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Combining controlled-release urea and normal urea with appropriate nitrogen application rate to reduce wheat stem lodging risk and increase grain yield and yield stability

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Journal of Integrative Agriculture 2023年第10期22卷 3006-3021页

作者： ZHANG Guang-xin ZHAO De-hao fan heng-zhi LIU Shi-ju LIAO Yun-cheng HAN Juan College of Agriculture Shanxi Agricultural UniversityTaigu 030801P.R.China State Key Laboratory of Sustainable Dryland Agriculture Shanxi Agricultural UniversityTaiyuan 030031P.R.China College of Agronomy Northwest A&F UniversityYangling 712100P.R.China

A mixture of controlled-release urea and normal urea(CRUNU)is an efficient nitrogen(N)fertilizer type,but little is known about its effects on stem lodging resistance,grain yield,and yield stability of *** this study,a 4-year field experiment(from 2017 to 2021)was conducted to analyze the effects of N fertilizer types(CRUNU and normal urea(NU))and application rates(low level(L),135 kg ha^(–1);medium level(M),180 kg ha^(–1);high level(H),225 kg ha^(–1))on population lodging resistance,basal internode strength,lignin content and synthetase activity,stem lodging resistance,grain yield,and yield stability of *** results showed that the two N fertilizer types had the highest lodging rate under high N application rates,and the M-CRUNU treatment showed the lowest lodging *** with NU,CRUNU improved the wheat population lodging resistance under the three N application rates,mainly related to improving wheat population characteristics and breaking the strength of the second basal *** analysis showed that the breaking strength of the second basal internode was related to the physical characteristics,chemical components,and micro-structure of the *** with NU,CRUNU significantly increased wheat grain yield by 4.47,14.62,and 3.12%under low,medium,and high N application rates,*** addition,CRUNU showed no significant difference in grain yield under medium and high N application rates,but it presented the highest yield stability under the medium N application *** summary,CRUNU,combined with the medium N application rate,is an efficient agronomic management strategy for wheat production.

关键词： controlled-release urea lodging grain yield yield stability wheat

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NP-8 Moderate Brain Injury Causes Neurobehavioral Deficits and Effects of Aerobic Exercise

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神经药理学报 2018年第4期8卷 106-107页

作者： WANG Ji-hui fan zhi-heng PAN Hui-ju OU Yang-wei College of Physical Education and Health SciencesZhejiang Normal UniversityJinhua3210004China

Objective:Moderate traumatic brain injury(TBI)can lead to a lifetime of physical,cognitive,emotional,and behavioral ***,the secondary brain injury(SBI)during subacute and chronic phase after TBI could be blamed for these *** is widely recognized as promoting health and improving bad moods,but the mechanisms by which exercise affects SBI are still ***:Lateral fluid percussion(LFP)method was used to fabricate moderate TBI in motor and somatosensory cortex of the C57 BL/6 J mice.A 4-weeks voluntary running wheel exercise with 6-day training per week was modified based on the previous *** status,sensorimotor function,spatial memory,electrophysiological,post-traumatic stress disorder(PTSD)associated anxiety and depression,cortical pathohistological changes were assessed to evaluate effects TBI and exercise ***:After moderate LFP injury,the TBI mice showed severe motor deficits at the early stage in acute phase but gradually *** acute and subacute phase after TBI,novel object recognition(NOR)ability and spatial memory functions were consistently impaired in TBI mice;hippocampal firing frequency and burst probability were *** of the altered burst firing shows a clear hippocampal theta rhythm *** electrophysiological impacts were associated with substantially lowered NOR preference as compared with the sham group during adulthood.4-weeks voluntary wheel running performed prior to induction of a moderate TBI,combined with 2 weeks voluntary motor skill training after TBI was found to inhibit plasma TNF-α,improve locomotor activity levels,alleviate anxiety and depression and promote spatial working memory recovery in *** the meantime,histopathological deterioration was eased in the hippocampus in exercised ***:moderate TBI could induce neurological and neurobehavior impairments in *** exercise rehabilitation alleviated above mentioned deficit

关键词： traumatic brain injury neurobehavior deficits electrophysiological changes aerobic exercise

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白杨素与瘦素蛋白相互作用研究

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中国中药杂志 2018年第12期43卷 2563-2569页

作者：梅杰彭晓旋范智恒魏小勇广州中医药大学基础医学院

利用紫外和荧光光谱及原子力显微镜技术,研究白杨素与瘦素之间的相互作用关系,深入阐明白杨素抗肥胖的作用机制。采用紫外光谱、荧光光谱,测定白杨素与瘦素蛋白相互作用的结合方式,结合力,结合常数,利用原子力显微镜观察白杨素对瘦素表... 详细信息

利用紫外和荧光光谱及原子力显微镜技术,研究白杨素与瘦素之间的相互作用关系,深入阐明白杨素抗肥胖的作用机制。采用紫外光谱、荧光光谱,测定白杨素与瘦素蛋白相互作用的结合方式,结合力,结合常数,利用原子力显微镜观察白杨素对瘦素表面形态的影响。紫外光谱结果显示,随着白杨素的加入,瘦素肽键特征峰处出现10 nm的红移,并且270 nm处出现新的峰;荧光光谱结果显示白杨素能与瘦素发生强结合,两者相互作用机制为静态猝灭机制,在p H 7.4及温度25,37℃条件下,两者的结合常数（Ka）分别为（0.41±0.05）×106和（3.26±0.46）×106L·mol-1,结合位点数（n）为1.02±0.04及0.51±0.01,其结合力主要是疏水作用力。原子力显微镜显示,白杨素可以改变瘦素蛋白表面形态,通过疏水作用,使瘦素蛋白发生团聚。以上结果表明白杨素可以通过与瘦素结合并改变其结构,影响瘦素功能,从而参与瘦素水平的调节,其构效关系为白杨素抗肥胖机制提供理论依据。

关键词：白杨素瘦素紫外光谱荧光光谱原子力显微镜

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基于DSP矿井继电保护系统的设计

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煤矿机械 2013年第4期34卷 248-250页

作者：江永玲尚何敏杨少智范恒智安徽理工大学电气与信息工程学院安徽淮南232001 淮沪煤电有限公司田集发电厂安徽淮南232001 皖北煤电集团安徽宿州234000

矿井供电系统是煤矿安全生产的枢纽,继电保护系统可保障供电系统的安全运行。针对传统继电保护系统在矿井供电中存在的问题,以及矿井供电系统保护装置维护的需要,提出了一种基于DSP控制的微机继电保护系统的设计方案。此方案可满足矿井... 详细信息

矿井供电系统是煤矿安全生产的枢纽,继电保护系统可保障供电系统的安全运行。针对传统继电保护系统在矿井供电中存在的问题,以及矿井供电系统保护装置维护的需要,提出了一种基于DSP控制的微机继电保护系统的设计方案。此方案可满足矿井供电系统稳定运行的要求,并提高电力系统的安全运行水平。

关键词：煤矿安全继电保护 DSP 电力系统

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang fan Yang Jian-Qin Liu Jie Chen zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun Tang fan fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

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芍药苷、薄荷脑对葛根素在Calu-3细胞模型转运过程中膜流动性、钠-钾离子ATP酶和钙离子ATP酶的影响

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中国中药杂志 2018年第4期43卷 731-735页

作者：张林王停杜守颖陆洋范志恒马军明谭佳威薛宇涛北京中医药大学北京中医药研究院北京100029 北京中医药大学中药学院北京100029

研究芍药苷、薄荷脑对葛根素在细胞模型转运过程中对Calu-3细胞膜生理功能的影响。以Calu-3细胞作为模拟鼻黏膜组织的体外细胞模型，采用荧光漂白恢复技术及超微量酶活性检测方法，考察细胞膜流动性、Na＋-K’-ATP酶和ca^2＋．ATP酶活... 详细信息

研究芍药苷、薄荷脑对葛根素在细胞模型转运过程中对Calu-3细胞膜生理功能的影响。以Calu-3细胞作为模拟鼻黏膜组织的体外细胞模型，采用荧光漂白恢复技术及超微量酶活性检测方法，考察细胞膜流动性、Na＋-K’-ATP酶和ca^2＋．ATP酶活性，探索配伍药物促进葛根素转运的作用机制。结果表明，配伍低、中、高浓度薄荷脑或同时配伍低、中、高浓度芍药苷和薄荷脑时，与单独使用葛根素相比，Calu-3细胞膜荧光漂白恢复率显著升高，Na^＋-K＋-ATP酶活性未发生明显改变，Ca^2＋-ATP酶活性显著增强，由此证实薄荷脑起到主要渗透促进作用，并且其作用机制可能与增加流动性、激活Ca^2＋-ATP酶活性密切相关。

关键词：薄荷脑 Calu-3细胞细胞膜流动性 Na+-K+-ATP酶 Ca2+-ATP酶

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基于PLC的坩埚氦质谱检漏装置设计

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自动化与仪表 2022年第4期37卷 81-84,98页

作者：陈易然杨大志范志恒杨宗泽四川轻化工大学机械工程学院宜宾644000

针对坩埚在进行检漏时,大多为水检法、皂泡法等人工检漏的方法,为解决效率低,时间久等问题,提出一种基于PLC坩埚氦质谱检漏装置平台。通过对检漏平台进行总体方案设计,确定工作流程,重点解决坩埚内部真空、上位机和氦质谱仪通讯、上位机... 详细信息

针对坩埚在进行检漏时,大多为水检法、皂泡法等人工检漏的方法,为解决效率低,时间久等问题,提出一种基于PLC坩埚氦质谱检漏装置平台。通过对检漏平台进行总体方案设计,确定工作流程,重点解决坩埚内部真空、上位机和氦质谱仪通讯、上位机和PLC通讯等问题。对系统硬件方面,进行了电气控制原理设计与选型、PLC型号选择、真空管道的设计、接线图设计;对控制系统软件方面,通过STEP 7-Microwin SMART,对作为主控器的PLC进行了控制程序的编写,再通过Visual Studio 2015进行人机交互界面的设计,以及通过与SQL2012数据库连接,将测得的数据放入数据库,最后通过上位机编译实现人机交互,实验平台开机运行调试。最终实验结果显示,整个平台实现了对坩埚的密封、检漏、检漏数据的存储,其中检漏同一坩埚10次检漏率值标准偏差S≤2.84,满足工业生产要求。

关键词：坩埚氦质谱检漏自动化控制系统

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Efficient implementation of quantum arithmetic operation circuits

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Science China(Physics,Mechanics & Astronomy) 2021年第1期64卷 116-117页

作者： heng fan Institute of Physics Chinese Academy of SciencesBeijing100190China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing100190China Songshan Lake Material Laboratory Dongguan523000China

Realization of robust quantum computing is a tremendous *** one hand,one must reduce errors as many as possible using various means[1-3];on the other hand,one may make large error rates tolerable via fault-tolerant *** achieving tolerant against noises,the cost to pay is the increased number of gates ***,an efficient implementation of fault-tolerant gates is *** already evidenced,Clifford gates with a T gate can form a universal set of fault-tolerant gates.

关键词： quantum arithmetic Efficient

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自主运动和益赛普对于创伤性脑损伤小鼠的神经保护作用

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生理学报 2022年第3期74卷 333-352页

作者：甘甜甜廖琪汪际慧范志恒曹健潘慧炬娄高峰董雪芬欧阳玮浙江师范大学体育与健康科学学院金华321004 浙江金华广福医院内分泌科金华321004

运动在创伤性脑损伤(traumatic brain injury,TBI)后的神经保护作用机制仍有待揭示。目前也缺乏针对TBI的有效治疗手段。本研究旨在考察自主运动和注射益赛普(Yisaipu,TNFR-IgG融合蛋白,TNF抑制剂)联用方式对TBI模型小鼠的影响。雄性C57... 详细信息

运动在创伤性脑损伤(traumatic brain injury,TBI)后的神经保护作用机制仍有待揭示。目前也缺乏针对TBI的有效治疗手段。本研究旨在考察自主运动和注射益赛普(Yisaipu,TNFR-IgG融合蛋白,TNF抑制剂)联用方式对TBI模型小鼠的影响。雄性C57BL/6J小鼠被随机分为对照组和自主运动组,然后观察6周预防性预自主运动(prophylactic preconditioning exercise,PE)和/或TBI后注射Yisaipu对中度TBI小鼠的影响。结果显示,与单一干预措施比较,PE和Yisaipu的联合干预能更有效减少TBI小鼠的感觉运动和步态功能障碍。同时,这些功能改善伴随着外周血清TNF-α水平下降、系统性炎症减轻、脑内自噬流途径增强和皮层损伤灶体积缩小。鉴于上述神经保护作用,诸如运动和TNF抑制剂联用方式可能是促进TBI患者功能恢复的有效策略,值得进一步研究。

关键词：自主运动益赛普创伤性脑损伤神经功能缺陷运动障碍

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