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[Recent progress in mass spectrometry imaging using nanospray desorption electrospray ionization]

Se pu = Chinese journal of chromatography 2025年第1期43卷 43-49页

作者： Jing-Bo Wang Xiao-Lan Li Rui-Xia fan ping Lü Rui-Chuan Yin West China School of Pharmacy Sichuan University Chengdu 610041 China.

Ambient mass spectrometry imaging (MSI) enables hundreds of analytes in tissue sections to be directly mapped at atmospheric pressure with minimal sample preparation. This field is currently experiencing rapid growth, with numerous reported ambient ionization techniques resulting in a "hundred flowers bloom" situation. Nanospray desorption electrospray ionization (nano-DESI), developed by the Laskin group in 2010, is a widely used liquid-extraction-based ambient ionization technique that was first used for mass spectrometry imaging of tissue in 2012. The nano-DESI probe comprises a primary capillary and a nanospray capillary, with the latter efficiently transferring analyte-containing droplets via a tiny liquid bridge formed between the probe and sample surface, thereby enabling nanoelectrospray ionization (nano-ESI) in front of the inlet of a mass spectrometer. The advantages of nano-DESI MSI include minimal sample preparation, high spatial resolution, and high sensitivity. These features are well-suited for imaging various sample types, including frozen tissue sections, microbial communities, and environmental samples. A PubMed-database search using the "nano-DESI" keyword revealed 72 related articles in the 2010-2024 period, with 34 of them published between 2021 and 2024, which indicates that nano-DESI has rapidly developed as an ambient ionization technique over recent years. Herein, we briefly introduce key nano-DESI-MSI research progress reported in the past three years with the aim of better understanding and facilitating the use of this technology. We first discuss advances in ion-source development. Since no commercial nano-DESI source exists, designing and constructing ion sources remain technical challenges that limit its development. Nano-DESI has been successfully coupled with various types of mass spectrometer, including LTQ Orbitrap, quadrupole-Orbitrap (Q Exactive), 6560 IM QTOF, timsTOF Pro2, triple quadrupole, and FTICR. These couplings have signi

关键词： ambient mass spectrometry imaging nanospray desorption electrospray ionization spatial proteomics structural characterization of lipid

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Evaluating the AS-level Internet models:beyond topological characteristics

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Chinese Physics B 2012年第2期21卷 591-595页

作者： fan Zheng-ping Department of Automation Sun Yat-Sen UniversityGuangzhou 510275China

A surge number of models has been proposed to model the Internet in the past decades. However, the issue on which models are better to model the Internet has still remained a problem. By analysing the evolving dynamics of the Internet, we suggest that at the autonomous system （AS） level, a suitable Internet model, should at least be heterogeneous and have a linearly growing mechanism. More importantly, we show that the roles of topological characteristics in evaluating and differentiating Internet models are apparently over-estimated from an engineering perspective. Also, we find that an assortative network is not necessarily more robust than a disassortative network and that a smaller average shortest path length does not necessarily mean a higher robustness, which is different from the previous observations. Our analytic results are helpful not only for the Internet, but also for other general complex networks.

关键词： AS-level Internet scale-free model robustness

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Parametric estimation of ultra wideband radar targets

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Journal of Systems Engineering and Electronics 2009年第3期20卷 499-503页

作者： fan ping Jing Zhanrong School of Electronics and Information Northwestern Polytechnical Univ. Xi'an 710072 P. R. China

Based on the analysis of impulse response properties, a scattering model of ultra wideband （UWB） radar targets is developed to estimate the target parameters exactly. With this model, two algorithms of multiple signal classification （MUSIC）, and matrix pencil （MP）, are introduced to calculate the scattering center parameters of targets and their performances are compared. The simulation experiments show that there are no differences in the estimation precision of MUSIC and MP methods when the signal-to-noise ratio （SNR） is larger than 13 dB. However, the MP method has a better performance than that of MUSIC method when the SNR is smaller than 13 dB. Besides, the time consuming of MP method is less than that of MUSIC method. Therefore, the MP algorithm is preferred for the parametric estimation of UWB radar targets.

关键词： ultra wideband radar parametric estimation scattering center modeling

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Unifying logic rules and machine learning for entity enhancing

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Science China(Information Sciences) 2020年第7期63卷 142-160页

作者： Wenfei fan ping LU Chao TIAN School of Informatics University of Edinburgh Shenzhen Institute of Computing Sciences Shenzhen University Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University Alibaba Group

This paper proposes a notion of entity enhancing, which unifies entity resolution and conflict resolution, to identify tuples that refer to the same real-world entity and at the same time, correct semantic inconsistencies. We propose to unify rule-based and machine learning(ML) methods for entity enhancing, by embedding ML classifiers as predicates in logic rules. We model entity enhancing by extending the chase. We show that the chase warrants correctness justification and the Church-Rosser property. Moreover, we settle fundamental problems associated with entity enhancing, including the enhancing, consistency, satisfiability,and implication problems, ranging from NP-complete and coNP-complete to Π~p-complete. Taken together,these provide a new theoretical framework for unifying entity resolution and conflict resolution.

关键词： logic rules machine learning entity enhancing entity resolution conflict resolution

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Reduction of nitrobenzene by the catalyzed Fe/Cu process

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Journal of Environmental Sciences 2008年第8期20卷 915-921页

作者： XU Wenying LI ping fan Jinhong The National Engineering Research Center for Urban Pollution Control Tongji University Shanghai 200092 China

The polarization behavior of the couple Fe/Cu in 100 mg/L nitrobenzene aqueous solution was studied using Evans coupling *** results indicated that the iron corrosion was limited by both anodic and cathodic half-cell reactions under the neutral conditions,and cathodically controlled under the alkaline *** experiments were performed to study the effect of solution pH,reaction duration,concentration,type of electrolyte,and dissolved oxygen(DO)on the reduction of nitrobenzene by the catal...

关键词： nitrobenzene Evans coupling diagram reduction mechanisms influencing factors

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Facile tuning of hydrogel properties by manipulating cationic-aromatic monomer sequences

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Science China Chemistry 2021年第9期64卷 1560-1568页

作者： Hailong fan Yirong Cai Jian ping Gong Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporo001-0021Japan Graduate School of Life Science Hokkaido UniversitySapporo001-0021Japan Faculty of Advanced Life Science Hokkaido UniversitySapporo001-0021Japan Global Station for Soft Matter GI-CoRE Hokkaido UniversitySapporo001-0021Japan

Copolymer hydrogels formed from cationic and aromatic monomers with identical monomer compositions but different average sequences were synthesized by free-radical copolymerization in various *** found that hydrogels with one-componentrich segments are mechanically stronger than those with adjacent-rich monomer sequences in water,while hydrogels with a rich cation-πadjacent sequence showed excellent mechanical strength and underwater adhesion in saltwater(0.7 M Na Cl).The molecular mechanisms for these behaviors are discussed in terms of polymer *** work reveals the importance of monomeric sequences in determining hydrogel properties and provides a facile approach to develop hydrogels with different properties but the same monomer composition.

关键词： free-radical polymerization monomer sequence hydrogel cation-πinteractions underwater adhesion

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Optical and electrical properties of InGaZnON thin films

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Chinese Physics B 2020年第1期29卷 475-481页

作者： Jian Ke Yao fan Ye ping fan Shenzhen Key Laboratory of Advanced Thin Films and Applications College of Physics and EnergyShenzhen UniversityShenzhen 518060China

The substrate temperature(Ts)and N2 partial pressure(PN2)dependent optical and electrical properties of sputtered InGaZnON thin films are *** the increased Ts and PN2,the thin film becomes more crystallized and *** Hall mobility,free carrier concentration(Ne),and electrical conductivity increase with the lowered interfacial potential barrier during crystal *** photoluminescence(PL)intensity decreases with the increased *** band gap(Eg)narrows and the linear refractive index(n1)increases with the increasing concentration of N in the thin *** Stokes shift between the PL peak and absorption edge decreases with *** n1,dispersion energy,average oscillator wavelength,and oscillator length strength all increase with *** single oscillator energy decreases with *** nonlinear refractive index and third order optical susceptibility increase with *** Seebeck coefficient,electron effective mass,mean free path,scattering time,and plasma energy are all Ne dependent.

关键词： InGaZnON thin films linear and nonlinear optical properties Seebeck coefficient electron effective mass

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Theory of Critical Phenomena with Memory

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Chinese Physics Letters 2022年第12期39卷 1-7页

作者： Shaolong Zeng Sue ping Szeto fan Zhong State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-Sen UniversityGuangzhou 510275China

Memory is a ubiquitous characteristic of complex systems,and critical phenomena are one of the most intriguing phenomena in ***,we propose an Ising model with memory,develop a corresponding theory of critical phenomena with memory for complex systems,and discover a series of surprising novel *** show that a naive theory of a usual Hamiltonian with a direct inclusion of a power-law decaying long-range temporal interaction violates radically a hyperscaling law for all spatial dimensions even at and below the upper critical *** entails both indispensable consideration of the Hamiltonian for dynamics,rather than the usual practice of just focusing on the corresponding dynamic Lagrangian alone,and transformations that result in a correct theory in which space and time are inextricably interwoven,leading to an effective spatial dimension that repairs the hyperscaling *** theory gives rise to a set of novel mean-field critical exponents,which are different from the usual Landau ones,as well as new universality *** exponents are verified by numerical simulations of the Ising model with memory in two and three spatial dimensions.

关键词： critical Hamiltonian scaling

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Topological Stability and Pseudo-orbit Tracing Property for Homeomorphisms on Uniform Spaces

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Acta Mathematica Sinica,English Series 2022年第2期38卷 431-442页

作者： Ke Song YAN fan ping ZENG School of Information and Statistics Guangxi University of Finance and EconomicsNanning 530003P.R.China

In this paper,we investigate the topological stability and pseudo-orbit tracing property for homeomorphisms on uniform *** introduce the concept of topological stability for homeomorphisms on compact uniform spaces and prove that if a homeomorphism on a compact uniform space is expansive and has pseudo-orbit tracing property,then it is topologically ***,we discuss the topological stability for homeomorphisms on uniform spaces from the view of *** introduce definitions of topologically stable point and shadowable point for homeomorphisms on uniform spaces and show that every shadowable point of an expansive homeomorphism on a compact uniform space is topologically stable.

关键词： Topological stability pseudo-orbit tracing property expansiveness uniform space

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