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Marek’s disease virus-encoded microRNAs: genomics, expression and function

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Science China(Life Sciences) 2010年第10期53卷 1174-1180页

作者： LUO Jun TENG Man fan jianming WANG fangYu ZHOU Ling DENG RuiGuang ZHANG GaiPing Key Laboratory of Animal Immunology of Ministry of Agriculture Henan Provincial Key Laboratory of Animal ImmunologyHenan Academy of Agricultural SciencesZhengzhou 450002China Laboratory of Toxicology College of Public HealthZhengzhou UniversityZhengzhou 450001China

MicroRNAs (miRNAs) are the recently discovered small non-coding RNA molecules that have post-transcriptional regulatory functions in many important biological processes. A large number of miRNAs have been found to be encoded by viral genomes, especially in herpesviruses. Previous research regarding miRNAs encoded by herpesviruses, including Marek’s disease virus (MDV), has demonstrated their involvement in lytic replication, latent infection, T-lymphocyte transformation and tumorigenesis. MDV is an oncogenic alphaherpesvirus, with the ability to induce tumors in natural hosts; however, formation of these tumors can be prevented by immunization with attenuated or nonpathogenic forms of the virus. Marek’s disease is considered to be a good biomedical model for investigating the biology, genetics, and immunology of tumorigenesis. In this paper, we review the discovery and identification of MDV-encoded miRNAs, along with their genomics, expression profiles, and currently known functions. We also discuss the prospects and techniques possibly applicable to the further investigation of the biological roles of MDV-encoded miRNAs.

关键词： MDV miRNA herpesvirus cancer tumorigenesis

An almost full reversible lithium-rich cathode: Revealing the mechanism of high initial coulombic efficiency

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Journal of Energy Chemistry 2021年第11期30卷 120-126,I0003页

作者： Dong Luo jianming fan Zhuo Yao Huixian Xie Jiaxiang Cui Yajun Yang Xiaokai Ding Jiapeng Ji Shuxing Wu Ming Ling Chenyu Liu Zhan Lin Guangzhou Key Laboratory of Clean Transportation Energy Chemistry School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 510006GuangdongChina Fujian Provincial Key Laboratory of Clean Energy Materials College of Chemistry and MaterialsLongyan UniversityLongyan 364012FujianChina Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina

Low initial Coulombic efficiency (ICE) is an important impediment to practical application of Li-rich layered oxides (LLOs), which is due to the irreversible oxygen release. It is generally considered that surface oxygen vacancies are conducive to the improvement of ICE of LLOs. To reveal the relation of oxygen vacancies and ICE, sample PLO (Li-Mn-Cr-O) and its treated product (TLO) are comprehensive investigated in this work. During the treated process, part of oxygen atoms return to original constructed vacancies. It makes oxygen vacancies in sample TLO much poorer than those in sample PLO, and induces the formation of Li-poor spinel-layered integrated structure. Electrochemical measurement indicates the ICE of sample PLO is only 80.8%, while sample TLO is almost full reversible with the ICE of ~97.1%. In term of high-energy X-ray diffraction, scanning transmission electron microscopy, X-ray photoelectron spectroscopy and synchrotron hard/soft X-ray absorption spectroscopy, we discover that the ICE is difficult to be improved significantly just by building oxygen vacancies. LLOs with high ICE not only have to construct suitable oxygen vacancies, but also require other components with Li-poor structure to stabilize oxygen. This work provides deep insight into the mechanism of high ICE, and will contribute to the design and development of LLOs for next-generation high-energy lithium-ion batteries.

关键词： Li-ion batteries Li-rich layered oxides Initial coulombic efficiency Oxygen vacancies

Development technologies for Triassic Chang 7 shale oil in Ordos Basin: A case study of Qingcheng Oilfield, NW China

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Petroleum Exploration and Development 2023年第6期50卷 1426-1444页

作者： HE Yonghong XUE Ting LI Zhen BAI Xiaohu fan jianming ZHANG Xuze PetroChina Changqing Oilfield Company Xi’an 710018China National Engineering Laboratory for Exploration and Development of Low Permeability Oil&Gas Fields Xi’an 710018China Research Institute of Exploration&Development PetroChina Changqing Oilfield CompanyXi’an 710018China Oil&Gas Technology Research Institute PetroChina Changqing Oilfield CompanyXi’an 710018China

The reservoirs in the seventh member of the Triassic Yanchang Formation (Chang 7 Member) in the Qingcheng Oilfield of the Ordos Basin are characterized by thin sandbody, tight rocks, high heterogeneity, low formation pressure coefficient, and complex geomorphology. Through the efforts in the stages of exploration, appraisal, pilot testing and development, a series of key technologies have been formed, including “sweet spot” optimization, differentiated three-dimensional well deployment, fast drilling and completion of large-cluster horizontal well, intensively-staged volume fracturing in long horizontal well, and optimization of rational production system. Furthermore, a production organization mode represented by factory-like operations on loess platform has been implemented. Application of these technologies has enabled to significantly improve the single-well production of the Qingcheng Oilfield, reduce the investment cost, and realize a large-scale and beneficial development at a full cost below $55 per barrel. In 2022, the annual production of Chang 7 shale oil in the Ordos Basin reached 221×10^(4) t, accounting for 70% of the annual shale oil production of China. The practice of development technologies in the Qingcheng Oilfield provides valuable references for efficient development of continental shale oil.

关键词： Ordos Basin shale oil development technology development effect Qingcheng Oilfield

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高铝煤矸石铝硅分级提取实验研究

无机盐工业 2019年第11期51卷 65-68页

作者：范剑明鄂尔多斯职业学院内蒙古自治区煤基固废高值化利用工程实验室

分级研究了热活化条件下高铝煤矸石在盐酸和氢氧化钠溶液中的铝硅溶出行为。采用X射线衍射仪(XRD)、扫描电镜(SEM)和比表面积测定仪(BET)对煤矸石试样做了表征分析。通过正交实验分析了反应温度、反应时间、初始酸碱浓度和固液比对热活... 详细信息

分级研究了热活化条件下高铝煤矸石在盐酸和氢氧化钠溶液中的铝硅溶出行为。采用X射线衍射仪(XRD)、扫描电镜(SEM)和比表面积测定仪(BET)对煤矸石试样做了表征分析。通过正交实验分析了反应温度、反应时间、初始酸碱浓度和固液比对热活化处理后高铝煤矸石中Al2O3和酸浸渣SiO2溶出率的影响。结果表明:酸浸溶出Al2O3反应过程中,固液质量比和酸浸时间对溶出率的影响最为显著,酸浸过程的最优工艺条件:初始盐酸质量分数为20%、酸浸温度为90℃、酸浸时间为2.5 h、固液质量比为1∶6,在此条件下,Al2O3的浸取率达82.95%;强碱溶解酸浸渣溶出SiO2反应过程最优工艺条件:碱溶温度为95℃、碱溶时间为2.0 h、NaOH质量分数为20%、固液质量比为1∶10,在此条件下SiO2溶出率为69.74%,碱溶温度和碱液浓度对溶出率的影响最为显著。

关键词：高铝煤矸石三氧化二铝二氧化硅分级提取

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厢式货车气动减阻装置的减阻效果研究

汽车工程 2019年第6期41卷 688-695页

作者：许建民范健明厦门理工学院机械与汽车工程学院厦门361024 福建省客车及特种车辆研发协同创新中心厦门361024

为降低某厢式货车的气动阻力系数,设计了不同形状的仿生导流罩、尾部减阻装置和仿生非光滑表面结构,分析不同单一减阻装置对整车风阻系数的影响,详细探讨了不同单一减阻装置的减阻机理。最后研究了不同单一减阻装置同时加装在同一货车... 详细信息

为降低某厢式货车的气动阻力系数,设计了不同形状的仿生导流罩、尾部减阻装置和仿生非光滑表面结构,分析不同单一减阻装置对整车风阻系数的影响,详细探讨了不同单一减阻装置的减阻机理。最后研究了不同单一减阻装置同时加装在同一货车模型的综合减阻效果。结果表明:仿生导流罩的减阻效果要好于传统导流罩,随着导流罩侧裙延伸长度的增加,货车整车阻力系数逐渐变小。当底部导流板倾角θ=45°时模型的阻力系数获得最小值。基于生物表面仿生减阻理论在货车侧面布置半球面凹坑和半椭球面凹坑均具有较好的减阻效果。复合减阻装置货车模型的最大减阻率达22.7%。

关键词：厢式货车仿生导流罩尾部减阻装置仿生非光滑表面复合减阻装置

Preparation and light-induced carbon monoxide delivery properties of Ru-CORM@ hydrogel hybrid

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Preparation and light-induced carbon monoxide delivery prope...

高危化工行业视域下高校实验室安职环管理机制建设探讨

中国化学会第十届全国无机化学学术会议

作者： Lu Qiao Mixia Hu jianming fan Baohua Zhu College of Chemistry and Chemical Engineering Inner Mongolia University Key Lab of Fine Organic Synthesis Inner Mongolia Autonomous Region

Many studies have recently shown that low and safe dose of CO has been linked to display various physiological effects, such as anti-inflammatory, anti-apoptotic, anti-proliferative and vasodilation . However, it is also best known that CO is a highly toxic gas because of its high affinity toward hemoglobin to affect the oxygen transport, which restricts its practicability as inhaled gas for therapeutic application. Therefore, transition metal CO-releasing molecules(CORMs) were designed and developed in order to present an alternative way to deliver controlled amounts CO to cells and target tissues. Furthermore, the hydrogels are usually used as drug carrier due to their low irritation and good biocompatibility, which are similar to those of extracellular matrices . Herein, we report the preparation of the new phototriggered CO-releasing material, Ru-CORM@CS-PVA, by reactions of the Ru carbonyl complex with pH responsive hydrogel(CS-PVA) and its light-induced CO delivery properties.

关键词： Ru carbonyl complex CO release CS-PVA pH responsive

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实验技术与管理 2019年第9期36卷 233-235页

作者：范剑明鄂尔多斯职业学院化学工程系

提出高校实验室安全管理工作可借鉴高危化工行业成熟经验,从单一的安全管理扩展到安全、职业健康与环保一体化管理,提高管理层对安职环管理工作整体性和重要性的认识,建立适合高校实验室自身特征的安职环应急管理机制,反馈行业主管部门... 详细信息

提出高校实验室安全管理工作可借鉴高危化工行业成熟经验,从单一的安全管理扩展到安全、职业健康与环保一体化管理,提高管理层对安职环管理工作整体性和重要性的认识,建立适合高校实验室自身特征的安职环应急管理机制,反馈行业主管部门健全监管体系,对促进高校内涵发展具有重要作用。

关键词：高校高危化工行业安职环管理机制

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应用应力补偿法定量测量透明固体中的声应力

石油物探 1989年第2期28卷 101-107页

作者：范建明地质矿产部石油物探研究所

把静态光弹试验中的应力补偿法运用到动态光弹测试中,可以定量测定透明固体中任一点的声应力。本文介绍了定量测量的方法和原理,并且定量测定了脉冲纵波掠入射(玻璃平自由表面)及其反射横波的应力。

关键词：应力补偿法透明固体声应力

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基于正交试验法的厢式货车气动减阻优化

重庆大学学报（自然科学版） 2020年第3期43卷 12-26页

作者：许建民范健明厦门理工学院机械与汽车工程学院福建厦门361024 福建省客车及特种车辆研发协同创新中心福建厦门361024

为了优化某厢式货车的气动阻力系数,设计了驾驶室前部仿生减阻结构、顶部和侧部涡流发生器、底部涡流发生器等3种气动减阻装置。研究了3种单一气动减阻装置主要相关参数对气动阻力的影响,分别从货车外流场的速度轨迹、压力分布和湍动能... 详细信息

为了优化某厢式货车的气动阻力系数,设计了驾驶室前部仿生减阻结构、顶部和侧部涡流发生器、底部涡流发生器等3种气动减阻装置。研究了3种单一气动减阻装置主要相关参数对气动阻力的影响,分别从货车外流场的速度轨迹、压力分布和湍动能分布等3方面详细分析了各单一气动减阻装置的减阻效果。在此基础上采用正交试验法对3种气动减阻装置的主要参数进行优化,获得最优减阻货车模型。研究表明:驾驶室前部突出部分的长度对货车整车气动阻力系数的影响比倾角更大;最优货车头部形状的倾角和长度分别为135°和300 mm,该模型的气动阻力系数为0.7214,相对于货车原始模型的减阻率为8.93%;涡流发生器的高度和位置对货车的减阻效果均有较大的影响;涡流发生器可以增加货车尾部分离区流场的能量,使得尾涡区减小,气动压差阻力减小;3种气动减阻装置对货车气动阻力系数的影响大小依次为:底部涡流发生器、货车前部仿生减阻结构、顶部和侧部涡流发生器,其最优厢式货车模型的空气阻力系数为0.6833,其复合减阻装置的最佳减阻率为13.8%。

关键词：厢式货车仿生减阻结构涡流发生器正交试验法复合减阻