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月面巡视探测器地面试验方法与技术综述

航天器环境工程 2014年第5期31卷 464-469页

作者：贾阳申振荣庞彧党兆龙樊世超顾征陈百超北京空间飞行器总体设计部北京100094 北京卫星环境工程研究所北京100094

"嫦娥三号"任务的圆满完成标志着我国已经突破了软着陆、巡视勘察、月夜生存等一系列深空探测关键技术。由于任务目标以及月面环境的复杂性,对巡视器的地面试验验证工作提出了很高的要求。在研制过程中,不但开展了常规航天器必做的试验... 详细信息

"嫦娥三号"任务的圆满完成标志着我国已经突破了软着陆、巡视勘察、月夜生存等一系列深空探测关键技术。由于任务目标以及月面环境的复杂性,对巡视器的地面试验验证工作提出了很高的要求。在研制过程中,不但开展了常规航天器必做的试验项目,还开展了大量的专项试验,充分的地面试验对确保任务的成功发挥了重要作用。文章对"嫦娥三号"巡视器的地面验证需求、验证试验要求、验证试验实施情况进行了分析和总结,主要包括低重力模拟、月表地形地貌模拟、工程模拟月壤的制备与整备、光照环境模拟、月尘模拟等方面,对深空探测器试验方法与技术的发展方向提出了建议。

关键词：嫦娥三号月面巡视器地面试验低重力模拟月壤

基于扎根理论的民办高校教师组织认同的影响因素研究

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黑龙江高教研究 2025年第1期43卷 124-134页

作者：范伟西安翻译学院陕西西安710105

组织认同反映的是教师个体对其所在学校的支持度和认同度,对减少教师流失、强化教师队伍建设具有重要现实意义。运用扎根理论方法,对19名民办高校教师的访谈资料进行编码分析,探究了影响民办高校教师组织认同的影响因素。研究表明,工作... 详细信息

组织认同反映的是教师个体对其所在学校的支持度和认同度,对减少教师流失、强化教师队伍建设具有重要现实意义。运用扎根理论方法,对19名民办高校教师的访谈资料进行编码分析,探究了影响民办高校教师组织认同的影响因素。研究表明,工作压力、组织声誉、组织支持、感知到的领导力等外部刺激因素,加剧了民办高校教师个体的工作不安全感、相对剥夺感和身心耗竭,进而影响了民办高校教师的组织认同水平。建议从政府、学校和教师等三个层面,不断优化政策供给,构建优良校园生态,培育教育情怀,以提升民办高校教师组织认同。

关键词：民办高校教师组织认同扎根理论刺激-有机体-反应(S-O-R)理论

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海南岛东部海岸带地质环境评价

中国资源综合利用 2022年第2期40卷 88-90页

作者：蒋俊祎马梓程宋艳伟彭林浩樊世超丁愿立中国地质调查局海口海洋地质调查中心海口570100 湖北省国土测绘院武汉430019 中南冶金地质研究所湖北宜昌443000

地质环境与地质灾害存在密切的联系。本文通过对海南岛东部海岸带的地质灾害信息进行提取,结合高程、降水量、植被覆盖度等自然地理条件及地层、构造等基础地质条件,综合评估海南岛东部海岸带的地质环境。主要目的是使人对区域地质形成... 详细信息

地质环境与地质灾害存在密切的联系。本文通过对海南岛东部海岸带的地质灾害信息进行提取,结合高程、降水量、植被覆盖度等自然地理条件及地层、构造等基础地质条件,综合评估海南岛东部海岸带的地质环境。主要目的是使人对区域地质形成科学的认识,有效地规避城镇规划建设中的地质隐患,强化地质灾害的监测预警。

关键词：地质环境地质灾害评价海南岛海岸带

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Impregnating photo-stable gold precursor onto uncalcined TS-1 to boost catalytic hydro-oxidation of propane

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Science China Chemistry 2025年

作者： Zhihua Zhang Erchuan Yang fan Liu Kesheng Xu Yuxia Zhong Jinwei Sun Shudong Shi Xuezhi Duan Xinggui Zhou State Key Laboratory of Chemical Engineering East China University of Science and Technology

Immobilizing highly dispersed Au nanoparticles onto titanium silicalite-1 (TS-1) by a simple impregnation method under light is still a challenging *** this work,a high photostable Au precursor protected by thiol ligands was firstly synthesized,and the as-prepared Au precursor displayed excellent stability under light for over 30 days,while the Au precursor without thiol ligands formed precipitates after just 2 h under ***,the Au precursor protected by thiol ligands was immobilized on the external surface of uncalcined TS-1 (i.e.,TS-1-B) by the incipient wetness impregnation method (IWI method) to prepare Au/TS-1-B *** activity of as-prepared Au/TS-1-B catalyst in the hydro-oxidation of propane to acetone was 1.4 times higher than that of the catalyst prepared by the deposition-precipitation urea method (DPU method).The structures of the Au/TS-1-B catalysts prepared by different methods were analyzed by multiple *** to the Au/TS-1-B catalyst prepared by the DPU method,the Au/TS-1-B catalyst synthesized by the IWI method exhibited a narrower size distribution of Au nanoparticles and had more small Au particles (<2 nm),which is the main reason for its superior ***,the effects of gold loadings,reaction temperature and Si/Ti molar ratio on the catalytic performance of the Au/TS-1-B catalyst prepared by the IWI method were also *** addition,the Au/TS-1-B catalyst prepared by the IWI method also exhibited excellent stability for over 140 h.

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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng fan Zhiwen Luo Xueran Kang Renwen Wan fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting Luo Bin Feng Min Liu fan Zheng Shuang Huang Yanpeng fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin fan Wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

Red-emissive carbon quantum dots minimize phototoxicity for rapid and long-term lipid droplet monitoring

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Chinese Chemical Letters 2024年第10期35卷 341-347页

作者： Fengkai Zou Borui Su Han Leng Nini Xin shichao Jiang Dan Wei Mei Yang Youhua Wang Hongsong fan Department of Orthopedics Affiliated Hospital of Nantong UniversityNantong 226001China Graduate School Dalian Medical UniversityDalian 116044China National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064China School of Chemistry and Chemical Engineering Liaoning Normal UniversityDalian 116029China

Long-term fluorescence monitoring of subcellular organelles is crucial for cellular physiology and pathology *** droplets(LDs)are increasingly recognized for their involvement in various biological processes,to influence disease development through diverse behaviors However,existing LD probes face challenges in achieving high targeting and long-term monitoring due to poor photostability and long-term *** quantum dots(CQDs)have gained prominence due to their exceptional fluorescence properties,but their prevalent blue excitation wavelength presents difficulties for long-term ***,we synthesized red-emissive carbon quantum dot(R-CQDs)with superior photobleaching resistance and red-emission,thus enabling harmlessly fluorescence monitoring of cells longer than3 *** addition,R-CQD exhibits suitable amphiphilicity and remarkable solvatochromic effect,allowing rapid targeting to LDs for immediate imaging without cumbersome washing ***,R-CQD shows high performance for extended observation of dynamic LD behavior in various biological processes,which is confirmed by documenting the course of LDs during starvation as well as *** to commercial probes,R-CQD extends live cell imaging time by at least 9-fold,facilitating the study of LD behavioral characteristics under diverse physiological or pathological *** work provides a reliable fluorescence tool for tracking intercellular microenvironment dynamically thus to understand the divers biological or disease mechanism.

关键词： Carbon quantum dots Solvatochromism Lipid droplet probe Fluorescence imaging Wash-free

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习近平文化思想科学体系阐释论纲

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 16-33,F0002页

作者：范玉刚山东大学文艺美学研究中心山东济南250100 南方科技大学全球城市文明典范研究院广东深圳518055

习近平文化思想是逻辑自恰、相互贯通、结构完整并集时代性、系统性、原创性于一体的开放性科学体系。深刻把握和领会习近平文化思想的核心要义与主导逻辑,需要建构具有有效性的理论阐释框架。文本通过提炼五个重大学术命题,即坚持党对... 详细信息

习近平文化思想是逻辑自恰、相互贯通、结构完整并集时代性、系统性、原创性于一体的开放性科学体系。深刻把握和领会习近平文化思想的核心要义与主导逻辑,需要建构具有有效性的理论阐释框架。文本通过提炼五个重大学术命题,即坚持党对文化工作的全面领导和巩固党的文化领导权,坚定文化自信、建设社会主义文化强国,在不断健全文化体系中增强国家文化软实力,以“两个结合”特别是“第二个结合”引领中华文明发展,在文明互鉴中增强中华文明的传播力影响力,以此为四梁八柱构建阐释习近平文化思想科学体系的理论框架。

关键词：习近平文化思想科学体系文化基本理论重大学术命题理论框架