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月腺大戟中酚酸类化学成分的研究

中国中药杂志 2017年第15期42卷 2995-2998页

作者：张倩王安华范三鹏马骁驰王超贾景明沈阳药科大学中药资源教研室辽宁沈阳110016 大连医科大学药学院辽宁大连116044

该文综合运用各种色谱技术对月腺大戟根进行化学成分研究,利用1D NMR,2D NMR,HR-ESI-MS等波谱技术鉴定了所分离化合物的结构。从月腺大戟根中分离得到4个酚酸类成分,分别鉴定为1,3,4,5-四羟基-2-O-β-D-[6'-O-没食子酰基吡喃葡萄糖基]... 详细信息

该文综合运用各种色谱技术对月腺大戟根进行化学成分研究,利用1D NMR,2D NMR,HR-ESI-MS等波谱技术鉴定了所分离化合物的结构。从月腺大戟根中分离得到4个酚酸类成分,分别鉴定为1,3,4,5-四羟基-2-O-β-D-[6'-O-没食子酰基吡喃葡萄糖基]异戊苷(1),6'-O-没食子酰基葡萄糖异丙苷(2),鞣花酸(3)和3,4'-二甲氧基-鞣花酸(4)。其中,化合物1为新化合物,2,4为首次从大戟属中分离得到。

关键词：月腺大戟酚酸类化学成分结构鉴定

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying peng Yantao fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di fan Wan Wang Bin Wang Ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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五味子中1个新的降碳倍半萜

中国中药杂志 2022年第6期47卷 1582-1586页

作者：杨用成魏江春刘鲁齐范三鹏陈民王安华贾景明沈阳药科大学中药学院辽宁沈阳110016 辽宁中医药大学附属医院辽宁沈阳110033

利用硅胶、Sephadex LH-20、MCI、反相中低压制备和半制备HPLC等色谱技术对五味子Schisandra chinensis茎叶的化学成分进行研究。通过理化性质和MS、NMR、UV、ECD等谱学数据共鉴定了3个降碳的倍半萜类化合物,分别为(3R,4R,5R,6S,7E)-3,4... 详细信息

利用硅胶、Sephadex LH-20、MCI、反相中低压制备和半制备HPLC等色谱技术对五味子Schisandra chinensis茎叶的化学成分进行研究。通过理化性质和MS、NMR、UV、ECD等谱学数据共鉴定了3个降碳的倍半萜类化合物,分别为(3R,4R,5R,6S,7E)-3,4,5,6-四羟基-7-巨豆烯-9-酮(1)、(3S,5R,6R,7E)-3,5,6-三羟基-7-巨豆烯-9-酮(2)、(3S,4R,9R)-3,4,9-三羟基巨豆烯-5-烯(3),其中化合物1为新化合物,通过计算ECD确定了其绝对构型。化合物2和3均为首次从五味子属植物中分离得到。

关键词：五味子降碳倍半萜化学成分结构鉴定

Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying fang Xiao-Rui Pan Xin-Xing Zeng Zheng-Zheng Li Bo-fan Chen Hai-Min Zeng Jie peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

ChatGPT影响民主的技术逻辑、研判分析及应对策略

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海南大学学报（人文社会科学版） 2025年第1期43卷 76-85页

作者：王宝贵范鹏施韶亭兰州大学马克思主义学院甘肃兰州730000 甘肃省计算中心甘肃兰州730030

ChatGPT的持续爆火再次引起人们对人工智能影响问题的普遍关注。系统研究和评估ChatGPT对民主的影响具有理论和现实的双重意义。ChatGPT是人工智能技术发展新的里程碑,同样是一把双刃剑,其技术扩散嵌入政治领域是影响民主的逻辑起点。Ch... 详细信息

ChatGPT的持续爆火再次引起人们对人工智能影响问题的普遍关注。系统研究和评估ChatGPT对民主的影响具有理论和现实的双重意义。ChatGPT是人工智能技术发展新的里程碑,同样是一把双刃剑,其技术扩散嵌入政治领域是影响民主的逻辑起点。ChatGPT既有民主共治、共享、共商、共建的机遇和潜能,也有民主困境、失效、危机、异化、治理和话语权的挑战与风险。ChatGPT通过技术操控侵蚀民主、影响西方民主实施过程,通过话术游说影响民主决策及立法公正性,通过加深数字鸿沟削弱民主治理能力,通过话语权垄断维护西式民主话语霸权。我国要抓住机遇、迎接挑战,在价值设计、政党治理、社会治理、技术治理、素养提升等多个层面,建立和完善针对性的新型多元民主治理体系,用最新科技武装全过程人民民主的实践。

关键词： ChatGPT 民主人工智能技术逻辑

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五味子成花特性及花粉离体萌发培养基优化

黑龙江农业科学 2021年第10期 117-122页

作者：范三鹏陈巍范志强王东东杨用成胡高升贾景明沈阳药科大学中药学院辽宁沈阳110016

为促进五味子栽培育种,通过对五味子花期和小孢子发育过程的观察及花芽分化过程中营养物质变化规律,对五味子成花特性进行了研究。并通过单因素试验和正交试验,对五味子花粉离体萌发培养基进行了优化。结果表明:辽宁省五味子花期为4月23... 详细信息

为促进五味子栽培育种,通过对五味子花期和小孢子发育过程的观察及花芽分化过程中营养物质变化规律,对五味子成花特性进行了研究。并通过单因素试验和正交试验,对五味子花粉离体萌发培养基进行了优化。结果表明:辽宁省五味子花期为4月23日-5月5日;其花药横切面呈蝶形,每枚雄蕊具有4个小孢子囊,同一花内小孢子发育基本同步;花芽分化过程中叶片总糖和游离氨基酸在不同枝类叶片含量变化趋势基本一致,但含量高低存在显著差异;花粉萌发的最佳培养基配方为30 mg·L^(-1)硼酸、7.5 g·L^(-1)蔗糖、50 mg·L^(-1)氯化钙,此配方下北五味子花粉萌发率最高,达49.84%,花粉管长度为83.35μm。培养基中添加30 mg·L^(-1)硼酸、5.0 g·L^(-1)蔗糖、40 mg·L^(-1)氯化钙,花粉管长度最大,达161.29μm,花粉萌发率为42.81%。

关键词：五味子成花特性花粉萌发花芽分化

Rigidity of subfamilies of hypersurfaces in P^n with maximal length of Griffiths-Yukawa coupling

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Science China Mathematics 2014年第7期57卷 1419-1426页

作者： peng fan Department of Mathematics East China Normal University

Let f ： X → U be a family of smooth hypersurfaces in P nof degree d ＆gt; n＋1 over a smooth curve *** that the Griffiths-Yukawa coupling of f is *** f is ***,we generalize it to the case when the Griffiths-Yukawa c... 详细信息

关键词： families of hypersurfaces Griffiths-Yukawa coupling Higgs bundle variation of Hodge structures

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糖尿病早期视网膜神经变性研究新进展

国际眼科杂志 2025年第1期25卷 76-81页

作者：魏凡彭立谢青中南大学湘雅医学院附属海口医院眼科海南省海口市570208

糖尿病视网膜病变(DR)是由慢性高血糖引起的晚期微神经血管并发症,可导致血-视网膜屏障受损和视网膜功能障碍。近年来研究发现,糖尿病视网膜神经变性(DN)可能是糖尿病的视网膜改变最早事件之一,主要表现包括:新诊断糖尿病患者的视网膜... 详细信息

糖尿病视网膜病变(DR)是由慢性高血糖引起的晚期微神经血管并发症,可导致血-视网膜屏障受损和视网膜功能障碍。近年来研究发现,糖尿病视网膜神经变性(DN)可能是糖尿病的视网膜改变最早事件之一,主要表现包括:新诊断糖尿病患者的视网膜电图反应缺陷;发病初期,小胶质细胞和Müller细胞在几周内自我激活并激活相关蛋白;神经递质(如DOPA/GABA)活性降低,损害神经节信号传递;早期线粒体功能障碍,如Drp1-Fis1持续裂变及mtDNA甲基化和碱基错配之间的潜在串扰等。探讨糖尿病早期视网膜神经变性的分子基础对于理解DN的发病机制及早期治疗至关重要。文章总结糖尿病早期视网膜感光功能及神经胶质细胞、神经递质、线粒体和其他因子的病理变化及机制,旨在为研究DN早期机制及靶向治疗提供理论依据。

关键词：糖尿病视网膜病变糖尿病视网膜神经变性视网膜电图线粒体自噬神经胶质细胞多巴胺