检索结果-南通市图书馆

Phase-transforming mechanical metamaterials with dynamically controllable shape-locking performance

在线全文

学校读者我要写书评

暂无评论

National Science Review 2023年第9期10卷 270-285页

作者： Yiding Zhong Wei Tang Huxiu Xu Kecheng Qin Dong Yan xujun fan Yang Qu Zhaoyang Li Zhongdong Jiao Huayong Yang Jun Zou State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University School of Mechanical Engineering Zhejiang University Institute of Process Equipment College of Energy EngineeringZhejiang University

Active mechanical metamaterials with customizable structures and deformations,active reversible deformation,dynamically controllable shape-lo cking performance and stretchability are highly suitable for applications in soft robotics and flexible electronics,yet it is challenging to integrate them due to their mutual ***,we introduce a class of phase-transforming mechanical metamaterials(PMMs) that integrate the above *** arranging basic actuating units according to the designed pattern configuration and positional relationship,PMMs can customize complex and diverse structures and ***-vapor phase transformation provides active reversible large deformation while a silicone matrix offers *** contained carbonyl iron powder endows PMMs with dynamically controllable shape-lo cking performance,thereby achieving magnetically assisted shape locking and energy storing in different working *** build a theoretical model and finite element simulation to guide the design process of PMMs,so as to develop a variety of PMMs with different functions suitable for different applications,such as a programmed PMM,reconfigurable antenna,soft lens,soft mechanical memory,biomimetic hand,biomime tic flytrap and self-contained soft *** are applicable to achieve various 2D deformations and 2D-to-3D deformations,and integrate multiple properties,including customizable structures and deformations,active reversible deformation,rapid reversible shape locking,adjustable energy storing and stretchability,which could open a new application avenue in soft robotics and flexible ele ctronics.

关键词： active mechanical metamaterials shape locking energy storage liquid–vapor phase transform soft robotics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

超高压水射流在电厂汽轮机叶片清洗中的应用

清洗世界 2004年第11期20卷 13-15页

作者：范旭军上海杨树浦电力实业有限公司上海200090

火力发电机组运行一段时间后,汽轮机叶片、隔板喷嘴都必须进行清洗,以保持机组运行正常和经济性。随着科学技术的发展,目前,电厂越来越多地采用超高压水清洗技术,而逐步淘汰一些老的清洗方法,以保护设备和环境。

关键词：电厂火力发电机组机组运行保护设备隔板水清洗超高压汽轮机叶片经济性喷嘴

超声内镜联合64排双源计算机断层扫描检查对胃癌局部临床分期和腹膜转移的预测价值

在线全文

学校读者我要写书评

暂无评论

中华消化杂志 2018年第2期38卷 98-104页

作者：林言郑祺闫昆陈平吴枫叶华郑成范燕萍胡旭军陈云杰宁波市第二医院消化内科浙江省315010 宁波市第二医院普外科浙江省315010 宁波市第二医院影像科浙江省315010

目的分析超声内镜联合64排双源计算机断层扫描（DSCT）检查对胃癌患者局部临床分期和腹膜转移的预测价值。方法纳入2011年7月至2017年5月经胃镜病理检查诊断为胃癌的365例患者，行超声内镜和DSCT检查，并以术后病理诊断为金标准，评估... 详细信息

目的分析超声内镜联合64排双源计算机断层扫描（DSCT）检查对胃癌患者局部临床分期和腹膜转移的预测价值。方法纳入2011年7月至2017年5月经胃镜病理检查诊断为胃癌的365例患者，行超声内镜和DSCT检查，并以术后病理诊断为金标准，评估超声内镜、DSCT检查与联合检查判断胃癌原发肿瘤、区域淋巴结和腹膜转移的准确性，计算其准确度、敏感度、特异度、阳性预测值、阴性预测值、一致性（Kappa值）和AUC值。结果263例患者纳入肿瘤浸润深度、区域淋巴结临床分期研究，289例患者纳入腹膜转移临床预测研究。超声内镜检查对肿瘤浸润深度临床分期的准确度为75.29%，对区域淋巴结分期的敏感度、特异度、Kappa值和AUC值分别为86.26%、81.81%、0.681和0.840。DSCT检查对区域淋巴结分期的敏感度、特异度、Kappa值和AUC值分别为74.81%、87.12%、0.620和0.813。超声内镜检查对预测腹膜转移的敏感度、特异度、Kappa值和AUC值分别为38.24%、97.25%、0.432和0.668，DSCT检查对预测腹膜转移的敏感度、特异度、Kappa值和AUC值分别为41.18%、100.00%、0.553和0.706。超声内镜和DSCT联合检查对肿瘤浸润深度临床分期的准确度和Kappa值分别为75.29%和0.639；对区域淋巴结临床分期的敏感度、特异度、阳性预测值、阴性预测值、Kappa值和AUC值分别为93.13%、87.88%、88.41%、92.80%、0.810和0.905，对腹膜转移临床预测的敏感度、特异度、阳性预测值、阴性预测值、Kappa值和AUC值分别为58.82%、97.25%、74.07%、94.66%、0.616和0.774。结论超声内镜联合DSCT检查对胃癌肿瘤浸润深度、区域淋巴结临床分期有较大价值，对腹膜转移临床预测有一定价值，优于单项检查。联合检查能提高肿瘤浸润深度、区域淋巴结临床分期和腹膜转移临床预测的准确性，两种检查方法互为补充。

关键词：胃肿瘤腔内超声检查肿瘤分期断层摄影术

Ala-Gln improves varicocele-induced testicular injury by increasing HSP70 and antioxidant activity in male rats

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2021年第2期45卷 323-329页

作者： LEI YU ZHEN fan HONGQIANG WANG WENXIAN LI TAO JING QIANG LI SHENQIAN LI PEITAO WANG xujun XUAN Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan250100China Department of Andrology The Affiliated Hospital of Qingdao UniversityQingdao266003China Department of Ophthalmology Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser Hospital)Qingdao266034China Department of Urology The Affiliated Hospital of Qingdao UniversityQingdao266003China

This worked aimed to test the hypothesis that L-alanyl-L-glutamine(Ala-Gln)improves the varicocele-induced testicular injury,which causes male *** this purpose,fifty adult male Wistar rats received the varicocele(VC)surgery at the left renal *** were determined 2,4,and 8 weeks after VC(n=10/each detection).Four weeks after VC,rats received Ala-Gln(1.125 g/kg)treatment with and or saline for 1 week(n=10/each group).Rats in the sham group were also detected for biomarkers at 2,4,and 8 weeks(n=10/each detection).VC caused testicular injury detected by hematoxylin–eosin(H&E)staining,immunohistochemistry,and TUNEL ***70 mRNA was detected quantitative RT-PCR,SOD,and CAT by nitroblue tetrazolium(NBT)method and 8-OHDG by *** results showed that varicocele induced injury in the *** weight of the left testes was lower than that of the right testes in VC-bearing rats(p<0.01).The relative numbers of sustentacular and spermatogenic cells were decreased after VC(p<0.01).In sham-4 wk,VC-4wk,VC-5wk and Ala-Gln groups,the apoptosis index was 5.10±1.14,13.22±3.63,33.62±3.56 and 22.33±2.61,relative level of HSP70 mRNA 1.00±0.12,0.53±0.05,0.51±0.04 and 1.62±0.15 fold,SOD 16.4±0.23,13.4±0.17,10.01±1.06 and 19.53±2.26 U/mg protein,CAT 2.16±0.31,1.07±0.28,and 1.31±0.26 and 3.46±0.71 U/mg,8-OHDG 5.23±0.67,6.81±0.78,7.16±1.22 and 4.14±0.73 pg/μg DNA,respectively(p<0.01).Our results suggest that Ala-Gln prevented the VC-induced testicular *** have firstly reported that Ala-Gln protects against varicocele-induced testicular injuries by up-regulation of HSP70 and antioxidants,SOD and CAT,and down-regulation of oxidant 8-OHDG,resulting in reducing apoptosis in the testis.

关键词： Varicocele Ala-Gln HSP70 SOD CAT 8-OHDG

Geological and geochemical prediction on deeply-seated ore-bodies in Haigou gold deposit of Jilin,China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Geology 2011年第2期14卷 67-72页

作者： LI xujun fan Zhenhua fan Wenliang REN Shanfeng College of Earth Sciences Jilin Universily Changchun 130026 China Haigou Gold Mining Company Ltd. Antu 133617 Jilin China

Lode 28 is the largest gold-bearing quartz vein in Haigou gold deposit, and the lode itself contains more than 301 of gold. Geochemical study shows that 12 trace elements related gold mineralization can be divided into 5 metallogenic factors （element assemblages）. The high values of F1 , F2 and F4 together indicate overlapped of multiple stages of gold mineralization, revealing high potential of gold mineralization at depth ; the single high value of F4 represents the root of an existing ore body while high values of F3 and F4 show the intervals of barton sectors in the lode. Comprehensive geochemical studies show the high prospeetion potential below the 14^th level and between lines 39-71. It is also prospective to look for blind ore-bodies between lines 15-29 and below the 10^th level.

关键词： blind ore-hody geochemical prediction enrichment sequence Haigou gnld deposit Jilin

Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223/NLRP3/pyroptosis axis:Toward a precision therapy

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第12期30卷 169-183页

作者： Weixuan Liu Anqi Liu xujun Li Ziyang Sun Zhenghua Sun Yaru Liu Gang Wang Dan Huang Hao Xiong Shiyang Yu Xintao Zhang Cunyi fan Department of Sports Medicine Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen518036China Shanghai Engineering Research Center for Orthopedic Material Innovation and Tissue Regeneration Shanghai201306China Department of Orthopedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China Department of Orthodontics Shanghai Stomatological Hospital&School of StomatologyFudan UniversityShanghai200001China Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Fudan UniversityShanghai200001China Minhang Hospital Fudan UniversityShanghai201199China

Osteoarthritis(OA)is the most common disabling joint disease with no effective disease modifying *** vesicles released by several types of mesenchymal stem cells could promote cartilage repair and ameliorate OA pathology in animal models,representing a novel therapeutic *** this study,we demonstrated that extracellular vesicles derived from human umbilical cord mesenchymal stem cells(hUC-EVs)could maintain chondrocyte homeostasis and alleviate OA,and further revealed a novel molecular mechanism of this therapeutic ***-223,which could directly bind with the 3′UTR of NLRP3 mRNA,was found to be a key miRNA for hUC-EVs to exert beneficial effects on inflammation inhibiting and cartilage *** enhancing the effect on mitigating osteoarthritis,exogenous miR-223 was loaded into hUC-EVs by electroporation,and a collagen II-targeting peptide(WYRGRL)was modified onto the surface of hUC-EVs by genetic engineering to achieve a more targeted and efficient RNA delivery to the *** dual-engineered EVs showed a maximal effect on inhibiting the NLRP3 inflammasome activation and chondrocyte pyroptosis,and offered excellent results for the treatment of *** study provides a novel theoretical basis and a promising therapeutic strategy for the application of engineered extracellular vesicles in OA treatment.

关键词： Osteoarthritis Extracellular vesicles NLRP3 inflammasome Pyroptosis Cartilage-targeting

Geological and geochemical indicators and prediction of deep-seated ore bodies in Jiudian gold deposit of Pingdu,Shandong Province

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Geology 2012年第4期15卷 257-264页

作者： LIANG Bensheng LI xujun fan Wenliang WEN Zhimin JIANG Shenguang College of Earth Sciences Jilin University Qingdao Jinxing Mining Limited Liability Company

Based on the geology and geochemistry of gold-bearing quartz veins in the Jiudian gold deposit of Pingdu,Shandong Province,the geological and geochemical indicators of occurrence of deep-seated ore bodies in the Jiudian gold deposit have been *** occurrence of wide,intensive,varied alteration zones around the gold-bearing quartz veins and continual presence of diorite porphyrite and lamprophyry indicate the probable occurrence of deep-seated ore bodies at depth of gold ***,Sb and Hg belong to the head halo elements, and their anomalies could reveal the probable occurrence of the deep-seated ore bodies below.

关键词： Jiudian gold deposit metallogenic law overlapped geochemical halo prediction deep-seated orebodies

miRNA219-5P靶向调控Smad4表达影响TGF-β1诱导肌腱成纤维细胞纤维化的研究

在线全文

学校读者我要写书评

暂无评论

中国修复重建外科杂志 2016年第5期30卷 641-646页

作者：阮洪江范大鹏陈帅李旭军范存义上海交通大学附属第六人民医院骨科

目的探讨mi RNA219-5P(mi R219-5P)调控Smad4在TGF-β1诱导人肌腱成纤维细胞(tendon derived fibroblasts,TDFs)纤维化过程中的作用。方法取患者自愿捐赠的肌腱组织分离培养TDFs,取第3代细胞进行实验。化学合成mi R219-5P类似物(mimics... 详细信息

目的探讨mi RNA219-5P(mi R219-5P)调控Smad4在TGF-β1诱导人肌腱成纤维细胞(tendon derived fibroblasts,TDFs)纤维化过程中的作用。方法取患者自愿捐赠的肌腱组织分离培养TDFs,取第3代细胞进行实验。化学合成mi R219-5P类似物(mimics)、阻遏物(inhibitor)及阴性对照序列,分别转染TDFs 48 h后,采用实时定量PCR及Western blot法分别检测mi R219-5P基因及Smad4蛋白表达情况;以正常细胞作为空白对照。信息学软件预测mi R219-5P与Smad4基因3’UTR区结合位点,构建Smad4预测基因3’UTR-PGL3重组质粒,构建野生型及突变型报告基因表达载体,并通过荧光素酶报告基因实验进行靶位验证。取正常及转染后TDFs,采用TGF-β1诱导细胞发生纤维化,于培养24、48、72 h采用细胞计数试剂盒8法检测细胞增殖活性变化,72 h时采用Western blot法检测纤维化相关蛋白指标。结果 mi R219-5P mimics转染TDFs可明显上调mi R219-5P表达、下调Smad4蛋白表达,而mi R219-5P inhibitor抑制细胞内mi R219-5P表达、增加Smad4蛋白表达,与空白对照组比较差异均有统计学意义(P0.05)。与空白对照组比较,TGF-β诱导培养72 h后细胞增殖活性明显增强(P<0.01),同时上调细胞纤维化相关蛋白指标的表达(P<0.01);与直接诱导组比较,mi R219-5P过表达且诱导组TDFs细胞增殖活性和纤维化蛋白指标升高趋势得到抑制,而mi R219-5P表达抑制且诱导组细胞增殖活性和纤维化蛋白指标则进一步增强,差异有统计学意义(P<0.01)。结论 mi R219-5P可通过抑制其靶基因Smad4表达,显著抑制TGF-β诱导TDFs纤维化。

关键词：肌腱粘连肌腱成纤维细胞 miRNA219-5P Smad4 纤维化

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

风电齿轮箱检修方法的研究与进展

机械强度 2021年第2期43卷 261-267页

作者：范志锋苏续军张融李芳环武昌工学院机械工程学院武汉430065 绿色风机制造湖北省协同创新中心武汉430065 陆军工程大学石家庄校区石家庄050003

风电齿轮箱是风力发电机组中的重要部件,在长期运行过程中不可避免会发生各类故障,其检修方法必然成为学者研究的焦点。通过对风电齿轮箱状态监测方法与手段、故障特征提取方法、维修策略的研究现状进行分析,总结检修方法研究存在的主... 详细信息

风电齿轮箱是风力发电机组中的重要部件,在长期运行过程中不可避免会发生各类故障,其检修方法必然成为学者研究的焦点。通过对风电齿轮箱状态监测方法与手段、故障特征提取方法、维修策略的研究现状进行分析,总结检修方法研究存在的主要问题,提出开展基于多传感器的风电齿轮箱在线监测方法和手段研究、基于多源信息融合的风电齿轮箱智能故障诊断方法研究、基于寿命分布和实时监测数据的风电齿轮箱预防性维修策略研究等方面的建议,为风电齿轮箱检修方法的研究提供借鉴。

关键词：风电齿轮箱状态监测故障诊断维修策略现状与发展