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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min lin Mai Xiang Wen-Hui Wei Shu-Hui fan li chen Jie Wang Xiao-Qian yang Chun-Hao yang Shi-jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-yan Huang Yi-De Zhang Jie chen Hai-Di fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Single-cell omics: experimental workflow, data analyses and applications

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Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying sun Haoyan li Dongqing sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui fan chen li chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

对数动态骨架本构模型的多维实现及其在ABAQUS中的应用

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岩土工程学报 2025年第1期47卷 192-199页

作者：董青陈苏李小军董云陈亚东周正华朱俊淮阴工学院建筑工程学院江苏淮安223003 北京工业大学城建学部北京100124 南京工业大学交通运输工程学院江苏南京210009

对数动态骨架本构以对数函数作为骨架曲线,引入“修正动骨架曲线”和“阻尼比退化系数”的概念,考虑试验阻尼对滞回曲线的影响,实现试验阻尼和滞回阻尼在数学上自洽的非线性动力本构。该本构只适用于一维土层场地时域非线性地震反应分... 详细信息

对数动态骨架本构以对数函数作为骨架曲线,引入“修正动骨架曲线”和“阻尼比退化系数”的概念,考虑试验阻尼对滞回曲线的影响,实现试验阻尼和滞回阻尼在数学上自洽的非线性动力本构。该本构只适用于一维土层场地时域非线性地震反应分析。基于对数动态骨架本构函数关系式,给出对数动态骨架参数的求解方法,并推导出加卸载曲线的时变切线剪切模量。通过ABAQUS软件的操作平台和等效剪应变算法,开发了基于对数动态骨架本构模型的显式子程序模块,该模型适用于二维和三维土层场地非线性地震反应分析。选取含软弱淤泥质土层场地作为计算模型,将从基岩输入不同加速度峰值的EI centro地震动的数值模拟结果进行对比,验证可考虑土体阻尼效应的对数动态骨架本构以及开发子程序的合理性和可用性。

关键词：对数动骨架本构阻尼比场地地震反应时变切线剪切模量

Au cluster anchored on TiO_(2)/Ti_(3)C_(2) hybrid composites for efficient photocatalytic CO_(2) reduction

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Rare Metals 2022年第9期41卷 3045-3059页

作者： yang li ya-li yang Gui chen Jia-Jie fan Quan-jun Xiang School of Environment and Civil Engineering Dongguan University of TechnologyDongguan523808China State Key Laboratory of Electronic Thin Film and Integrated Devices School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu610054China yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China

The size of metal nanoparticles is a key factor to enhance the photocatalytic activity of ***,the mechanism of this factor to the improvement of photocatalytic CO_(2) reduction performance is still ***,Au cluster/TiO_(2)/Ti_(3)C_(2) and Au nanoparticle/TiO_(2)/Ti_(3)C_(2) were successfully prepared by deposition-precipitation *** experimental results show that the photocatalytic CO_(2) reduction performance of Au cluster/TiO_(2)/Ti_(3)C_(2) with quantum size effect is stronger than that of Au nanoparticle/TiO_(2)/Ti_(3)C_(2) with surface plasmon *** enhanced photocatalytic CO_(2) reduction activity is assigned to the establishment of an overlapping orbital between the lowest unoccupied molecular orbital(LUMO)of the Au cluster and the anti-bonding orbital of CO_(2),which greatly promotes the activation efficiency of CO_(2).The existence of Au cluster and the mechanism of photocatalytic CO_(2) reduction performance were certified by high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)and in situ Fourier transform infrared spectroscopy(ISFTIR).This work may open new opportunities for the establishment of stable and active metal nanocatalysts.

关键词： Au cluster Au nanoparticle Exciton state Photocatalytic CO_(2)reduction TiO_(2)

The catassembled generation of naphthalene diimide coordination networks with lone pair-π interactions

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Science China Chemistry 2016年第11期59卷 1492-1497页

作者： Yong chen Jian-jun liu Chang-Rong fan jun-Qian li mei-Jin lin College of Chemistry Fuzhou University State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences

Catassembly is a new concept in molecular assembly that is analogous to catalysis in chemical synthesis. However, for most molecular-assembled processes, the catassembler contributions are rather inconspicuous due to the low activation barriers. As a result, few systems dealing with the catassembly are available until now. In this paper, we report that naphthalene diimide coordination networks are formed under the catassembly of lone-pair-bearing catassemblers(e.g., N,N-dimethylacetamide, N-methylpyrrolidin-2-one). During such molecular assembly, a stable transition state between the electron-deficient naphthalene diimide tectons and catassemblers via the less common lone pair-π interactions was observed, which is supposed to play the key role in the enhancement of coordination abilities of organic tectons and thus formation of the final coordination networks.

关键词： catassembly coordination network naphthalene diimide lone pair-π interaction

城市老年人抑郁与认知功能的相关性及性别差异研究

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中国全科医学 2025年第1期28卷 47-52页

作者：田英汉刘乐伟杨铖凌晨杨小雪凡豪杰赵鑫李军夏磊刘寰忠安徽医科大学附属巢湖医院精神科安徽省合肥市238000 安徽省精神医学中心安徽省合肥市238000 江苏省泰州市第五人民医院精神科 225300 脑库构建及资源利用安徽省重点实验室安徽省合肥市230032

背景我国人口老龄化问题日趋严重,抑郁是老年人群中较为常见的精神疾病之一,可导致显著的残疾和死亡风险增加。研究发现抑郁与认知障碍之间关联密切,并且这种关系可能受到性别的影响。在老年人群中,抑郁与认知功能及不同认知领域之间相... 详细信息

背景我国人口老龄化问题日趋严重,抑郁是老年人群中较为常见的精神疾病之一,可导致显著的残疾和死亡风险增加。研究发现抑郁与认知障碍之间关联密切,并且这种关系可能受到性别的影响。在老年人群中,抑郁与认知功能及不同认知领域之间相关性的性别差异尚不明确。目的对城市老年人抑郁和认知功能状况进行调查,并分析抑郁与认知功能的相关性及性别差异。方法2022年9—10月采用分层抽样方法,选取安徽省合肥市某社区的65岁及以上老年居民作为调查对象。收集其一般资料,采用老年抑郁量表(GDS)、痴呆简易筛查量表(BSSD)分别对抑郁和认知功能状况进行评估,探讨老年人抑郁的相关因素,并分析抑郁、性别因素及二者的交互作用对认知功能的影响。结果共纳入328名老年人,抑郁的总体检出率为14.9%。回归分析结果显示,饮酒(OR=0.362,95%CI=0.155~0.847)、与子女居住(OR=2.445,95%CI=1.021~5.853)是抑郁的独立相关因素(P<0.05)。析因设计的方差分析显示,抑郁老年人的BSSD总分及语言(命令)理解、计算/注意、地点定向、时间定向和即刻记忆因子分均低于非抑郁老年人(P<0.05)。女性BSSD总分及常识/图片理解和地点定向因子分均低于男性,而语言(命令)理解得分高于男性(P<0.05)。抑郁与性别在常识/图片理解、语言(命令)理解和地点定向上的交互作用显著(P<0.05)。结论城市老年人抑郁风险较高,合并抑郁的老年人可能存在一定的认知功能减退,并伴有性别差异。应加强关注老年人抑郁和痴呆等精神问题,尤其是针对女性老年群体,有必要制定个体化的综合干预措施,提高老年人心理健康水平和生活质量。

关键词：抑郁老年人认知功能障碍性别差异

Efficient SO_(2)removal using aqueous ionic liquid at low partial pressure

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Chinese Journal of Chemical Engineering 2023年第6期58卷 355-363页

作者： Yutong Jiang Yifeng chen Fuliu yang Jixue fan jun li Zhuhong yang Xiaoyan Ji College of Chemical Engineering Nanjing Tech UniversityNanjing 211816China Institute of Chemical Industry of Forest Products CAFKey Laboratory of Biomass Energy and MaterialJiangsu ProvinceNanjing 210042China Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China Energy Engineering Division of Energy ScienceLuleå University of TechnologyLuleå97187Sweden

The development of novel absorbents is essential for SO_(2)*** this study,a novel ionic liquid(IL,[BHEP][HSO_(4)])was prepared,and water was selected as the *** density and viscosity of aqueous[BHEP][HSO_(4)]were measured and the SO_(2)absorption performance was systematically ***,the thermodynamic properties of SO_(2)in aqueous[BHEP][HSO_(4)]were ***,the mechanism of SO_(2)absorption in aqueous[BHEP][HSO_(4)]was confirmed using Fouriertransform infrared and nuclear magnetic resonance *** showed that[BHEP][HSO_(4)]absorbed0.302 g·g^(-1)(g SO_(2)/g IL)at an SO_(2)partial pressure of 2000μl·L^(-1)at 303.2 K,and the SO_(2)desorption enthalpy was-39.63 k J·mol^(-1).The mechanistic study confirmed the chemical absorption of SO_(2)in aqueous[BHEP][HSO_(4)].

关键词： Ionic liquids sulfur dioxide Absorption capacity Desorption enthalpy

Effects of ECAP Extrusion on the Microstructure, Mechanical Properties and Biodegradability of Mg–2Zn–xGd–0.5Zr Alloys

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Acta Metallurgica Sinica(English Letters) 2021年第2期34卷 205-216页

作者： jun-Xiu chen Xiang-Ying Zhu li-li Tan Ke yang Xu-Ping su Key Laboratory of Materials surface Science and Technology of Jiangsu Province Changzhou UniversityChangzhou 213164China Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering Changzhou UniversityChangzhou 213164China National Experimental Teaching Demonstration Center of Materials Science and Engineering Changzhou UniversityChangzhou 213164China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Effects of equal channel angular pressing(ECAP)extrusion on the microstructure,mechanical properties and biodegradability of Mg–2Zn–xGd–0.5Zr(x=0,0.5,1,2 wt%)alloys were studied in this *** analysis,tensile test at ambient temperature,immersion test and electrochemical test in Hank’s solution were carried *** results showed that Gd could further enhance the grain refinement during the ECAP *** Gd addition and ECAP extrusion could improve the mechanical properties of the alloys,and the extrusion played the dominant *** addition of Gd(0.5–1 wt%)could obviously enhance the corrosion resistance of the *** some extent,ECAP extrusion improved the corrosion resistance of the alloys due to the change of second phases distribution and the refinement of *** increase in extrusion pass was detrimental to the improvement of the corrosion resistance as a result of increment of the grain boundaries.

关键词： Mg alloys Gd addition ECAP extrusion pass Mechanical property Biodegradable behavior