable strain *** sensor’s exceptional performance across a spectrum of applications,from micro-strain to large-strain detection,highlights its potential for a wide range of real-world uses,demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

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Relationship Between Developmental Intensity of Landslide and Malan Loess Cohesion at a Regional Horizontal Space Scale

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Journal of Earth Science 2025年

作者： Yongheng zhou Yaming Tang Bo Hong fan Feng Longhui Wang Institute of Geological Survey， China University of Geosciences (Wuhan) Institute of Earth Environment， Chinese Academy of Sciences Xi'an Geological Survey Center China Geological Survey Chinese Academy of Geological Sciences

Malan loess is highly water-sensitive， with its shear strength， particularly cohesive strength， significantly decreasing under the influence of water. The Western Shanxi Loess Plateau （WSLP） is especially prone to loess landslides， which are closely linked to rainfall infiltration. Understanding the regional variation of Malan loess cohesion (cm) and its distribution in relation to the developmental intensity of landslides in this area can provide essential scientific evidence for effective landslide prevention. Loess landslides and Malan loess were selected as the objects of study for the current research. The regional variation and distribution pattern of the cmwere revealed through undisturbed loess direct shear tests and Inverse Distance Weighting （IDW） interpolation. The relationship between the developmental intensity of landslide and the regional variation of the cmwas explored using the Cumulative Sum Variable Dimension Fractal （CSVDF）， Frequency Ratio （FR） model， and Certainty Factor （CF） model. The following conclusions were drawn: Results from the direct shear tests and IDW method indicate that the cmtends to decrease from south to north and exhibits a positively skewed spatial distribution pattern. The CSVDF results indicates a similarity between the regional variation of the cmand the development intensity of loess landslides. The FR and CF results reveal that loess landslides are more likely to occur when the cmis between 0 and 16.14 kPa.

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Long-read sequencing reveals novel genetic polymorphisms in the major histocompatibility complex region and their impacts on the Han Chinese population

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Science China Life Sciences 2025年

作者： Cong zhou Tingting Gong Shuhang Li Li Jin Shaohua fan State Key Laboratory of Genetic Engineering Lab for Evolutionary Synthesis School of Life Sciences Human Phenome Institute Fudan University Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences

Human leukocyte antigen(HLA) genes in the major histocompatibility complex(MHC) region are crucial for immunity and are associated with numerous diseases and phenotypes. The MHC region's complexity and high genetic diversity make it challenging to analyze using short-read sequencing(SRS) technology. We sequence the MHC region of 100 Han Chinese individuals using both long-read sequencing(LRS) and SRS platforms at approximately 30X coverage to study genetic alterations and their potential functional impacts. LRS provides significantly greater coverage of the MHC region and eight classical HLA genes, particularly at the HLA-DRB1 locus, compared with SRS. We detect 78,249 single nucleotide polymorphisms(SNPs) using LRS, with 26.0% undetectable by SRS. Based on SNP and inferred HLA allele types, we construct an LRS-based MHC reference panel for the Han Chinese, containing approximately 2.6 times more genetic variants than the SRS-based Han-MHC reference panel. A phenome-wide association study assessing 26,024 phenotypes across 15 categories identifies significant associations for 7,879 independent variants(including 809 LRS-specific SNPs) with 409 phenotypes in nine categories. This analysis reveals 24 unreported HLA allele associations in the bioelectric and cellular categories. The conditional analysis identifies 530independent signals across the 409 phenotypes, including 28 previously unreported signals of eight classical HLA genes associated with 33phenotypes. Of the top-associated SNPs, 191 are detected by LRS only. Fine-mapping identifies 126 independent candidate causal SNPs for three immune-related cellular phenotypes, with 17 detected exclusively by LRS. Our study reveals previously unreported variants and their functional impacts in the MHC region, enhancing our understanding of genetic diversity and its potential biological implications in the Han Chinese population.

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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min zhou Luying Peng Yantao fan qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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A Review about Thermal Comfort in Aircraft

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Journal of Thermal Science 2019年第2期28卷 169-183页

作者： fan juli.zhou qi.ngyao Nanjing University of Aeronautics and Astronautics

Thermal comfort is an important factor which affects both work efficiency and life quality. On the basis of satisfying the normal life of the crew and reliable work of equipment, the thermal comfort is increasingly pursued through the design of the environmental control system of modern craft. Thus, a comprehensive survey of the thermal comfort in the cockpit is carried out. First of all, factors affecting the thermal comfort in aircraft cabin are summarized, including low relative humidity, mean radiant temperature, colored light, human metabolic rate and gender, among which the first three factors are environmental factors and the other two are human factors. Although noise is not a factor affecting thermal comfort, it is an important factor in the overall satisfaction of the aircraft cabin environment. Then the thermal comfort prediction models are introduced, including thermal comfort models suitable for steady state uniform environment and thermal comfort models suitable for transient non-uniform environment. Then the limitations of the typical thermal comfort models applied to aircraft are discussed. Since the concept of thermal adaptation has been gradually accepted in recent years, many field studies on thermal adaptation have been carried out. Therefore, the adaptive thermal comfort models are summarized and analyzed systematically in this paper. At present, mixing ventilation(MV) system is widely used in most commercial aircraft. However, the air quality under the MV system is very poor, and contaminants cannot be effectively eliminated. So a noticeable shift is the design of ventilation system for cabin drawing lessons from the surface buildings. Currently, the most interesting question is that whether the traditional mixing ventilation(MV) system in an aircraft can be replaced by or combined with displacement ventilation(DV) system without decreasing thermal comfort. A reduction of energy consumption is a valuable gain. Additionally, various seat persona

关键词： aircraft thermal comfort energy efficient ventilation system numerical simulation

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Impregnating photo-stable gold precursor onto uncalcined TS-1 to boost catalytic hydro-oxidation of propane

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Science China Chemistry 2025年

作者： Zhihua Zhang Erchuan Yang fan Liu Kesheng Xu Yuxia Zhong Jinwei Sun Shudong Shi Xuezhi Duan Xinggui zhou State Key Laboratory of Chemical Engineering East China University of Science and Technology

Immobilizing highly dispersed Au nanoparticles onto titanium silicalite-1 (TS-1) by a simple impregnation method under light is still a challenging *** this work,a high photostable Au precursor protected by thiol ligands was firstly synthesized,and the as-prepared Au precursor displayed excellent stability under light for over 30 days,while the Au precursor without thiol ligands formed precipitates after just 2 h under ***,the Au precursor protected by thiol ligands was immobilized on the external surface of uncalcined TS-1 (i.e.,TS-1-B) by the incipient wetness impregnation method (IWI method) to prepare Au/TS-1-B *** activity of as-prepared Au/TS-1-B catalyst in the hydro-oxidation of propane to acetone was 1.4 times higher than that of the catalyst prepared by the deposition-precipitation urea method (DPU method).The structures of the Au/TS-1-B catalysts prepared by different methods were analyzed by multiple *** to the Au/TS-1-B catalyst prepared by the DPU method,the Au/TS-1-B catalyst synthesized by the IWI method exhibited a narrower size distribution of Au nanoparticles and had more small Au particles (<2 nm),which is the main reason for its superior ***,the effects of gold loadings,reaction temperature and Si/Ti molar ratio on the catalytic performance of the Au/TS-1-B catalyst prepared by the IWI method were also *** addition,the Au/TS-1-B catalyst prepared by the IWI method also exhibited excellent stability for over 140 h.

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Polybenzimidazolium-reinforced polyimide separators to inhibit dendrites for high-security lithium-ion batteries

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Science China Chemistry 2025年

作者： Guohua Sun Jiaqi Cui qingsong Zhang Yisong zhou Xinluo Li Yingying Zhang Zhanao Zhang Xin Zhang Jiantao fan Pengpeng Li Lianlong Hou Nanjun Chen Hebei Key Laboratory of Flexible Functional Materials School of Materials Science and Engineering Hebei University of Science and Technology State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University

Lithium dendrite formation poses a significant safety hazard in lithium-ion batteries（LIBs）, severely impeding their widespread adoption and further technological advancements. Here, we present a novel quaternized polybenzimidazolium（q-PBI） to armor polyimide（PI） nanofiber separator（q-PBI@PI）, in which the q-PBI containing lithiophilicity and anionphilicity sites serves as the multifunctional nano-layers to suppress the Li dendrite and reinforce the mechanical properties of PI nanofiber ***, the q-PBI@PI separator displays an unprecedented mechanical strength of 82.8 MPa, significantly outperforming previously reported PI nanofiber membranes（typically below 50.0 MPa）. Besides, we demonstrate that the q-PBI@PI separator simultaneously possesses low nucleation overpotential（59 mV） and exceptional average coulombic efficiency due to the suppression of Li dendrite. Importantly, q-PBI@PI-based Li||Li battery enables a stable Li plating-stripping at 1.0 m A cm-2for600 h. Attributing to these exceptional merits, the armored PI separator-based LIBs display remarkable specific capability and capacity retention. The density function theory calculations reveal that q-PBI is conducive to the desolvation of Li+and can immobilize Li+and PF6-ions near affinity sites of PI nanofibers for inhibiting the formation of Li dendrites. Our work paves a new avenue for the design of next-generation high-performing separators in LIBs.

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