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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui yang Nan Mo Le Tong jianhong Dong Ziwei fan Mengxian Jia Juanqing Yue ying wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui fan Li Chen Jie wang Xiao-Qian yang Chun-Hao yang Shi-Jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei fan Mengxian Jia jian zhou zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua jianhong Dong Zheyu fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu ying wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Biodegradable Polypeptide-based Vesicles with Intrinsic Blue Fluorescence for Antibacterial Visualization

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Chinese Journal of Polymer Science 2021年第11期39卷 1412-1420页

作者： Yu-ying yang Ling-Shan Chen Min Sun Cong-Yu wang Zhen fan jian-Zhong du Department of Orthopedics Shanghai Tenth People's HospitalTongji UniversityShanghai 200072China Department of Polymeric Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China Institute for Advanced Study Tongji UniversityShanghai 200092China

Fluorescence imaging has been an indispensable tool to provide dynamic information about the localization and quantity of ***,due to the intrinsic hollow structure and modularized biofunctionalities,polymer vesicles have been widely applied in biomedical ***,most polymer vesicles are embedded with organic fluorophores for fluorescence imaging,which have certain drawbacks such as leakage and possible ***,we present a biodegradable polypeptide-based vesicle with intrinsic blue fluorescence without introducing any fluorophore for real-time visualization of antibacterial *** modular design to integrate multiple functional fragments,poly(ε-caprolactone)-block-poly(tryptophan)-block-poly(lysine-stat-phenylalanine)[PCL25-b-PTrp2-b-P(Lys13-statPhe4)]was synthesized,where PCL chains form the hydrophobic membrane,P(Lys-stat-Phe)and PTrp provide intrinsic fluorescence and broadspectrum antibacterial *** is noteworthy that the fluorescence emission was shifted from invisible ultraviolet range of amino acids to visible range(emission maximum at 436 nm),which makes it possible to visualize the antibacterial *** addition,through utilizing the intrinsic fluorescence of vesicles,confocal fluorescent imaging of vesicles with bacteria validated the specific adhesion of vesicle towards bacteria,and the bacterial death through membrane ***,we provided a novel approach to developing biodegradable fluorescent polypeptide-based vesicles for real-time visualization of antibacterial process.

关键词： Polypeptide-based vesicles Intrinsic fluorescence Antibacterial visualization

Illuminating Neural Circuits in Alzheimer’s Disease

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Neuroscience Bulletin 2021年第8期37卷 1203-1217页

作者： yang ying jian-Zhi wang Department of Pathophysiology School of Basic MedicineMinistry of Education Key Laboratory for Neurological DisordersHubei Key Laboratory for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Alzheimer’s disease(AD)is the most common neurodegenerative disorder and there is currently no *** circuit dysfunction is the fundamental mechanism underlying the learning and memory deficits in patients with ***,it is important to understand the structural features and mechanisms underlying the deregulated circuits during AD progression,by which new tools for intervention can be ***,we briefly summarize the most recently established cutting-edge experimental approaches and key techniques that enable neural circuit tracing and manipulation of their *** also discuss the advantages and limitations of these ***,we review the applications of these techniques in the discovery of circuit mechanisms underlyingβ-amyloid and tau pathologies during AD progression,and as well as the strategies for targeted AD treatments.

关键词： Neural circuit Alzheimer’s disease Single cell RNA sequencing Neural circuit tracing Optogenetics Chemogenetics

Spherical parametrization of genus-zero meshes by minimizing discrete harmonic energy

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第9期7卷 1589-1595页

作者： LI ying yang zhou-wang DENG jian-song Department of Mathematics University of Science and Technology of China Hefei 230026 China

The problem of spherical parametrization is that of mapping a genus-zero mesh onto a spherical surface. For a given mesh, different parametrizations can be obtained by different methods. And for a certain application, some parametrization results might behave better than others. In this paper, we will propose a method to parametrize a genus-zero mesh so that a surface fitting algorithm with PHT-splines can generate good result. Here the parametrization results are obtained by minimizing discrete har- monic energy subject to spherical constraints. Then some applications are given to illustrate the advantages of our results. Based on PHT-splines, parametric surfaces can be constructed efficiently and adaptively to fit genus-zero meshes after their spherical parametrization has been obtained.

关键词： Genus-zero meshes Spherical parametrization Discrete harmonic energy Constrained optimization

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di fan Wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

NETWORK ANALYSIS OF TERRORIST ACTIVITIES

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Journal of Systems Science & Complexity 2014年第6期27卷 1079-1094页

作者： FU Julei fan ying wang yang wang Shouyang College of Information System and Management National University of Defense Technology Department of Systems Science School of Management and Center for Complexity ResearchBeijing Normal University Department of Physics Bar-Ilan UniversityRamat Gan 52900Israel Academy of Mathematics and Systems Science Chinese Academy of Sciences

This paper uses an extensive network approach to "East Turkistan" activities by building both the one-mode and the bipartite networks for these *** the one-mode network,centrality analysis and spectrum analysis are used to describe the importance of each *** this basis,two types of core vertices——The center of communities and the intermediary vertices among communities— are *** weighted extreme optimization(WEO) algorithm is also applied to detect communities in the one-mode *** the "terrorist-terrorist organization" bipartite network,the authors adopt centrality analysis as well as clustering analysis based on the original bipartite network in order to calculate the importance of each vertex,and apply the edge clustering coefficient algorithm to detect the *** comparative and empirical analysis indicates that this research has been proved to be an effective way to identify the core members,key organizations,and communities in the network of "East Turkistan" terrorist *** results can provide a scientific basis for the analysis of "East Turkistan" terrorist activity,and thus provide decision support for the real work of "anti-terrorism".

关键词： Anti-terrorism complex networks terrorist activity network vertex centrality.

Synthesis of 1,2-allenic ketones through oxidation of homopropargyl alcohols with CrO_3(cat.)/TBHP under MWI

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Chinese Chemical Letters 2011年第3期22卷 268-271页

作者： Xin ying Zhang ying ying Qu yang yang wang Xue Sen fan School of Chemistry and Environmental Science Henan Key Laboratory for Environmental Pollution Control Henan Normal University Xinxiang 453007 China

A CrO3 catalyzed oxidation of homopropargyl alcohols with tert-butyl hydroperoxide under microwave irradiation was found to be an efficient and rapid alternative for the preparation of 1,2-allenic *** advantages of th... 详细信息

关键词： Allenic ketones Oxidation Microwave irradiation Chromium(Ⅵ) oxide tert-Butyl hydroperoxide