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Functional gastrointestinal disorders,mental health,genetic susceptibility,and incident chronic kidney disease

Chinese Medical Journal 2024年第9期137卷 1088-1094页

作者： Mengyi Liu Panpan He Ziliang Ye Sisi Yang Yanjun Zhang Qimeng Wu Chun Zhou Yuanyuan Zhang fan fan Hou Xianhui qin Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangzhouGuangdong 510515China

Background:Whether functional gastrointestinal disorders(FGIDs)are associated with the long-term risk of chronic kidney disease(CKD)remains *** aimed to investigate the prospective association of FGIDs with CKD and examine whether mental health mediated the ***:About 416,258 participants without a prior CKD diagnosis enrolled in the UK Biobank between 2006 and 2010 were *** with FGIDs(including irritable bowel syndrome[IBS],dyspepsia,and other functional intestinal disorders[FIDs;mainly composed of constipation])were the exposure group,and non-FGID participants were the non-exposure *** primary outcome was incident CKD,ascertained from hospital admission and death registry records.A Cox proportional hazard regression model was used to investigate the association between FGIDs and CKD,and the mediation analysis was performed to investigate the mediation proportions of mental ***:At baseline,33,156(8.0%)participants were diagnosed with FGIDs,including 21,060(5.1%),8262(2.0%),and 6437(1.6%)cases of IBS,dyspepsia,and other FIDs,*** a mean follow-up period of 12.1 years,11,001(2.6%)participants developed *** were significantly associated with a higher risk of incident CKD compared to the absence of FGIDs(hazard ratio[HR],1.36;95%confidence interval[CI],1.28-1.44).Similar results were observed for IBS(HR,1.27;95%CI,1.17-1.38),dyspepsia(HR,1.30;95%CI,1.17-1.44),and other FIDs(HR,1.60;95%CI,1.43-1.79).Mediation analyses suggested that the mental health score significantly mediated 9.05%of the association of FGIDs with incident CKD and 5.63-13.97%of the associations of FGID subtypes with ***,the positive associations of FGIDs and FGID subtypes with CKD were more pronounced in participants with a high genetic risk of ***:Participants with FGIDs had a higher risk of incident CKD,which was partly explained by mental health scores and was more pronounced in those with high gen

关键词： Functional gastrointestinal disorders Chronic kidney diseases Genetic susceptibility Mental health

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Ultra-Robust and High-Performance Rotational Triboelectric Nanogenerator by Bearing Charge Pumping

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Energy & Environmental Materials 2024年第2期7卷 347-353页

作者： Xianpeng Fu Yuhan qin Zhi Zhang Guoxu Liu Jie Cao Beibei fan Zhaozheng Wang Zheng Wang Chi Zhang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micronano Energy and Sensor Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences School of Nanoscience and Technology University of Chinese Academy of Sciences Center on Nanoenergy Research School of Physical Science and Technology Guangxi University

As an emerging technology to convert environmental high-entropy energy into electrical energy, triboelectric nanogenerator(TENG) has great demands for further enhancing the service lifetime and output performance in practical applications. Here, an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG) by bearing charge pumping is proposed. The R-TENG composes of a pumping TENG(P-TENG), an output TENG(O-TENG), a voltage-multiplying circuit(VMC), and a buffer *** P-TENG is designed with freestanding mode based on a rolling ball bearing, which can also act as the rotating mechanical energy harvester. The output low charge from the P-TENG is accumulated and pumped to the noncontact O-TENG, which can simultaneously realize ultralow mechanical wear and high output performance. The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min. Furthermore, the transferring charge of R-TENG can remain 95% during 15 days(6.4 × 10～6cycles)continuous operation. This work presents a realizable method to further enhance the durability of TENG, which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy.

关键词： bearing charge pumping triboelectric nanogenerators ultralow mechanical wear ultra-robust voltage-multiplying circuit

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Hydraulic fracturing behaviors of shale under coupled stress and temperature conditions simulating different burial depths

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International Journal of Mining Science and Technology 2024年第6期34卷 783-797页

作者： qin Zhou Zheming Zhu Wei Liu Huijun Lu Zidong fan Xiaofang Nie Cunbao Li Jun Wang Li Ren MOE Key Laboratory of Deep Earth Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Downhole Operating Company CNPC Chuanqing Drilling and Exploration Engineering Co.Ltd.Shenzhen 518060China School of Architecture and Civil Engineering Xihua UniversityChengdu 610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Shenzhen UniversityShenzhen 518060China

Fracture propagation in shale under in situ conditions is a critical but poorly understood mechanical process in hydraulic fracturing for deep shale gas reservoirs. To address this, hydraulic fracturing experiments were conducted on hollow double-wing crack specimens of the Longmaxi shale under conditions simulating the ground surface(confining pressure σ_(cp)=0, room temperature(Tr)) and at depths of 1600 m(σ_(cp)=40 MPa, Ti=70 ℃) and 3300 m(σ_(cp)=80 MPa, high temperature Ti=110 ℃) in the study *** in situ stress was found to significantly increase fracture toughness through constrained microcracking and particle frictional bridging mechanisms. Increasing the temperature enhances rather than weakens the fracture resistance because it increases the grain debonding length, which dissipates more plastic energy and enlarges grains to close microdefects and generate compressive stress to inhibit microcracking. Interestingly, the fracture toughness anisotropy in the shale was found to be nearly constant across burial depths, despite reported variations with increasing confining pressure. Heated water was not found to be as important as the in situ environment in influencing shale fracture. These findings emphasize the need to test the fracture toughness of deep shales under coupled in situ stress and temperature conditions rather than focusing on either in situ stress or temperature alone.

关键词： Hydraulic fracturing Fracture toughness Shale Anisotropy Deep rock mechanics

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Characteristics of the HIV/AIDS Epidemic among People Aged≥50 Years in China during 2018–2021

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Biomedical and Environmental Sciences 2024年第4期37卷 399-405页

作者： HOU Yu Shan JIN Yi Chen CAI Chang TANG Hou Lin qin Qian Qian LYU fan National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to *** also aimed to recommend targeted interventions for the prevention and treatment of HIV/AIDS in elderly *** Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the *** tests and spatial analyses were also *** Between 2018 and 2021,237,724 HIV/AIDS cases were reported among patients aged≥50 years in *** main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in *** proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for *** spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern *** In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual *** primary modes of infection were CHC and *** were variations in the sex ratio among different age groups,infected through various sexual ***/AIDS cases exhibited spatial *** on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

关键词： HIV/AIDS Aged≥50 years China

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Silencing transformer and transformer-2 in Zeugodacus cucurbitae causes defective sex determination with inviability of most pseudomales

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Journal of Integrative Agriculture 2024年第3期23卷 938-947页

作者： qin Ma Zizhen fan Ping Wang Siya Ma Jian Wen Fengqin Cao Xianwu Lin Rihui Yan Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests of Ministry of Education School of Plant ProtectionHainan UniversityHaikou 570228China School of Life Sciences HainanUniversityHaikou 570228China Hainan Yazhou Bay Seed Lab Sanya 572000China

transformer is a switch gene for sex determination in many insects, which cooperates with transformer-2 that is expressed in both sexes to regulate female differentiation, particularly in dipterans. Zeugodacus cucurbitae(Coquillett) is a very destructive pest worldwide, however, its sex determination pathway remains largely uncharacterized. Here, we show that the female sex ratio is sharply reduced with knockdown of either transformer or transformer-2 by RNA interference in early embryos of Z. cucurbitae. Most of the males grown from the embryos with transient transformer and transformer-2 suppression mated with wild-type females and produced mixed sex progeny, with one exception that produced only female progeny, and all of the few remaining males failed to mate with wild-type females and produced no progeny. The exceptional male and those males with mating failure were XX pseudomales as determined by the detection of Y chromosome-linked Maleness-on-the-Y, indicating that most XX pseudomales are not viable. The phenotypes of transformer and transformer-2 suggest that they play a key role in regulating sex determination and are required for female sexual development of Z. cucurbitae. Our results will be beneficial to the understanding of sex determination in Z. cucurbitae and can facilitate the development of genetic sexing strains for its biological control.

关键词： Zeugodacus cucurbitae transformer transformer-2 sex determination RNA interference biological control

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Progress and Achievements of Fengyun Meteorological Satellite Program since 2022

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空间科学学报 2024年第4期44卷 712-721页

作者： GUAN Min WANG Jingsong ZHAO Xiangang qin Danyu fan Cunqun XIAN Di LIU Chang National Satellite Meteorological Center(National Centre for Space Weather) Beijing 100081 Innovation Center for Fengyun Meteorological Satellite(FYSIC) Beijing 100081 Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites/Key Laboratory of Space Weather China Meteorological AdministrationBeijing 100081

Fengyun meteorological satellites have undergone a series of significant developments over the past 50 *** generations,four types,and 21 Fengyun satellites have been developed and launched,with 9 currently operational in *** data obtained from Fengyun satellites is employed in a multitude of applications,including weather forecasting,meteorological disaster prevention and reduction,climate change,global environmental monitoring,and space *** data products and services are made available to the global community,resulting in tangible social and economic *** 2023,two Fengyun meteorological satellites were successfully *** report presents an overview of the two recently launched Fengyun satellites and currently in orbit Fengyun satellites,including an evaluation of their remote sensing instruments since ***,it addresses the subject of Fengyun satellite data archiving,data services,application services,international cooperation,and supporting ***,the development prospects have been outlined.

关键词： Fengyun meteorological satellites Data services and application International cooperation and support

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复合调理剂对栽培基质性能及蔬菜生长的影响

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江苏农业学报 2018年第4期34卷 887-896页

作者：范如芹罗佳张振华农业部农业环境重点实验室北京100081 江苏省农业科学院农业资源与环境研究所江苏南京210014

以农业废弃物替代珍贵的泥炭资源成为栽培基质的主要原料是设施农业发展的必经之路。但农业废弃物原料基质普遍存在持水性差、养分保蓄能力差、容重大、易板结、孔隙性差等问题,大大限制了其应用推广。本研究以发酵床废弃垫料(SPLC)为... 详细信息

以农业废弃物替代珍贵的泥炭资源成为栽培基质的主要原料是设施农业发展的必经之路。但农业废弃物原料基质普遍存在持水性差、养分保蓄能力差、容重大、易板结、孔隙性差等问题,大大限制了其应用推广。本研究以发酵床废弃垫料(SPLC)为原料的配方基质为研究对象,通过高吸水树脂(SAP)、生物炭、硅藻土以不同比例混合,配制成不同基质复合调理剂,研究调理剂在废弃垫料以不同比例替代泥炭条件下对基质性能的影响,并进一步验证不同复合调理剂对基质栽培空心菜生长的影响。结果表明,未添加调理剂情况下,随SPLC比例提高及泥炭比例的降低,配方基质持水性、总孔隙度、通气孔隙度均明显降低,而电导率则显著升高;相应地,空心菜出苗率及株高、地上和地下生物量等生长指标也逐渐降低。添加复合调理剂后,各处理基质理化性质及空心菜生长差异明显,总体而言,调理剂中SAP的添加显著提高了基质持水性,促进了空心菜出苗及生长;随生物炭添加比例的增加,配方基质孔隙度及持水量呈上升趋势,但电导率也迅速上升;随硅藻土比例的增加,基质容重逐渐增加,但对基质电导率有降低作用。各复合调理剂综合作用结果显示,0.8 g/L SAP+5%生物炭+5%硅藻土及0.8 g/L SAP+10%生物炭+10%硅藻土2个调理剂配方明显改善了配方基质各项理化性状和空心菜生长,在SPLC比例由30%增至50%,泥炭比例由30%降至10%的情况下,仍然提高了空心菜产量。说明这2个复合调理剂可以有效改善配方基质性能,有助于农业废弃物替代泥炭成为蔬菜栽培基质的原料。

关键词：生物炭保水剂硅藻土栽培基质蔬菜

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Influence of sea-land breeze on the formation and dissipation of severe dense fog and its burst reinforcement in the Yellow Sea coastal area,China

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Science China Earth Sciences 2024年第2期67卷 432-449页

作者： Ya GAO Duanyang LIU Shuqi YAN Wenjun ZHOU Hongbin WANG fan ZU qin MEI Chuanxiang YI Ye SHENG Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing210041China Yancheng Meteorological Bureau Yancheng224000China Nanjing Joint Institute for Atmospheric Sciences Nanjing210041China Key Laboratory of Disaster Weather Chinese Academy of Meteorological SciencesBeijing100086China

Based on the global reanalysis data of the National Centers for Environmental Prediction(NCEP)/National Center for Atmospheric Research,the surface meteorological observation data,sounding data and satellite observation data,this paper comprehensively analyzes the evolution process and formation mechanism of a persistent severe dense fog process occurred on February 15–17,2015 in Yancheng,eastern *** the numerical simulation experiment of Weather Research and Forecast(WRF)model,we further analyze the impact of sea-land breeze on the formation and burst reinforcement of *** show that the precipitation caused by the southwesterly airflow in front of the upper-level trough and the low-pressure inverted trough are conducive to the formation of early rain fog,while the nighttime clear radiance under the control of surface cold high and the infiltration of weak cold advection are conducive to the formation and development of later radiation-advection *** WRF model simulates the fog evolution process,which is basically consistent with the actual fog area,and the simulation results are credible to a certain *** simulation results show that the establishment of sea breeze has an advection cooling effect on the near surface layer,which is conducive to the formation and development of the inversion layer on the near surface,providing stable stratification conditions for the formation and burst reinforcement of *** one hand,the strengthening of sea breeze circulation can continuously transport water vapor to the study *** the other,the occurrence of ultra-low level jet is favorable for the accumulation of low-level water *** the same time,the inversion intensity further strengthens,which is in favor of the burst reinforcement and long-term maintenance of fog.

关键词： Radiation-advection fog Sea-land breeze Atmospheric boundary layer Fog burst reinforcement WRF model

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水击基本方程的改进

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水利学报 2007年第8期38卷 948-952页

作者：杨玲霞李树慧侯咏梅范如琴郑州大学环水学院河南郑州450002 黄河勘测规划设计有限公司河南郑州450003

本文首先指出了当前用于水击计算的数学模型中的连续性方程式在恒定流时不能成立的问题,并通过进一步的理论推导,得到了新的水击波速计算公式和新的连续性方程。新的水击波速计算公式表明水击波速并非是一个常量,它的大小随流体动能沿... 详细信息

本文首先指出了当前用于水击计算的数学模型中的连续性方程式在恒定流时不能成立的问题,并通过进一步的理论推导,得到了新的水击波速计算公式和新的连续性方程。新的水击波速计算公式表明水击波速并非是一个常量,它的大小随流体动能沿程变化率与压强势能沿程变化率之比的变化而变化,同时也随管道断面相对变化量与压强相对变化量之比的变化而变化。新的连续性方程改善了老方程存在的不合理现象。本文还通过对水击现象的计算比较,进一步说明了老方程的确存在不合理现象,而新方程的计算结果是合理的。最后,分析指出了当前用于水击计算的连续性方程式在恒定流时不能成立的原因所在。

关键词：水击压强水击方程水击理论

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Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

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Regenerative Biomaterials 2024年第1期3卷 44-57页

作者： Xi Hua Mingzhuang Hou Lei Deng Nanning Lv Yong Xu Xuesong Zhu Huilin Yang qin Shi Hao Liu fan He Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Suzhou Medical CollegeSoochow UniversitySuzhou 215000China Department of Orthopedics Suzhou Wuzhong People’s HospitalSuzhouJiangsu Province 215128China Department of Orthopedic Surgery Lianyungang Clinical College of Xuzhou Medical UniversityLianyungang 222003China

The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone *** challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture ***,the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical support and controlled release of proosteogenic *** this study,a poly(L-lactic acid)(PLLA)/hyaluronic acid(HA)-based nanofibrous membrane was fabricated using the coaxial electrospinning *** incorporation of irisin into the core-shell structure of PLLA/HA nanofibers(PLLA/HA@Irisin)achieved its sustained *** vitro experiments demonstrated that the PLLA/HA@Irisin membranes exhibited favorable *** osteogenic differentiation of bone marrow mesenchymal stem cells(BMMSCs)was improved by PLLA/HA@Irisin,as evidenced by a significant increase in alkaline phosphatase activity and matrix ***,PLLA/HA@Irisin significantly enhanced the mitochondrial function of BMMSCs via the activation of the sirtuin 3 antioxidant *** assess the therapeutic effectiveness,PLLA/HA@Irisin membranes were implanted in situ into critical-sized calvarial defects in *** results at 4 and 8 weeks post-surgery indicated that the implantation of PLLA/HA@Irisin exhibited superior efficacy in promoting vascularized bone formation,as demonstrated by the enhancement of bone matrix synthesis and the development of new blood *** results of our study indicate that the electrospun PLLA/HA@Irisin nanofibers possess characteristics of a biomimetic periosteum,showing potential for effectively treating critical-sized bone defects by improving the mitochondrial function and maintaining redox homeostasis of BMMSCs.

关键词： periosteum irisin mitochondrial function critical-sized bone defect redox homeostasis

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